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Author Jyoti Sharma

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Structure of Macrolide Efflux Protein (MefA/E) in Streptococcus pneumoniae: An in silico approach

Sreeram Chandra Murthy Peela, Jyoti Sharma, Sujatha Sistla,

Abstract Background Macrolides are one of the commonest antibiotics used to treat bacterial respiratory tract infections. Resistance to this class of antibiotics is on the rise and is mediated by macrolide efflux (MefA/E) protein as one of the mechanisms. Despite its importance, the structure of this protein is not known ... Read more >>

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Putting a halt to unnecessary transfers: Do patients with isolated subarachnoid hemorrhage and Glasgow Coma Scale of 13 to 15 need a trauma center?

Jyoti Sharma, Danielle Defoe, Jenna Gillen, Yen-Hong Kuo, Javier Perez, Setu Dalal, Saraswati Dayal, Elizabeth Kiselak, Kelly Rippey, Sanjeev Kaul, Stephen Cohn,

OBJECTIVES:Trauma patients with isolated subarachnoid hemorrhage (iSAH) presenting to nontrauma centers are typically transferred to an institution with neurosurgical availability. However, recent studies suggest that iSAH is a benign clinical entity with an excellent prognosis. This investigation aims to evaluate the neurosurgical outcomes of traumatic iSAH with Glasgow Coma Scale ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(1):222-225]

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Diagnostic accuracy of point-of-care devices for detection of anemia in community settings in India.

Sutapa Bandyopadhyay Neogi, Jyoti Sharma, Shivam Pandey, Nausheen Zaidi, Maitreyee Bhattacharya, Rakhee Kar, Sitanshu Sekhar Kar, Abhishek Purohit, Sanjib Bandyopadhyay, Renu Saxena,

BACKGROUND:Accurate diagnosis of anemia by community workers using a point-of-care device is a challenge. The objective of the study was to establish the diagnostic accuracy of point-of-care devices for detecting anemia in community settings. METHODS:It was diagnostic accuracy study with cross-sectional design on adult patients attending the outpatient department of ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):468]

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Extubation is as important as intubation in COVID 19.

Prashant Kumar, Jyoti Sharma,

J Clin Anesth (Journal of clinical anesthesia)
[2020, 66:109934]

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Beneficial effect of standardized extracts of Amorphophallus paeoniifolius tuber and its active constituents on experimental constipation in rats.

Yadu Nandan Dey, Manish M Wanjari, Bhavana Srivastava, Dharmendra Kumar, Deepti Sharma, Jyoti Sharma, Sudesh Gaidhani,

The tubers of Amorphophallus paeoniifolius (Elephant foot yam), principally consumed as crop food and vegetables, are used in ethno-medicinal practices in mitigation of constipation and piles. Hence, present study evaluated the effect of tubers of A. paeoniifolius and its active constituents glucomannan and betulinic acid on experimentally-induced constipation. The tuber and ... Read more >>

Heliyon (Heliyon)
[2020, 6(5):e04023]

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Characterization of Nucleocapsid (N) Protein from Novel Coronavirus SARS-CoV-2

Abhishek Kumar, Alisha Parveen, Narendra Kumar, Sneha Bairy, Vibha Kaushik, Chetan Chandola, Jyoti Sharma, Phulwanti Sharma, Akhil Agarwal, Akhilesh Pandey, Pankaj Goyal, Muniasamy Neerathilingam,

Severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) has caused the global pandemic as COVID-19, which is the most notorious global public health crisis in the last 100 years. SARS-CoV-2 is composed of four structural proteins and several non-structured proteins. The multi-facet nucleocapsid (N) protein is the major component of ... Read more >>

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Pharmacological approaches for targeting cystic fibrosis nonsense mutations.

Jyoti Sharma, Kim M Keeling, Steven M Rowe,

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder. The clinical manifestations of the disease are caused by ∼2,000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It is unlikely that any one approach will be efficient in correcting all defects. The recent approvals of ivacaftor, lumacaftor/ivacaftor and ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112436]

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Rotational synchronization of camphor ribbons in different geometries.

Jyoti Sharma, Ishant Tiwari, Dibyendu Das, P Parmananda, Véronique Pimienta,

We present experiments on multiple pinned self-propelled camphor ribbons, which is a rectangular piece of paper with camphor infused in its matrix. Experiments were performed on three, four, and five ribbons placed in linear and polygonal geometries. The pinned ribbons rotate on the surface of water, due to the surface ... Read more >>

Phys Rev E (Physical review. E)
[2020, 101(5-1):052202]

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Preventing Unnecessary Trauma Transfers: Triage Guidelines for Patients with Isolated Subarachnoid Hemorrhage and GCS 13 to 15.

Jyoti Sharma,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, :]

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Ataluren/ivacaftor combination therapy: Two N-of-1 trials in cystic fibrosis patients with nonsense mutations.

Jacelyn E Peabody Lever, Venkateshwar Mutyam, Heather Y Hathorne, Ning Peng, Jyoti Sharma, Lloyd J Edwards, Steven M Rowe,

Premature termination codons (PTCs) in cystic fibrosis transmembrane conductance regulator (CFTR) produce nonfunctional protein. No approved therapies exist for PTC mutations, including W1282X. We hypothesized that ivacaftor, combined with readthrough therapy, may benefit W1282X patients. Two N-of-1 clinical trials were conducted with ataluren and ivacaftor in various combinations. No meaningful ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(7):1838-1842]

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Proximal subungual onychomycosis of digitus minimus due to Aspergillus brasiliensis.

Manjula Mehta, Jyoti Sharma, Sonia Bhonchal Bhardwaj,

Onychomycosis is a common nail infection caused by dermatophytes, non-dermatophytic molds (NDMs) and yeast. Aspergillus spp. are emerging etiological agents of non-dermatophyte mold onychomycosis (NDMO). Though this is usually of cosmetic concern, it may also cause pain and discomfort to the patient. The toenail is more commonly involved as compared ... Read more >>

Pan Afr Med J (The Pan African medical journal)
[2020, 35:79]

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Upgrading of microalgal consortia with CO2 from fermentation of wheat straw for the phycoremediation of domestic wastewater.

Jyoti Sharma, Smita S Kumar, Vivek Kumar, Sandeep K Malyan, Thangavel Mathimani, Narsi R Bishnoi, Arivalagan Pugazhendhi,

Algae have been considered as a best feedstock for combating CO2. In the present study, two mixed microalgal cultures i.e. MAC1 and MAC2 were evaluated in batch mode with an extraneous supply of CO2 from the fermentation of wheat straw. Both the mixed cultures displayed promising CO2 sequestration potentials of ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 305:123063]

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DNA interaction, in vivo and in vitro cytotoxicity, reactive oxygen species, lipid peroxidation of -N, S donor Re(I) metal complexes.

Reena R Varma, Juhee G Pandya, Jyoti Sharma, Chandramani Pathak, Mohan N Patel,

N, S donor ligands (L1-L5){L1-L5 = 1,5-bis(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L1), 1-(4-bromophenyl)-5-(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L2), 5-(4-chlorophenyl)-3-(thiophen-2-yl)-1-(p-tolyl)-4,5-dihydro-1H-pyrazole (L3), 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L4), 5-(4-chlorophenyl)-1-(4-nitrophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L5)} were synthesized by Claisen-Schmidt condensation and characterized by spectrometric methods. The complexes (I-V) were synthesized by ligand combination followed by metal chelation. The binding of the rhenium complexes to Herrin sperm DNA was monitored by UV ... Read more >>

Mol. Divers. (Molecular diversity)
[2020, :]

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Phosphoproteomics Profiling to Identify Altered Signaling Pathways and Kinase-Targeted Cancer Therapies.

Barnali Deb, Irene A George, Jyoti Sharma, Prashant Kumar,

Phosphorylation is one of the most extensively studied posttranslational modifications (PTM), which regulates cellular functions like cell growth, differentiation, apoptosis, and cell signaling. Kinase families cover a wide number of oncoproteins and are strongly associated with cancer. Identification of driver kinases is an intense area of cancer research. Thus, kinases ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2020, 2051:241-264]

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Guiding Flexible-Tipped Bougie Under Videolaryngoscopy: An Alternative to Fiberoptic Nasotracheal Intubation in Maxillofacial Surgeries.

Prashant Kumar, Jyoti Sharma, Sanjay Johar, Virendra Singh,

Background:Maxillofacial surgeries are known to have difficulty in airway management due to anatomical and functional reasons. Tumors of maxillofacial region and diseases of TM joint limit mouth opening as well as airway space. Various methods have been tried with success for nasotracheal intubation including fiberoptic-aided as well as blind nasal ... Read more >>

J Maxillofac Oral Surg (Journal of maxillofacial and oral surgery)
[2020, 19(2):324-326]

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Clinical Outcomes and Shoulder Kinematics for the "Gray Zone" Extra-articular Scapula Fracture in 5 Patients.

Jyoti Sharma, Candice Maenza, Andrea Myers, Erik B Lehman, Andrew R Karduna, Robert L Sainburg, April D Armstrong,

Aims:There is a subset of scapula fractures, which can be considered in the "gray zone," where treatment guidelines are not clear-cut, based on published literature. Our paper presents the outcomes of five such scapula fractures treated non-operatively. Methods:Adult patients who had been treated non-operatively at our institution for an isolated ... Read more >>

Int J Orthop (International journal of orthopedics)
[2020, 3(1):]

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An HPLC method for simultaneous quantification of sunitinib and its active metabolite, SU12662, using hydrophilic interaction chromatography principle.

Murari Gurjar, Parsshava Mehta, Jyoti Sharma, Sneha Patil, Preeti Kulkarni, Anand Patil, Manjunath Nookala, Amit Joshi, Vikram Gota,

Aim: To develop a sensitive HPLC method for the quantitation of sunitinib (SU) and its active metabolite N-desethyl-sunitinib (SU12662) in human plasma. Materials & methods: The analytes were extracted from 500 μl of plasma using liquid-liquid extraction followed by protein precipitation. Chromatographic separation of two analytes and internal standard, vandetenib, was ... Read more >>

Bioanalysis (Bioanalysis)
[2020, 12(2):75-85]

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Characterisation of the Hippo signalling pathway during bovine preimplantation embryo development.

Jyoti Sharma, Pavneesh Madan,

Blastocyst formation is an important milestone during preimplantation embryo development. During murine preimplantation embryogenesis, the Hippo signalling pathway is known to play a significant role in lineage segregation and henceforth the formation of blastocysts. However, the role of this cell signalling pathway during bovine embryogenesis remains unknown. Thus, the aim ... Read more >>

Reprod. Fertil. Dev. (Reproduction, fertility, and development)
[2020, 32(4):392-401]

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Comparison of conventional with Parker flex-tip tracheal tube for intubation through air-Q intubating laryngeal airway.

Jatin Lal, Teena Bansal, Gaurav Dhawan, Susheela Taxak, Manu Smriti, Jyoti Sharma, Deepali Thaper,

Background and Aims:The problem of difficult and failed intubation led to increased development of equipment for airway management. A number of supraglottic airways have now been developed to facilitate the passage of tracheal tubes. Conventional PVC tracheal tubes are recommended for intubation through the air-Q ILA. No study has compared ... Read more >>

J Anaesthesiol Clin Pharmacol (Journal of anaesthesiology, clinical pharmacology)
[2020, 36(1):43-48]

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Congenital Nephrotic Syndrome in India in the Current Era: A Multicenter Case Series.

Rajiv Sinha, Anil Vasudevan, Indira Agarwal, Sidharth Kumar Sethi, Abhijeet Saha, Subal Pradhan, Sudha Ekambaram, Nilam Thaker, Manoj Matnani, Sushmita Banerjee, Jyoti Sharma, Jyoti Singhal, Shazia Ashraf, Kausik Mandal,

BACKGROUND:There is a paucity of information on epidemiology, diagnosis, and treatment outcomes of congenital nephrotic syndrome (CNS) in developing countries. METHODS:Retrospective (2012-2017) review of case records undertaken across 12 Indian pediatric nephrology centers. RESULTS:Sixty-five children (58% male, median birth weight 2.4 kg [interquartile range (IQR) 2.1-2.86]) were identified with CNS. ... Read more >>

Nephron (Nephron)
[2020, 144(1):21-29]

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Use of Bone Morphogenetic Protein in Pediatric Cranioplasty With Pre- and Postoperative Radiation Therapy.

Jyoti Sharma, Fatma Betul Tuncer, Barbu Gociman, Faizi Siddiqi,

INTRODUCTION:Bone morphogenetic protein (BMP) is a signaling protein that has proven efficacy in the setting of bone repair. It has been widely used in orthopedic surgery and is being implemented more in the field of craniofacial surgery, although there is limited report on its use in pediatric patients. CASE:A 6-year-old ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2019, 30(7):e677-e679]

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In Vitro and Ex Vivo Models for Functional Testing of Therapeutic Anti-scarring Drug Targets in Keloids.

Jyoti R Sharma, Maribanyana Lebeko, Elvis B Kidzeru, Nonhlanhla P Khumalo, Ardeshir Bayat,

Significance: Keloids are benign fibro-proliferative raised dermal lesions that spread beyond the original borders of the wound, continue to grow, rarely regress, and are the most common in pigmented individuals after an abnormal wound healing response. The current treatment failure and respective challenges involved highlighting the underlying issue that the ... Read more >>

Adv Wound Care (New Rochelle) (Advances in wound care)
[2019, 8(12):655-670]

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Microalgal consortia for municipal wastewater treatment - Lipid augmentation and fatty acid profiling for biodiesel production.

Jyoti Sharma, Vivek Kumar, Smita S Kumar, Sandeep K Malyan, Thangavel Mathimani, Narsi R Bishnoi, Arivalagan Pugazhendhi,

The present study investigates the phycoremediation potentials of two microalgal consortia (MAC1 and MAC2) for treating sewage water and producing biomass with high lipid, protein and chlorophyll contents. During the study, the microalgal strains were tested for lipid enhancement, biomass production and contaminant removal from wastewater. The microalgal consortia showed ... Read more >>

J. Photochem. Photobiol. B, Biol. (Journal of photochemistry and photobiology. B, Biology)
[2020, 202:111638]

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A comprehensive review on enzymatic degradation of the organophosphate pesticide malathion in the environment.

Smita S Kumar, Pooja Ghosh, Sandeep K Malyan, Jyoti Sharma, Vivek Kumar,

A comprehensive review of available bioremediation technologies for the pesticide malathion is presented. This review article describes the usage and consequences of malathion in the environment, along with a critical discussion on modes of metabolism of malathion as a sole source of carbon, phosphorus, and sulfur for bacteria, and fungi ... Read more >>

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews)
[2019, 37(4):288-329]

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Genetics on early onset inflammatory bowel disease: An update.

Johnson Nameirakpam, Rashmi Rikhi, Sanjay Singh Rawat, Jyoti Sharma, Deepti Suri,

Inflammatory bowel disease (IBD) is more common in adults than in children. Onset of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD (VEO-IBD) for children who are diagnosed before 6 years of age, infantile IBD who had ... Read more >>

Genes Dis (Genes & Diseases)
[2020, 7(1):93-106]

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