Full Text Journal Articles by
Author Juthaporn Cowan

Advertisement

Find full text journal articles






A High-Throughput NanoBiT-Based Serological Assay Detects SARS-CoV-2 Seroconversion.

Taha Azad, Reza Rezaei, Ragunath Singaravelu, Taylor R Jamieson, Mathieu J F Crupi, Abera Surendran, Joanna Poutou, Parisa Taklifi, Juthaporn Cowan, Donald William Cameron, Carolina S Ilkow,

High-throughput detection strategies for antibodies against SARS-CoV-2 in patients recovering from COVID-19, or in vaccinated individuals, are urgently required during this ongoing pandemic. Serological assays are the most widely used method to measure antibody responses in patients. However, most of the current methods lack the speed, stability, sensitivity, and specificity ... Read more >>

Nanomaterials (Basel) (Nanomaterials (Basel, Switzerland))
[2021, 11(3):]

Cited: 0 times

View full text PDF listing >>



Polyvalent Immunoglobulin as a Potential Treatment Option for Patients with Recurrent COPD Exacerbations.

Dana Unninayar, Sara J Abdallah, D William Cameron, Juthaporn Cowan,

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and episodes of worsening respiratory symptoms and pulmonary function, termed acute exacerbations of COPD (AECOPD). AECOPD episodes are associated with heightened airway inflammation and are often triggered by infection. A subset of COPD patients develops frequent exacerbations despite maximal ... Read more >>

Int J Chron Obstruct Pulmon Dis (International journal of chronic obstructive pulmonary disease)
[2021, 16:545-552]

Cited: 0 times

View full text PDF listing >>



Advertisement

Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians.

Murdoch Leeies, Hayley B Gershengorn, Emmanuel Charbonney, Anand Kumar, Dean Fergusson, Alexis F Turgeon, Juthaporn Cowan, Bojan Paunovic, John Embil, Donald S Houston, Brett Houston, Emily Rimmer, Faisal Siddiqui, Bill Cameron, Srinivas Murthy, John C Marshall, Rob Fowler, Ryan Zarychanski,

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians.

Murdoch Leeies, Hayley B Gershengorn, Emmanuel Charbonney, Anand Kumar, Dean Fergusson, Alexis F Turgeon, Juthaporn Cowan, Bojan Paunovic, John Embil, Allan Garland, Donald S Houston, Brett Houston, Emily Rimmer, Faisal Siddiqui, Bill Cameron, Srinivas Murthy, John C Marshall, Rob Fowler, Ryan Zarychanski,

<h4>Purpose</h4>This national survey evaluated the perceived efficacy and safety of intravenous immune globulin (IVIG) in septic shock, self-reported utilization patterns, barriers to use, the population of interest for further trials and willingness to participate in future research of IVIG in septic shock.<h4>Methods</h4>We conducted a cross-sectional survey of critical care and ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Safety and Tolerability of Subcutaneous IgPro20 at High Infusion Parameters in Patients with Primary Immunodeficiency: Findings from the Pump-Assisted Administration Cohorts of the HILO Study.

John T Anderson, Vincent R Bonagura, Juthaporn Cowan, Connie Hsu, S Shahzad Mustafa, Niraj C Patel, John M Routes, Panida Sriaroon, Donald C Vinh, Jutta H Hofmann, Michaela Praus, Mikhail A Rojavin,

<h4>Purpose</h4>To evaluate the safety and tolerability of subcutaneous IgPro20 (Hizentra<sup>®</sup>, CSL Behring, King of Prussia, PA, USA) administered at high infusion parameters (> 25 mL and > 25 mL/h per injection site) in patients with primary immunodeficiency.<h4>Methods</h4>The Hizentra<sup>®</sup> Label Optimization (HILO) study was an open-label, parallel-arm, non-randomized study (NCT03033745) of IgPro20 using a forced ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2021, 41(2):458-469]

Cited: 1 time

View full text PDF listing >>



Evaluation of the protein gap for detection of abnormal serum gammaglobulin level: an imperfect predictor.

Adam Suleman, D William Cameron, Vicente Corrales-Medina, Christopher McCudden, Juthaporn Cowan,

<h4>Objectives</h4>The value of the serum protein gap (PG, difference between total protein and albumin) in the detection of hyper- or hypogammaglobulinemia is not well established. We assessed the performance of PG for the detection of hyper- or hypogammaglobulinemia in a large sample of patients.<h4>Methods</h4>We reviewed all paired measurements of serum ... Read more >>

Clin Chem Lab Med (Clinical chemistry and laboratory medicine)
[2021, 59(5):869-874]

Cited: 0 times

View full text PDF listing >>



Vedolizumab treatment across antiretroviral treatment interruption in chronic HIV infection: the HAVARTI protocol for a pilot dose-ranging clinical trial to assess safety, tolerance, immunological and virological activity.

Michaeline McGuinty, Jonathan B Angel, Curtis L Cooper, Juthaporn Cowan, Paul A MacPherson, Ashok Kumar, Sanjay Murthy, Richmond Sy, Michelle Dennehy, Nancy Tremblay, Siddappa N Byrareddy, D William Cameron,

<h4>Introduction</h4>Continuous antiretroviral therapy (ART) suppresses HIV plasma viral load (pVL) to very low levels, which allows for some immune recovery. Discontinuation of ART leads to pVL rebound from reservoirs of persistence and latency, and progressive immunodeficiency. One promising but controversial strategy targeting CD4<sup>+</sup> T lymphocytes with a monoclonal antibody (mAb) ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e041359]

Cited: 0 times

View full text PDF listing >>



Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study.

Juthaporn Cowan, Vincent R Bonagura, Patricia L Lugar, Paul J Maglione, Niraj C Patel, Donald C Vinh, Jutta H Hofmann, Michaela Praus, Mikhail A Rojavin,

<h4>Purpose</h4>To evaluate the safety and tolerability of IgPro20 manual push (also known as rapid push) infusions at flow rates of 0.5-2.0 mL/min.<h4>Methods</h4>Patients with primary immunodeficiency (PID) with previous experience administering IgPro20 (Hizentra<sup>®</sup>, CSL Behring, King of Prussia, PA, USA) were enrolled in the Hizentra<sup>®</sup> Label Optimization (HILO) study (NCT03033745) and assigned ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2021, 41(1):66-75]

Cited: 1 time

View full text PDF listing >>



Discontinuation of immunoglobulin replacement therapy in patients with secondary antibody deficiency.

Vishesh Patel, Juthaporn Cowan,

<h4>Introduction</h4>Secondary immunodeficiency is becoming a greater medical concern as the usage of immunosuppressive and biological treatments has increased. Individuals with certain medical conditions, such as hematological malignancies, can also have secondary immunodeficiency. Immunoglobulin replacement therapy (IGRT), which has been used for decades in inherited or primary immunodeficiency, provides some protection ... Read more >>

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2020, 16(7):711-716]

Cited: 0 times

View full text PDF listing >>



Shift in Epidemiology of Cryptococcal Infections in Ottawa with High Mortality in Non-HIV Immunocompromised Patients.

Vishesh Patel, Marc Desjardins, Juthaporn Cowan,

Cryptococcus neoformans is a fungus that can cause life-threatening infections. While human immunodeficiency virus (HIV)-positive status historically had the highest risk for cryptococcal infection and was associated with high mortality rates, there have been changes in HIV treatment and the epidemiology of other acquired immunodeficiencies, such as hematological malignancies. We ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2019, 5(4):]

Cited: 1 time

View full text PDF listing >>



Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency.

Tri Dinh, Jun Oh, Donald William Cameron, Seung-Hwan Lee, Juthaporn Cowan,

Patients with primary or secondary antibody deficiency (PAD or SAD) are at increased risk of recurrent infections that can be alleviated by immunoglobulin replacement therapy (IRT). In addition to replenishing antibody levels, IRT has been suggested to modulate immune response in patients with antibody deficiency. Although both commonly treated with ... Read more >>

PLoS One (PloS one)
[2019, 14(10):e0223861]

Cited: 0 times

View full text PDF listing >>



Clinical outcomes of polyvalent immunoglobulin use in solid organ transplant recipients: A systematic review and meta-analysis - Part II: Non-kidney transplant.

Samuel Bourassa-Blanchette, Vishesh Patel, Greg A Knoll, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D William Cameron, Juthaporn Cowan,

Immunoglobulin (IG) is commonly used to desensitize and treat antibody-mediated rejection in solid organ transplant (SOT) recipients. The impact of IG on other outcomes such as infection, all-cause mortality, graft rejection, and graft loss is not clear. We conducted a similar systematic review and meta-analysis to our previously reported Part ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(7):e13625]

Cited: 0 times

View full text PDF listing >>



Disseminated cryptococcal infection in a patient with treatment-naïve chronic lymphocytic leukemia (CLL).

Adam Suleman, Ruth Padmore, Carolyn Faught, Juthaporn Cowan,

We report a case of disseminated cryptococcosis in a treatment-naïve chronic lymphocytic leukemia (CLL) patient. A 60-year-old man presented with a two-week history of intermittent fevers, frontal headaches, night sweats, weight loss and multiple pink papules on hands and face. Cryptococcemia was found by blood culture unexpectedly. Further investigation confirmed ... Read more >>

IDCases (IDCases)
[2019, 17:e00566]

Cited: 3 times

View full text PDF listing >>



Clinical outcomes of polyvalent immunoglobulin use in solid organ transplant recipients: A systematic review and meta-analysis.

Samuel Bourassa-Blanchette, Greg A Knoll, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D William Cameron, Juthaporn Cowan,

Polyvalent immunoglobulin is commonly used for desensitization and treatment of antibody-mediated rejection in kidney transplantation but its impact on other outcomes is not known. This systematic review investigated the impact of immunoglobulin prophylaxis on infection, rejection, graft loss, and death following kidney transplantation. A comprehensive literature search located 18 studies ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(6):e13560]

Cited: 0 times

View full text PDF listing >>



Evaluation of a Personalized Subcutaneous Immunoglobulin Treatment Program for Neurological Patients.

Adam Suleman, Lynda Theoret, Pierre Bourque, Elizabeth Pringle, D William Cameron, Juthaporn Cowan,

<h4>Background</h4>Subcutaneous immunoglobulin (SCIg) treatment has been shown to control symptoms and improve overall satisfaction in patients with neurological disorders. However, a large injection volume can be overwhelming and a barrier to successful SCIg treatment. We established a nurse-led individualized approach program to facilitate a smooth and successful treatment transition from ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2019, 46(1):38-43]

Cited: 1 time

View full text PDF listing >>



Incidence Rate of Post-Kidney Transplant Infection: A Retrospective Cohort Study Examining Infection Rates at a Large Canadian Multicenter Tertiary-Care Facility.

Juthaporn Cowan, Alexandria Bennett, Nicholas Fergusson, Cheynne McLean, Ranjeeta Mallick, D William Cameron, Greg Knoll,

<h4>Background</h4>Reducing post-operative infections among kidney transplant patients is critical to improve long-term outcomes. With shifting disease demographics and implementation of new transplantation protocols, frequent evaluation of infection rate and type is necessary.<h4>Objective</h4>Our objectives were to assess the incidence and types of post-operative infections in kidney transplant recipients at a large ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2018, 5:2054358118799692]

Cited: 2 times

View full text PDF listing >>



Study protocol: a randomized, double-blind, parallel, two-arm, placebo control trial investigating the feasibility and safety of immunoglobulin treatment in COPD patients for prevention of frequent recurrent exacerbations.

Juthaporn Cowan, Sunita Mulpuru, Shawn Aaron, Gonzalo Alvarez, Antonio Giulivi, Vicente Corrales-Medina, Venkatesh Thiruganasambandamoorthy, Kednapa Thavorn, Ranjeeta Mallick, D William Cameron,

Background:Chronic obstructive pulmonary disease (COPD) is a chronic progressive inflammatory disease of the airways, associated with frailty, disability, co-morbidity, and mortality. Individuals with COPD experience increased risk and rates of acute exacerbation as their lung disease worsens. Current treatments to prevent acute exacerbation of COPD (AECOPD) are only modestly effective. ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2018, 4:135]

Cited: 1 time

View full text PDF listing >>



Effectiveness of immunoglobulin prophylaxis in reducing clinical complications of hematopoietic stem cell transplantation: a systematic review and meta-analysis.

Hilalion Ahn, Jason Tay, Beverley Shea, Brian Hutton, Risa Shorr, Greg A Knoll, Donald William Cameron, Juthaporn Cowan,

BACKGROUND:Prophylactic immunoglobulin has been used with varying efficacy to reduce complications in hematopoietic stem cell transplant recipients. STUDY DESIGN AND METHODS:A systematic review and meta-analysis was conducted of randomized controlled trials that assessed clinical outcomes (overall survival, transplant-related mortality, graft-versus-host disease [GVHD], veno-occlusive disease [VOD], interstitial pneumonitis, disease relapse, cytomegalovirus ... Read more >>

Transfusion (Transfusion)
[2018, 58(10):2437-2452]

Cited: 3 times

View full text PDF listing >>



Prevalence of Hypogammaglobulinemia in Adult Invasive Pneumococcal Disease.

Juthaporn Cowan, Thuy Linh Do, Sacha Desjardins, Karamchand Ramotar, Vicente Corrales-Medina, Donald William Cameron,

Background:Patients with humoral immune deficiency are susceptible to invasive pneumococcal disease (IPD). This study estimates the prevalence of underlying hypogammaglobulinemia in admitted IPD cases and examines whether IPD cases had received preventative treatment. Methods:All adult IPD cases (Streptococcus pneumoniae in blood or cerebrospinal fluid) admitted to The Ottawa Hospital (TOH) ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(4):564-569]

Cited: 2 times

View full text PDF listing >>



Chronic obstructive pulmonary disease exacerbation frequency and serum IgG levels.

Juthaporn Cowan, Sunita Mulpuru, Gonzalo Alvarez, Vicente Corrales-Medina, Donald W Cameron,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2018, 141(2):830-831]

Cited: 1 time

View full text PDF listing >>



A national survey of screening and management of hypogammaglobulinemia in Canadian transplantation centers.

Samuel Bourassa-Blanchette, Greg Knoll, Jason Tay, Christopher Bredeson, Donald W Cameron, Juthaporn Cowan,

<h4>Background</h4>Infection remains one of the most common transplant-related causes of death in patients undergoing transplantation. Secondary hypogammaglobulinemia (HGG) as a component of immune suppression and deficiency is associated with both solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT). Available data and clinical experience for the supplementation of immunoglobulin (Ig) ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2017, 19(4):]

Cited: 4 times

View full text PDF listing >>



A Retrospective Longitudinal Within-Subject Risk Interval Analysis of Immunoglobulin Treatment for Recurrent Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Juthaporn Cowan, Logan Gaudet, Sunita Mulpuru, Vicente Corrales-Medina, Steven Hawken, Chris Cameron, Shawn D Aaron, D William Cameron,

<h4>Background</h4>Recurrent acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are common, debilitating, costly and often difficult to prevent.<h4>Methods</h4>We reviewed records of patients who had COPD and immunoglobulin (Ig) treatment as adjunctive preventative treatment for AECOPD, and documented all AECOPD episodes for one year before and after initiation of Ig treatment. ... Read more >>

PLoS One (PloS one)
[2015, 10(11):e0142205]

Cited: 10 times

View full text PDF listing >>



Clinical outcomes of immunoglobulin use in solid organ transplant recipients: protocol for a systematic review and meta-analysis.

Juthaporn Cowan, Brian Hutton, Nicholas Fergusson, Alexandria Bennett, Jason Tay, D William Cameron, Greg A Knoll,

<h4>Background</h4>Transplantation improves survival and the quality of life of patients with end-stage organ failure. Infection, due to surgical issues, host factors such as diabetes, immunosuppression, and hypogammaglobulinemia, is a major post-transplant complication. Clinical outcomes of prophylaxis or treatment of hypogammaglobulinemia in solid organ transplant recipients are not well established and ... Read more >>

Syst Rev (Systematic reviews)
[2015, 4:167]

Cited: 3 times

View full text PDF listing >>



Protocol for updating a systematic review of randomised controlled trials on the prophylactic use of intravenous immunoglobulin for patients undergoing haematopoietic stem cell transplantation.

Juthaporn Cowan, D W Cameron, Greg Knoll, Jason Tay,

<h4>Introduction</h4>Haematopoietic stem cell transplantation (HSCT) is commonly employed in the management of haematological malignancies. This intervention results in an increased risk of infectious and immune-related complications. Prophylactic immunoglobulin therapy has been used to prevent post-HSCT complications, including infections, with varying efficacy. We sought to update the current evidence supporting the ... Read more >>

BMJ Open (BMJ open)
[2015, 5(8):e008316]

Cited: 3 times

View full text PDF listing >>



The effects of lysine analogs during pelvic surgery: a systematic review and meta-analysis.

Rodney H Breau, Madzouka B Kokolo, Nahid Punjani, Ilias Cagiannos, Andrew Beck, Naomi Niznick, Chieny Buenaventura, Juthaporn Cowan, Gregory Knoll, Franco Momoli, Chris Morash, Marcel Ruzicka, Svetlana Schachkina, Alan Tinmouth, Hai Yan Xie, Dean A Fergusson,

Pelvic vasculature is complex and inconsistent while pelvic bones impede access to pelvic organs. These anatomical characteristics render pelvic surgery inherently difficult, and some of these procedures are frequently associated with blood loss that necessitates blood transfusion. The aim of this study was to review the literature on the use ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2014, 28(3):145-155]

Cited: 4 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0839 s