Full Text Journal Articles by
Author Karla L Miller

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Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis.

Chaoyue Wang, Sean Foxley, Olaf Ansorge, Sarah Bangerter-Christensen, Mark Chiew, Anna Leonte, Ricarda Al Menke, Jeroen Mollink, Menuka Pallebage-Gamarallage, Martin R Turner, Karla L Miller, Benjamin C Tendler,

Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem, whole-brain data. Using this pipeline, we compare the resulting quantitative maps in brains from patients ... Read more >>

Neuroimage (NeuroImage)
[2020, :117216]

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Longitudinal connections and the organization of the temporal cortex in macaques, great apes, and humans.

Lea Roumazeilles, Nicole Eichert, Katherine L Bryant, Davide Folloni, Jerome Sallet, Suhas Vijayakumar, Sean Foxley, Benjamin C Tendler, Saad Jbabdi, Colin Reveley, Lennart Verhagen, Lori B Dershowitz, Martin Guthrie, Edmund Flach, Karla L Miller, Rogier B Mars,

The temporal association cortex is considered a primate specialization and is involved in complex behaviors, with some, such as language, particularly characteristic of humans. The emergence of these behaviors has been linked to major differences in temporal lobe white matter in humans compared with monkeys. It is unknown, however, how ... Read more >>

PLoS Biol. (PLoS biology)
[2020, 18(7):e3000810]

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Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP.

Benjamin C Tendler, Sean Foxley, Moises Hernandez-Fernandez, Michiel Cottaar, Connor Scott, Olaf Ansorge, Karla L Miller, Saad Jbabdi,

Diffusion-weighted steady-state free precession (DW-SSFP) is an SNR-efficient diffusion imaging method. The improved SNR and resolution available at ultra-high field has motivated its use at 7T. However, these data tend to have severe B1 inhomogeneity, leading not only to spatially varying SNR, but also to spatially varying diffusivity estimates, confounding ... Read more >>

Neuroimage (NeuroImage)
[2020, 220:117113]

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The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.

Thomas J Littlejohns, Jo Holliday, Lorna M Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D Bell, Chris Boultwood, Rory Collins, Megan C Conroy, Nicola Crabtree, Nicola Doherty, Alejandro F Frangi, Nicholas C Harvey, Paul Leeson, Karla L Miller, Stefan Neubauer, Steffen E Petersen, Jonathan Sellors, Simon Sheard, Stephen M Smith, Cathie L M Sudlow, Paul M Matthews, Naomi E Allen,

UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):2624]

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Confound modelling in UK Biobank brain imaging.

Fidel Alfaro-Almagro, Paul McCarthy, Soroosh Afyouni, Jesper L R Andersson, Matteo Bastiani, Karla L Miller, Thomas E Nichols, Stephen M Smith,

Dealing with confounds is an essential step in large cohort studies to address problems such as unexplained variance and spurious correlations. UK Biobank is a powerful resource for studying associations between imaging and non-imaging measures such as lifestyle factors and health outcomes, in part because of the large subject numbers. ... Read more >>

Neuroimage (NeuroImage)
[2020, :117002]

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Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations.

Stephen M Smith, Lloyd T Elliott, Fidel Alfaro-Almagro, Paul McCarthy, Thomas E Nichols, Gwenaëlle Douaud, Karla L Miller,

Brain imaging can be used to study how individuals' brains are aging, compared against population norms. This can inform on aspects of brain health; for example, smoking and blood pressure can be seen to accelerate brain aging. Typically, a single 'brain age' is estimated per subject, whereas here we identified ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 2 times

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Modeling an equivalent b-value in diffusion-weighted steady-state free precession.

Benjamin C Tendler, Sean Foxley, Michiel Cottaar, Saad Jbabdi, Karla L Miller,

PURPOSE:Diffusion-weighted steady-state free precession (DW-SSFP) is shown to provide a means to probe non-Gaussian diffusion through manipulation of the flip angle. A framework is presented to define an effective b-value in DW-SSFP. THEORY:The DW-SSFP signal is a summation of coherence pathways with different b-values. The relative contribution of each pathway ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2020, 84(2):873-884]

Cited: 1 time

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THE UNINTENDED CONSEQUENCES OF SEAMLESS IMPLEMENTATION OF A RURAL TELEMEDICINE CLINIC.

Samantha Solimeo, Melissa J Steffen, Aaron Seaman, Karla L Miller,

AbstractOsteoporosis is largely undetected and untreated in older men who are at-risk, with even lower rates of detection and treatment in rural communities. In this presentation we report the consequences for primary care providers (PCPs) of the implementation of an osteoporosis telemedicine clinic that targeted rural patients and is purposefully ... Read more >>

Innov Aging (Innovation in aging)
[2019, 3(Suppl 1):S607-S608]

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Improved statistical efficiency of simultaneous multi-slice fMRI by reconstruction with spatially adaptive temporal smoothing.

Mark Chiew, Karla L Miller,

We introduce an approach to reconstruction of simultaneous multi-slice (SMS)-fMRI data that improves statistical efficiency. The method incorporates regularization to adjust temporal smoothness in a spatially varying, encoding-dependent manner, reducing the g-factor noise amplification per temporal degree of freedom. This results in a net improvement in tSNR and GLM efficiency, ... Read more >>

Neuroimage (NeuroImage)
[2019, 203:116165]

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Relating diffusion tensor imaging measurements to microstructural quantities in the cerebral cortex in multiple sclerosis.

Rebecca McKavanagh, Mario Torso, Mark Jenkinson, James Kolasinski, Charlotte J Stagg, Margaret M Esiri, Jennifer A McNab, Heidi Johansen-Berg, Karla L Miller, Steven A Chance,

To investigate whether the observed anisotropic diffusion in cerebral cortex may reflect its columnar cytoarchitecture and myeloarchitecture, as a potential biomarker for disease-related changes, we compared postmortem diffusion magnetic resonance imaging scans of nine multiple sclerosis brains with histology measures from the same regions. Histology measurements assessed the cortical minicolumnar ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(15):4417-4431]

Cited: 1 time

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Joint modelling of diffusion MRI and microscopy.

Amy Fd Howard, Jeroen Mollink, Michiel Kleinnijenhuis, Menuka Pallebage-Gamarallage, Matteo Bastiani, Michiel Cottaar, Karla L Miller, Saad Jbabdi,

The combination of diffusion MRI (dMRI) with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired in the same sample. Microscopy is frequently used to validate dMRI microstructure models, addressing the indirect nature of dMRI signals. Typically, these modalities are analysed separately, and microscopy is taken ... Read more >>

Neuroimage (NeuroImage)
[2019, 201:116014]

Cited: 1 time

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Estimation of brain age delta from brain imaging.

Stephen M Smith, Diego Vidaurre, Fidel Alfaro-Almagro, Thomas E Nichols, Karla L Miller,

It is of increasing interest to study "brain age" - the apparent age of a subject, as inferred from brain imaging data. The difference between brain age and actual age (the "delta") is typically computed, reflecting deviation from the population norm. This therefore may reflect accelerated aging (positive delta) or ... Read more >>

Neuroimage (NeuroImage)
[2019, 200:528-539]

Cited: 7 times

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Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex.

Holly Bridge, Andrew H Bell, Matthew Ainsworth, Jerome Sallet, Elsie Premereur, Bashir Ahmed, Anna S Mitchell, Urs Schüffelgen, Mark Buckley, Benjamin C Tendler, Karla L Miller, Rogier B Mars, Andrew J Parker, Kristine Krug,

Lesions of primary visual cortex (V1) lead to loss of conscious visual perception with significant impact on human patients. Understanding the neural consequences of such damage may aid the development of rehabilitation methods. In this rare case of a Rhesus macaque (monkey S), likely born without V1, the animal's in-group ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 2 times

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A 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab acquisition.

Erpeng Dai, Yuhsuan Wu, Wenchuan Wu, Rui Guo, Simin Liu, Karla L Miller, Zhe Zhang, Hua Guo,

PURPOSE:To propose a novel 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab (SMSlab) acquisition and demonstrate its efficacy in high-resolution imaging. METHODS:First, it is illustrated in theory how the inter-slab gap interferes with the formation of the SMSlab 3D k-space. Then, joint RF and gradient encoding are applied ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2019, 82(3):1012-1024]

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The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure.

Jeroen Mollink, Stephen M Smith, Lloyd T Elliott, Michiel Kleinnijenhuis, Marlies Hiemstra, Fidel Alfaro-Almagro, Jonathan Marchini, Anne-Marie van Cappellen van Walsum, Saad Jbabdi, Karla L Miller,

Microscopic features (that is, microstructure) of axons affect neural circuit activity through characteristics such as conduction speed. To what extent axonal microstructure in white matter relates to functional connectivity (synchrony) between brain regions is largely unknown. Using MRI data in 11,354 subjects, we constructed multivariate models that predict functional connectivity of ... Read more >>

Nat. Neurosci. (Nature neuroscience)
[2019, 22(5):809-819]

Cited: 3 times

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Diffusion Acceleration with Gaussian process Estimated Reconstruction (DAGER).

Wenchuan Wu, Peter J Koopmans, Jesper L R Andersson, Karla L Miller,

PURPOSE:Image acceleration provides multiple benefits to diffusion MRI, with in-plane acceleration reducing distortion and slice-wise acceleration increasing the number of directions that can be acquired in a given scan time. However, as acceleration factors increase, the reconstruction problem becomes ill-conditioned, particularly when using both in-plane acceleration and simultaneous multislice imaging. ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2019, 82(1):107-125]

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A method for correcting breathing-induced field fluctuations in T2*-weighted spinal cord imaging using a respiratory trace.

S Johanna Vannesjo, Stuart Clare, Lars Kasper, Irene Tracey, Karla L Miller,

PURPOSE:Spinal cord MRI at ultrahigh field is hampered by time-varying magnetic fields associated with the breathing cycle, giving rise to ghosting artifacts in multi-shot acquisitions. Here, we suggest a correction approach based on linking the signal from a respiratory bellows to field changes inside the spinal cord. The information is ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2019, 81(6):3745-3753]

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Resonate: Reflections and recommendations on implicit biases within the ISMRM.

Esther A H Warnert, Krishna Nayak, Ravi Menon, Curt Rice, John Port, Elizabeth A Morris, Daniel K Sodickson, Pia Sundgren, Karla L Miller, Udunna C Anazodo,

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2019, 49(6):1509-1511]

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Genome-wide association studies of brain imaging phenotypes in UK Biobank.

Lloyd T Elliott, Kevin Sharp, Fidel Alfaro-Almagro, Sinan Shi, Karla L Miller, Gwenaëlle Douaud, Jonathan Marchini, Stephen M Smith,

The genetic architecture of brain structure and function is largely unknown. To investigate this, we carried out genome-wide association studies of 3,144 functional and structural brain imaging phenotypes from UK Biobank (discovery dataset 8,428 subjects). Here we show that many of these phenotypes are heritable. We identify 148 clusters of ... Read more >>

Nature (Nature)
[2018, 562(7726):210-216]

Cited: 46 times

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Epidemiology of Swallowing Disorders in Rheumatoid Arthritis: Prevalence, Risk Factors, and Quality of Life Burden.

Nelson Roy, Kristine M Tanner, Ray M Merrill, Charisse Wright, Jenny L Pierce, Karla L Miller,

This investigation examined the prevalence, symptoms, risk factors, and quality-of-life burden of swallowing disorders in rheumatoid arthritis (RA), a chronic, progressive autoimmune inflammatory disease.One hundred individuals with RA (84 women, 16 men; mean age = 61.1 years, SD = 13.1) were interviewed regarding the presence, nature, and impact of swallowing ... Read more >>

Ann. Otol. Rhinol. Laryngol. (The Annals of otology, rhinology, and laryngology)
[2018, 127(9):577-587]

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Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.

Alard Roebroeck, Karla L Miller, Manisha Aggarwal,

This review discusses ex vivo diffusion magnetic resonance imaging (dMRI) as an important research tool for neuroanatomical investigations and the validation of in vivo dMRI techniques, with a focus on the human brain. We review the challenges posed by the properties of post-mortem tissue, and discuss state-of-the-art tissue preparation methods ... Read more >>

NMR Biomed (NMR in biomedicine)
[2019, 32(4):e3941]

Cited: 5 times

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Recovering task fMRI signals from highly under-sampled data with low-rank and temporal subspace constraints.

Mark Chiew, Nadine N Graedel, Karla L Miller,

Recent developments in highly accelerated fMRI data acquisition have employed low-rank and/or sparsity constraints for image reconstruction, as an alternative to conventional, time-independent parallel imaging. When under-sampling factors are high or the signals of interest are low-variance, however, functional data recovery can be poor or incomplete. We introduce a method ... Read more >>

Neuroimage (NeuroImage)
[2018, 174:97-110]

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Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology.

Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A L Menke, Istvan N Huszar, Mark Jenkinson, Benjamin C Tendler, Chaoyue Wang, Saad Jbabdi, Martin R Turner, Karla L Miller, Olaf Ansorge,

BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detecting the pathological signature and tracking disease progression in ALS. However, the microstructural and ... Read more >>

BMC Neurosci (BMC neuroscience)
[2018, 19(1):11]

Cited: 4 times

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Template-based field map prediction for rapid whole brain B0 shimming.

Yuhang Shi, S Johanna Vannesjo, Karla L Miller, Stuart Clare,

PURPOSE:In typical MRI protocols, time is spent acquiring a field map to calculate the shim settings for best image quality. We propose a fast template-based field map prediction method that yields near-optimal shims without measuring the field. METHODS:The template-based prediction method uses prior knowledge of the B0 distribution in the ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2018, 80(1):171-180]

Cited: 1 time

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Spatiotemporal characterization of breathing-induced B0 field fluctuations in the cervical spinal cord at 7T.

S Johanna Vannesjo, Karla L Miller, Stuart Clare, Irene Tracey,

Magnetic resonance imaging and spectroscopy of the spinal cord stand to benefit greatly from the increased signal-to-noise ratio of ultra-high field. However, ultra-high field also poses considerable technical challenges, especially related to static and dynamic B0 fields. Breathing causes the field to fluctuate with the respiratory cycle, giving rise to ... Read more >>

Neuroimage (NeuroImage)
[2018, 167:191-202]

Cited: 5 times

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