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Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets.

Kristen Uchtmann, Electa R Park, Alexis Bergsma, Justin Segula, Mathew J Edick, Cindy K Miranti,

Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling. Conversely, mild but enhanced integrin αIIbβ3 activation and hyperaggregation is observed in CD9 and CD63 ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2015, 339(2):261-269]

Cited: 8 times

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