Full Text Journal Articles by
Author Kai Wen Cheng

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Changes in alcoholic beverage preference and consumption in Taiwan following accession to the World Trade Organization.

Cheng-Che Chen, Kai-Wen Cheng, Hsin-Yi Chang, Shu-Sen Chang,

BACKGROUND AND AIMS:Given the growing concerns that international trade agreements may increase the supply of health-harming commodities, including alcohol, this study aimed to investigate the changes in alcoholic beverage preference and consumption after Taiwan's accession to the World Trade Organization (WTO). DESIGN:A before-and-after comparison analysis using data from two waves ... Read more >>

Addiction (Addiction (Abingdon, England))
[2020, :]

Cited: 0 times

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Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes.

I-Ju Chen, Yi-An Cheng, Kai-Wen Ho, Wen-Wei Lin, Kai-Wen Cheng, Yun-Chi Lu, Yuan-Chin Hsieh, Chien-Chiao Huang, Chih-Hung Chuang, Fang-Ming Chen, Yu-Cheng Su, Steve R Roffler, Tian-Lu Cheng,

Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the anti-cancer effects of targeted antibodies combined with mPEGylated liposomes (mPEG-liposomes), we describe a bispecific antibody in which an anti-methoxy-polyethylene glycol scFv (αmPEG scFv) was fused to the C-terminus of an anti-HER2 (αHER2) antibody to ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, 111:386-397]

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Stoma complications and quality of life in patients with Indiana pouch versus appendico/neo-appendico-umbilicostomy urinary diversions.

Kai Wen Cheng, Wesley Yip, Ankeet Shah, Luis G Medina, Alireza Ghoreifi, Gus Miranda, Anne Schuckman, Siamak Daneshmand, Hooman Djaladat,

OBJECTIVES:To evaluate three subtypes of continent-cutaneous urinary diversion (CCUD); Indiana pouch (IP), right colon pouch with appendico-umbilicostomy (AU), and right colon pouch with neo-appendico-umbilicostomy (NAU), by investigating diversion-specific complications and quality-of-life outcomes. MATERIALS AND METHODS:A retrospective review of an IRB-approved database was conducted for perioperative and outcome data. The EORTC ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Weathering COVID-19 storm: Successful control measures of five Asian countries.

Ning Lu, Kai-Wen Cheng, Nafees Qamar, Kuo-Cherh Huang, James A Johnson,

Am J Infect Control (American journal of infection control)
[2020, 48(7):851-852]

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Costs of vaping: evidence from ITC Four Country Smoking and Vaping Survey.

Kai-Wen Cheng, Ce Shang, Hye Myung Lee, Frank J Chaloupka, Geoffrey T Fong, Ron Borland, Bryan W Heckman, Sara C Hitchman, Richard J O'Connor, David T Levy, K Michael Cummings,

STUDY OBJECTIVES:To compare the prices paid for nicotine vaping products (NVPs) and supplies among current NVP users to prices paid for cigarettes among current smokers. DATA:The 2016 International Tobacco Control Four Country Vaping and Smoking Survey (4CV1). Key measures included: (1) self-reported prices paid for reusable NVPs (eg, rechargeable devices ... Read more >>

Tob Control (Tobacco control)
[2020, :]

Cited: 0 times

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Determination of synthetic cathinone α-pyrrolidinovalero-phenone and its metabolite in urine using solid-phase extraction and gas chromatography-mass spectrometry.

Kai-Wen Cheng, Chien-Ming Hsieh, Huei-Wen Chen, Pin-Chieh Chi, Da-Peng Yang, She-Hung Chan, Ju-Yu Chen, Hsaio-Lin Hwa, Cheng-Chung Fang, Te-I Weng, Pai-Shan Chen,

RATIONALE:The presence of α-pyrrolidinovalerophenone (α-PVP) and its metabolites in urine is evidence of the administration of α-PVP. A toxicological challenge is that the metabolites of α-PVP exhibit amphoteric properties, which make them unsuitable for detection using gas chromatography-mass spectrometry (GC/MS). In the study reported, proper derivatization and sample extraction were ... Read more >>

Rapid Commun. Mass Spectrom. (Rapid communications in mass spectrometry : RCM)
[2020, 34 Suppl 1:e8579]

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E-cigarette Product Preferences among Adult Smokers: A Discrete Choice Experiment.

Ce Shang, Scott R Weaver, Justin S White, Jidong Huang, James Nonnemaker, Kai-Wen Cheng, Frank J Chaloupka,

Objectives:In this study, we used a discrete choice experiment (DCE) conducted August-October 2017 to examine electronic nicotine delivery systems (ENDS) product preferences in a national sample of adult smokers (N = 1154) who were also using ENDS or had not ruled out future use. Methods:The DCE evaluated 5 ENDS attributes: ... Read more >>

Tob Regul Sci (Tobacco regulatory science)
[2020, 6(1):66-80]

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State-Level Affordability of Factory-Made Cigarettes among Current US Smokers: Findings from the ITC US Survey, 2003-2015.

Pete Driezen, Nigar Nargis, Mary E Thompson, K Michael Cummings, Geoffrey T Fong, Frank J Chaloupka, Ce Shang, Kai-Wen Cheng,

Cigarette affordability measures the price smokers pay for cigarettes in relation to their incomes. Affordability can be measured using the relative income price of cigarettes (RIP), or the price smokers pay to purchase 100 packs of 20 cigarettes divided by their per capita household income. Using longitudinal data from 7046 ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(13):]

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Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.

Yi-An Cheng, I-Ju Chen, Yu-Cheng Su, Kai-Wen Cheng, Yun-Chi Lu, Wen-Wei Lin, Yuan-Chin Hsieh, Chien-Han Kao, Fang-Ming Chen, Steve R Roffler, Tian-Lu Cheng,

For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the intrinsic low sensitivity to doxorubicin. A very large increase in drug accumulation by active targeting may enhance the therapeutic efficacy of PLD. We established a humanized bispecific antibody (BsAb; mPEG × HER2) ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(8):3404-3417]

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Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy.

Yun-Chi Lu, Chih-Hung Chuang, Kuo-Hsiang Chuang, I-Ju Chen, Bo-Cheng Huang, Wen-Han Lee, Hsin-Ell Wang, Jia-Je Li, Yi-An Cheng, Kai-Wen Cheng, Jaw-Yuan Wang, Yuan-Chin Hsieh, Wen-Wei Lin, Tian-Lu Cheng,

During rheumatoid arthritis (RA) treatment, long-term injection of antitumor necrosis factor α antibodies (anti-TNFα Abs) may induce on-target toxicities, including severe infections (tuberculosis [TB] or septic arthritis) and malignancy. Here, we used an immunoglobulin G1 (IgG1) hinge as an Ab lock to cover the TNFα-binding site of Infliximab by linking ... Read more >>

PLoS Biol (PLoS biology)
[2019, 17(6):e3000286]

Cited: 1 time

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Prices, use restrictions and electronic cigarette use-evidence from wave 1 (2016) US data of the ITC Four Country Smoking and Vaping Survey.

Kai-Wen Cheng, Frank J Chaloupka, Ce Shang, Anh Ngo, Geoffrey T Fong, Ron Borland, Bryan W Heckman, David T Levy, K Michael Cummings,

AIMS:To determine if there are associations between changes in the explicit (i.e. price) and implicit (i.e. use restrictions in public places) costs of cigarettes and nicotine vaping products (NVPs) and their use patterns in the United States. METHODS:Data came from wave 1 (2016) US data of the ITC Four Country ... Read more >>

Addiction (Addiction (Abingdon, England))
[2019, 114 Suppl 1:115-122]

Cited: 1 time

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The impact of vaping and regulatory environment on cigarette demand: behavioral economic perspective across four countries.

Bryan W Heckman, Geoffrey T Fong, Ron Borland, Sara Hitchman, Richard J O'Connor, Warren K Bickel, Jeffrey S Stein, Hua-Hie Yong, Georges J Nahhas, Derek A Pope, Ce Shang, Kai-Wen Cheng, David T Levy, K Michael Cummings,

BACKGROUND AND AIMS:Government regulations of nicotine vaping products (NVP) have evolved rapidly during the past decade. The impact of NVP regulatory environment and vaping on cigarette demand is unknown. The current study aims to investigate whether or not respondents' reported cigarette demand, as measured by a hypothetical cigarette purchase task, ... Read more >>

Addiction (Addiction (Abingdon, England))
[2019, 114 Suppl 1:123-133]

Cited: 2 times

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Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.

Kai-Wen Cheng, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yu-Lin Leu, Ta-Chun Cheng, Jaw-Yuan Wang, Jia-Ming Chang, Yun-Chi Lu, Chiu-Min Cheng, I-Ju Chen, Yi-An Cheng, Yeh-Long Chen, Tian-Lu Cheng,

Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequently is exported into the intestine, where SN-38 G ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2019, 139:41-49]

Cited: 1 time

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The Association between Potential Exposure to Magazine Ads with Voluntary Health Warnings and the Perceived Harmfulness of Electronic Nicotine Delivery Systems (ENDS).

Ce Shang, Scott R Weaver, Nahleen Zahra, Jidong Huang, Kai-Wen Cheng, Frank J Chaloupka,

(1) Background: Several brands of electronic nicotine delivery systems (ENDS) carry voluntary health warning messages. This study examined how potential exposure to ENDS magazine ads with these voluntary health warnings were associated with the perceived harmfulness of ENDS. (2) Methods: Risk perception measures and self-reported exposure to ENDS ads were ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(4):]

Cited: 3 times

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Global Evidence on the Association between Cigarette Graphic Warning Labels and Cigarette Smoking Prevalence and Consumption.

Anh Ngo, Kai-Wen Cheng, Ce Shang, Jidong Huang, Frank J Chaloupka,

Background: In 2011, the courts ruled in favor of tobacco companies in preventing the implementation of graphic warning labels (GWLs) in the US, stating that FDA had not established the effectiveness of GWLs in reducing smoking. Methods: Data came from various sources: the WHO MPOWER package (GWLs, MPOWER policy measures, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(3):]

Cited: 2 times

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Global evidence on the effect of point-of-sale display bans on smoking prevalence.

Yanyun He, Ce Shang, Jidong Huang, Kai-Wen Cheng, Frank J Chaloupka,

Since Iceland became the first country to impose a ban on point-of-sale (POS) tobacco product displays in 2001, 20 countries have implemented POS display bans as of 2016. This study examined the effect that POS display bans have on smoking prevalence.Data were sourced from Euromonitor International and the WHO MPOWER ... Read more >>

Tob Control (Tobacco control)
[2018, :]

Cited: 6 times

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In utero and early childhood exposure to secondhand smoke in Taiwan: a population-based birth cohort study.

Kai-Wen Cheng, Wan-Lin Chiang, Tung-Liang Chiang,

OBJECTIVES:This study provides secondhand smoke (SHS) exposure data in utero and after birth when children were at 18 months, 36 months and 66 months old, and it identifies risk factors for the early childhood SHS among 18-month-old infants living in smoker and non-smoker households. STUDY DESIGN:The data come from the ... Read more >>

BMJ Open (BMJ open)
[2017, 7(6):e014016]

Cited: 2 times

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Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity.

Kai-Wen Cheng, Chih-Hua Tseng, Chia-Ning Yang, Cherng-Chyi Tzeng, Ta-Chun Cheng, Yu-Lin Leu, Yu-Chung Chuang, Jaw-Yuan Wang, Yun-Chi Lu, Yeh-Long Chen, Tian-Lu Cheng,

The direct inhibition of bacterial β-glucuronidase (βG) activity is expected to reduce the reactivation of glucuronide-conjugated drugs in the intestine, thereby reducing drug toxicity. In this study, we report on the effects of pyrazolo[4,3-c]quinolines acting as a new class of bacterial βG-specific inhibitors in a pH-dependent manner. Refinement of this ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2017, 60(22):9222-9238]

Cited: 3 times

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Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains.

I-Ju Chen, Chih-Hung Chuang, Yuan-Chin Hsieh, Yun-Chi Lu, Wen-Wei Lin, Chien-Chiao Huang, Ta-Chun Cheng, Yi-An Cheng, Kai-Wen Cheng, Yeng-Tseng Wang, Yeng-Tseng Wang, Fang-Ming Chen, Tian-Lu Cheng, Shey-Cherng Tzou,

Systemic injection of therapeutic antibodies may cause serious adverse effects due to on-target toxicity to the antigens expressed in normal tissues. To improve the targeting selectivity to the region of disease sites, we developed protease-activated pro-antibodies by masking the binding sites of antibodies with inhibitory domains that can be removed ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):11587]

Cited: 8 times

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Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe.

Michael Chen, Kai-Wen Cheng, Yi-Jou Chen, Chang-Hung Wang, Ta-Chun Cheng, Kuo-Chien Chang, An-Pei Kao, Kuo-Hsiang Chuang,

Intestinal bacterial β-glucuronidase (βG) hydrolyzes glucuronidated metabolites to their toxic form in intestines, resulting in intestinal damage. The development of a method to inhibit βG is thus important but has been limited by the difficulty of directly assessing enzyme activity in live animals. Here, we utilized a fluorescent probe, fluorescein ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):3142]

Cited: 3 times

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The Association between Warning Label Requirements and Cigarette Smoking Prevalence by Education-Findings from the Global Adult Tobacco Survey (GATS).

Ce Shang, Jidong Huang, Kai-Wen Cheng, Yanyun He, Frank J Chaloupka,

The Guidelines for the implementation of Article 11 of the World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) require that cigarette health warning labels should include pictures and take up 50% or more of the principal display area. This study examined how the association between large pictorial warnings, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2017, 14(1):]

Cited: 4 times

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Graphic Warning Labels and the Cost Savings from Reduced Smoking among Pregnant Women.

John A Tauras, Richard M Peck, Kai-Wen Cheng, Frank J Chaloupka,

Introduction: The U.S. Food and Drug Administration (FDA) has estimated the economic impact of Graphic Warning Labels (GWLs). By omitting the impact on tobacco consumption by pregnant women, the FDA analysis underestimates the economic benefits that would occur from the proposed regulations. There is a strong link between the occurrence ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2017, 14(2):]

Cited: 1 time

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The effect of MPOWER scores on cigarette smoking prevalence and consumption.

Anh Ngo, Kai-Wen Cheng, Frank J Chaloupka, Ce Shang,

BACKGROUND:The World Health Organization (WHO) introduced the MPOWER package to support policy implementation under the Framework Convention on Tobacco Control (FCTC). This study examined the effect of MPOWER policies on smoking prevalence and cigarette consumption in a global context. METHODS:The MPOWER composite score was constructed by adding up the six ... Read more >>

Prev Med (Preventive medicine)
[2017, 105S:S10-S14]

Cited: 10 times

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Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules.

Wen-Wei Lin, Yuan-Chin Hsieh, Yi-An Cheng, Kuo-Hsiang Chuang, Chien-Chiao Huang, Chih-Hung Chuang, I-Ju Chen, Kai-Wen Cheng, Yun-Chi Lu, Ta-Chun Cheng, Yeng-Tseng Wang, Steve R Roffler, Tian-Lu Cheng,

Sensitive determination of the pharmacokinetics of PEGylated molecules can accelerate the process of drug development. Here, we combined different anti-PEG Fab expressing 293T cells as capture cells (293T/3.3, 293T/6.3, and 293T/15-2b cells) with four detective anti-PEG antibodies (3.3, 6.3, 7A4, or 15-2b) to optimize an anti-PEG cell-based sandwich ELISA. Then, ... Read more >>

Anal. Chem. (Analytical chemistry)
[2016, 88(24):12371-12379]

Cited: 5 times

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Global Evidence on the Association between POS Advertising Bans and Youth Smoking Participation.

Ce Shang, Jidong Huang, Kai-Wen Cheng, Qing Li, Frank J Chaloupka,

BACKGROUND:Point-of-sale (POS) tobacco advertising has been linked to youth smoking susceptibility and experimental smoking. However, there is limited evidence of the association between POS advertising bans and youth smoking participation. This study aims to examine how such bans are associated with current smoking, daily smoking, and regular smoking (≥ 1 ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2016, 13(3):]

Cited: 8 times

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