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Author Kalle Kurppa

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Impact of diagnostic delay to the clinical presentation and associated factors in pediatric inflammatory bowel disease: a retrospective study.

Emmiina Sulkanen, Marleena Repo, Heini Huhtala, Pauliina Hiltunen, Kalle Kurppa,

<h4>Background</h4>Undelayed diagnosis is thought to be a major determinant for good prognosis in pediatric inflammatory bowel disease (PIBD). However, factors predicting diagnostic delay and the consequences of this remain poorly defined. We investigated these issues in a well-defined cohort of PIBD patients.<h4>Methods</h4>Comprehensive electronic data were collected from 136 PIBD patients ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2021, 21(1):364]

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Editorial: coeliac disease-it's a family affair. Authors' reply.

Saana Paavola, Katri Kaukinen, Kalle Kurppa,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):969]

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25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children: A Case-Control Study.

Carin Andrén Aronsson, Xiang Liu, Jill M Norris, Ulla Uusitalo, Martha D Butterworth, Sibylle Koletzko, Suvi M Virtanen, Iris Erlund, Kalle Kurppa, William A Hagopian, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Daniel Agardh,

<b>Objectives:</b> An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated with the risk of celiac disease autoimmunity (CDA) in ... Read more >>

Front Nutr (Frontiers in nutrition)
[2021, 8:720041]

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Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives.

Saana Paavola, Katri Lindfors, Laura Kivelä, Juliana Cerqueira, Heini Huhtala, Päivi Saavalainen, Riku Tauschi, Katri Kaukinen, Kalle Kurppa,

<h4>Background</h4>Family screening has been advocated as a means to reduce the major underdiagnosis of coeliac disease. However, the precise risk of the disease in relatives and the impact of patient- and relative-related individual factors remain obscure.<h4>Aims</h4>To investigate the individual risk of coeliac disease among patients' relatives.<h4>Methods</h4>Altogether 2943 relatives of 624 ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(6):805-813]

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Letter: risk of coeliac disease-do microbial derived factors promote and protect? Authors' reply.

Ketil Størdal, Christian Kahrs, German Tapia, Daniel Agardh, Kalle Kurppa, Lars C Stene,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(12):1328]

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Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.

Dawit A Yohannes, Katri Kaukinen, Kalle Kurppa, Päivi Saavalainen, Dario Greco,

<h4>Background</h4>Deep immune receptor sequencing, RepSeq, provides unprecedented opportunities for identifying and studying condition-associated T-cell clonotypes, represented by T-cell receptor (TCR) CDR3 sequences. However, due to the immense diversity of the immune repertoire, identification of condition relevant TCR CDR3s from total repertoires has mostly been limited to either "public" CDR3 sequences ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2021, 22(1):159]

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Nonbiopsy Approach for Celiac Disease Is Accurate When Using Exact Duodenal Histomorphometry: Prospective Study in 2 Countries.

Alina Popp, Taina Arvola, Juha Taavela, Laura Kivelä, Adina Ene, Kaija Laurila, Päivi Saavalainen, Markku Mäki, Kalle Kurppa,

<h4>Goals</h4>To test the accuracy of serology-based criteria for diagnosing celiac disease utilizing quantitative histomorphometry.<h4>Background</h4>The revised European pediatric guidelines allow noninvasive celiac disease diagnosis for a subgroup of children. However, in some of the studies on this issue, the positive predictive value (PPV) of serology has remained suboptimal, possibly because of ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, 55(3):227-232]

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Iron Transporter Protein Expressions in Children with Celiac Disease.

Marleena Repo, Markus Hannula, Juha Taavela, Jari Hyttinen, Jorma Isola, Pauliina Hiltunen, Alina Popp, Katri Kaukinen, Kalle Kurppa, Katri Lindfors,

Anemia is a frequent finding in children with celiac disease but the detailed pathophysiological mechanisms in the intestine remain obscure. One possible explanation could be an abnormal expression of duodenal iron transport proteins. However, the results have so far been inconsistent. We investigated this issue by comparing immunohistochemical stainings of ... Read more >>

Nutrients (Nutrients)
[2021, 13(3):]

Cited: 1 time

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An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood.

Ezio Bonifacio, Andreas Weiß, Christiane Winkler, Markus Hippich, Marian J Rewers, Jorma Toppari, Åke Lernmark, Jin-Xiong She, William A Hagopian, Jeffrey P Krischer, Kendra Vehik, Desmond A Schatz, Beena Akolkar, Anette-Gabriele Ziegler, ,

<h4>Objective</h4>Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve screening for presymptomatic type 1 diabetes.<h4>Research design and methods</h4>The Environmental Determinants of Diabetes in the Young study prospectively monitored 8,556 ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes.

Juliana X M Cerqueira, Päivi Saavalainen, Kalle Kurppa, Pilvi Laurikka, Heini Huhtala, Matti Nykter, Lotta L E Koskinen, Dawit A Yohannes, Elina Kilpeläinen, Anastasia Shcherban, Aarno Palotie, Katri Kaukinen, Katri Lindfors,

The phenotype of coeliac disease varies considerably for incompletely understood reasons. We investigated whether established coeliac disease susceptibility variants (SNPs) are individually or cumulatively associated with distinct phenotypes. We also tested whether a polygenic risk score (PRS) based on genome-wide associated (GWA) data could explain the phenotypic variation. The phenotypic ... Read more >>

J Hum Genet (Journal of human genetics)
[2021, 66(6):613-623]

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Letter: no-biopsy pathway for diagnosing adult coeliac disease-authors' reply.

Kalle Kurppa, Laura Kivelä, Katri Kaukinen,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(2):359]

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Effects of In Vivo Gluten Challenge on PBMC Gene Expression Profiles in Diet Treated Celiac Disease.

Dawit A Yohannes, Andrea de Kauwe, Katri Kaukinen, Kalle Kurppa, Markku Mäki, Robert P Anderson, Sten Linnarsson, Dario Greco, Päivi Saavalainen,

The pathological mechanisms that lead to the onset and reactivation of celiac disease (CD) remain largely unknown. While gluten free diet (GFD) improves the intestinal damage and associated clinical symptoms in majority of cases, it falls short of providing full recovery. Additionally, late or misdiagnosis is also common as CD ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:594243]

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Review article: exposure to microbes and risk of coeliac disease.

Ketil Størdal, Christian Kahrs, German Tapia, Daniel Agardh, Kalle Kurppa, Lars C Stene,

<h4>Background</h4>Coeliac disease is an immune-mediated intestinal disease characterised by lifelong intolerance to dietary gluten in genetically predisposed individuals. Microbial factors including infections or bacterial microbiota have long been suspected to be involved in the aetiology, but the scientific literature on the topic is scattered and heterogeneous.<h4>Aims</h4>To review human observational studies ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(1):43-62]

Cited: 2 times

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Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.

Laura Airaksinen, Pilvi Laurikka, Heini Huhtala, Kalle Kurppa, Teea Salmi, Päivi Saavalainen, Katri Kaukinen, Katri Lindfors,

The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients' response to a gluten-free diet. The ... Read more >>

Nutrients (Nutrients)
[2020, 12(12):]

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Prevalence and clinical significance of esophageal abnormalities in children with celiac disease.

Meri Smolander, Samuli Nurminen, Marleena Repo, Laura Kivelä, Juho E Kivistö, Pauliina Hiltunen, Heini Huhtala, Satu-Liisa Pauniaho, Kalle Kurppa,

Variable endoscopic and histological findings of esophageal lining are often detected in celiac disease, with unknown significance. We investigated the frequency and significance of such abnormalities in children. Macroscopic esophageal findings as reported by endoscopist and histological results by pathologist were compared between 316 celiac disease patients and 378 disease ... Read more >>

Dis Esophagus (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus)
[2020, 33(11):]

Cited: 1 time

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Type 1 tyrosinemia in Finland: a nationwide study.

Linnea Äärelä, Pauliina Hiltunen, Tea Soini, Nina Vuorela, Heini Huhtala, Pasi I Nevalainen, Markku Heikinheimo, Laura Kivelä, Kalle Kurppa,

<h4>Background</h4>Introduction of nitisinone and newborn screening (NBS) have transformed the treatment of type 1 tyrosinemia, but the effects of these changes on the long-term outcomes remain obscure. Also, the predictors for later complications, the significance of drug levels and the normalization of laboratory and imaging findings are poorly known. We ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):281]

Cited: 1 time

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Type 1 tyrosinemia in Finland: a nationwide study

Linnea Äärelä, Pauliina Hiltunen, Tea Soini, Nina Vuorela, Heini Huhtala, Pasi Nevalainen, Markku Heikinheimo, Laura Kivelä, Kalle Kurppa,

<h4>Background: </h4> Introduction of nitisinone and newborn screening (NBS) have transformed the treatment of type 1 tyrosinemia, but the effects of these changes on the long-term outcomes remain obscure. Also, the predictors for later complications, the significance of drug levels and the normalization of laboratory and imaging findings are poorly ... Read more >>

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Non-Biopsy Serology-Based Diagnosis of Celiac Disease in Adults Is Accurate with Different Commercial Kits and Pre-Test Probabilities.

Venla Ylönen, Katri Lindfors, Marleena Repo, Heini Huhtala, Valma Fuchs, Päivi Saavalainen, Alex Musikka, Kaija Laurila, Katri Kaukinen, Kalle Kurppa,

Non-biopsy diagnosis of celiac disease is possible in children with anti-transglutaminase 2 antibodies (TGA) > 10× the upper limit of normal (ULN) and positive anti-endomysial antibodies (EMA). Similar criteria have been suggested for adults, but evidence with different TGA assays is scarce. We compared the performance of four TGA tests ... Read more >>

Nutrients (Nutrients)
[2020, 12(9):]

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Clinical characteristics and long-term health in celiac disease patients diagnosed in early childhood: Large cohort study.

Sara Koskimaa, Laura Kivelä, Taina Arvola, Pauliina Hiltunen, Heini Huhtala, Katri Kaukinen, Kalle Kurppa,

<h4>Background</h4>Early detection of celiac disease could theoretically prevent most of the disease-associated complications, but long-term effects of this approach are unclear.<h4>Aims</h4>To investigate features at diagnosis and adulthood health in celiac disease patients diagnosed in early childhood in 1965-2014.<h4>Methods</h4>Medical data on 978 pediatric patients were collected and study questionnaires sent to ... Read more >>

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2020, 52(11):1315-1322]

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Differences Between Familial and Sporadic Celiac Disease.

Laura Airaksinen, Lauri Myllymäki, Katri Kaukinen, Päivi Saavalainen, Heini Huhtala, Katri Lindfors, Kalle Kurppa,

<h4>Background</h4>It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study.<h4>Methods</h4>Altogether 1064 patients were analyzed for celiac disease-associated serology, predisposing HLA-DQ, and non-HLA ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(6):1981-1988]

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A combined risk score enhances prediction of type 1 diabetes among susceptible children.

Lauric A Ferrat, Kendra Vehik, Seth A Sharp, Åke Lernmark, Marian J Rewers, Jin-Xiong She, Anette-G Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey P Krischer, Michael N Weedon, Richard A Oram, William A Hagopian, , ,

Type 1 diabetes (T1D)-an autoimmune disease that destroys the pancreatic islets, resulting in insulin deficiency-often begins early in life when islet autoantibody appearance signals high risk<sup>1</sup>. However, clinical diabetes can follow in weeks or only after decades, and is very difficult to predict. Ketoacidosis at onset remains common<sup>2,3</sup> and is ... Read more >>

Nat Med (Nature medicine)
[2020, 26(8):1247-1255]

Cited: 14 times

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X-ray microtomography is a novel method for accurate evaluation of small-bowel mucosal morphology and surface area.

Johannes Virta, Markus Hannula, Ilmari Tamminen, Katri Lindfors, Katri Kaukinen, Alina Popp, Juha Taavela, Päivi Saavalainen, Pauliina Hiltunen, Jari Hyttinen, Kalle Kurppa,

The often poorly orientated small-bowel mucosal biopsies taken for the diagnostics of celiac disease and other intestinal disorders are prone to misinterpretation. Furthermore, conventional histopathology has suboptimal sensitivity for early histopathological changes observed in short-term challenge studies. X-ray microtomography (micro-CT) is a promising new method for accurate imaging of human-derived ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):13164]

Cited: 3 times

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Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.

Kendra Vehik, Ezio Bonifacio, Åke Lernmark, Liping Yu, Alistair Williams, Desmond Schatz, Marian Rewers, Jin-Xiong She, Jorma Toppari, William Hagopian, Beena Akolkar, Anette G Ziegler, Jeffrey P Krischer, ,

<h4>Objective</h4>The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The Environmental Determinants of Diabetes in the Young (TEDDY) study.<h4>Research design and methods</h4>Eligible children with increased ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(9):2066-2073]

Cited: 3 times

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Severity of Villous Atrophy at Diagnosis in Childhood Does Not Predict Long-term Outcomes in Celiac Disease.

Sofia Kröger, Kalle Kurppa, Marleena Repo, Heini Huhtala, Katri Kaukinen, Katri Lindfors, Taina Arvola, Laura Kivelä,

<h4>Objectives</h4>Current pediatric guidelines allow noninvasive diagnosis of celiac disease in selected children. We investigated in a large cohort study whether the severity of villous atrophy at diagnosis is associated with clinical characteristics or long-term health outcomes, thus having a prognostic significance.<h4>Methods</h4>Comprehensive medical data on 906 children with celiac disease were ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, 71(1):71-77]

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First Scandinavian case of successful pregnancy during nitisinone treatment for type 1 tyrosinemia.

Linnea Äärelä, Pasi I Nevalainen, Kalle Kurppa, Pauliina Hiltunen,

Background Type 1 tyrosinemia is a hereditary metabolic disease in which tyrosine metabolites damage the liver and kidneys. Nitisinone medication revolutionized the treatment, but the effects of the drug during human pregnancy are unknown. Case presentation A 17-year-old tyrosinemia patient became pregnant. Nitisinone was continued throughout pregnancy with a varying ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(5):661-664]

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