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Author Kanako Watanabe

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Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]

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In Vivo Metabolites of AB-PINACA in Solid Tissues Obtained from Its Abuser: Comparison with In Vitro Experiment.

Kayoko Minakata, Koutaro Hasegawa, Itaru Yamagishi, Hideki Nozawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe,

In this study, solid tissues such as the lung, liver, kidney and urine were highlighted to profile the AB-PINACA in vivo metabolites in a fatal abuse case, although such metabolite analysis is usually made with urine specimens. We compared the relative peak intensities of in vivo metabolites of AB-PINACA in ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2021, 44(9):1027-1035]

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Quantification of Major Metabolites of AB-FUBINACA in Solid Tissues Obtained from An Abuser.

Kayoko Minakata, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe,

AB-FUBINACA M3 was reported to be a major metabolite of the drug, but its in vivo concentration in authentic human solid tissues has not been quantified yet. Another metabolite AB-FUBINACA M4 did not receive much attention previously and also has not been quantified yet in any authentic human specimens. The ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2020, :]

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Postmortem distribution/redistribution of buformin in body fluids and solid tissues in an autopsy case using liquid chromatography-tandem mass spectrometry with QuEChERS extraction method.

Amin Wurita, Koutaro Hasegawa, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki,

An autopsy for a suicidal case of a male in his 40s, who had died of poisoning due to ingestion of a large amount of buformin, was performed at our department. Buformin is biganide class agent used for patients of diabetes mellitus, which can occasionally cause severe lactic acidosis. The ... Read more >>

Forensic Sci Int (Forensic science international)
[2020, 314:110376]

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Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants.

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh,

BACKGROUND:Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES:To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104256]

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Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants.

Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants.<h4>Methods</h4>In this prospective study, we evaluated stool ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):501-506]

Cited: 2 times

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2635. Outbreak of Enterovirus D68 Among Children in Japan and Simultaneous Circulation of Clade B3 in Europe.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]

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2586. Human Breast Milk Inhibits the Replication of Parechovirus-A3.

Ryohei Izumita, Kazuki Kon, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. We previously reported that maternal antibodies against PeV-A3 are important to protect neonates and young infants from the infection. Recent studies showed that (1) breastfeeding had a protective effect against enterovirus, which is closely-related virus ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S899-S899]

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2585. Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan

Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]

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Persistence of High Neutralizing Antibody Titers After Neonatal and Early Infantile Infection with Parechovirus-A3.

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

This 3-year follow-up study evaluated neutralizing antibody titers (NATs) against parechovirus-A3 (PeV-A3) in neonates and young infants who developed PeV-A3 infection. All children had low NATs at disease onset and high NATs after infection during infancy. At age 3 years, all 16 patients tested had high NATs (≥1:512) against PeV-A3 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(7):e159-e161]

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2349. Long-Term Neurological Outcome and Neutralizing Antibody Titers Against Paraechovirus-A3 (PeV-A3) in Children who Developed PeV-A3-Related Diseases in Neonatal and Infantile Periods.

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundParechovirus-A3 (PeV-A3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. We previously reported that maternal antibodies against PeV-A3 are important to protect neonates and young infants from the infection. We showed that all neonates and infants who developed PeV-A3-related diseases had low neutralizing antibody titers ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S698-S699]

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A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP.

Itaru Yamagishi, Kayoko Minakata, Hideki Nozawa, Koutaro Hasegawa, Masako Suzuki, Takuya Kitamoto, Osamu Suzuki, Kanako Watanabe,

We report a case of intoxication with a mixture of three synthetic cannabinoids and a synthetic cathinone, which have been disclosed by a highly sensitive progressing technology. A man was found dead, and his forensic autopsy was performed at our department. After further examinations of his specimens, EAM-2201 and α-PVP ... Read more >>

Leg Med (Tokyo) (Legal medicine (Tokyo, Japan))
[2018, 35:44-49]

Cited: 2 times

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Fatal zolpidem poisoning due to its intravenous self-injection: Postmortem distribution/redistribution of zolpidem and its predominant metabolite zolpidem phenyl-4-carboxylic acid in body fluids and solid tissues in an autopsy case.

Koutaro Hasegawa, Amin Wurita, Hideki Nozawa, Itaru Yamagishi, Kayoko Minakata, Kanako Watanabe, Osamu Suzuki,

We experienced a curious fatal case, in which a male in his 20s self-administered zolpidem intravenously. The victim was found dead lying on floor of his apartment room, with a tourniquet band and new injection marks on his right forearm. Nearby the body, a medical disposal syringe containing small-volume solution ... Read more >>

Forensic Sci Int (Forensic science international)
[2018, 290:111-120]

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Expression of glyceraldehyde-3-phosphate dehydrogenase on the surface of Clostridium perfringens cells.

Nozomu Matsunaga, Haruka Shimizu, Kanako Fujimoto, Kanako Watanabe, Tsutomu Yamasaki, Naoya Hatano, Eiji Tamai, Seiichi Katayama, Yasuo Hitsumoto,

During research to identify fibronectin (Fn)-binding proteins (Fbps) on the surface of Clostridium perfringens cells, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a candidate Fbp. GAPDH is a glycolytic enzyme found in a wide range of prokaryotes and eukaryotes. The Fn-binding activity of recombinant C. perfringens GAPDH (rGAPDH) was investigated using both ... Read more >>

Anaerobe (Anaerobe)
[2018, 51:124-130]

Cited: 2 times

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Elevated Level of Myeloperoxidase-Deoxyribonucleic Acid Complex in the Middle Ear Fluid Obtained From Patients With Otitis Media Associated With Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

Shinya Morita, Yuji Nakamaru, Daigo Nakazawa, Fumihiko Hattanda, Haruki Shida, Yoshihiro Kusunoki, Kanako Watanabe, Sakiko Masuda, Dai Takagi, Masanobu Suzuki, Kimiko Hoshino, Atsushi Fukuda, Utano Tomaru, Akihiro Homma, Akihiro Ishizu,

OBJECTIVE:The purpose was to explore the presence of myeloperoxidase (MPO)-deoxyribonucleic acid (DNA) complex as a surrogate marker of neutrophil extracellular traps (NETs) in the middle ear fluid, and to clarify the correlation between its quantifiable level and hearing outcome in patients with otitis media associated with antineutrophil cytoplasmic antibody (ANCA)-associated ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2018, 39(4):e257-e262]

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Antiviral Activity of Peptide Nucleic Acid against Human Parechovirus Type 3.

Taketo O tsuka, Ryohei Izumita, Kanako Watanabe, Akihiko Saitoh,

AbstractBackgroundHuman parechovirus (HPeV) type 3 (HPeV3) is an emerging pathogen causing sepsis and meningoencephalitis in neonates and young infants. However, specific treatment for HPeV3 infection is currently unavailable. The application of antisense technology, such as peptide nucleic acids (PNAs), to viral infection has opened a new era of therapeutics. The ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S521-S521]

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Can We Distinguish between Human Parechovirus Type 3 and Enteroviruses Infection in Neonates and Young Infants Based on their Clinical and Laboratory Findings?

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundHuman parechovirus type 3 (HPeV3) and enteroviruses (EVs) are the major viral pathogens causing severe diseases in neonates and young infants. Although two infections typically occur in summer, and initial clinical presentations are similar, differences in clinical and laboratory characteristics of HPeV3- and EV- infections are not well described.MethodsFrom January ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S693-S693]

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Identification and quantification of predominant metabolites of synthetic cannabinoid MAB-CHMINACA in an authentic human urine specimen.

Koutaro Hasegawa, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki,

An autopsy case in which the cause of death was judged as drug poisoning by two synthetic cannabinoids, including MAB-CHMINACA, was investigated. Although unchanged MAB-CHMINACA could be detected from solid tissues, blood and stomach contents in the case, the compound could not be detected from a urine specimen. We obtained ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2018, 10(2):365-371]

Cited: 4 times

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Asymptomatic Adults and Children Can Transmit Human Parechoviruses and Enteroviruses to Neonates and Young Infants

Ryohei Izumita, Yuta Aizawa, Kanako Watanabe, Akihiko Saitoh,

Abstract <h4>Background</h4> Human parechovirus (HPeV) type 3 and enteroviruses (EVs) are the common viruses causing severe diseases in neonates and young infants. Given no specific therapy is currently available and the morbidity and mortality of the diseases are high, understanding the detailed transmission routes is critical for the prevention. <h4>Methods</h4> ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S459-S459]

Cited: 0 times

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[A Case of Fanconi's Syndrome Induced by Adefovir in Hepatitis Type B Patient].

Kanako Watanabe, Seiji Hashimoto, Tomochika Maoka, Rie Yamamoto, Nobuhiko Okamoto, Takao Koike,

Nihon Naika Gakkai Zasshi (Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine)
[2016, 105(6):1026-1033]

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Clinical utility of serum samples for human parechovirus type 3 infection in neonates and young infants: The 2014 epidemic in Japan.

Yuta Aizawa, Yuko Suzuki, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh,

During the 2014 human parechovirus type 3 (HPeV3) epidemic in Niigata, Japan, this prospective observational study identified HPeV3 from 43/85 (51%) febrile young infants <4 months using PCR analysis of serum (n = 42) and/or cerebrospinal fluid (CSF) (n = 32) and genetic sequencing of the VP1 region of HPeV3. HPeV3-infected patients (median age, ... Read more >>

J Infect (The Journal of infection)
[2016, 72(2):223-232]

Cited: 14 times

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Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.

Yuta Aizawa, Kanako Watanabe, Tomohiro Oishi, Harunobu Hirano, Isao Hasegawa, Akihiko Saitoh,

Human parechovirus type 3 (HPeV3) is an emerging pathogen that causes sepsis and meningoencephalitis in young infants. To test the hypothesis that maternal antibodies can protect this population, we measured neutralizing antibody titers (NATs) to HPeV3 and other genotypes (HPeV1 and HPeV6) in 175 cord blood samples in Japan. The ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2015, 21(11):1966-1972]

Cited: 22 times

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Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants.

Yuta Aizawa, Takayuki Yamanaka, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh,

<h4>Background</h4>Human parechovirus type 3 (HPeV3) epidemics occur worldwide and can lead to severe disease in neonates and young infants. Little is known about the source of HPeV3 infection.<h4>Objectives</h4>To investigate the source of HPeV3 infection and the role of asymptomatic children in the families of infected children.<h4>Study design</h4>During a 2014 HPeV3 ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2015, 70:105-108]

Cited: 11 times

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Identification and quantification of metabolites of AB-CHMINACA in a urine specimen of an abuser.

Amin Wurita, Koutaro Hasegawa, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Osamu Suzuki, Kanako Watanabe,

We experienced an autopsy case in which the cause of death was judged as poisoning by multiple new psychoactive substances, including AB-CHMINACA, 5-fluoro-AMB and diphenidine [Forensic Toxicol. 33 (2015): 45-53]. Although unchanged AB-CHMINACA could be detected from 8 solid tissues, it could neither be detected from blood nor urine specimens. ... Read more >>

Leg Med (Tokyo) (Legal medicine (Tokyo, Japan))
[2016, 19:113-118]

Cited: 7 times

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Postmortem distribution of flunitrazepam and its metabolite 7-aminoflunitrazepam in body fluids and solid tissues in an autopsy case: Usefulness of bile for their detection.

Koutaro Hasegawa, Amin Wurita, Kayoko Minakata, Kunio Gonmori, Hideki Nozawa, Itaru Yamagishi, Kanako Watanabe, Osamu Suzuki,

We experienced an autopsy case of a woman in her 70s, in which the direct cause of her death was judged as asphyxia due to the occlusion of food in the trachea. The postmortem interval was estimated at about 2days. The specimens dealt with were femoral vein blood, right heart ... Read more >>

Leg Med (Tokyo) (Legal medicine (Tokyo, Japan))
[2015, 17(5):394-400]

Cited: 1 time

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