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Author Jyoti Sharma

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Anticoagulation therapy in patients with traumatic brain injury: An Eastern Association for the Surgery of Trauma multicenter prospective study.

Kazuhide Matsushima, Stefan W Leichtle, Jeffrey Wild, Katelyn Young, Grace Chang, Demetrios Demetriades, ,

BACKGROUND:Trauma care providers often face a dilemma regarding anticoagulation therapy initiation in patients with traumatic brain injury owing to the associated risks of traumatic brain injury progression. The aims of this study were the following: (1) to describe the current practice of anticoagulation therapy in traumatic brain injury patients and ... Read more >>

Surgery (Surgery)
[2020, :]

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Editorial: Multi-Omics Approaches to Study Signaling Pathways.

Jyoti Sharma, Lavanya Balakrishnan, Sandeep Kaushik, Manoj Kumar Kashyap,

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2020, 8:829]

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Duplication of the internal jugular vein - A rare anatomical variation.

Sandeep Bhoriwal, Jyoti Sharma, Kunal Dhall, Amitabha Mandal, Madiwalesh Chhebbi, T S H V Surya,

Oral Oncol (Oral oncology)
[2020, :104985]

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Role of hospital anxiety and depression on the healing of chronic leg ulcer: A prospective study.

Navin Kumar, Farhanul Huda, Rishit Mani, Tanuj Singla, Ashikesh Kundal, Jyoti Sharma, Bhargav Gajula,

A chronic leg ulcer is a debilitating illness, owing to the local condition of the wound and a decrease in physical activity and productivity, resulting in anxiety and depression among patients. The study aimed to find any association of anxiety and depression in the healing of chronic wounds. A total ... Read more >>

Int Wound J (International wound journal)
[2020, :]

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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers.

M Judith Peterschmitt, Nigel P S Crawford, Sebastiaan J M Gaemers, Allena J Ji, Jyoti Sharma, Theresa T Pham,

Venglustat is a small-molecule glucosylceramide synthase (GCS) inhibitor designed to reduce the production of glucosylceramide (GL-1) and thus is expected to substantially reduce formation of glucosylceramide-based glycosphingolipids. Because of its effect on glycosphingolipid formation, GCS inhibition has therapeutic potential across many disorders affecting glycosphingolipid metabolism. Therefore, venglustat is under development ... Read more >>

Clin Pharmacol Drug Dev (Clinical pharmacology in drug development)
[2020, :]

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Structure of Macrolide Efflux Protein (MefA/E) in Streptococcus pneumoniae: An in silico approach

Sreeram Chandra Murthy Peela, Jyoti Sharma, Sujatha Sistla,

Abstract Background Macrolides are one of the commonest antibiotics used to treat bacterial respiratory tract infections. Resistance to this class of antibiotics is on the rise and is mediated by macrolide efflux (MefA/E) protein as one of the mechanisms. Despite its importance, the structure of this protein is not known ... Read more >>

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Early Detection of Deep Venous Thrombosis in Trauma Patients.

Stanton Nielsen, David O'Connor, Sanjeev Kaul, Jyoti Sharma, Massimo Napolitano, Gregory Simonian, Melissa Blatt, Tania Zielonka, Themba Nyirenda, Stephen Cohn,

Background This study was performed to determine whether trauma patients are at an increased risk of developing deep venous thrombosis (DVT) within the first 48 hours of hospitalization. Materials and methods A retrospective review was performed using a prospectively maintained database of patients admitted to a trauma center during a ... Read more >>

Cureus (Cureus)
[2020, 12(7):e9370]

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Authors' reply: Preventing unnecessary trauma transfers: Triage guidelines for patients with isolated subarachnoid hemorrhage and GCS 13 to 15.

Jyoti Sharma,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(2):e24]

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Putting a halt to unnecessary transfers: Do patients with isolated subarachnoid hemorrhage and Glasgow Coma Scale of 13 to 15 need a trauma center?

Jyoti Sharma, Danielle Defoe, Jenna Gillen, Yen-Hong Kuo, Javier Perez, Setu Dalal, Saraswati Dayal, Elizabeth Kiselak, Kelly Rippey, Sanjeev Kaul, Stephen Cohn,

OBJECTIVES:Trauma patients with isolated subarachnoid hemorrhage (iSAH) presenting to nontrauma centers are typically transferred to an institution with neurosurgical availability. However, recent studies suggest that iSAH is a benign clinical entity with an excellent prognosis. This investigation aims to evaluate the neurosurgical outcomes of traumatic iSAH with Glasgow Coma Scale ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(1):222-225]

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Diagnostic accuracy of point-of-care devices for detection of anemia in community settings in India.

Sutapa Bandyopadhyay Neogi, Jyoti Sharma, Shivam Pandey, Nausheen Zaidi, Maitreyee Bhattacharya, Rakhee Kar, Sitanshu Sekhar Kar, Abhishek Purohit, Sanjib Bandyopadhyay, Renu Saxena,

BACKGROUND:Accurate diagnosis of anemia by community workers using a point-of-care device is a challenge. The objective of the study was to establish the diagnostic accuracy of point-of-care devices for detecting anemia in community settings. METHODS:It was diagnostic accuracy study with cross-sectional design on adult patients attending the outpatient department of ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):468]

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Extubation is as important as intubation in COVID 19.

Prashant Kumar, Jyoti Sharma,

J Clin Anesth (Journal of clinical anesthesia)
[2020, 66:109934]

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Comparative evaluation of the predictive value of cariogram and informal caries risk assessment among school-going children in the age group of 8-9 years of Yamuna Nagar District, Haryana.

Jyoti Sharma, Monika Gupta, Inder Kumar Pandit, Neeraj Gugnani, Lata Kiran Mehta,

Aim:This longitudinal, observational study was conducted in the schools of Yamunanagar, Haryana, to evaluate and compare the predictive value of formal type of caries risk assessment using reduced Cariogram software, including only seven factors and informal type among 8-9 years' school-going children. Materials: and: Methods:A.total of 111 school-going children were ... Read more >>

J Indian Soc Pedod Prev Dent (Journal of the Indian Society of Pedodontics and Preventive Dentistry)
[2020, 38(3):266-273]

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Determinants of suboptimal breastfeeding in Haryana - An analysis of national family health survey-4 data.

Jyoti Sharma, Shivam Pandey, Preeti Negandhi,

Background:Infant and child feeding practices are a prevalent challenge in Haryana. Objectives:The present study aimed to determine factors associated with non-initiation of breastfeeding within 1 h of birth, no exclusive breastfeeding (EBF) and no continued breastfeeding in Haryana. Methods:National Family Health Survey-4 data for the state of Haryana was used ... Read more >>

Indian J Public Health (Indian journal of public health)
[2020, 64(3):285-294]

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Beneficial effect of standardized extracts of Amorphophallus paeoniifolius tuber and its active constituents on experimental constipation in rats.

Yadu Nandan Dey, Manish M Wanjari, Bhavana Srivastava, Dharmendra Kumar, Deepti Sharma, Jyoti Sharma, Sudesh Gaidhani,

The tubers of Amorphophallus paeoniifolius (Elephant foot yam), principally consumed as crop food and vegetables, are used in ethno-medicinal practices in mitigation of constipation and piles. Hence, present study evaluated the effect of tubers of A. paeoniifolius and its active constituents glucomannan and betulinic acid on experimentally-induced constipation. The tuber and ... Read more >>

(Heliyon)
[2020, 6(5):e04023]

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Characterization of Nucleocapsid (N) Protein from Novel Coronavirus SARS-CoV-2

Abhishek Kumar, Alisha Parveen, Narendra Kumar, Sneha Bairy, Vibha Kaushik, Chetan Chandola, Jyoti Sharma, Phulwanti Sharma, Akhil Agarwal, Akhilesh Pandey, Pankaj Goyal, Muniasamy Neerathilingam,

Severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) has caused the global pandemic as COVID-19, which is the most notorious global public health crisis in the last 100 years. SARS-CoV-2 is composed of four structural proteins and several non-structured proteins. The multi-facet nucleocapsid (N) protein is the major component of ... Read more >>

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Pharmacological approaches for targeting cystic fibrosis nonsense mutations.

Jyoti Sharma, Kim M Keeling, Steven M Rowe,

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder. The clinical manifestations of the disease are caused by ∼2,000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It is unlikely that any one approach will be efficient in correcting all defects. The recent approvals of ivacaftor, lumacaftor/ivacaftor and ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112436]

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Rotational synchronization of camphor ribbons in different geometries.

Jyoti Sharma, Ishant Tiwari, Dibyendu Das, P Parmananda, Véronique Pimienta,

We present experiments on multiple pinned self-propelled camphor ribbons, which is a rectangular piece of paper with camphor infused in its matrix. Experiments were performed on three, four, and five ribbons placed in linear and polygonal geometries. The pinned ribbons rotate on the surface of water, due to the surface ... Read more >>

Phys Rev E (Physical review. E)
[2020, 101(5-1):052202]

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Ataluren/ivacaftor combination therapy: Two N-of-1 trials in cystic fibrosis patients with nonsense mutations.

Jacelyn E Peabody Lever, Venkateshwar Mutyam, Heather Y Hathorne, Ning Peng, Jyoti Sharma, Lloyd J Edwards, Steven M Rowe,

Premature termination codons (PTCs) in cystic fibrosis transmembrane conductance regulator (CFTR) produce nonfunctional protein. No approved therapies exist for PTC mutations, including W1282X. We hypothesized that ivacaftor, combined with readthrough therapy, may benefit W1282X patients. Two N-of-1 clinical trials were conducted with ataluren and ivacaftor in various combinations. No meaningful ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(7):1838-1842]

Cited: 2 times

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Proximal subungual onychomycosis of digitus minimus due to Aspergillus brasiliensis.

Manjula Mehta, Jyoti Sharma, Sonia Bhonchal Bhardwaj,

Onychomycosis is a common nail infection caused by dermatophytes, non-dermatophytic molds (NDMs) and yeast. Aspergillus spp. are emerging etiological agents of non-dermatophyte mold onychomycosis (NDMO). Though this is usually of cosmetic concern, it may also cause pain and discomfort to the patient. The toenail is more commonly involved as compared ... Read more >>

Pan Afr Med J (The Pan African medical journal)
[2020, 35:79]

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Upgrading of microalgal consortia with CO2 from fermentation of wheat straw for the phycoremediation of domestic wastewater.

Jyoti Sharma, Smita S Kumar, Vivek Kumar, Sandeep K Malyan, Thangavel Mathimani, Narsi R Bishnoi, Arivalagan Pugazhendhi,

Algae have been considered as a best feedstock for combating CO2. In the present study, two mixed microalgal cultures i.e. MAC1 and MAC2 were evaluated in batch mode with an extraneous supply of CO2 from the fermentation of wheat straw. Both the mixed cultures displayed promising CO2 sequestration potentials of ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 305:123063]

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DNA interaction, in vivo and in vitro cytotoxicity, reactive oxygen species, lipid peroxidation of -N, S donor Re(I) metal complexes.

Reena R Varma, Juhee G Pandya, Jyoti Sharma, Chandramani Pathak, Mohan N Patel,

N, S donor ligands (L1-L5){L1-L5 = 1,5-bis(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L1), 1-(4-bromophenyl)-5-(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L2), 5-(4-chlorophenyl)-3-(thiophen-2-yl)-1-(p-tolyl)-4,5-dihydro-1H-pyrazole (L3), 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L4), 5-(4-chlorophenyl)-1-(4-nitrophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole (L5)} were synthesized by Claisen-Schmidt condensation and characterized by spectrometric methods. The complexes (I-V) were synthesized by ligand combination followed by metal chelation. The binding of the rhenium complexes to Herrin sperm DNA was monitored by UV ... Read more >>

Mol. Divers. (Molecular diversity)
[2020, :]

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Phosphoproteomics Profiling to Identify Altered Signaling Pathways and Kinase-Targeted Cancer Therapies.

Barnali Deb, Irene A George, Jyoti Sharma, Prashant Kumar,

Phosphorylation is one of the most extensively studied posttranslational modifications (PTM), which regulates cellular functions like cell growth, differentiation, apoptosis, and cell signaling. Kinase families cover a wide number of oncoproteins and are strongly associated with cancer. Identification of driver kinases is an intense area of cancer research. Thus, kinases ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2051:241-264]

Cited: 1 time

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Guiding Flexible-Tipped Bougie Under Videolaryngoscopy: An Alternative to Fiberoptic Nasotracheal Intubation in Maxillofacial Surgeries.

Prashant Kumar, Jyoti Sharma, Sanjay Johar, Virendra Singh,

Background:Maxillofacial surgeries are known to have difficulty in airway management due to anatomical and functional reasons. Tumors of maxillofacial region and diseases of TM joint limit mouth opening as well as airway space. Various methods have been tried with success for nasotracheal intubation including fiberoptic-aided as well as blind nasal ... Read more >>

J Maxillofac Oral Surg (Journal of maxillofacial and oral surgery)
[2020, 19(2):324-326]

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Editorial: Multi-Omics Approaches to Study Signaling Pathways

Jyoti Sharma, Lavanya Balakrishnan, Sandeep Kaushik, Manoj Kumar Kashyap,

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2020, 8:]

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Clinical Outcomes and Shoulder Kinematics for the "Gray Zone" Extra-articular Scapula Fracture in 5 Patients.

Jyoti Sharma, Candice Maenza, Andrea Myers, Erik B Lehman, Andrew R Karduna, Robert L Sainburg, April D Armstrong,

Aims:There is a subset of scapula fractures, which can be considered in the "gray zone," where treatment guidelines are not clear-cut, based on published literature. Our paper presents the outcomes of five such scapula fractures treated non-operatively. Methods:Adult patients who had been treated non-operatively at our institution for an isolated ... Read more >>

Int J Orthop (International journal of orthopedics)
[2020, 3(1):]

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