Full Text Journal Articles by
Author Kari Hemminki

Advertisement

Find full text journal articles






Second Primary Cancers After Gastric Cancer, and Gastric Cancer as Second Primary Cancer.

Guoqiao Zheng, Kristina Sundquist, Jan Sundquist, Tianhui Chen, Asta Försti, Akseli Hemminki, Kari Hemminki,

<h4>Background</h4>Second primary cancers (SPCs) are increasing, which may negatively influence patient survival. Gastric cancer (GC) has poor survival and when it is diagnosed as SPC it is often the cause of death. We wanted to analyze the risk of SPCs after GC and the risk of GC as SPC after ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2021, 13:515-525]

Cited: 0 times

View full text PDF listing >>



Combinations of Low-Frequency Genetic Variants Might Predispose to Familial Pancreatic Cancer

Emily P. Slater, Lisa M. Wilke, Lutz Benedikt Böhm, Konstantin Strauch, Manuel Lutz, Norman Gercke, Elvira Matthäi, Kari Hemminki, Asta Försti, Matthias Schlesner, Nagarajan Paramasivam, Detlef K. Bartsch,

Familial pancreatic cancer (FPC) is an established but rare inherited tumor syndrome that accounts for approximately 5% of pancreatic ductal adenocarcinoma (PDAC) cases. No major causative gene defect has yet been identified, but germline mutations in predisposition genes BRCA1/2, CDKN2A and PALB2 could be detected in 10–15% of analyzed families. ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(7):]

Cited: 0 times

View full text PDF listing >>



Advertisement

Search for AL amyloidosis risk factors using Mendelian randomization.

Charlie N Saunders, Subhayan Chattopadhyay, Stefanie Huhn, Niels Weinhold, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Börge Schmidt, Stefano Landi, Hartmut Goldschmidt, Paolo Milani, Giampaolo Merlini, Dorota Rowcieno, Philip Hawkins, Ute Hegenbart, Giovanni Palladini, Ashutosh Wechalekar, Stefan O Schönland, Asta Försti, Richard Houlston, Kari Hemminki,

In amyloid light chain (AL) amyloidosis, amyloid fibrils derived from immunoglobulin light chain are deposited in many organs, interfering with their function. The etiology of AL amyloidosis is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited by Mendelian randomization (MR) methodology to search ... Read more >>

Blood Adv (Blood advances)
[2021, 5(13):2725-2731]

Cited: 0 times

View full text PDF listing >>



Survival in colon and rectal cancers in Finland and Sweden through 50 years.

Kari Hemminki, Asta Försti, Akseli Hemminki,

<h4>Objectives</h4>Global survival studies have shown favourable development in colon and rectal cancers but few studies have considered extended periods or covered populations for which medical care is essentially free of charge.<h4>Design</h4>We analysed colon and rectal cancer survival in Finland and Sweden over a 50-year period (1967-2016) using data from the ... Read more >>

BMJ Open Gastroenterol (BMJ open gastroenterology)
[2021, 8(1):]

Cited: 0 times

View full text PDF listing >>



Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

Global survival studies have shown favorable development in renal cell carcinoma (RCC) treatment but few studies have considered extended periods or covered populations for which medical care is essentially free of charge. We analyzed RCC survival in Finland and Sweden over a 50-year period (1967-2016) using data from the NORDCAN ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0253236]

Cited: 0 times

View full text PDF listing >>



DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations.

Yasmeen Niazi, Hauke Thomsen, Bozena Smolkova, Ludmila Vodickova, Sona Vodenkova, Michal Kroupa, Veronika Vymetalkova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Marta Staruchova, Per Hoffmann, Markus M Nöthen, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Kari Hemminki, Asta Försti,

DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). Non-specific CAs have been used in the monitoring of individuals exposed to potential carcinogenic chemicals and radiation. The frequency of CAs in peripheral blood lymphocytes (PBLs) ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:691947]

Cited: 0 times

View full text PDF listing >>



Bladder and upper urinary tract cancers as first and second primary cancers.

Guoqiao Zheng, Kristina Sundquist, Jan Sundquist, Asta Försti, Otto Hemminki, Kari Hemminki,

<h4>Background</h4>Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter.<h4>Aims</h4>To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as ... Read more >>

Cancer Rep (Hoboken) (Cancer reports (Hoboken, N.J.))
[2021, :e1406]

Cited: 0 times

View full text PDF listing >>



Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations.

Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki,

Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):12370]

Cited: 0 times

View full text PDF listing >>



Incidence trends in lung and bladder cancers in the Nordic Countries before and after the smoking epidemic.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

Cigarette smoking epidemic, which started before the World War II, completely changed the cancer landscape. Reliable incidence data spanning the stepwise spreading epidemic are rare, but the Nordic cancer registries are unique sources in being able to catch the pre-epidemic situation in the female population where smoking became more prevalent ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

Cited: 0 times

View full text PDF listing >>



Incidence trends in bladder and lung cancers between Denmark, Finland and Sweden may implicate oral tobacco (snuff/snus) as a possible risk factor.

Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg, Otto Hemminki,

<h4>Background</h4>The dominant risk factor for urinary bladder cancer has been cigarette smoking, but, as smoking prevalence is decreasing in many populations, other risk factors may become uncovered. Such new risk factors could be responsible for halting the declining incidence of bladder cancer. We hypothesize that snuff use by Swedish men ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):604]

Cited: 0 times

View full text PDF listing >>



Anticancer agents: qualitative and quantitative aspects

Kari Hemminki, Harri Vainio,

()
[, :]

Cited: 0 times

View full text PDF listing >>



A Novel Low-Risk Germline Variant in the SH2 Domain of the SRC Gene Affects Multiple Pathways in Familial Colorectal Cancer.

Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Kuświk, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

Colorectal cancer (CRC) shows one of the largest proportions of familial cases among different malignancies, but only 5-10% of all CRC cases are linked to mutations in established predisposition genes. Thus, familial CRC constitutes a promising target for the identification of novel, high- to moderate-penetrance germline variants underlying cancer susceptibility ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(4):]

Cited: 0 times

View full text PDF listing >>



Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts.

Juan Sainz, Francisco José García-Verdejo, Manuel Martínez-Bueno, Abhishek Kumar, José Manuel Sánchez-Maldonado, Anna Díez-Villanueva, Ludmila Vodičková, Veronika Vymetálková, Vicente Martin Sánchez, Miguel Inacio Da Silva Filho, Belém Sampaio-Marques, Stefanie Brezina, Katja Butterbach, Rob Ter Horst, Michael Hoffmeister, Paula Ludovico, Manuel Jurado, Yang Li, Pedro Sánchez-Rovira, Mihai G Netea, Andrea Gsur, Pavel Vodička, Víctor Moreno, Kari Hemminki, Hermann Brenner, Jenny Chang-Claude, Asta Försti,

The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

Cited: 0 times

View full text PDF listing >>



Whole Exome Sequencing Identifies Novel Germline Variants of SLC15A4 Gene as Potentially Cancer Predisposing in Familial Colorectal Cancer

Diamanto Skopelitou, Aayushi Srivastava, Beiping Miao, Abhishek Kumar, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

About 15% of colorectal cancer (CRC) patients have first-degree relatives affected by the same malignancy. However, for most families the cause of familial aggregation of CRC is unknown. In order to identify novel high-to-moderate penetrant germline variants underlying CRC susceptibility, we performed whole exome sequencing (WES) on four CRC cases ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



A Novel Low-Risk Germline Variant in the SH2 Domain of the SRC Gene Affects Multiple Pathways in Familial Colorectal Cancer

Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Kuświk, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

Colorectal cancer (CRC) shows one of the largest proportions of familial cases among different malignancies, but only 5-10% of all CRC cases are linked to mutations in established predisposition genes. Thus, familial CRC constitutes a promising target for the identification of novel, high- to moderate-penetrance germline variants underlying cancer susceptibility ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.

Aayushi Srivastava, Sara Giangiobbe, Diamanto Skopelitou, Beiping Miao, Nagarajan Paramasivam, Chiara Diquigiovanni, Elena Bonora, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

Familial inheritance in non-medullary thyroid cancer (NMTC) is an area that has yet to be adequately explored. Despite evidence suggesting strong familial clustering of non-syndromic NMTC, known variants still account for a very small percentage of the genetic burden. In a recent whole genome sequencing (WGS) study of five families ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:600682]

Cited: 1 time

View full text PDF listing >>



DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.

Yasmeen Niazi, Hauke Thomsen, Bozena Smolkova, Ludmila Vodickova, Soňa Vodenkova, Michal Kroupa, Veronika Vymetalkova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Marta Staruchova, Per Hoffmann, Markus M Nöthen, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Asta Försti, Kari Hemminki,

Nonspecific structural chromosomal aberrations (CAs) can be found at around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. The frequency of CAs has been measured in occupational monitoring and an increased frequency of CAs has also been associated ... Read more >>

DNA Repair (Amst) (DNA repair)
[2021, 101:103079]

Cited: 0 times

View full text PDF listing >>



Characterization of rare germline variants in familial multiple myeloma.

Calogerina Catalano, Nagarajan Paramasivam, Joanna Blocka, Sara Giangiobbe, Stefanie Huhn, Matthias Schlesner, Niels Weinhold, Rolf Sijmons, Mirjam de Jong, Christian Langer, Klaus-Dieter Preuss, Björn Nilsson, Brian Durie, Hartmut Goldschmidt, Obul Reddy Bandapalli, Kari Hemminki, Asta Försti,

Blood Cancer J (Blood cancer journal)
[2021, 11(2):33]

Cited: 0 times

View full text PDF listing >>



Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.

Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Kuswick, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubinski, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

Germline mutations in predisposition genes account for only 20% of all familial colorectal cancers (CRC) and the remaining genetic burden may be due to rare high- to moderate-penetrance germline variants that are not explored. With the aim of identifying such potential cancer-predisposing variants, we performed whole exome sequencing on three ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

Cited: 0 times

View full text PDF listing >>



Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer

Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Kuświk, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli,

Germline mutations in predisposition genes account for only 20% of all familial colorectal cancer (CRC) and the remaining genetic burden may be due to rare high-to-moderate-penetrance germline variants that are not explored. With the aim of identifying such potential cancer predisposing variants, we performed whole exome sequencing on three CRC ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



A rare large duplication of MLH1 identified in Lynch syndrome.

Abhishek Kumar, Nagarajan Paramasivam, Obul Reddy Bandapalli, Matthias Schlesner, Tianhui Chen, Rolf Sijmons, Dagmara Dymerska, Katarzyna Golebiewska, Magdalena Kuswik, Jan Lubinski, Kari Hemminki, Asta Försti,

<h4>Background</h4>The most frequently identified strong cancer predisposition mutations for colorectal cancer (CRC) are those in the mismatch repair (MMR) genes in Lynch syndrome. Laboratory diagnostics include testing tumors for immunohistochemical staining (IHC) of the Lynch syndrome-associated DNA MMR proteins and/or for microsatellite instability (MSI) followed by sequencing or other techniques, ... Read more >>

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2021, 19(1):10]

Cited: 0 times

View full text PDF listing >>



Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.

Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki,

<h4>Background</h4>Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the ... Read more >>

Autoimmune Dis (Autoimmune diseases)
[2021, 2021:8815297]

Cited: 0 times

View full text PDF listing >>



Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients.

Michal Kroupa, Sivaramakrishna Rachakonda, Veronika Vymetalkova, Kristyna Tomasova, Vaclav Liska, Sona Vodenkova, Andrea Cumova, Andrea Rossnerova, Ludmila Vodickova, Kari Hemminki, Pavel Soucek, Rajiv Kumar, Pavel Vodicka,

Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL ... Read more >>

Mutagenesis (Mutagenesis)
[2020, 35(6):491-497]

Cited: 0 times

View full text PDF listing >>



Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden.

Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki,

Giant cell arteritis (GCA, also called temporal arteritis) is a rare and Takayasu arteritis (TA) is an even rarer autoimmune disease (AID), both of which present with inflammatory vasculitis of large and medium size arteries. The risk factors are largely undefined but disease susceptibility has been associated with human leukocyte ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20887]

Cited: 0 times

View full text PDF listing >>



Familial associations for Addison's disease and between Addison's disease and other autoimmune diseases.

Hauke Thomsen, Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki,

<h4>Design</h4>Addison's disease (AD) is a rare autoimmune disease (AID) of the adrenal cortex, present as an isolated AD or part of autoimmune polyendocrine syndromes (APSs) 1 and 2. Although AD patients present with a number of AID co-morbidities, population-based family studies are scarce, and we aimed to carry out an ... Read more >>

Endocr Connect (Endocrine connections)
[2020, 9(11):1114-1120]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1503 s