Full Text Journal Articles by
Author Kara S Hughan

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Longitudinal Changes in Cardiac Structure and Function From Adolescence to Young Adulthood in Participants With Type 2 Diabetes Mellitus: The TODAY Follow-Up Study.

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BACKGROUND:Heart failure is a prominent complication of type 2 diabetes mellitus (T2D). The goal of this study was to provide longitudinal data on cardiac structure and function (and cross-sectional comparison to normal-weight and obese controls without T2D) in individuals followed from adolescence with youth-onset T2D. METHODS:In the TODAY study (Treatment ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2020, 13(6):e006685]

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Glycemic control and FEV1 recovery during pulmonary exacerbations in pediatric cystic fibrosis-related diabetes.

William Okoniewski, Kara S Hughan, Gabriel A Weiner, Daniel J Weiner, Erick Forno,

RATIONALE:Whether short-term glucose control in cystic fibrosis-related diabetes (CFRD) is associated with FEV1 recovery during acute pulmonary exacerbations is unclear. METHODS:Data from all patients with CFRD ages 6-21 years hospitalized in 2010-2016 for pulmonary exacerbations at our CF Center were analyzed, including CFRD status at each encounter, all FEV1 recorded ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2020, 19(3):460-465]

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Adrenal function in cystic fibrosis.

Maria Socorro Rayas, Andrea Kelly, Kara S Hughan, Tanicia Daley, David Zangen,

Cystic fibrosis (CF) is not known to directly affect the adrenal gland, but commonly used CF therapies do impact the function of the hypothalamic-pituitary-adrenal (HPA) axis. By binding to the glucocorticoid receptor, medications such as inhaled and oral corticosteroids can enhance the systemic effects of cortisol and result in iatrogenic ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2019, 18 Suppl 2:S74-S81]

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Female reproductive health in cystic fibrosis.

Kara S Hughan, Tanicia Daley, Maria Socorro Rayas, Andrea Kelly, Andrea Roe,

Women with cystic fibrosis (CF) are living longer and healthier lives, and opportunities for childbearing are increasingly promising. However, this population can also face sexual and reproductive health concerns, including menstrual irregularities, unplanned pregnancies, infertility and pregnancy complications. Additionally, more women are entering menopause and are at risk for the ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2019, 18 Suppl 2:S95-S104]

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 5 times

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The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth.

Joon Young Kim, Sara F Michaliszyn, Alexis Nasr, SoJung Lee, Hala Tfayli, Tamara Hannon, Kara S Hughan, Fida Bacha, Silva Arslanian,

OBJECTIVE:The shape of the glucose response curve during an oral glucose tolerance test (OGTT), monophasic versus biphasic, identifies physiologically distinct groups of individuals with differences in insulin secretion and sensitivity. We aimed to verify the value of the OGTT-glucose response curve against more sensitive clamp-measured biomarkers of type 2 diabetes ... Read more >>

Diabetes Care (Diabetes care)
[2016, 39(8):1431-1439]

Cited: 15 times

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SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Yen-Chun Lai, Diana M Tabima, John J Dube, Kara S Hughan, Rebecca R Vanderpool, Dmitry A Goncharov, Claudette M St Croix, Adolfo Garcia-Ocaña, Elena A Goncharova, Stevan P Tofovic, Ana L Mora, Mark T Gladwin,

Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic syndrome. No adequate animal model of PH-HFpEF is available, and no effective therapies have been identified to date. A recent study suggested that dietary nitrate improves insulin resistance in endothelial nitric ... Read more >>

Circulation (Circulation)
[2016, 133(8):717-731]

Cited: 67 times

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Early Biomarkers of Subclinical Atherosclerosis in Obese Adolescent Girls with Polycystic Ovary Syndrome.

Kara S Hughan, Hala Tfayli, Julia G Warren-Ulanch, Emma Barinas-Mitchell, Silva A Arslanian,

Because in obese youth, pulse wave velocity (PWV), an early cardiovascular disease marker, is elevated, we tested if obese girls with polycystic ovary syndrome (OB-PCOS) have higher PWV and carotid intima-media thickness (cIMT) compared with obese girls without PCOS (OB-non-PCOS) and normal-weight girls without PCOS (NW-non-PCOS) and whether PWV and ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2016, 168:104-11.e1]

Cited: 11 times

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Health disparities in cardiovascular disease risk in obese youth.

Kara S Hughan, Radhika Muzumdar,

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2015, 21(2):208-210]

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β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents.

Kara S Hughan, Riccardo C Bonadonna, SoJung Lee, Sara F Michaliszyn, Silva A Arslanian,

OBJECTIVE:Overweight/obese (OW/OB) African American (AA) adolescents have a more diabetogenic insulin secretion/sensitivity pattern compared with their American white (AW) peers. The present study investigated β-cell lipotoxicity to test whether increased free fatty acid (FFA) levels result in greater β-cell dysfunction in AA vs AW OW/OB adolescents. RESEARCH DESIGN AND METHODS:Glucose-stimulated ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2013, 98(5):2062-2069]

Cited: 11 times

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