Full Text Journal Articles by
Author Kamran Nazmi

Advertisement

Find full text journal articles






Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes.

Alsya J Affandi, Joanna Grabowska, Katarzyna Olesek, Miguel Lopez Venegas, Arnaud Barbaria, Ernesto Rodríguez, Patrick P G Mulder, Helen J Pijffers, Martino Ambrosini, Hakan Kalay, Tom O'Toole, Eline S Zwart, Geert Kazemier, Kamran Nazmi, Floris J Bikker, Johannes Stöckl, Alfons J M van den Eertwegh, Tanja D de Gruijl, Gert Storm, Yvette van Kooyk, Joke M M den Haan,

Priming of CD8+ T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1+ antigen-presenting cells using gangliosides as targeting ligands. Ganglioside-liposomes specifically bound to CD169 and were internalized by in ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(44):27528-27539]

Cited: 0 times

View full text PDF listing >>



Human Salivary Histatin-1 Promotes Osteogenic Cell Spreading on Both Bio-Inert Substrates and Titanium SLA Surfaces.

Wei Sun, Dandan Ma, Jan G M Bolscher, Kamran Nazmi, Enno C I Veerman, Floris J Bikker, Ping Sun, Haiyan Lin, Gang Wu,

Promoting cell spreading is crucial to enhance bone healing and implant osteointegration. In this study, we investigated the stimulatory effect of human salivary histatin-1 (Hst-1) on the spreading of osteogenic cells in vitro as well as the potential signaling pathways involved. Osteogenic cells were seeded on bio-inert glass slides with ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2020, 8:584410]

Cited: 0 times

View full text PDF listing >>



Advertisement

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

Cited: 0 times

View full text PDF listing >>



Elevated Baseline Salivary Protease Activity May Predict the Steadiness of Gingival Inflammation During Periodontal Healing: A 12-Week Follow-Up Study on Adults.

Ulvi Kahraman Gürsoy, Dareen Fteita, Floris J Bikker, Maria Anastasia Grande, Kamran Nazmi, Mervi Gürsoy, Eija Könönen, Daniel Belstrøm,

Aim was to profile salivary total protease, Porphyromonas gingivalis gingipain, and neutrophil elastase activities in relation to the resolution of periodontal inflammation, salivary macrophage-derived chemokine (MDC), and macrophage inflammatory protein-1α concentrations. Nonsurgical periodontal treatment was performed in 24 periodontitis patients in a prospective interventional study design. Periodontal clinical parameters were ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(9):]

Cited: 0 times

View full text PDF listing >>



A stepwise approach investigating salivary responses upon multisensory food cues.

Paulina Morquecho-Campos, Floris J Bikker, Kamran Nazmi, Kees de Graaf, Marja L Laine, Sanne Boesveldt,

Exposure to sensory food cues such as smell, vision, taste and/or texture may trigger anticipatory physiological responses such as salivation, participating on adequate metabolism of the signaled food. However, the individual contribution of each sensory modality as well as the impact of particular food products on salivation and salivary composition ... Read more >>

Physiol Behav (Physiology & behavior)
[2020, 226:113116]

Cited: 0 times

View full text PDF listing >>



Survival of the Halophilic Archaeon Halovarius luteus after Desiccation, Simulated Martian UV Radiation and Vacuum in Comparison to Bacillus atrophaeus.

Niloofar Feshangsaz, Farid Semsarha, Saeed Hesami Tackallou, Kamran Nazmi, Euan P Monaghan, Andreas Riedo, Jack J W A van Loon,

Extraterrestrial environments influence the biochemistry of organisms through a variety of factors, including high levels of radiation and vacuum, temperature extremes and a lack of water and nutrients. A wide variety of terrestrial microorganisms, including those counted amongst the most ancient inhabitants of Earth, can cope with high levels of ... Read more >>

Orig Life Evol Biosph (Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.

Dandan Ma, Wei Sun, Kamran Nazmi, Enno C I Veerman, Floris J Bikker, Richard T Jaspers, Jan G M Bolscher, Gang Wu,

Human salivary histatin 1 (Hst1) and Hst2 exhibit a series of cell-activating properties (e.g., promoting adhesion, spreading, migration and metabolic activity of mammalian cells). In contrast, Hst5 shows an anti-fungal property but no cell-activating properties. Previous findings suggest that their uptake and association with subcellular targets may play a determinant ... Read more >>

Cells (Cells)
[2020, 9(4):]

Cited: 1 time

View full text PDF listing >>



LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

Rosalie Zwiggelaar, Håvard Lindholm, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno Oudhoff,

ABSTRACT Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify new regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro.

Wei Sun, Andi Shi, Dandan Ma, Jan G M Bolscher, Kamran Nazmi, Enno C I Veerman, Floris J Bikker, Haiyan Lin, Gang Wu,

Cell-based bone tissue engineering techniques utilize both osteogenic cells and biomedical materials, and have emerged as a promising approach for large-volume bone repair. The success of such techniques is highly dependent on cell adhesion, spreading, and osteogenic activities. In this study, we investigated the effect of co-administration of all-trans retinoic ... Read more >>

FEBS Open Bio (FEBS open bio)
[2020, 10(3):396-406]

Cited: 2 times

View full text PDF listing >>



Diversity of SpaP in genetic and salivary agglutinin mediated adherence among Streptococcus mutans strains.

Jingmei Yang, Dongmei Deng, Bernd W Brandt, Kamran Nazmi, Yafei Wu, Wim Crielaard, Antoon J M Ligtenberg,

Streptococcus mutans SpaP mediates the binding of this cariogenic bacteria to tooth surfaces. It was reported that the SpaP of S. mutans clinical isolates could be classified to 2 genotypes, type A and B. Our aims are to examine spaP genotypes in often-used S. mutans laboratory strains as well as ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19943]

Cited: 0 times

View full text PDF listing >>



Gingival tissue human beta-defensin levels in relation to infection and inflammation.

Meltem Özdemir, Feriha Caglayan, Floris J Bikker, Pirkko Pussinen, Eija Könönen, Nermin Yamalik, Mervi Gürsoy, Dareen Fteita, Kamran Nazmi, Güliz N Güncü, Milla Pietiäinen, Mimmi Tolvanen, Ulvi Kahraman Gürsoy,

AIM:To profile gingival tissue levels of human beta-defensin (hBD)-2 and hBD-3 in relation to gingival inflammation, Th17-related cytokine concentrations, Porphyromonas gingivalis counts, and gingipain and total protease activities. MATERIALS AND METHODS:Gingival tissue and subgingival plaque samples were collected from 21 periodontitis patients including 48 periodontal pocket sites with marginal, mild, ... Read more >>

J Clin Periodontol (Journal of clinical periodontology)
[2020, 47(3):309-318]

Cited: 0 times

View full text PDF listing >>



DMBT1 inhibition of Pseudomonas aeruginosa twitching motility involves its N-glycosylation and cannot be conferred by the Scavenger Receptor Cysteine-Rich bacteria-binding peptide domain.

Jianfang Li, Stephanie J Wan, Matteo M E Metruccio, Sophia Ma, Kamran Nazmi, Floris J Bikker, David J Evans, Suzanne M J Fleiszig,

The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer consensus sequence peptide, SRCRP2. Previously, we showed that DMBT1 bound Pseudomonas aeruginosa pili, and inhibited twitching motility, a pilus-mediated movement ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13146]

Cited: 0 times

View full text PDF listing >>



Salivary Total Protease Activity Based on a Broad-Spectrum Fluorescence Resonance Energy Transfer Approach to Monitor Induction and Resolution of Gingival Inflammation.

Floris J Bikker, Gustavo G Nascimento, Kamran Nazmi, Angelika Silbereisen, Georgios N Belibasakis, Wendy E Kaman, Rodrigo Lopez, Nagihan Bostanci,

OBJECTIVE:Salivary total protease and chitinase activities were measured by a broad-spectrum fluorescence resonance energy transfer approach as predictors of induction and resolution of gingival inflammation in healthy individuals by applying an experimental human gingivitis model. METHODS:Dental biofilm accumulated (21 days, Induction Phase) by omitting oral hygiene practices followed by a 2-week ... Read more >>

Mol Diagn Ther (Molecular diagnosis & therapy)
[2019, 23(5):667-676]

Cited: 0 times

View full text PDF listing >>



Lactoferrin Disaggregates Pneumococcal Biofilms and Inhibits Acquisition of Resistance Through Its DNase Activity.

Uriel A Angulo-Zamudio, Jorge E Vidal, Kamran Nazmi, Jan G M Bolscher, Claudia Leon-Sicairos, Brenda S Antezana, Adrián Canizalez-Roman, Nidia León-Sicairos,

Streptococcus pneumoniae colonizes the upper airways of children and the elderly. Colonization progresses to persistent carriage when S. pneumoniae forms biofilms, a feature required for the development of pneumococcal disease. Nasopharyngeal biofilms are structured with a matrix that includes extracellular DNA (eDNA), which is sourced from the same pneumococci and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2386]

Cited: 0 times

View full text PDF listing >>



Impact of food odors signaling specific taste qualities and macronutrient content on saliva secretion and composition.

Paulina Morquecho-Campos, Floris J Bikker, Kamran Nazmi, Kees de Graaf, Marja L Laine, Sanne Boesveldt,

Olfactory food cues can induce appetite for similar food products in humans. Odors may thus signal essential information about a foods' composition such as taste or even macronutrient content and may stimulate specific physiological responses in anticipation of food intake. Several studies have shown that sensory food cues could stimulate ... Read more >>

Appetite (Appetite)
[2019, 143:104399]

Cited: 1 time

View full text PDF listing >>



Synergistic effects of LFchimera and antibiotic against planktonic and biofilm form of Aggregatibacter actinomycetemcomitans.

Marie Rossini Carmela T Lachica, Chitchanok Anutrakunchai, Saengsome Prajaneh, Kamran Nazmi, Jan G M Bolscher, Suwimol Taweechaisupapong,

Adjunctive use of antibiotics in periodontal treatment have limitations and disadvantages including bacterial resistance. Antimicrobial peptides (AMPs) are potential new agents that can combat bacterial infection. In this study, antimicrobial activity of different concentrations of conventional antibiotics minocycline (MH), doxycycline (DOX), and antimicrobial peptides LL-37, LL-31, Lactoferrin chimera (LFchimera) and ... Read more >>

PLoS One (PloS one)
[2019, 14(7):e0217205]

Cited: 0 times

View full text PDF listing >>



A rapid, non-invasive tool for periodontitis screening in a medical care setting.

Martijn J L Verhulst, Wijnand J Teeuw, Sergio Bizzarro, Joris Muris, Naichuan Su, Elena A Nicu, Kamran Nazmi, Floris J Bikker, Bruno G Loos,

BACKGROUND:Since periodontitis is bi-directionally associated with several systemic diseases, such as diabetes mellitus and cardiovascular diseases, it is important for medical professionals in a non-dental setting to be able examine their patients for symptoms of periodontitis, and urge them to visit a dentist if necessary. However, they often lack the ... Read more >>

BMC Oral Health (BMC oral health)
[2019, 19(1):87]

Cited: 3 times

View full text PDF listing >>



D-LL-31 in combination with ceftazidime synergistically enhances bactericidal activity and biofilm destruction in Burkholderia pseudomallei.

Saharut Wongkaewkhiaw, Suwimol Taweechaisupapong, Chitchanok Anutrakunchai, Kamran Nazmi, Jan G M Bolscher, Surasakdi Wongratanacheewin, Sakawrat Kanthawong,

Melioidosis is a severe disease caused by Burkholderia pseudomallei. The biofilm of B. pseudomallei acquires resistance to several antibiotics and may be related to relapse in melioidosis patients. Here, the killing activity of antimicrobial peptides (LL-37, LL-31) and the D-enantiomers (D-LL-37, D-LL-31) in combination with ceftazidime (CAZ) against B. pseudomallei ... Read more >>

Biofouling (Biofouling)
[2019, 35(5):573-584]

Cited: 1 time

View full text PDF listing >>



Characterization of oral polymorphonuclear neutrophils in periodontitis patients: a case-control study.

Elena A Nicu, Patrick Rijkschroeff, Eva Wartewig, Kamran Nazmi, Bruno G Loos,

BACKGROUND:Maintaining oral health is a continuous and dynamic process that also involves the immune system. Polymorphonuclear neutrophils (PMNs) migrate from blood circulation and become apparent in the oral fluid. Controversies exist regarding the specific role of the oral PMNs (oPMNs) in the presence of chronic oral inflammation, such as periodontitis. ... Read more >>

BMC Oral Health (BMC oral health)
[2018, 18(1):149]

Cited: 7 times

View full text PDF listing >>



LFchimera protects HeLa cells from invasion by Yersinia spp. in vitro.

Tjitske Sijbrandij, Antoon J Ligtenberg, Kamran Nazmi, Petra A M van den Keijbus, Enno C I Veerman, Jan G M Bolscher, Floris J Bikker,

Yersinia pestis is the causative agent of plague. As adequate antibiotic treatment falls short and currently no effective vaccine is available, alternative therapeutic strategies are needed. In order to contribute to solving this problem we investigated the therapeutic potential of the peptide construct LFchimera against the safer-to-handle Y. pestis simulants ... Read more >>

Biometals (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine)
[2018, 31(6):941-950]

Cited: 0 times

View full text PDF listing >>



Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro.

Floris J Bikker, Michel A Hoogenkamp, Amine Malhaoui, Kamran Nazmi, Jessica Neilands, Bastiaan P Krom,

Dental biofilms are formed in a multistep process that is initiated by the adhesion of oral bacteria to the dental hard surface. As dental biofilms are associated with oral diseases their control is necessary in order to maintain oral health. Recently, it was revealed that phytosphingosine (PHS)-treated hydroxyapatite discs showed ... Read more >>

Caries Res (Caries research)
[2018, 52(1-2):7-13]

Cited: 0 times

View full text PDF listing >>



Killing activity of LFchimera on periodontopathic bacteria and multispecies oral biofilm formation in vitro.

Sopita Ruangcharoen, Waraporn Suwannarong, Marie Rossini Carmela T Lachica, Jan G M Bolscher, Kamran Nazmi, Watcharee Khunkitti, Suwimol Taweechaisupapong,

Lactoferrin chimera (LFchimera), a heterodimeric peptide containing lactoferrampin (LFampin265-284) and a part of lactoferricin (LFcin17-30), possesses a broad spectrum of antimicrobial activity. However, there is no report on the inhibitory effects of LFchimera against multispecies oral biofilms. This study aimed to determine the effects of LFchimera in comparison to chlorhexidine ... Read more >>

World J Microbiol Biotechnol (World journal of microbiology & biotechnology)
[2017, 33(9):167]

Cited: 0 times

View full text PDF listing >>



Killing activity of LFchimera on periodontopathic bacteria and multispecies oral biofilm formation in vitro

Sopita Ruangcharoen, Waraporn Suwannarong, Marie Rossini Carmela T. Lachica, Jan G. M. Bolscher, Kamran Nazmi, Watcharee Khunkitti, Suwimol Taweechaisupapong,

Lactoferrin chimera (LFchimera), a heterodimeric peptide containing lactoferrampin (LFampin265–284) and a part of lactoferricin (LFcin17–30), possesses a broad spectrum of antimicrobial activity. However, there is no report on the inhibitory effects of LFchimera against multispecies oral biofilms. This study aimed to determine the effects of LFchimera in comparison to chlorhexidine ... Read more >>

World J Microbiol Biotechnol (World journal of microbiology & biotechnology)
[2017, 33(9):167]

Cited: 1 time

View full text PDF listing >>



EphA2 Targeted Doxorubicin-Nanoliposomes for Osteosarcoma Treatment.

Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, Kamran Nazmi, Jantine Posthuma De Boer, Behrouz Zandieh-Doulabi, Tymour Forouzanfar, Marco N Helder,

PURPOSE:To employ Doxorubicin-loaded liposomes, modified with YSA-peptide to target EphA2, to reduce adverse effects against primary bone cells and maximize toxicity against Saos-2 osteosarcoma cells. METHODS:PEGylated liposomes were prepared by thin film method using Dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearylphosphatidylethanolamine-polyethyleneglycol conjugate (DSPE-mPEG) in 67.9:29.1:3 M ratios, and loaded with DOX (L-DOX) by ... Read more >>

Pharm Res (Pharmaceutical research)
[2017, 34(12):2891-2900]

Cited: 4 times

View full text PDF listing >>



Lactoferricin Peptides Increase Macrophages' Capacity To Kill Mycobacterium avium.

Tânia Silva, Ana C Moreira, Kamran Nazmi, Tânia Moniz, Nuno Vale, Maria Rangel, Paula Gomes, Jan G M Bolscher, Pedro N Rodrigues, Margarida Bastos, Maria Salomé Gomes,

Mycobacterial infections cause a significant burden of disease and death worldwide. Their treatment is long, toxic, costly, and increasingly prone to failure due to bacterial resistance to currently available antibiotics. New therapeutic options are thus clearly needed. Antimicrobial peptides represent an important source of new antimicrobial molecules, both for their ... Read more >>

mSphere (mSphere)
[2017, 2(4):]

Cited: 7 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0989 s