Full Text Journal Articles by
Author Jyoti Sharma

Advertisement

Find full text journal articles






Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations.

Venkateshwar Mutyam, Jyoti Sharma, Yao Li, Ning Peng, Jianguo Chen, Li Ping Tang, Emily Falk Libby, Ashvani K Singh, Katja Conrath, Steven M Rowe,

Premature-termination codons (PTCs) in CFTR (cystic fibrosis [CF] transmembrane conductance regulator) result in nonfunctional CFTR protein and are the proximate cause of ∼11% of CF-causing alleles, for which no treatments exist. The CFTR corrector lumacaftor and the potentiator ivacaftor improve CFTR function with terminal PTC mutations and enhance the effect ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, 64(5):604-616]

Cited: 0 times

View full text PDF listing >>



Wiskott Aldrich Syndrome: A Multi-Institutional Experience From India.

Deepti Suri, Rashmi Rikhi, Ankur K Jindal, Amit Rawat, Murugan Sudhakar, Pandiarajan Vignesh, Anju Gupta, Anit Kaur, Jyoti Sharma, Jasmina Ahluwalia, Prateek Bhatia, Alka Khadwal, Revathi Raj, Ramya Uppuluri, Mukesh Desai, Prasad Taur, Ambreen A Pandrowala, Vijaya Gowri, Manisha R Madkaikar, Harsha Prasada Lashkari, Sagar Bhattad, Harish Kumar, Sanjeev Verma, Kohsuke Imai, Shigeaki Nonoyama, Osamu Ohara, Koon W Chan, Pamela P Lee, Yu Lung Lau, Surjit Singh,

<h4>Background</h4>Wiskott Aldrich syndrome (WAS) is characterized by bleeding manifestations, recurrent infections, eczema, autoimmunity, and malignancy. Over the last decade, improved awareness and better in-house diagnostic facilities at several centers in India has resulted in increased recognition of WAS. This study reports collated data across major primary immunodeficiency diseases (PID) centers ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:627651]

Cited: 0 times

View full text PDF listing >>



Advertisement

Function and evolution of allelic variation of Sr13 conferring resistance to stem rust in tetraploid wheat (Triticum turgidum L.).

Baljeet K Gill, Daryl L Klindworth, Matthew N Rouse, Jinglun Zhang, Qijun Zhang, Jyoti S Sharma, Chenggen Chu, Yunming Long, Shiaoman Chao, Pablo D Olivera, Timothy L Friesen, Shaobin Zhong, Yue Jin, Justin D Faris, Jason D Fiedler, Elias M Elias, Shuyu Liu, Xiwen Cai, Steven S Xu,

Resistance gene Sr13 is one of the most important genes in durum wheat for controlling stem rust caused by Puccinia graminis f. sp. tritici (Pgt). The Sr13 functional gene CNL13 has haplotypes R1, R2, and R3. The R1/R3 and R2 haplotypes were originally designated as alleles Sr13a and Sr13b, respectively. ... Read more >>

Plant J (The Plant journal : for cell and molecular biology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The Ability of Upper Extremity Surgeons to Assess Patient's Functional Status.

Louis C Grandizio, Max D Gehrman, Jove Graham, C Liam Dwyer, Jyoti Sharma, Steven Goldberg, Joel C Klena,

<h4>Purpose</h4>To compare surgeon and patient assessment of upper extremity functional status at the time of initial consultation. We hypothesized that surgeons and patients demonstrate low levels of agreement with respect to assessing pain scores, functional status, and self-efficacy.<h4>Methods</h4>One hundred forty-three consecutive new patients were evaluated by 1 of 5 fellowship-trained ... Read more >>

J Hand Surg Am (The Journal of hand surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Corneal reconstruction in chemically damaged cornea using temperature responsive surface assisted mesenchymal stem cell transplantation in rabbits.

Jyoti Sharma, Ravi Kumar Sharma, Pankaj Gupta, Nalini Gupta, Nirbhai Singh,

<h4>Purpose</h4>Transplantation of autologous stem cells over damaged cornea seems to be a promising approach for corneal reconstruction. Use of a biocompatible carrier is still a challenge in bedside translation of transplantation. We investigated corneal reconstruction and tissue remodelling by transplantation of mesenchymal stem cells (MSCs) using temperature responsive membranes in ... Read more >>

Graefes Arch Clin Exp Ophthalmol (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Hypertension in African Populations: Review and Computational Insights.

Sihle E Mabhida, Lebohang Mashatola, Mandeep Kaur, Jyoti R Sharma, Teke Apalata, Babu Muhamed, Mongi Benjeddou, Rabia Johnson,

Hypertension (HTN) is a persistent public health problem affecting approximately 1.3 billion individuals globally. Treatment-resistant hypertension (TRH) is defined as high blood pressure (BP) in a hypertensive patient that remains above goal despite use of ≥3 antihypertensive agents of different classes including a diuretic. Despite a plethora of treatment options ... Read more >>

Genes (Basel) (Genes)
[2021, 12(4):]

Cited: 0 times

View full text PDF listing >>



Recent advances in the stereoselective synthesis of acyclic all-carbon tetrasubstituted alkenes.

Floris Buttard, Jyoti Sharma, Pier Alexandre Champagne,

Alkenes bearing four carbon-based groups are ubiquitous motifs in chemical sciences due to their various applications from medicinal to materials chemistry, and as chemical platforms for the synthesis of complex, chiral molecules. As such, tremendous research efforts are currently ongoing in order to develop general procedures for the challenging stereoselective ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(34):4071-4088]

Cited: 0 times

View full text PDF listing >>



Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications.

Jasdeep Singh, Jasmine Samal, Vipul Kumar, Jyoti Sharma, Usha Agrawal, Nasreen Z Ehtesham, Durai Sundar, Syed Asad Rahman, Subhash Hira, Seyed E Hasnain,

SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus 2) has accumulated multiple mutations during its global circulation. Recently, three SARS-CoV-2 lineages, B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1), have emerged in the United Kingdom, South Africa and Brazil, respectively. Here, we have presented global viewpoint on implications of emerging SARS-CoV-2 variants based on ... Read more >>

Viruses (Viruses)
[2021, 13(3):]

Cited: 0 times

View full text PDF listing >>



Umbilical Fascial Defects are Common and Predict Trocar Site Hernias After Laparoscopic Appendectomy.

Steven M Hernandez, Elizabeth A Kiselak, Tania Zielonka, Scarlett Tucker, Melissa Blatt, Javier M Perez, Sanjeev Kaul, Saraswati Dayal, Jyoti Sharma, Setu Dalal, Kelly Rippey, Yen-Hong Kuo, Stephen M Cohn,

<h4>Introduction</h4>Investigations have demonstrated that trocar site hernia (TSH) is an under-appreciated complication of laparoscopic surgery, occurring in as many as 31%. We determined the incidence of fascial defects prior to laparoscopic appendectomy and its impact relative to other risk factors upon the development of TSH.<h4>Methods</h4>TSH was defined as a fascial ... Read more >>

Am Surg (The American surgeon)
[2021, :3134821995063]

Cited: 0 times

View full text PDF listing >>



Correction to: Pathophysiology of Hereditary Angioedema (HAE) Beyond the SERPING1 Gene.

Jyoti Sharma, Ankur Kumar Jindal, Aaqib Zaffar Banday, Anit Kaur, Amit Rawat, Surjit Singh, Hilary Longhurst,

Clin Rev Allergy Immunol (Clinical reviews in allergy & immunology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis.

Jyoti Sharma, Monica Antenos, Pavneesh Madan,

The time required for successful blastocyst formation varies among multiple species. The formation of a blastocyst is governed by numerous molecular cell signaling pathways, such as the Hippo signaling pathway. The Hippo signaling pathway is initiated by increased cell-cell contact and via apical polarity proteins (AMOT, PARD6, and NF2) during ... Read more >>

Genes (Basel) (Genes)
[2021, 12(2):]

Cited: 0 times

View full text PDF listing >>



Prevalence of Hypertension and Its Associated Risk Factors in a Rural Black Population of Mthatha Town, South Africa.

Jyoti Rajan Sharma, Sihle E Mabhida, Bronwyn Myers, Teke Apalata, Edward Nicol, Mongi Benjeddou, Christo Muller, Rabia Johnson,

<i>Background</i>: The occurrence of hypertension has been increasing alarmingly in both low and middle-income countries. Despite acknowledging hypertension as the most common life-threatening risk factor for cardiovascular disease (CVD), a dearth of data is available on the prevalence, awareness, and determinants of hypertension in rural parts of South Africa. The ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(3):]

Cited: 0 times

View full text PDF listing >>



Exploring the Role of Gut Microbiome in Colon Cancer.

Indranil Chattopadhyay, Ruby Dhar, Karthikeyan Pethusamy, Ashikh Seethy, Tryambak Srivastava, Ramkishor Sah, Jyoti Sharma, Subhradip Karmakar,

Dysbiosis of the gut microbiome has been associated with the development of colorectal cancer (CRC). Gut microbiota is involved in the metabolic transformations of dietary components into oncometabolites and tumor-suppressive metabolites that in turn affect CRC development. In a healthy colon, the major of microbial metabolism is saccharolytic fermentation pathways. ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2021, :]

Cited: 2 times

View full text PDF listing >>



Validation of a novel causality assessment scale for adverse events in non-small cell lung carcinoma patients treated with platinum and pemetrexed doublet chemotherapy.

Jyoti Bhagatram Sharma, Manjunath Nookala Krishnamurthy, Ankita Awase, Amit Joshi, Vijay Patil, Vanita Noronha, Kumar Prabhash, Vikram Gota,

<h4>Aim</h4>Accurate causality assessment (CA) of adverse events (AEs) is important in clinical research and routine clinical practice. The Naranjo scale (NS) used for CA lacks specificity, leading to a high rate of false positive causal associations. NS is a simple scale for CA; however, its limitations have reduced its popularity ... Read more >>

Ther Adv Drug Saf (Therapeutic advances in drug safety)
[2021, 12:2042098621991280]

Cited: 0 times

View full text PDF listing >>



Consensus Guidelines on Management of Steroid-Resistant Nephrotic Syndrome.

Anil Vasudevan, Ranjeet Thergaonkar, Mukta Mantan, Jyoti Sharma, Priyanka Khandelwal, Pankaj Hari, Aditi Sinha, Arvind Bagga, ,

<h4>Justification</h4>The management of steroid resistant nephrotic syndrome (SRNS) is challenging. These guidelines update existing 2009 Indian Society of Pediatric Nephrology recommendations on its management.<h4>Objectives</h4>To frame revised guidelines on diagnosis and evaluation, treatment and follow up, and supportive care of patients with the illness.<h4>Process</h4>The guidelines combine evidence-based recommendations and expert opinion. ... Read more >>

Indian Pediatr (Indian pediatrics)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Rotavirus Gastroenteritis Hospitalizations Among Under-5 Children in Northern India.

Jyoti Sharma, Sanjiv Chaudhary, Mohit Bajaj, Nayana P Nair, Varunkumar Thiyagarajan,

<h4>Objective</h4>To study epidemiological profile, prevalence, and molecular epidemiology of RVGE in hospitalized under-5 children at a tertiary care teaching rural hospital located in sub-Himalayan belt of Northern India.<h4>Methods</h4>This was a hospital-based surveillance study done over 4 y (2016-2019) including under-5 children hospitalized with acute gastroenteritis (AGE). Demographic and clinical parameters ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2021, 88(Suppl 1):28-34]

Cited: 0 times

View full text PDF listing >>



Determining the optimal cholecalciferol dosing regimen in children with CKD: a randomized controlled trial.

Arpana Iyengar, Nivedita Kamath, Hamsa V Reddy, Jyoti Sharma, Jyoti Singhal, Susan Uthup, Sudha Ekambaram, Sumithra Selvam, Anja Rahn, Dagmar-C Fischer, Mandy Wan, Rukshana Shroff,

<h4>Background and objectives</h4>The optimal treatment regimen for correcting 25-hydroxyvitamin D (25OHD) deficiency in children with chronic kidney disease (CKD) is not known. We compared cholecalciferol dosing regimens for achieving and maintaining 25OHD concentrations ≥30ng/ml in children with CKD stages 2-4.<h4>Design</h4>An open-label multicenter randomized controlled trial randomized children with 25OHD concentrations<30ng/ml ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pathophysiology of Hereditary Angioedema (HAE) Beyond the SERPING1 Gene.

Jyoti Sharma, Ankur Kumar Jindal, Aaqib Zaffar Banday, Anit Kaur, Amit Rawat, Surjit Singh, Hilary Longhurst,

Hereditary Angioedema (HAE) is an autosomal dominant disorder characterized clinically by recurrent episodes of swelling involving subcutaneous tissues, gastrointestinal tract, and oro-pharyngeal area. Gene mutations are the most common genetic cause of HAE and observed in more than 90% of patients. More than 700 mutation variants have been described so ... Read more >>

Clin Rev Allergy Immunol (Clinical reviews in allergy & immunology)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Evaluation of audible leak versus pressure volume loop closure for polyvinyl chloride cuff and polyurethane microcuff in endotracheal tube inflated with air: a prospective randomized study.

Prashant Kumar, Abhilasha, Jyoti Sharma, Kiranpreet Kaur, Mamta Bharadwaj, Anu Singh,

Cuff pressure of endotracheal tube (ETT) must be high enough to seal the trachea, and must be low enough to allow adequate perfusion of tracheal mucosa. Compared with polyvinyl chloride (PVC) cuffed tubes, polyurethane cuffed tubes protect more efficiently. Different methods of ETT cuff pressure maintenance in practice have been ... Read more >>

Med Gas Res (Medical gas research)
[2021, 11(1):6-11]

Cited: 0 times

View full text PDF listing >>



Chimeralike states in a minimal network of active camphor ribbons.

Jyoti Sharma, Ishant Tiwari, Dibyendu Das, P Parmananda,

A chimeralike state is the spatiotemporal pattern in an ensemble of homogeneous coupled oscillators, described as the emergence of coexisting coherent (synchronized) and incoherent (unsynchronized) groups. We demonstrate the existence of these states in three active camphor ribbons, which are camphor infused rectangular pieces of paper. These pinned ribbons rotate ... Read more >>

Phys Rev E (Physical review. E)
[2021, 103(1-1):012214]

Cited: 0 times

View full text PDF listing >>



COVID-19 in children treated with immunosuppressive medication for kidney diseases.

Matko Marlais, Tanja Wlodkowski, Samhar Al-Akash, Petr Ananin, Varun Kumar Bandi, Veronique Baudouin, Olivia Boyer, Luciola Vásquez, Sukanya Govindan, Nakysa Hooman, Iftikhar Ijaz, Reyner Loza, Marta Melgosa, Nivedita Pande, Lars Pape, Anshuman Saha, Dmitry Samsonov, Michiel F Schreuder, Jyoti Sharma, Sahar Siddiqui, Rajiv Sinha, Heather Stewart, Velibor Tasic, Burkhard Tönshoff, Katherine Twombley, Kiran Upadhyay, Marina Vivarelli, Donald J Weaver, Robert Woroniecki, Franz Schaefer, Kjell Tullus,

<h4>Background</h4>Children are recognised as at lower risk of severe COVID-19 compared with adults, but the impact of immunosuppression is yet to be determined. This study aims to describe the clinical course of COVID-19 in children with kidney disease taking immunosuppressive medication and to assess disease severity.<h4>Methods</h4>Cross-sectional study hosted by the ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

Cited: 1 time

View full text PDF listing >>



An Insight into the Mechanism of Holamine- and Funtumine-Induced Cell Death in Cancer Cells.

Jelili A Badmus, Okobi E Ekpo, Jyoti R Sharma, Nicole Remaliah S Sibuyi, Mervin Meyer, Ahmed A Hussein, Donavon C Hiss,

Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of <i>Holarrhena</i>. The selective anti-proliferative and cell cycle arrest effects of holamine and funtumine on cancer cells have been previously reported. The present study evaluated the anti-proliferative mechanism of action of these ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(23):]

Cited: 0 times

View full text PDF listing >>



A Novel G542X CFTR Rat Model of Cystic Fibrosis Is Sensitive to Nonsense Mediated Decay.

Jyoti Sharma, Joseph Abbott, Lauren Klaskala, Guojun Zhao, Susan E Birket, Steven M Rowe,

Nonsense mutations that lead to the insertion of a premature termination codon (PTC) in the cystic fibrosis transmembrane conductance regulator (CFTR) transcript affect 11% of patients with cystic fibrosis (CF) worldwide and are associated with severe disease phenotype. While CF rat models have contributed significantly to our understanding of CF ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:611294]

Cited: 0 times

View full text PDF listing >>



Anticoagulation therapy in patients with traumatic brain injury: An Eastern Association for the Surgery of Trauma multicenter prospective study.

Kazuhide Matsushima, Stefan W Leichtle, Jeffrey Wild, Katelyn Young, Grace Chang, Demetrios Demetriades, ,

<h4>Background</h4>Trauma care providers often face a dilemma regarding anticoagulation therapy initiation in patients with traumatic brain injury owing to the associated risks of traumatic brain injury progression. The aims of this study were the following: (1) to describe the current practice of anticoagulation therapy in traumatic brain injury patients and ... Read more >>

Surgery (Surgery)
[2021, 169(2):470-476]

Cited: 0 times

View full text PDF listing >>



Editorial: Multi-Omics Approaches to Study Signaling Pathways.

Jyoti Sharma, Lavanya Balakrishnan, Sandeep Kaushik, Manoj Kumar Kashyap,

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2020, 8:829]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0466 s