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Author K Mullin

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Cognitive complaints in age-related chronic conditions: A systematic review.

Nikki L Hill, Sakshi Bhargava, Monique J Brown, Hyejin Kim, Iris Bhang, Kaitlyn Mullin, Kathleen Phillips, Jacqueline Mogle,

<h4>Introduction</h4>Cognitive complaints in older adults may be indicative of progressive cognitive decline including Alzheimer's disease (AD), but also occur in other age-related chronic conditions, complicating identification of early AD symptoms. To better understand cognitive complaints in aging, we systematically reviewed the evidence to determine their prevalence and characterization among older ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0253795]

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Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2

Dmitry Prokopenko, Sanghun Lee, Julian Hecker, Kristina Mullin, Sarah Morgan, Yuriko Katsumata, Michael Weiner, David Fardo, Nan Laird, Lars Bertram, Winston Hide, Christoph Lange, Rudolph Tanzi, ,

Alzheimer’s disease (AD) is a genetically complex disease for which roughly 30 genes have been identified via genome-wide association studies. We attempted to identify rare variants (minor allele frequency <0.01) associated with AD in a region-based, whole genome sequencing (WGS) association study (GSAS) of two independent AD family datasets (NIMH/NIA; ... Read more >>

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Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.

Dmitry Prokopenko, Sarah L Morgan, Kristina Mullin, Oliver Hofmann, Brad Chapman, Rory Kirchner, , Sandeep Amberkar, Inken Wohlers, Christoph Lange, Winston Hide, Lars Bertram, Rudolph E Tanzi,

<h4>Introduction</h4>Genome-wide association studies have led to numerous genetic loci associated with Alzheimer's disease (AD). Whole-genome sequencing (WGS) now permits genome-wide analyses to identify rare variants contributing to AD risk.<h4>Methods</h4>We performed single-variant and spatial clustering-based testing on rare variants (minor allele frequency [MAF] ≤1%) in a family-based WGS-based association study of ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2021, :]

Cited: 1 time

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A smoothed version of the Lassosum penalty for fitting integrated risk models

Georg Hahn, Dmitry Prokopenko, Sharon Lutz, Kristina Mullin, Rudolph Tanzi, Christoph Lange,

Polygenic risk scores are a popular means to predict the disease risk or disease susceptibility of an individual based on its genotype information. When adding other important epidemiological covariates such as age or sex, we speak of an integrated risk model. Methodological advances for fitting more accurate integrated risk models ... Read more >>

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Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.

Simon Dujardin, Caitlin Commins, Aurelien Lathuiliere, Pieter Beerepoot, Analiese R Fernandes, Tarun V Kamath, Mark B De Los Santos, Naomi Klickstein, Diana L Corjuc, Bianca T Corjuc, Patrick M Dooley, Arthur Viode, Derek H Oakley, Benjamin D Moore, Kristina Mullin, Dinorah Jean-Gilles, Ryan Clark, Kevin Atchison, Renee Moore, Lori B Chibnik, Rudolph E Tanzi, Matthew P Frosch, Alberto Serrano-Pozo, Fiona Elwood, Judith A Steen, Matthew E Kennedy, Bradley T Hyman,

Nat Med (Nature medicine)
[2021, 27(2):356]

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Meta-analysis of the strength of exploratory suicide prediction models; from clinicians to computers.

Michelle Corke, Katherine Mullin, Helena Angel-Scott, Shelley Xia, Matthew Large,

<h4>Background</h4>Suicide prediction models have been formulated in a variety of ways and are heterogeneous in the strength of their predictions. Machine learning has been a proposed as a way of improving suicide predictions by incorporating more suicide risk factors.<h4>Aims</h4>To determine whether machine learning and the number of suicide risk factors ... Read more >>

BJPsych Open (BJPsych open)
[2021, 7(1):e26]

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Impact of MEK inhibitor therapy on neurocognition in neurofibromatosis type 1

Karin Walsh, Pamela Wolters, Brigitte Widemann, Allison del Castillo, Maegan Sady, Tess Inker, Marie Claire Roderick, Staci Martin, Mary Anne Toledo-Tamula, Kari Struemph, Iris Paltin, Victoria Collier, Kathy Mullin, Michael Fisher, Roger Packer,

<h4>Objective</h4> NF1-associated cognitive impairments carry significant life-long morbidity. The lack of targeted biologic treatments remains a significant unmet need. We examine changes in cognition in patients with NF1 in the first 48 weeks of MEK inhibitor (MEKi) treatment. <h4>Methods</h4> 59 NF1 patients ages 5-27 on a MEKi clinical trial treating ... Read more >>

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Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development

Dmitry Prokopenko, Sarah Morgan, Kristina Mullin, Oliver Hofmann, Brad Chapman, Rory Kirchner, Sandeep Amberkar, Inken Wohlers, Christoph Lange, Winston Hide, Lars Bertram, Rudolph Tanzi,

<h4>INTRODUCTION</h4> Genome-wide association studies have led to numerous genetic loci associated with Alzheimer’s disease (AD). Whole-genome sequencing (WGS) now permit genome-wide analyses to identify rare variants contributing to AD risk. <h4>METHODS</h4> We performed single-variant and spatial clustering-based testing on rare variants (minor allele frequency ≤1%) in a family-based WGS-based association ... Read more >>

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875. Pseudo-outbreak of Clostridioides (Clostridium) difficile amongst post-operative Oncology Patients

Daniel Kagedan, Roderich Schwarz, Jillianna Wasiura, Nikolaos Almyroudis, Robin Patel, Robin Patel, Brahm H Segal, Katherine M Mullin,

Abstract <h4>Background</h4> Clostridioides difficile infection rates are subject to infection prevention surveillance as a quality measure within the hospital setting. A large spike in Clostridioides difficile infections in post-operative patients, the majority of whom were gastrointestinal surgery (GIS) patients, was noted within a six month period (June through November 2019) ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S475-S475]

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Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.

Simon Dujardin, Caitlin Commins, Aurelien Lathuiliere, Pieter Beerepoot, Analiese R Fernandes, Tarun V Kamath, Mark B De Los Santos, Naomi Klickstein, Diana L Corjuc, Bianca T Corjuc, Patrick M Dooley, Arthur Viode, Derek H Oakley, Benjamin D Moore, Kristina Mullin, Dinorah Jean-Gilles, Ryan Clark, Kevin Atchison, Renee Moore, Lori B Chibnik, Rudolph E Tanzi, Matthew P Frosch, Alberto Serrano-Pozo, Fiona Elwood, Judith A Steen, Matthew E Kennedy, Bradley T Hyman,

Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline<sup>1</sup>. The spread of tau aggregates (neurofibrillary tangles) across the cerebral cortex parallels symptom severity<sup>2,3</sup>. We hypothesized that the kinetics of tau spread may vary if the properties of ... Read more >>

Nat Med (Nature medicine)
[2020, 26(8):1256-1263]

Cited: 39 times

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Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.

Dmitry Prokopenko, Julian Hecker, Rory Kirchner, Brad A Chapman, Oliver Hoffman, Kristina Mullin, Winston Hide, Lars Bertram, Nan Laird, Dawn L DeMeo, Christoph Lange, Rudolph E Tanzi,

With the advent of whole genome-sequencing (WGS) studies, family-based designs enable sex-specific analysis approaches that can be applied to only affected individuals; tests using family-based designs are attractive because they are completely robust against the effects of population substructure. These advantages make family-based association tests (FBATs) that use siblings as ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5029]

Cited: 7 times

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Lithium-Battery Anode Gains Additional Functionality for Neuromorphic Computing through Metal-Insulator Phase Separation.

Juan Carlos Gonzalez-Rosillo, Moran Balaish, Zachary D Hood, Neel Nadkarni, Dimitrios Fraggedakis, Kun Joong Kim, Kaitlyn M Mullin, Reto Pfenninger, Martin Z Bazant, Jennifer L M Rupp,

Specialized hardware for neural networks requires materials with tunable symmetry, retention, and speed at low power consumption. The study proposes lithium titanates, originally developed as Li-ion battery anode materials, as promising candidates for memristive-based neuromorphic computing hardware. By using ex- and in operando spectroscopy to monitor the lithium filling and ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2020, 32(9):e1907465]

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Potential for treatment benefit of small molecule CGRP receptor antagonist plus monoclonal antibody in migraine therapy.

Kathleen Mullin, David Kudrow, Robert Croop, Meghan Lovegren, Charles M Conway, Vladimir Coric, Richard B Lipton,

OBJECTIVE:To provide the first clinical report that 2 calcitonin gene-related peptide (CGRP) therapies, a small molecule CGRP receptor antagonist and an anti-CGRP receptor antibody, can be used concomitantly to treat refractory migraine. METHODS:Case reports are presented of 2 patients participating in a long-term safety study of rimegepant 75 mg oral ... Read more >>

Neurology (Neurology)
[2020, 94(20):e2121-e2125]

Cited: 7 times

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Patient-Reported Outcomes from a 1-Year, Real-World, Head-to-Head Comparison of OnabotulinumtoxinA and Topiramate for Headache Prevention in Adults With Chronic Migraine.

Andrew M Blumenfeld, Atul T Patel, Ira M Turner, Kathleen B Mullin, Aubrey Manack Adams, John F Rothrock,

<h4>Introduction/objective</h4>Chronic migraine (CM) is associated with impaired health-related quality of life and substantial socioeconomic burden, but many people with CM are underdiagnosed and do not receive appropriate preventive treatment. OnabotulinumtoxinA and topiramate have demonstrated <i>efficacy</i> (treatment benefit under ideal conditions) for the prevention of headaches in people with CM in ... Read more >>

J Prim Care Community Health (Journal of primary care & community health)
[2020, 11:2150132720959936]

Cited: 1 time

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Cluster of Sphingomonas paucimobilis Bacteremias Linked to Diversion of Intravenous Hydromorphone.

Jillianna Wasiura, Brahm H Segal, Katherine M Mullin,

N Engl J Med (The New England journal of medicine)
[2019, 381(6):584-585]

Cited: 0 times

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Stem Cell Transplantation Patients and Situational Meaning: A Prospective and Longitudinal View

Jennifer Blosser, Roy Sabo, Kathryn Candler, Karen Mullin, Amir Toor, Denna Chaber,

<h4>ABSTRACT</h4> <h4>Background</h4> Though there is thorough examination of psychosocial issues in SCT, there are few longitudinal studies examining the meaning SCT patients attribute to their treatment. <h4>Objective</h4> The object of this study was to examine change in situational appraisal over time, and to explore potential modifiers of that change. <h4>Methods</h4> ... Read more >>

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The economic recession and subjective well-being in older adults in the Republic of Ireland.

R M Duffy, K Mullin, S O'Dwyer, M Wrigley, B D Kelly,

<h4>Objective</h4>Subjective well-being in older people is strongly associated with emotional, physical and mental health. This study investigates subjective well-being in older adults in Ireland before and after the economic recession that commenced in 2008.<h4>Methods</h4>Cross-sectional data from the biennial European Social Survey (2002-2012) were analysed for two separate groups of older ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2019, 36(2):99-104]

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Comparison of persistent organic pollutants (POPs) between small cetaceans in coastal and estuarine waters of the northern Gulf of Mexico.

Brian Balmer, Gina Ylitalo, Stephanie Watwood, Brian Quigley, Jennie Bolton, Keith Mullin, Patricia Rosel, Teri Rowles, Todd Speakman, Lynsey Wilcox, Eric Zolman, Lori Schwacke,

Small cetaceans continue to be exposed to elevated levels of persistent organic pollutants (POPs). The goals of this study were to use data from remote biopsy sampling and photographic-identification to compare POP concentrations between small cetacean stocks in the northern Gulf of Mexico. During 2015-2017, 74 remote biopsies were collected ... Read more >>

Mar Pollut Bull (Marine pollution bulletin)
[2019, 145:239-247]

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Hepatic selective internal radiation therapy: how well does pretreatment 99mTc-macroaggregated albumin activity distribution and quantification agree with post-therapy bremsstrahlung imaging?

Nathan J Dickinson, Charnie Kalirai, Richard A O'Connor, Karen Mullin,

<h4>Aim</h4>The aim of this study was to examine the agreement of pretreatment Tc-macroaggregated albumin imaging performed for selective internal radiation therapy (SIRT) workup with Y percentage lung shunt (PLS) and regional hepatic distribution in subsequent post-therapy bremsstrahlung imaging.<h4>Patients and methods</h4>Planar images were used to calculate PLS. The significant Y bremsstrahlung ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2018, 39(9):809-817]

Cited: 1 time

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Do community-dwelling Māori and Pacific peoples present with dementia at a younger age and at a later stage compared with NZ Europeans?

Sarah Cullum, Katherine Mullin, Irene Zeng, Susan Yates, Vahid Payman, Mark Fisher, Gary Cheung,

OBJECTIVE:Ethnicity may affect presentation to clinical services in people with dementia; however, no studies have examined this in Māori or Pacific peoples in New Zealand (NZ). Our objective was to examine the routinely collected clinical data from a memory assessment service in South Auckland to examine the presentation of dementia ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2018, 33(8):1098-1104]

Cited: 3 times

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Pharmacokinetics of cefquinome in healthy and Pasteurella multocida-infected rabbits.

S T Elazab, D E Schrunk, R W Griffith, S M Ensley, G Dell'Anna, K Mullin, M G Elsayed, M S Amer, S M El-Nabtity, W H Hsu,

The pharmacokinetics of cefquinome were studied in healthy and Pasteurella multocida-infected rabbits after a single intramuscular (IM) injection at 2 mg/kg of its sulfate salt. Twelve female New Zealand white rabbits (2.0-2.5 kg) were used; six of them served as controls, and the other six had been infected with P. multocida; the experiments ... Read more >>

J Vet Pharmacol Ther (Journal of veterinary pharmacology and therapeutics)
[2018, 41(3):374-377]

Cited: 3 times

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Disseminated Mycobacterium chimaera infection associated with heater-cooler units after aortic valve surgery without endocarditis.

Tannaz Asadi, Katherine Mullin, Eric Roselli, Douglas Johnston, Carmela D Tan, E Rene Rodriguez, Steven Gordon,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2018, 155(6):2369-2374]

Cited: 1 time

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Persistent organic pollutants (POPs) in blood and blubber of common bottlenose dolphins (Tursiops truncatus) at three northern Gulf of Mexico sites following the Deepwater Horizon oil spill.

Jennifer E Balmer, Gina M Ylitalo, Teresa K Rowles, Keith D Mullin, Randall S Wells, Forrest I Townsend, Ronald W Pearce, Jennie L Bolton, Eric S Zolman, Brian C Balmer, Lori H Schwacke,

Common bottlenose dolphins (Tursiops truncatus), including those impacted by the 2010 Deepwater Horizon (DWH) oil spill, inhabit the coastal and estuarine waters of the northern Gulf of Mexico (GoM). In response to the spill, dolphin health assessments conducted in Barataria Bay, Louisiana - a site that experienced heavy and prolonged ... Read more >>

Sci Total Environ (The Science of the total environment)
[2018, 621:130-137]

Cited: 1 time

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Density, abundance, survival, and ranging patterns of common bottlenose dolphins (Tursiops truncatus) in Mississippi Sound following the Deepwater Horizon oil spill.

Keith D Mullin, Trent McDonald, Randall S Wells, Brian C Balmer, Todd Speakman, Carrie Sinclair, Eric S Zolman, Fawn Hornsby, Shauna M McBride, Krystan A Wilkinson, Lori H Schwacke,

After the Deepwater Horizon (DWH) oil spill began in April 2010, studies were initiated on northern Gulf of Mexico common bottlenose dolphins (Tursiops truncatus) in Mississippi Sound (MSS) to determine density, abundance, and survival, during and after the oil spill, and to compare these results to previous research in this ... Read more >>

PLoS One (PloS one)
[2017, 12(10):e0186265]

Cited: 4 times

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Skin Transcriptomes of common bottlenose dolphins (Tursiops truncatus) from the northern Gulf of Mexico and southeastern U.S. Atlantic coasts.

Marion G Neely, Jeanine S Morey, Paul Anderson, Brian C Balmer, Gina M Ylitalo, Eric S Zolman, Todd R Speakman, Carrie Sinclair, Melannie J Bachman, Kevin Huncik, John Kucklick, Patricia E Rosel, Keith D Mullin, Teri K Rowles, Lori H Schwacke, Frances M Van Dolah,

Common bottlenose dolphins serve as sentinels for the health of their coastal environments as they are susceptible to health impacts from anthropogenic inputs through both direct exposure and food web magnification. Remote biopsy samples have been widely used to reveal contaminant burdens in free-ranging bottlenose dolphins, but do not address ... Read more >>

Mar Genomics (Marine genomics)
[2018, 38:45-58]

Cited: 3 times

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