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Author Kartik Cherabuddi

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Efficacy of Losartan in Hospitalized Patients With COVID-19-Induced Lung Injury: A Randomized Clinical Trial.

Michael A Puskarich, Nicholas E Ingraham, Lisa H Merck, Brian E Driver, David A Wacker, Lauren Page Black, Alan E Jones, Courtney V Fletcher, Andrew M South, Thomas A Murray, Christopher Lewandowski, Joseph Farhat, Justin L Benoit, Michelle H Biros, Kartik Cherabuddi, Jeffrey G Chipman, Timothy W Schacker, Faheem W Guirgis, Helen T Voelker, Joseph S Koopmeiners, Christopher J Tignanelli, ,

<h4>Importance</h4>SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in preclinical models, although data in humans with COVID-19 remain mixed.<h4>Objective</h4>To test the efficacy of losartan to reduce lung injury in hospitalized patients with COVID-19.<h4>Design, setting, and ... Read more >>

JAMA Netw Open (JAMA network open)
[2022, 5(3):e222735]

Cited: 1 time

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Effect of losartan on hospitalized patients with COVID-19-induced lung injury: A randomized clinical trial

Michael Puskarich, Nicholas Ingraham, Lisa Merck, Brian Driver, David Wacker, Lauren Page Black, Alan Jones, Courtney Fletcher, Andrew South, Andrew Nelson, Thomas Murray, Christopher Tignanelli, Christopher Lewandowski, Joseph Farhat, Justin Benoit, Dana Byrne, Alex Hall, Ronald Reilkoff, Michelle Biros, Kartik Cherabuddi, Jeffrey Chipman, Timothy Schacker, Tyler Bold, Kenneth Beckman, Ryan Langlois, Matthew Aliota, Faheem Guirgis, James Galbriath, Margaret Beyer, Chas Salmen, Brian Roberts, David Wright, Helen Voelker, Joseph Koopmeiners,

<h4>Background</h4> SARS-CoV-2 viral entry may disrupt angiotensin II (Ang II) homeostasis in part via ACE2 downregulation, potentially contributing to COVID-19 induced lung injury. Preclinical models of viral pneumonias that utilize ACE2 demonstrate Ang II type 1 receptor (AT1R) blockade mitigates lung injury, though observational COVID-19 data addressing the effect of ... Read more >>

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