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Author Karthik Srinivasan

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Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs

Dongxing Chen, Cheng Dong, Guangping Dong, Karthik Srinivasan, Jinrong Min, Nicholas Noinaj, Rong Huang,

Abstract The interactions of a series of bisubstrate analogs with protein N-terminal methyltransferase 1 (NTMT1) were examined to probe the molecular properties of the NTMT1 active site through biochemical characterization and structural studies. Our results indicate that a 2-C to 4-C atom linker enables its respective bisubstrate analog to occupy ... Read more >>

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Diabetes mellitus in the Tamil Nadu State-Noncommunicable diseases nurse model in diabetic retinopathy screening.

Rengappa Ramakrishnan, Syed Mohideen Abdul Khadar, Karthik Srinivasan, Hariesh Kumar, Valaguru Vijayakumar,

Tamil Nadu is one of the states in India, where the diabetic retinopathy (DR) project was implemented in the Tirunelveli District. Aravind Eye Hospital, Tirunelveli was the mentoring institution and ophthalmology department of Tirunelveli Medical College and Hospital (TVMCH) was the implementing partner. The objective of the project was to ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(Suppl 1):S78-S82]

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A Novel Fracture Prediction Model Using Machine Learning in a Community-Based Cohort.

Sung Hye Kong, Daehwan Ahn, Buomsoo Raymond Kim, Karthik Srinivasan, Sudha Ram, Hana Kim, A Ram Hong, Jung Hee Kim, Nam H Cho, Chan Soo Shin,

The prediction of fracture risk in osteoporotic patients has been a topic of interest for decades, and models have been developed for the accurate prediction of fracture, including the fracture risk assessment tool (FRAX). As machine-learning methodologies have recently emerged as a potential model for medical prediction tools, we aimed ... Read more >>

JBMR Plus (JBMR plus)
[2020, 4(3):e10337]

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Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome.

Diane M Hargrove, Sudarkodi Alagarsamy, Glenn Croston, Régent Laporte, Steve Qi, Karthik Srinivasan, Javier Sueiras-Diaz, Kazimierz Wiśniewski, Jennifer Hartwig, Mark Lu, Alexander P Posch, Halina Wiśniewska, Claudio D Schteingart, Pierre J-M Rivière, Violetta Dimitriadou,

Glucagon-like peptide-2 (GLP-2) agonists have therapeutic potential in clinical indications in which the integrity or absorptive function of the intestinal mucosa is compromised, such as in short bowel syndrome (SBS). Native hGLP-2, a 33-amino acid peptide secreted from the small intestine, contributes to nutritional absorption but has a very short ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2020, 373(2):193-203]

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Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease.

Jozlyn R Clasman, Renata K Everett, Karthik Srinivasan, Andrew D Mesecar,

Coronavirus papain-like proteases (PLPs or PLpro), such as the one encoded in the genome of the infectious Middle East Respiratory Syndrome (MERS) virus, have multiple enzymatic activities that promote viral infection. PLpro acts as a protease and processes the large coronavirus polyprotein for virus replication. PLpro also functions as both ... Read more >>

Antiviral Res. (Antiviral research)
[2020, 174:104661]

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Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists.

Kazimierz Wiśniewski, Steve Qi, John Kraus, Brian Ly, Karthik Srinivasan, Hiroe Tariga, Glenn Croston, Erin La, Halina Wiśniewska, Carlos Ortiz, Régent Laporte, Pierre J-M Rivière, Gebhard Neyer, Diane M Hargrove, Claudio D Schteingart,

The vasopressin analogue desmopressin (desamino-d-arginine8 vasopressin, dDAVP, 1) is a potent vasopressin 2 (V2) receptor (V2R) agonist approved in many countries for the treatment of diabetes insipidus, primary nocturnal enuresis, nocturia, and coagulation disorders. Since 1 is primarily excreted via the kidneys, an age-related decline in kidney function leads to ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2019, 62(10):4991-5005]

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Erratum: Deep convolutional network for animal sound classification and source attribution using dual audio recordings [J. Acoust. Soc. Am. 145, 654 (2019)].

Tuomas Oikarinen, Karthik Srinivasan, Olivia Meisner, Julia B Hyman, Shivangi Parmar, Adrian Fanucci-Kiss, Robert Desimone, Rogier Landman, Guoping Feng,

J. Acoust. Soc. Am. (The Journal of the Acoustical Society of America)
[2019, 145(4):2209]

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Deep convolutional network for animal sound classification and source attribution using dual audio recordings.

Tuomas Oikarinen, Karthik Srinivasan, Olivia Meisner, Julia B Hyman, Shivangi Parmar, Adrian Fanucci-Kiss, Robert Desimone, Rogier Landman, Guoping Feng,

This paper introduces an end-to-end feedforward convolutional neural network that is able to reliably classify the source and type of animal calls in a noisy environment using two streams of audio data after being trained on a dataset of modest size and imperfect labels. The data consists of audio recordings ... Read more >>

J. Acoust. Soc. Am. (The Journal of the Acoustical Society of America)
[2019, 145(2):654]

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Deep Convolutional Network for Animal Sound Classification and Source Attribution using Dual Audio Recordings

Tuomas Oikarinen, Karthik Srinivasan, Olivia Meisner, Julia Hyman, Shivangi Parmar, Robert Desimone, Rogier Landman, Guoping Feng,

ABSTRACT We introduce an end-to-end feedforward convolutional neural network that is able to reliably classify the source and type of animal calls in a noisy environment using two streams of audio data after being trained on a dataset of modest size and imperfect labels. The data consists of audio recordings ... Read more >>

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Service provider perceptions of the trend in severity of symptoms and complications in women admitted following an incomplete abortion.

Athula Kaluarachchi, Sumithra Tissera, Achini C Jayatilleke, Suchira Suranga, Philip Guest, Karthik Srinivasan, Bela Ganatra,

Background:Sri Lankan abortion law which dates back to the year 1883, and still unchanged, only allows a legal termination when the mother's life is in danger. Many studies undertaken in the country estimates that even in the light of such a backdrop, and with a high contraceptive prevalence rate, many ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2018, 7(6):1521-1526]

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Prediction of Algal Blooms in the Great Lakes through a Convolution Neural Network of Remote Sensing Data

Karthik Srinivasan, Vikram Duvvur, Daniel Hess,

Abstract Harmful algal blooms (HABs) are the proliferation of algae due to eutrophication and have severe repercussions to the ecological balance in many water bodies, due to the toxins the algae produce. Additionally, the identification and prediction of these HABs has been a challenge in the scientific community due to ... Read more >>

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Effects of office workstation type on physical activity and stress.

Casey M Lindberg, Karthik Srinivasan, Brian Gilligan, Javad Razjouyan, Hyoki Lee, Bijan Najafi, Kelli J Canada, Matthias R Mehl, Faiz Currim, Sudha Ram, Melissa M Lunden, Judith H Heerwagen, Kevin Kampschroer, Esther M Sternberg,

OBJECTIVE:Office environments have been causally linked to workplace-related illnesses and stress, yet little is known about how office workstation type is linked to objective metrics of physical activity and stress. We aimed to explore these associations among office workers in US federal office buildings. METHODS:We conducted a wearable, sensor-based, observational ... Read more >>

Occup Environ Med (Occupational and environmental medicine)
[2018, 75(10):689-695]

Cited: 4 times

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Developing a Three-Layered Synthetic Microsurgical Simulation Vessel.

Lilli Cooper, Katia Sindali, Karthik Srinivasan, Martin Jones, Nora Nugent,

BACKGROUND: Microsurgery is increasingly relevant, and is difficult to learn. Simulation is relied upon ever more in microvascular training. While living models provide the ultimate physiological feedback, we are ethically obliged to optimize non-living models to replace, refine, and reduce the use of animals in training. There is currently no three-layered ... Read more >>

J Reconstr Microsurg (Journal of reconstructive microsurgery)
[2019, 35(1):15-21]

Cited: 1 time

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Enhanced Neural Processing by Covert Attention only during Microsaccades Directed toward the Attended Stimulus.

Eric Lowet, Bruno Gomes, Karthik Srinivasan, Huihui Zhou, Robert John Schafer, Robert Desimone,

Attention can be "covertly" directed without eye movements; yet, even during fixation, there are continuous microsaccades (MSs). In areas V4 and IT of macaques, we found that firing rates and stimulus representations were enhanced by attention but only following a MS toward the attended stimulus. The onset of neural attentional ... Read more >>

Neuron (Neuron)
[2018, 99(1):207-214.e3]

Cited: 9 times

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Selective and non-selective OT receptor agonists induce different locomotor behaviors in male rats via central OT receptors and peripheral V1a receptors.

Monica Wolfe, Halina Wisniewska, Hiroe Tariga, Gerardo Ibanez, James C Collins, Kazimierz Wisniewski, Steve Qi, Karthik Srinivasan, Diane Hargrove, Beatriz Fioravanti Lindstrom,

Oxytocin (OT) continues to inspire much research due to its diverse physiological effects. While the best-understood actions of OT are uterine contraction and milk ejection, OT is also implicated in maternal and bonding behaviors, and potentially in CNS disorders such as autism, schizophrenia, and pain. The dissection of the mechanism ... Read more >>

Neuropeptides (Neuropeptides)
[2018, 70:64-75]

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Unilateral optic nerve aplasia documented with optical coherence tomography-case report and literature review.

Neelam Pawar, Karthik Srinivasan, Samyukta Sadasivan, Meenakshi Ravindran, Devendra Maheshwari, Rengappa Ramakrishnan,

Optic nerve aplasia is a rare nonhereditary developmental anomaly characterized by congenital absence of the optic nerve, retinal blood vessels, retinal ganglion cells, and optic nerve fibers in a unilaterally malformed eye of an otherwise healthy individual. We report the case of a 6-year-old girl with unilateral optic nerve aplasia ... Read more >>

J AAPOS (Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus)
[2018, 22(2):152-154]

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Predicting High-Cost Patients at Point of Admission Using Network Science.

Karthik Srinivasan, Faiz Currim, Sudha Ram,

Data mining models for high-cost patient encounter prediction at the point-of-admission (HPEPP) in inpatient wards are scarce in the literature. This is due to the lack of availability of relevant features at such an early stage of treatment. In this study, we create a disease co-occurrence network (DCN) using a ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2018, 22(6):1970-1977]

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Establishment of human retinal mitoscriptome gene expression signature for diabetic retinopathy using cadaver eyes.

Gowthaman Govindarajan, Saumi Mathews, Karthik Srinivasan, Kim Ramasamy, Sundaresan Periasamy,

Diabetic retinopathy (DR) is a leading cause of blindness due to retinal microvasculature. We used microarray analysis for the first time to establish the retinal mitoscriptome gene expression signature for DR using human cadaver eyes. Among the 1042 genes, 60 (52-down, 8-up) and 39 (36-down, 3-up) genes were differentially expressed ... Read more >>

Mitochondrion (Mitochondrion)
[2017, 36:150-181]

Cited: 1 time

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Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.

Lillian Cooper, Karthik Srinivasan, Nora Nugent,

Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. A case is described of a woman aged 52 years presenting with ... Read more >>

BMJ Case Rep (BMJ case reports)
[2017, 2017:]

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Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance.

Kazimierz Wiśniewski, Javier Sueiras-Diaz, Guangcheng Jiang, Robert Galyean, Mark Lu, Dorain Thompson, Yung-Chih Wang, Glenn Croston, Alexander Posch, Diane M Hargrove, Halina Wiśniewska, Régent Laporte, John J Dwyer, Steve Qi, Karthik Srinivasan, Jennifer Hartwig, Nicky Ferdyan, Monica Mares, John Kraus, Sudarkodi Alagarsamy, Pierre J M Rivière, Claudio D Schteingart,

Glucagon-like peptide-2 receptor agonists have therapeutic potential for the treatment of intestinal diseases. The native hGLP-2, a 33 amino acid gastrointestinal peptide, is not a suitable clinical candidate, due to its very short half-life in humans. In search of GLP-2 receptor agonists with better pharmacokinetic characteristics, a series of GLP-2 ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2016, 59(7):3129-3139]

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Unilateral Crystalline Vitreoretinopathy: A Rare Entity Associated with Intraocular Inflammation.

Kaustubh B Harshey, Karthik Srinivasan, Ramakrishnan Rengappa, Kim Ramasamy,

A 31-year-old Indian male presented with floaters and diminution of vision in the right eye. Ocular examination showed features of old anterior uveitis with posterior subcapsular cataract and fine, refractile crystals in the vitreous cavity and on the retinal surface. A thorough workup for all known causes of crystalline retinopathy ... Read more >>

Case Rep Ophthalmol Med (Case reports in ophthalmological medicine)
[2015, 2015:460564]

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Gynaecomastia correction: A review of our experience.

Arvind Arvind, Muhammad Adil Abbas Khan, Karthik Srinivasan, Jeremy Roberts,

INTRODUCTION:Gynaecomastia is a common problem in the male population with a reported prevalence of up to 36%. Various treatment techniques have been described but none have gained universal acceptance. We reviewed all gynaecomastia patients operated on by one consultant over a 7-year period to assess the morbidity and complication rates ... Read more >>

Indian J Plast Surg (Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India)
[2014, 47(1):56-60]

Cited: 3 times

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Binocular fusion and invariant category learning due to predictive remapping during scanning of a depthful scene with eye movements.

Stephen Grossberg, Karthik Srinivasan, Arash Yazdanbakhsh,

How does the brain maintain stable fusion of 3D scenes when the eyes move? Every eye movement causes each retinal position to process a different set of scenic features, and thus the brain needs to binocularly fuse new combinations of features at each position after an eye movement. Despite these ... Read more >>

Front Psychol (Frontiers in psychology)
[2014, 5:1457]

Cited: 5 times

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Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling.

Dhananjay Shukla, Jay Kalliath, Karthik Srinivasan, Nithya Neelakantan, Anand Rajendran, Kannan B Naresh, Umesh C Behera,

PURPOSE: To compare the outcomes of vitrectomy with or without internal limiting membrane peeling for rhegmatogenous retinal detachment and coexisting macular hole. METHODS: Thirty-one consecutive patients (31 eyes) with macula-off retinal detachment, peripheral breaks and a coexisting macular hole were prospectively enrolled over a 3-year period. All patients underwent vitrectomy ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2013, 33(3):571-578]

Cited: 4 times

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Pediatric renal abscess: a 10-year single-center retrospective analysis.

Luis Seguias, Karthik Srinivasan, Amit Mehta,

OBJECTIVE:The objective of this retrospective series is to describe the demographics and treatment of patients with renal abscesses and to determine if abscess size influences management. METHODS:We reviewed all pediatric cases of renal abscesses treated over a 10-year period in our medical center. Clinical, laboratory, imaging data, and treatment modalities ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2012, 2(3):161-166]

Cited: 3 times

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