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Author Karina Rodriguez

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

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Ramsey hunt syndrome after antimonial treatment for American Cutaneous Leishmaniasis.

Melissa de Sousa Melo Cavalcante, Karina López Rodríguez, José Alejandro Lazo Diéguez, Luciana Mendes Dos Santos, Maria das Graças Vale Barbosa Guerra, Jorge Augusto de Oliveira Guerra,

Ramsay Hunt Syndrome (RHS), also known as herpes zoster oticus, is caused by the reactivation of varicella zoster virus (VZV) in the geniculate ganglion of the facial nerve. Herein, we report a case of Ramsey Hunt Syndrome in a patient after antimonial treatment for Cutaneous Leishmaniasis. The patient presented with ... Read more >>

Rev Soc Bras Med Trop (Revista da Sociedade Brasileira de Medicina Tropical)
[2020, 54:e20200012]

Cited: 0 times

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Management of Lobular Neoplasia Found on Core Needle Biopsy Performed for Calcifications Using Precise Radiologic-Pathologic Correlation.

Jean Kunjummen, Karina Rodriguez, Mary S Newell, Krisztina Hanley, Michael A Cohen,

<b>OBJECTIVE.</b> The purpose of our study was to evaluate the upgrade rate of calcified lobular neoplasia (LN) versus incidental noncalcified classic LN found on core needle biopsy performed for the evaluation of suspicious calcifications. <b>MATERIALS AND METHODS.</b> This retrospective study included 390 consecutive image-guided breast core needle biopsies with microcalcifications ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, 216(6):1476-1485]

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Plagues, past, and futures for the Yagan canoe people of Cape Horn, southern Chile

Gustavo Blanco-Wells, Macarena Libuy, Alberto Harambour, Karina Rodríguez,

The manner in which the COVID-19 pandemic has affected the indigenous Yagan people of Navarino Island in southern Chile is the topic of this paper. Like other First Nation communities, these nomadic people suffered decimation and disease in successive encounters with Europeans, and then, in the mid-twentieth century, forced sedentarization ... Read more >>

(Maritime Studies)
[2021, :1-13]

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Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.

Barbara Nicol, Karina Rodriguez, Humphrey H-C Yao,

Development and functions of the ovary rely on appropriate signaling and communication between various ovarian cell types. FOXL2, a transcription factor that plays a key role at different stages of ovarian development, is associated with primary ovarian insufficiency and ovarian cancer as a result of its loss-of-function or mutations. In ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, 103(5):966-977]

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In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice.

Karina F Rodriguez, Namya Mellouk, Erica K Ungewitter, Barbara Nicol, Chang Liu, Paula R Brown, Cynthia J Willson, Humphrey H-C Yao,

In utero exposure to arsenite (iAs) is known to increase disease risks later in life. We investigated the effect of in utero exposure to iAs in the drinking water on metabolic and reproductive parameters in male mouse offspring at postnatal and adult stages. Pregnant CD-1 mice were exposed to iAs ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:95-103]

Cited: 1 time

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Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus.

Gerardo G B Herrera, Sydney L Lierz, Emily A Harris, Lauren J Donoghue, Sylvia C Hewitt, Karina F Rodriguez, Wendy N Jefferson, John P Lydon, Francesco J DeMayo, Carmen J Williams, Kenneth S Korach, Wipawee Winuthayanon,

Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion of ESR1, we generated a ... Read more >>

Endocrinology (Endocrinology)
[2020, 161(2):]

Cited: 1 time

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SAT-348 Overexpression of the Notch Intracellular Domain Results in Abnormal Adrenal Development.

Olivia Reid, Karina Rodriguez, Kari Laprocina, Courtney Cleary, Yuan Kang, Humphrey Yao, Chen-Che Huang,

Abstract In the adrenal gland, stem and progenitor cells reside in the capsule and the outer part of the cortex, respectively. The newly formed cortical cells from stem/progenitor cells move inward to the corticomedullary boundary during development. Throughout this developmental process, adrenocortical cells express specific marker genes at different stages ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

Cited: 0 times

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Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh.

Chang Liu, Karina F Rodriguez, Paula R Brown, Humphrey H-C Yao,

Ovarian development requires coordinate communications among oocytes, granulosa cells, and theca cells. Two Hedgehog (Hh) pathway ligands, Desert hedgehog (Dhh) and Indian hedgehog (Ihh), are produced by the granulosa cells and work together to regulate theca cell specification and development. Mice lacking both Dhh and Ihh had loss of normal ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(7):2563-2575]

Cited: 4 times

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Brachial artery Doppler flux parameters before and after hot flush in Mexican postmenopausal women: preliminary report.

Sebastián Carranza-Lira, Karina Vázquez Rodríguez, Sergio Rosales Ortiz,

<h4>Objective</h4>To analyse brachial artery flux parameters in postmenopausal women before and after hot flush.<h4>Material and methods</h4>Two groups of postmenopausal women were studied: Group I, without vasomotor symptoms (n = 10) and Group II, with vasomotor symptoms (n = 10). In all them a brachial artery Doppler ultrasound was done, measuring ... Read more >>

Prz Menopauzalny (Przeglad menopauzalny = Menopause review)
[2016, 15(1):39-42]

Cited: 0 times

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Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice.

Fei Zhao, Heather L Franco, Karina F Rodriguez, Paula R Brown, Ming-Jer Tsai, Sophia Y Tsai, Humphrey H-C Yao,

The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts (Wolffian ducts) in the female degenerate owing to a lack of androgen. Here, we discovered that female mouse embryos lacking <i>Coup-tfII</i> (chicken ovalbumin upstream promoter transcription factor II) ... Read more >>

Science (Science (New York, N.Y.))
[2017, 357(6352):717-720]

Cited: 23 times

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Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus).

Juan Manuel Valverde, Karina Rodríguez, María Herrera, Álvaro Segura, Mariángela Vargas, Mauren Villalta, Mavis Montero, Jose María Gutiérrez, Guillermo León,

Adjuvant emulsions are widely used to enhance the antibody response of the animals used as immunoglobulin source for producing antivenoms. Usually, the adjuvant activity of emulsions is attributed both to their ability to trigger "danger" signals from cells in which they induce death, and to form depots from which immunogens ... Read more >>

Toxicon (Toxicon : official journal of the International Society on Toxinology)
[2017, 127:106-111]

Cited: 1 time

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Cost of intensive routine control and incremental cost of insecticide-treated curtain deployment in a setting with low Aedes aegypti infestation.

Alberto Baly, Maria Eugenia Toledo, Isora Lambert, Elizabeth Benítez, Karina Rodriguez, Esther Rodriguez, Veerle Vanlerberghe, Patrick Van der Stuyft,

<h4>Introduction</h4>Information regarding the cost of implementing insecticide-treated curtains (ITCs) is scarce. Therefore, we evaluated the ITC implementation cost, in addition to the costs of intensive conventional routine activities of the Aedes control program in the city of Guantanamo, Cuba.<h4>Methods</h4>A cost-analysis study was conducted from the perspective of the Aedes control ... Read more >>

Rev Soc Bras Med Trop (Revista da Sociedade Brasileira de Medicina Tropical)
[2016, 49(4):418-424]

Cited: 5 times

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Mapping lineage progression of somatic progenitor cells in the mouse fetal testis.

Chang Liu, Karina Rodriguez, Humphrey H-C Yao,

Testis morphogenesis is a highly orchestrated process involving lineage determination of male germ cells and somatic cell types. Although the origin and differentiation of germ cells are known, the developmental course specific for each somatic cell lineage has not been clearly defined. Here, we construct a comprehensive map of somatic ... Read more >>

Development (Development (Cambridge, England))
[2016, 143(20):3700-3710]

Cited: 23 times

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Response to "Comment on 'Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice'".

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):A46-7]

Cited: 7 times

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Frequency and molecular characterization of invasive isolates of Streptococcus pneumoniae serotypes 6C and 6D in Colombia.

Eliana Liseth Parra, Carolina Duarte, Karina Rodríguez, Olga Sanabria, Jaime Moreno,

<h4>Introduction</h4>Serogroup 6 of Streptococcus pneumoniae initially consisted of the 6A and 6B serotypes, but in recent years, the 6C and 6D serotypes were reported. The aim of this study was to determine the frequency and molecular characterization of invasive S. pneumoniae isolates serotypes 6C and 6D in Colombia, from 1994 ... Read more >>

Enferm Infecc Microbiol Clin (Enfermedades infecciosas y microbiologia clinica)
[2017, 35(5):283-286]

Cited: 0 times

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Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice.

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

<h4>Background</h4>Mice exposed to high levels of arsenic in utero have increased susceptibility to tumors such as hepatic and pulmonary carcinomas when they reach adulthood. However, the effects of in utero arsenic exposure on general physiological functions such as reproduction and metabolism remain unclear.<h4>Objectives</h4>We evaluated the effects of in utero exposure ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):336-343]

Cited: 17 times

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Phenotypic and genotypic characterization of Neisseria meningitidis serogroup B isolates from Cartagena, Colombia, 2012-2014.

Jaime Moreno, Olga Sanabria, Sandra Yamile Saavedra, Karina Rodríguez, Carolina Duarte,

<h4>Introduction</h4>Neisseria meningitidis is one of the leading causes of bacterial meningitis. In 2013, an increase in invasive disease caused by N. meningitidis serogroup B occurred in Cartagena, Colombia.<h4>Objective</h4>The aim of this study was to characterize serogroup B isolates recovered from patients with meningococcal meningitis in Cartagena during 2012 and 2014.<h4>Materials ... Read more >>

Biomedica (Biomedica : revista del Instituto Nacional de Salud)
[2015, 35(1):138-143]

Cited: 2 times

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The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

Christopher B Ball, Karina F Rodriguez, Deborah J Stumpo, Fernando Ribeiro-Neto, Kenneth S Korach, Perry J Blackshear, Lutz Birnbaumer, Silvia B V Ramos,

ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal amino acid residues have been deleted, ΔN-ZFP36L2, leads to fertilized eggs that arrest ... Read more >>

PLoS One (PloS one)
[2014, 9(5):e97324]

Cited: 17 times

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The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary.

Friederike L Jayes, Katherine A Burns, Karina F Rodriguez, Grace E Kissling, Kenneth S Korach,

Female ESR2-null mice (betaERKO) display defects in ovarian function and are subfertile. Follicular maturation is impaired and explains smaller litters, but betaERKO also produce fewer litters, which may be partially due to inadequate ovulatory signals. To test this, the amplitude and timing of the naturally occurring luteinizing hormone (LH) surge ... Read more >>

Biol Reprod (Biology of reproduction)
[2014, 90(2):24]

Cited: 10 times

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The absence of ER-β results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles.

April K Binder, Karina F Rodriguez, Katherine J Hamilton, Patricia S Stockton, Casey E Reed, Kenneth S Korach,

Determining the spatial and temporal expression of genes involved in the ovulatory pathway is critical for the understanding of the role of each estrogen receptor in the modulation of folliculogenesis and ovulation. Estrogen receptor (ER)-β is highly expressed in ovarian granulosa cells, and mice lacking ER-β are subfertile due to ... Read more >>

Endocrinology (Endocrinology)
[2013, 154(6):2174-2187]

Cited: 20 times

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Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model.

Katherine A Burns, Karina F Rodriguez, Sylvia C Hewitt, Kyathanahalli S Janardhan, Steven L Young, Kenneth S Korach,

Endometriosis results from ectopic invasion of endometrial tissue within the peritoneal cavity. Aberrant levels of the estrogen receptor (ER), ERα and ERβ, and higher incidence of autoimmune disorders are observed in women with endometriosis. An immunocompetent mouse model of endometriosis was used in which minced uterine tissue from a donor ... Read more >>

Endocrinology (Endocrinology)
[2012, 153(8):3960-3971]

Cited: 56 times

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Costs of dengue prevention and incremental cost of dengue outbreak control in Guantanamo, Cuba.

Alberto Baly, Maria E Toledo, Karina Rodriguez, Juan R Benitez, Maritza Rodriguez, Marleen Boelaert, Veerle Vanlerberghe, Patrick Van der Stuyft,

<h4>Objective</h4>To assess the economic cost of routine Aedes aegypti control in an at-risk environment without dengue endemicity and the incremental costs incurred during a sporadic outbreak.<h4>Methods</h4>The study was conducted in 2006 in the city of Guantanamo, Cuba. We took a societal perspective to calculate costs in months without dengue transmission ... Read more >>

Trop Med Int Health (Tropical medicine & international health : TM & IH)
[2012, 17(1):123-132]

Cited: 16 times

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Uterine gland formation in mice is a continuous process, requiring the ovary after puberty, but not after parturition.

C Allison Stewart, Sara J Fisher, Ying Wang, M David Stewart, Sylvia C Hewitt, Karina F Rodriguez, Kenneth S Korach, Richard R Behringer,

Uterine gland formation occurs postnatally in an ovary- and steroid-independent manner in many species, including humans. Uterine glands secrete substances that are essential for embryo survival. Disruption of gland development during the postnatal period prevents gland formation, resulting in infertility. Interestingly, stabilization of beta-catenin (CTNNB1) in the uterine stroma causes ... Read more >>

Biol Reprod (Biology of reproduction)
[2011, 85(5):954-964]

Cited: 23 times

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The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.

John F Couse, Mariana M Yates, Karina F Rodriguez, Jo Anne Johnson, Donald Poirier, Kenneth S Korach,

The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain expression of the type 3 (HSD17B3) isoform, which ... Read more >>

Endocrinology (Endocrinology)
[2006, 147(8):3666-3678]

Cited: 16 times

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