Full Text Journal Articles by
Author Kai Zacharowski

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Current concepts in the evaluation and management of preoperative anemia.

Vanessa Neef, Suma Choorapoikayil, Florian Piekarski, Tobias Schlesinger, Patrick Meybohm, Kai Zacharowski,

<h4>Purpose of review</h4>In the past years, patient blood management (PBM) has evolved to improve patient's care and safety. Anemia is one of the most common medical diseases in the world and is an independent risk factor for morbidity and mortality. Iron deficiency is the main cause for anemia and constitutes ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):352-356]

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Effects of an Animated Blood Clot Technology (Visual Clot) on the Decision-Making of Users Inexperienced in Viscoelastic Testing: Multicenter Trial.

Sadiq Said, Tadzio Raoul Roche, Julia Braun, Micheal Thomas Ganter, Patrick Meybohm, Johannes Herrmann, Kai Zacharowski, Florian Jürgen Raimann, Florian Piekarski, Eva Rivas, Eva Rivas, Manuel López-Baamonde, Manuel López-Baamonde, Donat R Spahn, Christoph Beat Nöthiger, David Werner Tscholl,

<h4>Background</h4>Viscoelastic test-guided coagulation management has become increasingly important in assessing hemostasis. We developed Visual Clot, an animated, 3D blood clot that illustrates raw rotational thromboelastometry (ROTEM) parameters in a user-centered and situation awareness-oriented method.<h4>Objective</h4>This study aimed to evaluate the applicability of Visual Clot by examining its effects on users that ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2021, 23(5):e27124]

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Importance</h4>Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.<h4>Objective</h4>To examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.<h4>Data ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :e210884]

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Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study.

Nicola Disma, Katalin Virag, Thomas Riva, Jost Kaufmann, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences.<h4>Methods</h4>We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study

Andreas Winter, Kai Zacharowski, Patrick Meybohm, Andreas Schnitzbauer, Peter Ruf, Claudia Kellermann, Horst Lindhofer,

<h4>Background: </h4> Intraoperative blood salvage (IBS) is regarded as an alternative to allogeneic blood transfusion excluding the risks associated with allogeneic blood. Currently, IBS is generally avoided in tumor surgeries due to concern for potential metastasis caused by residual tumor cells in the erythrocyte concentrate. <h4>Methods: </h4> The feasibility, efficacy ... Read more >>

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Treating patients across European Union borders: An international survey in light of the coronavirus disease-19 pandemic.

Elisabeth H Adam, Armin N Flinspach, Radmilo Jankovic, Stefan De Hert, Kai Zacharowski, ,

<h4>Background</h4>In light of the coronavirus disease-2019 (COVID-19) pandemic, how resources are managed and the critically ill are allocated must be reviewed. Although ethical recommendations have been published, strategies for dealing with overcapacity of critical care resources have so far not been addressed.<h4>Objectives</h4>Assess expert opinion for allocation preferences regarding the growing ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(4):344-347]

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Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE).

Nicola Disma, Francis Veyckemans, Katalin Virag, Tom G Hansen, Karin Becke, Pierre Harlet, Laszlo Vutskits, Suellen M Walker, Jurgen C de Graaff, Marzena Zielinska, Dusica Simic, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown.<h4>Methods</h4>This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Perioperatives Management.

Kai Zacharowski,

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2021, 56(3):157-158]

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[Perthes Syndrome after Roll-Over Trauma].

Linda Tanner, Julian Zabel, Kai Zacharowski, Elisabeth Adam,

Roll-over trauma and associated traumatic entrapments frequently result in serious polytraumatisation. In rare cases, severe extrathoracic compressions and a protracted entrapment period can lead to Perthes syndrome, also known as traumatic asphyxia. The Perthes syndrome manifests itself by a triad of craniocervical cyanosis, facial petechiae and subconjunctival haemorrhages, enabling a ... Read more >>

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2021, 56(2):135-140]

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Greater Fibrinolysis Resistance but No Greater Platelet Aggregation in Critically Ill COVID-19 Patients.

Christoph Heinz, Wolfgang Miesbach, Eva Herrmann, Michael Sonntagbauer, Florian J Raimann, Kai Zacharowski, Christian F Weber, Elisabeth H Adam,

<h4>Background</h4>The hemostatic balance in patients with coronavirus disease 2019 (COVID-19) seems to be shifted toward a hypercoagulable state. The aim of the current study was to assess the associated coagulation alterations by point-of-care-diagnostics, focusing on details of clot formation and lysis in these severely affected patients.<h4>Methods</h4>The authors' prospective monocentric observational ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 134(3):457-467]

Cited: 3 times

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Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs.

Benjamin Friedrichson, Haitham Mutlak, Kai Zacharowski, Florian Piekarski,

<h4>Background</h4>Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are predominantly treated with a venovenous (VV) approach. We hypothesized that mortality in Germany in ECLS therapy did not differ from previously reported ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):38]

Cited: 1 time

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Direct oral anticoagulants in point-of-care monitoring: an ex-vivo study (NOAPOC).

Matthias Klages, Florian J Raimann, Anna-Lena Philipp, Edelgard Lindhoff-Last, Kai Zacharowski, Haitham Mutlak,

<h4>Background</h4>Anticoagulatory activity of direct oral anticoagulants (DOACs) is not routinely measurable by point-of-care monitoring. Thus, the aim of this study was to evaluate the influence of dabigatran/rivaroxaban on point-of-care testing.<h4>Methods</h4>Samples from 34 participants under DOAC therapy were drawn at two time points. Before ingestion and two-to-three hours afterwards. Thrombelastometric (ROTEM) ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, :]

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The visually estimated blood volume in scaled canisters based on a simulation study.

Lara Gerdessen, Vanessa Neef, Florian J Raimann, Kai Zacharowski, Florian Piekarski,

<h4>Background</h4>The most common technique used worldwide to quantify blood loss during an operation is the visual assessment by the attending intervention team. In every operating room you will find scaled suction canisters that collect fluids from the surgical field. This scaling is commonly used by clinicians for visual assessment of ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2021, 21(1):54]

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Bone cement implantation syndrome in cemented hip hemiarthroplasty-a persistent risk.

Karoline Weingärtner, Philipp Störmann, David Schramm, Sebastian Wutzler, Kai Zacharowski, Ingo Marzi, Thomas Lustenberger,

<h4>Background</h4>Every year, ~ 210,000 initial implantations of hip endoprostheses are carried out in Germany alone. The "bone cement implantation syndrome" (BCIS) is considered a severe peri- and early-postoperative complication when implanting cemented prostheses. The origin of the BCIS and its impact on the clinical outcome are still uncertain. This study investigates ... Read more >>

Eur J Trauma Emerg Surg (European journal of trauma and emergency surgery : official publication of the European Trauma Society)
[2021, :]

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Analysis of Humoral Immune Responses in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Lisa Henss, Tatjana Scholz, Christine von Rhein, Imke Wieters, Frauke Borgans, Fabian J Eberhardt, Kai Zacharowski, Sandra Ciesek, Gernot Rohde, Maria Vehreschild, Christoph Stephan, Timo Wolf, Heike Hofmann-Winkler, Heinrich Scheiblauer, Barbara S Schnierle,

<h4>Background</h4>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and hundreds of thousands of deaths. The infection causes coronavirus disease 2019 (COVID-19), a disease of the respiratory system of divergent severity. In the current study, humoral immune responses were characterized ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 223(1):56-61]

Cited: 8 times

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ECMO for COVID-19 patients in Europe and Israel.

Roberto Lorusso, Alain Combes, Valeria Lo Coco, Maria Elena De Piero, Jan Belohlavek, , ,

Intensive Care Med (Intensive care medicine)
[2021, 47(3):344-348]

Cited: 3 times

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The effect of the interruption of agitation, temporary cooling, and pneumatic tube transportation on platelet quality during storage for transfusion.

Stephanie Böhmert, Sarah Kübel, Markus Matthias Müller, Christian Friedrich Weber, Elisabeth Hannah Adam, Stefan Dröse, Kai Zacharowski, Dania Fischer,

<h4>Background</h4>Conditions during blood product storage and transportation should maintain quality. The aim of this in vitro study was to investigate the effect of interruption of agitation, temporary cooling (TC), and pneumatic tube system transportation (PTST) on the aggregation ability (AA) and mitochondrial function (MF) of platelet concentrates (PC).<h4>Study design and ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Audit of international intraoperative hemotherapy and blood loss documentation on anesthetic records.

Florian Piekarski, George Zhong, Vanessa Neef, Jan Kloka, Florian Wunderer, Patrick Meybohm, Kai Zacharowski, Florian J Raimann,

<h4>Background</h4>Anesthetic records facilitate information transmission to the next healthcare professional and should contain all relevant information of perioperative care. While most anesthesia societies provide guidelines for record content, important topics like hemotherapy and hemostatic therapy are not well represented. We considered the quality of anesthetic records with regard to the ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(3):312-318]

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The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery - an observational study in a patient blood management centre.

Vanessa Neef, Linda Vo, Eva Herrmann, Chris Triphaus, Leonie Judd, Andreas Winter, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Introduction</h4>Cell salvage (CS) is an integral part of patient blood management (PBM) and aims to reduce allogeneic red blood cell (RBC) transfusion.<h4>Material and methods</h4>This observational study analysed patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB) between November 2015 and October 2018. Patients were divided into a CS group (patients ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):1-9]

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COVID-19 Induced Acute Respiratory Distress Syndrome-A Multicenter Observational Study.

Johannes Herrmann, Elisabeth Hannah Adam, Quirin Notz, Philipp Helmer, Michael Sonntagbauer, Peter Ungemach-Papenberg, Andreas Sanns, York Zausig, Thorsten Steinfeldt, Iuliu Torje, Benedikt Schmid, Tobias Schlesinger, Caroline Rolfes, Christian Reyher, Markus Kredel, Jan Stumpner, Alexander Brack, Thomas Wurmb, Daniel Gill-Schuster, Peter Kranke, Dirk Weismann, Hartwig Klinker, Peter Heuschmann, Viktoria Rücker, Stefan Frantz, Georg Ertl, Ralf Michael Muellenbach, Haitham Mutlak, Patrick Meybohm, Kai Zacharowski, Christopher Lotz,

<b>Background:</b> Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). <b>Methods:</b> This is a retrospective, observational multicentre study in five German secondary or tertiary ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:599533]

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Nrf2-A Molecular Target for Sepsis Patients in Critical Care.

Sandra Gunne, Ulrike Heinicke, Michael J Parnham, Volker Laux, Kai Zacharowski, Andreas von Knethen,

The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive oxygen species (ROS) seems obvious. In line with this, data obtained in cell culture experiments ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(12):]

Cited: 1 time

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Getting old.

Nancy Redfern, Paul Clyburn, Ioana Grigoras, Paul Calleja, Jannicke Mellin-Olsen, Vesna Novak-Jankovic, Ilona Bobek, Stefan De Hert, Kai Zacharowski, Edoardo De Robertis,

Eur J Anaesthesiol (European journal of anaesthesiology)
[2020, 37(12):1081-1083]

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Risk factors and outcomes associated with the carriage of tigecycline- and vancomycin-resistant Enterococcus faecium.

Johanna Kessel, Jennifer Bender, Guido Werner, Matas Griskaitis, Eva Herrmann, Annette Lehn, Hubert Serve, Kai Zacharowski, Stefan Zeuzem, Maria J G T Vehreschild, Thomas A Wichelhaus, Volkhard A J Kempf, Michael Hogardt,

<h4>Objectives</h4>Vancomycin-resistant E. faecium (VRE) is a common cause of healthcare-associated infections. The emergence of VRE with tigecycline resistance (TVRE) is increasing but its impact on patient outcome is still not well defined. This study aimed to assess risk factors for the acquisition of TVRE and of patient outcomes associated with ... Read more >>

J Infect (The Journal of infection)
[2021, 82(2):227-234]

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Implementation of an anaemia walk-in clinic: Feasibility and preliminary data from the Orthopedic University Hospital.

Vanessa Neef, David Meisenzahl, Paul Kessler, Florian J Raimann, Florian Piekarski, Suma Choorapoikayil, Christoph Fleege, Kai D Zacharowski, Patrick Meybohm, Andrea Meurer,

<h4>Background</h4>Approximately one in three patients suffers from preoperative anaemia. Even though haemoglobin is measured before surgery, anaemia management is not implemented in every hospital.<h4>Objective</h4>Here, we demonstrate the implementation of an anaemia walk-in clinic at an Orthopedic University Hospital. To improve the diagnosis of iron deficiency (ID), we examined whether reticulocyte ... Read more >>

Transfus Med (Transfusion medicine (Oxford, England))
[2020, 30(6):467-474]

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