Full Text Journal Articles by
Author Kai Hoehlig

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 0 times

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Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization.

Kamila Bujko, Sylwia Rzeszotek, Kai Hoehlig, Jun Yan, Axel Vater, Mariusz Z Ratajczak,

Several mechanisms have been postulated for orchestrating the mobilization of hematopoietic stem/progenitor cells (HSPCs), and we previously proposed that activation of the complement cascade plays a crucial role in the initiation and execution of the egress of HSPCs from bone marrow (BM) into peripheral blood (PB). In support of this ... Read more >>

Stem Cell Rev Rep (Stem cell reviews and reports)
[2017, 13(6):793-800]

Cited: 8 times

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Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade.

Dirk Zboralski, Kai Hoehlig, Dirk Eulberg, Anna Frömming, Axel Vater,

Immune checkpoint inhibitors promote T cell-mediated killing of cancer cells; however, only a subset of patients benefit from the treatment. A possible reason for this limitation may be that the tumor microenvironment (TME) is immune privileged, which may exclude cytotoxic T cells from the vicinity of cancer cells. The chemokine ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2017, 5(11):950-956]

Cited: 17 times

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A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis.

Daniel Ajona, Sergio Ortiz-Espinosa, Haritz Moreno, Teresa Lozano, María J Pajares, Jackeline Agorreta, Cristina Bértolo, Juan J Lasarte, Silvestre Vicent, Kai Hoehlig, Axel Vater, Fernando Lecanda, Luis M Montuenga, Ruben Pio,

Disruption of the programmed cell death protein 1 (PD-1) pathway with immune checkpoint inhibitors represents a major breakthrough in the treatment of non-small cell lung cancer. We hypothesized that combined inhibition of C5a/C5aR1 and PD-1 signaling may have a synergistic antitumor effect. The RMP1-14 antibody was used to block PD-1, ... Read more >>

Cancer Discov (Cancer discovery)
[2017, 7(7):694-703]

Cited: 32 times

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Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Laure Yatime, Christian Maasch, Kai Hoehlig, Sven Klussmann, Gregers R Andersen, Axel Vater,

L-Oligonucleotide aptamers (Spiegelmers) consist of non-natural L-configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated with organ damage, can be efficiently targeted by Spiegelmers. Here, we present the ... Read more >>

Nat Commun (Nature communications)
[2015, 6:6481]

Cited: 20 times

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Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.

Kai Hoehlig, Lucas Bethge, Sven Klussmann,

A major challenge for the application of RNA- or DNA-oligonucleotides in biotechnology and molecular medicine is their susceptibility to abundant nucleases. One intriguing possibility to tackle this problem is the use of mirror-image (l-)oligonucleotides. For aptamers, this concept has successfully been applied to even develop therapeutic agents, so-called Spiegelmers. However, ... Read more >>

PLoS ONE (PloS one)
[2015, 10(2):e0115328]

Cited: 2 times

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Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis.

Werner G Purschke, Kai Hoehlig, Klaus Buchner, Dirk Zboralski, Frank Schwoebel, Axel Vater, Sven Klussmann,

The sphingolipid S1P (sphingosine 1-phosphate) is known to be involved in a number of pathophysiological conditions such as cancer, autoimmune diseases and fibrosis. It acts extracellularly through a set of five G-protein-coupled receptors, but its intracellular actions are also well documented. Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) ... Read more >>

Biochem. J. (The Biochemical journal)
[2014, 462(1):153-162]

Cited: 9 times

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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.

Ping Shen, Toralf Roch, Vicky Lampropoulou, Richard A O'Connor, Ulrik Stervbo, Ellen Hilgenberg, Stefanie Ries, Van Duc Dang, Yarúa Jaimes, Capucine Daridon, Rui Li, Luc Jouneau, Pierre Boudinot, Siska Wilantri, Imme Sakwa, Yusei Miyazaki, Melanie D Leech, Rhoanne C McPherson, Stefan Wirtz, Markus Neurath, Kai Hoehlig, Edgar Meinl, Andreas Grützkau, Joachim R Grün, Katharina Horn, Anja A Kühl, Thomas Dörner, Amit Bar-Or, Stefan H E Kaufmann, Stephen M Anderton, Simon Fillatreau,

B lymphocytes have critical roles as positive and negative regulators of immunity. Their inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell-derived IL-10 can protect against autoimmune disease and increase susceptibility to pathogens. Here we identify IL-35-producing B cells as key players in the negative regulation of ... Read more >>

Nature (Nature)
[2014, 507(7492):366-370]

Cited: 338 times

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Activation of CD4⁺ Foxp3⁺ regulatory T cells proceeds normally in the absence of B cells during EAE.

Kai Hoehlig, Ping Shen, Vicky Lampropoulou, Toralf Roch, Bernard Malissen, Richard O'Connor, Stefanie Ries, Ellen Hilgenberg, Stephen M Anderton, Simon Fillatreau,

B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell activation depended ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2012, 42(5):1164-1173]

Cited: 24 times

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TLR-activated B cells suppress T cell-mediated autoimmunity.

Vicky Lampropoulou, Kai Hoehlig, Toralf Roch, Patricia Neves, Elisabeth Calderón Gómez, Claire H Sweenie, Yi Hao, Antonio A Freitas, Ulrich Steinhoff, Stephen M Anderton, Simon Fillatreau,

TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2008, 180(7):4763-4773]

Cited: 216 times

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Immune regulation by B cells and antibodies a view towards the clinic.

Kai Hoehlig, Vicky Lampropoulou, Toralf Roch, Patricia Neves, Elisabeth Calderon-Gomez, Stephen M Anderton, Ulrich Steinhoff, Simon Fillatreau,

B lymphocytes contribute to immunity in multiple ways, including production of antibodies, presentation of antigen to T cells, organogenesis of secondary lymphoid organs, and secretion of cytokines. Recent clinical trials have shown that depleting B cells can be highly beneficial for patients with autoimmune diseases, implicating B cells and antibodies ... Read more >>

Adv. Immunol. (Advances in immunology)
[2008, 98:1-38]

Cited: 14 times

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CD83 is a regulator of murine B cell function in vivo.

Minka Breloer, Birte Kretschmer, Katja Lüthje, Svenja Ehrlich, Uwe Ritter, Thomas Bickert, Christiane Steeg, Simon Fillatreau, Kai Hoehlig, Vassiliki Lampropoulou, Bernhard Fleischer,

The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2007, 37(3):634-648]

Cited: 29 times

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