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Postoperative outcomes of elderly patients undergoing partial nephrectomy.

Alexandre Ingels, Sophie Duc, Karim Bensalah, Pierre Bigot, Philippe Paparel, Jean-Baptiste Beauval, Laurent Salomon, Alexandre De La Taille, Hervé Lang, François-Xavier Nouhaud, José Batista Da Costa, Charles Dariane, Hervé Baumert, Morgan Roupret, Thibaut Waeckel, Cédric Lebacle, Jean-Alexandre Long, François Henon, Jean-Jacques Patard, Nicolas Doumerc, Arnaud Mejean, Marie-Neige Videau, Jean-Christophe Bernhard,

To describe clinical outcomes of patients aged 75 years and above after partial nephrectomy (PN), and to assess independent factors of postoperative complications. We retrospectively reviewed information from our multi-institutional database. Every patient over 75 years old who underwent a PN between 2003 and 2016 was included. Peri-operative and follow up data ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):17201]

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Metastatic clear cell renal cell carcinoma: computed tomography texture analysis as predictive biomarkers of survival in patients treated with nivolumab.

Zine-Eddine Khene, Romain Kokorian, Romain Mathieu, Anis Gasmi, Rioux-Leclercq Nathalie, Kammerer-Jacquet Solène-Florence, Shahrokh Shariat, Renaud de Crevoisier, Brigitte Laguerre, Karim Bensalah,

<h4>Introduction</h4>To evaluate the value of image-based texture analysis for predicting progression-free survival (PFS) and overall survival (OS) in patients with metastatic clear cell renal carcinoma (cCCR) treated with nivolumab.<h4>Methods</h4>This retrospective study included 48 patients with metastatic cCCR treated with nivolumab. Nivolumab was used as a second- or third-line monotherapy. Texture ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Radiogenomics in prostate cancer evaluation.

Ronan Thenault, Anis Gasmi, Zine-Edine Khene, Karim Bensalah, Romain Mathieu,

<h4>Purpose of review</h4>Radiogenomics, fusion between radiomics and genomics, represents a new field of research to improve cancer comprehension and evaluation. In this review, we give an overview of radiogenomics and its most recent and relevant applications in prostate cancer management.<h4>Recent findings</h4>Literature about radiogenomics in prostate cancer emerged last 5 years ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):424-429]

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Editorial: Artificial intelligence will shape the future of urology but good things come to those who wait.

Benjamin Pradere, Karim Bensalah,

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):369-370]

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Sunitinib Alone or After Nephrectomy for Patients with Metastatic Renal Cell Carcinoma: Is There Still a Role for Cytoreductive Nephrectomy?

Arnaud Méjean, Alain Ravaud, Simon Thezenas, Christine Chevreau, Karim Bensalah, Lionnel Geoffrois, Antoine Thiery-Vuillemin, Luc Cormier, Hervé Lang, Laurent Guy, Gwenaelle Gravis, Frederic Rolland, Claude Linassier, Eric Lechevallier, Stephane Oudard, Brigitte Laguerre, Marine Gross-Goupil, Jean Christophe Bernhard, Sandra Colas, Laurence Albiges, Thierry Lebret, Jean-Marc Treluyer, Marc-Olivier Timsit, Bernard Escudier,

<h4>Background</h4>The CARMENA trial in patients with metastatic renal cell carcinoma (mRCC) demonstrated that treatment with sunitinib alone was noninferior to cytoreductive nephrectomy (CN) followed by sunitinib (nephrectomy⬜sunitinib).<h4>Objective</h4>The objective of this study was to provide updated overall survival (OS) outcomes of CARMENA and assess whether some subgroups may still benefit from ... Read more >>

Eur Urol (European urology)
[2021, 80(4):417-424]

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THE MANAGEMENT OF DISTAL URETER DURING RADICAL NEPHROURETERECTOMY DOES NOT INFLUENCE BLADDER RECURRENCE.

Marina Pizzighella, Franck Bruyere, Benoit Peyronnet, Vivien Grafeille, Nicolas Brichart, Keiichiro Mori, Gregory Verhoest, Karim Bensalah, Marco Moschini, Evenguelos Xylinas, Benjamin Pradere,

<h4>Purpose</h4>The bladder cuff management and its surgical approach represent an essential and debated step in radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The objective of our study was to determine which bladder-cuff management has the best oncological outcomes in terms of bladder recurrence-free survival ( BRFS).<h4>Methods</h4>We retrospectively analyzed ... Read more >>

J Endourol (Journal of endourology)
[2021, :]

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Differences in oncological and toxicity outcomes between programmed cell death-1 and programmed cell death ligand-1 inhibitors in metastatic renal cell carcinoma: A systematic review and meta-analysis.

Keiichiro Mori, Benjamin Pradere, Fahad Quhal, Satoshi Katayama, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, David D'Andrea, Shin Egawa, Karim Bensalah, Manuela Schmidinger, Thomas Powles, Shahrokh F Shariat,

<h4>Background</h4>The programmed cell death ligand-1 (PD-L1)/programmed cell death-1 (PD-1) pathway is important in metastatic renal cell carcinoma (mRCC). However, some dissimilarities between anti-PD-1 and anti-PD-L1 inhibitors have emerged. We aimed to assess differences between anti-PD-1 and anti-PD-L1 combination immunotherapies as first-line treatments in mRCC patients.<h4>Methods</h4>Multiple databases (PubMed, Web of Science, ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2021, 99:102242]

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Salvage Robot-assisted Renal Surgery for Local Recurrence After Surgical Resection or Renal Mass Ablation: Classification, Techniques, and Clinical Outcomes.

Alberto Martini, Filippo Turri, Ravi Barod, Bernardo Rocco, Umberto Capitanio, Alberto Briganti, Francesco Montorsi, Alexandre Mottrie, Ben Challacombe, Brunolf W Lagerveld, Karim Bensalah, Ronney Abaza, Ketan K Badani, Reza Mehrazin, Maurizio Buscarini, Alessandro Larcher, ,

<h4>Background</h4>Salvage treatment for local recurrence after prior partial nephrectomy (PN) or local tumor ablation (LTA) for kidney cancer is, as of yet, poorly investigated.<h4>Objective</h4>To classify the treatments and standardize the nomenclature of salvage robot-assisted renal surgery, to describe the surgical technique for each scenario, and to investigate complications, renal function, ... Read more >>

Eur Urol (European urology)
[2021, :]

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Should patients with low-risk renal cell carcinoma be followed differently after nephron-sparing surgery vs radical nephrectomy?

Yasmin Abu-Ghanem, Thomas Powles, Umberto Capitanio, Christian Beisland, Petrus Järvinen, Grant D Stewart, Eirikur Gudmundsson, Thomas B L Lam, Lorenzo Marconi, Sergio Fernandéz-Pello, Harry Nisen, Richard P Meijer, Alessandro Volpe, Börje Ljungberg, Tobias Klatte, Karim Bensalah, Saeed Dabestani, Axel Bex,

<h4>Objective</h4>To investigate whether pT1 renal cell carcinoma (RCC) should be followed differently after partial (PN) or radical nephrectomy (RN) based on a retrospective analysis of a multicentre database (RECUR).<h4>Subjects</h4>A retrospective study was conducted in 3380 patients treated for nonmetastatic RCC between January 2006 and December 2011 across 15 centres from ... Read more >>

BJU Int (BJU international)
[2021, 128(3):386-394]

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Predicting Complications After Robotic Partial Nephrectomy: Back to Simplicity.

Zine-Eddine Khene, Clément Mazouin, Alessandro Larcher, Benoit Peyronnet, Anis Gasmi, Mathieu Roumiguié, Grégory Verhoest, Umberto Capitanio, Romain Mathieu, Nicolas Doumerc, Francesco Montorsi, Karim Bensalah,

<h4>Background</h4>Robotic partial nephrectomy (RPN) has a significant morbidity. Nephrometry scores have been described to predict the occurrence of complications. Their usefulness is debated.<h4>Objective</h4>To evaluate the clinical utility of three nephrometry scores (radius, exophytic/endophytic, nearness, anterior/posterior, location [RENAL], preoperative aspects and dimensions used for an anatomical [PADUA], and simplified PADUA Renal ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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3D-Image guided robotic-assisted partial nephrectomy: a multi-institutional propensity score-matched analysis (UroCCR study 51).

Clément Michiels, Zine-Eddine Khene, Thomas Prudhomme, Astrid Boulenger de Hauteclocque, François H Cornelis, Mélanie Percot, Hélène Simeon, Laure Dupitout, Henri Bensadoun, Grégoire Capon, Eric Alezra, Vincent Estrade, Franck Bladou, Grégoire Robert, Jean-Marie Ferriere, Nicolas Grenier, Nicolas Doumerc, Karim Bensalah, Jean-Christophe Bernhard,

<h4>Purpose</h4>Robot-assisted partial nephrectomy (RAPN) is a difficult procedure with risk of significant perioperative complications. The objective was to evaluate the impact of preoperative planning and intraoperative guidance with 3D model reconstructions on perioperative outcomes of RAPN.<h4>Methods</h4>We conducted a retrospective analysis of all patients who underwent RAPN for kidney tumor by ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Predictive factors of recurrence after surgery in patients with non-metastatic renal cell carcinoma with venous tumor thrombus (UroCCR-56 Study).

Michael Baboudjian, Bastien Gondran-Tellier, Zineddine Khene, Pierre Bigot, Arnaud Mejean, Hervé Lang, Cedric Lebacle, Nicolas Doumerc, Franck Bruyere, Francois-Xavier Nouhaud, Idir Ouzaid, Karim Bensalah, Jean Christophe Bernhard, Romain Boissier,

<h4>Purpose</h4>To assess the oncological outcomes of renal cell carcinoma (RCC) associated with tumor thrombus and identify predictive factors of recurrence.<h4>Methods</h4>Multi-institutional study that included patients with cT3-4N0-1M0 RCC with tumoral thrombus identified in the prospective UroCCR database (CNIL DR 2013-206; NCT03293563). pT3a without involvement of the renal vein were excluded. All ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Multiple metastatic clones assessed by an integrative multiomics strategy in clear cell renal carcinoma: a case study.

Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frédéric Chalmel, Nathalie Rioux-Leclercq,

The dynamics of metastatic evolution in clear cell renal cell carcinoma (ccRCC) are complex. We report a case study where tumour heterogeneity resulting from clonal evolution is a frequent feature and could play a role in metastatic dissemination.We used an integrative multiomics strategy combining genomic and transcriptomic data to classify ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2021, :]

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Complete Transurethral Resection before Radical Cystectomy May Improve Oncological Outcomes.

Vivien Graffeille, Grégory Verhoest, Alexandre Gryn, Solène-Florence Kammerer-Jacquet, Quentin Alimi, Jean-Baptiste Beauval, Luc Beuzit, Benjamin Pradère, Matthieu Thoulouzan, Zine Eddine Khene, François Guille, Nathalie Rioux-Leclercq, Romain Mathieu, Xavier Gamé, Karim Bensalah, Michel Soulié, Mathieu Roumiguié, Benoit Peyronnet,

<h4>Objectives</h4>The objective of this study was to assess the impact of complete transurethral resection of bladder tumors (TURBTs) before radical cystectomy on pathological and oncological outcomes of patients with muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC.<h4>Materials and methods</h4>The charts of all patients who underwent radical cystectomy for bladder cancer in ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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Propensity-score analysis comparing perioperative and functional outcomes between XPS 180 W-photovaporization and GreenLight laser enucleation of the prostate: reasons to discard vaporization and move to enucleation.

Anis Gasmi, Zine-Eddine Khene, Sonia Guérin, Karim Bensalah, Benoit Peyronnet, Romain Mathieu, Morgan Roupret, Enrique Rijo, Benjamin Pradère, Vincent Misrai,

<h4>Purpose</h4>To compare the perioperative and functional outcomes between 180_W XPS GreenLight photoselective vaporization (PVP) and 532-nm GreenLight laser enucleation of the prostate (GreenLEP) in the surgical management of benign prostatic obstruction (BPO).<h4>Methods</h4>Retrospective review of a prospectively maintained international database of patients managed with GreenLight laser surgery (PVP or GreenLEP) was ... Read more >>

World J Urol (World journal of urology)
[2021, 39(7):2269-2276]

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Percutaneous Ablation Versus Surgical Resection for Local Recurrence Following Partial Nephrectomy for Renal Cell Cancer: A Propensity Score Analysis (REPART Study-UroCCR 71).

Marie Brassier, Zine-Eddine Khene, Jean-Christophe Bernhard, Van Thi Dang, Idir Ouzaid, François Xavier Nouhaud, Jonathan Olivier, Cosmina Nedelcu, Nicolas Grenier, Luc Beuzit, Nicolas Doumerc, Karim Bensalah, Pierre Bigot, ,

<h4>Background</h4>Data comparing percutaneous ablation (PCA) and surgical resection (SR) for an isolated local recurrence (LR) following partial nephrectomy (PN) for renal cell carcinoma (RCC) are lacking.<h4>Objective</h4>To examine the outcomes between PCA and SR for an isolated LR following PN for RCC.<h4>Design, setting, and participants</h4>Patients who underwent PN for RCC and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis.

Zine-Eddine Khene, Gilles Dosin, Benoit Peyronnet, Anis Gasmi, Nicolas Doumerc, Idir Ouzaid, Benjamin Pradere, Marie Brassier, Mathieu Roumiguié, Romain Mathieu, Nathalie Rioux-Leclercq, Jay D Raman, Shahrokh Shariat, Karim Bensalah,

To investigate the association of adherent perinephric fat (APF) with perioperative outcomes, we conducted a systematic review and meta-analysis of the literature to clarify the impact of APF in patients undergoing partial nephrectomy. A systematic literature search using the Medline, Scopus, and Cochrane databases was performed in April 2019 and ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(4):636-646]

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Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma.

Maeva Dufies, Annelies Verbiest, Lindsay S Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andréas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pagès,

Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a HIF-2-dependent regulatory pathway drives Plk1 expression in clear cell ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):166]

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review.

Thomas Seisen, Andrea Mari, Riccardo Campi, Benoit Peyronnet, Karim Bensalah, Nathalie Rioux-Leclercq, Christian Pfister, Françoise Gobet, Alexandre De La Taille, Yves Allory, Evanguelos Xylinas, Yann Neuzillet, Camelia Radulescu, Jean-Luc Descotes, Géraldine Saada-Sebag, Jacques Irani, Céline Delpech-Debiais, Pierre Bigot, Caroline Eymerit, Sebastien Crouzet, Florence Mege-Lechevallier, Alain Ruffion, Myriam Decaussin-Petrucci, Stéphane Droupy, Pascal Roger, Xavier Durand, Philippe Camparo, Olivier Cussenot, Eva Compérat, Morgan Rouprêt,

<h4>Background</h4>The current pathological tumour-node-metastasis (pTNM) classification for upper tract urothelial carcinoma (UTUC) does not include any risk stratification of pT3 renal pelvicalyceal tumours.<h4>Objective</h4>To assess the prognostic impact of pT3 subclassification in a multicentre cohort of patients with UTUC of the renal pelvicalyceal system undergoing radical nephroureterectomy (RNU).<h4>Design, setting, and participants</h4>Data ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Comparing oncological outcomes of laparoscopic vs open radical nephroureterectomy for the treatment of upper tract urothelial carcinoma: A propensity score-matched analysis.

Marco Moschini, Stefania Zamboni, Luca Afferi, Benjamin Pradere, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Morgan Roupret, Alexandre De la Taille, Claudio Simeone, Agostino Mattei, Romain Mathieu, Karim Bensalah, Manfred Peter Wirth, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Giuseppe Simone, Michele Gallucci, Carlo Di Bona, Giancarlo Marra, Andrea Mari, Ettore Di Trapani, Mario Alvarez Maestro, Wojciech Krajewski, Shahrokh F Shariat, Evanguelos Xylinas, Philipp Baumeister,

<h4>Objectives</h4>To compare oncological outcomes of open (ORNU) and laparoscopic radical nephroureterectomy (LRNU) after controlling for preoperative patient-derived factors.<h4>Patients and methods</h4>We evaluated a multi-institutional collaborative database composed of 3984 patients diagnosed with upper tract urothelial carcinoma (UTUC) treated with RNU between 2006 and 2018. To adjust for potential selection bias, propensity ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):31-36]

Cited: 2 times

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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity.

Marjorie Gournay, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Sylvie Odent, Philippe Denizeau, Cécile Vigneau, Aurélien Morini, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet,

Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(4):793-799]

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Incidence and preoperative predictors for major complications following radical nephroureterectomy.

Neil J Kocher, David Canes, Karim Bensalah, Morgan Roupret, Costas Lallas, Vitaly Margulis, Shahrokh Shariat, Pierre Colin, Surena Matin, Chad Tracy, Evanguelos Xylinas, Andrew Wagner, Mathieu Roumiguie, Wassim Kassouf, Tobias Klatte, Jay D Raman,

<h4>Background</h4>Radical nephroureterectomy (RNU) is the referent standard for managing bulky, invasive, or high grade upper-tract urothelial carcinoma (UTUC). The UTUC patient population, however, generally harbor medical comorbidities thereby placing them at risk of surgical complications. This study reviews a large international cohort of RNU patients to define the risk of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1786-1793]

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Radiomics can predict tumour response in patients treated with Nivolumab for a metastatic renal cell carcinoma: an artificial intelligence concept.

Zine-Eddine Khene, Romain Mathieu, Benoit Peyronnet, Romain Kokorian, Anis Gasmi, Fares Khene, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet, Shahrokh Shariat, Brigitte Laguerre, Karim Bensalah,

World J Urol (World journal of urology)
[2020, :]

Cited: 1 time

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Exploring Biological Predictive Factors of Progression After Surgery in High-Risk Renal Cell Carcinoma: Results From the French Cohort of the Randomized S-TRAC Trial Patients.

Idir Ouzaid, Solène Florence Kammerer-Jacquet, Zineddine Khene, Alain Ravaud, Jean-Jacques Patard, Karim Bensalah, Nathalie Rioux-Leclercq,

<b>Objective:</b> We aimed to explore biological predictive factors of progression after surgery in nonmetastatic renal cell carcinoma (RCC) using the collected tumors in the French cohort of the randomized S-TRAC trial patients. <b>Patients and Methods:</b> We analyzed the tumors of the French cohort of STRAC that included 44 cases of ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:26]

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Oncologic and Functional Outcomes of Radical and Partial Nephrectomy in pT3a Pathologically Upstaged Renal Cell Carcinoma: A Multi-institutional Analysis.

Sunil H Patel, Robert G Uzzo, Alessandro Larcher, Benoit Peyronnet, Brian R Lane, Deepak Pruthi, Madhumitha Reddy, Umberto Capitanio, Shreyas Joshi, Sabrina Noyes, Ahmed Eldefrawy, Fady Ghali, Margaret F Meagher, Zachary A Hamilton, Kendrick Yim, Ryan Nasseri, Aaron W Bradshaw, Sumi Dey, Samer Kirmiz, Fang Wan, Michael A Liss, Karim Bensalah, Francesco Montorsi, Ithaar H Derweesh,

<h4>Background</h4>The efficacy of partial nephrectomy (PN) in setting of pT3a pathologic-upstaged renal cell carcinoma (RCC) is controversial. We compared oncologic and functional outcomes of radical nephrectomy (RN) and PN in patients with upstaged pT3a RCC.<h4>Patients and methods</h4>This was a multicenter retrospective analysis of patients with cT1-2N0M0 RCC upstaged to pT3a ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(6):e723-e729]

Cited: 2 times

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