Full Text Journal Articles by
Author Kanjiro Miyata

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Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model.

Masaya Sano, Daisuke Akagi, Mitsuru Naito, Katsuyuki Hoshina, Kanjiro Miyata, Kazunori Kataoka, Soichiro Ishihara,

Neointimal hyperplasia (NIH) after revascularization is a key unsolved clinical problem. Various studies have shown that attenuation of the acute inflammatory response on the vascular wall can prevent NIH. MicroRNA146a-5p (miR146a-5p) has been reported to show anti-inflammatory effects by inhibiting the NF-κB pathway, a well-known key player of inflammation of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(9):e22486]

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Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.

Mitsuru Naito, Yusuke Watanuki, Kazuko Toh, Jongmin Yum, Beob Soo Kim, Kaori Taniwaki, Satomi Ogura, Hiroki Ishida, Masaru Cho, Hiroyuki Chaya, Ken Miyajima, Yuichi Yamasaki, Kensuke Osada, Katsura Minegishi, Yoshitsugu Aoki, Kanjiro Miyata,

Muscle-targeted drug delivery is a major challenge in nanomedicine. The extravasation of nanomedicines (or nanoparticles) from the bloodstream into muscle tissues is hindered by the continuous endothelium, the so-called blood-muscle barrier. This study aimed to evaluate the optimal size of macromolecular drugs for extravasation (or passive targeting) into muscle tissues. ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2022, 347:607-614]

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