Full Text Journal Articles by
Author Justin Drake

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Social Media Mining for Postpartum Depression Prediction.

Alina Trifan, Dave Semeraro, Justin Drake, Radek Bukowski, José Luís Oliveira,

This study investigated the feasibility of a postpartum depression predictor based on social media writings. The current broad use of social media networks generates a large amount of digital data, which, when coupled with artificial intelligence methods, have the potential to disclose significant health related insights. In this paper we ... Read more >>

Stud Health Technol Inform (Studies in health technology and informatics)
[2020, 270:1391-1392]

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Targeting RET Kinase in Neuroendocrine Prostate Cancer.

Halena R VanDeusen, Johnny R Ramroop, Katherine L Morel, Song Yi Bae, Anjali V Sheahan, Zoi Sychev, Nathan A Lau, Larry C Cheng, Victor M Tan, Zhen Li, Ashley Petersen, John K Lee, Jung Wook Park, Rendong Yang, Justin H Hwang, Ilsa Coleman, Owen N Witte, Colm Morrissey, Eva Corey, Peter S Nelson, Leigh Ellis, Justin M Drake,

The increased treatment of metastatic castration-resistant prostate cancer (mCRPC) with second-generation antiandrogen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost dependence on androgen receptor (AR) signaling. These AR-independent tumors may also transdifferentiate to express neuroendocrine lineage markers and are ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2020, :]

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Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

Kathryn Ware, Santosh Gupta, Jared Eng, Gabor Kemeny, Bhairavy Puviindran, Wen-Chi Foo, Lorin Crawford, Garland Almquist, Daniella Runyambo, Beatrice Thomas, Maya Sheth, Anika Agarwal, Mariaelena Pierobon, Emanuel Petricoin, David Corcoran, Jennifer Freedman, Steven Patierno, Tian Zhang, Simon Gregory, Zoi Sychev, Justin Drake, Andrew Armstrong, Jason Somarelli,

Summary Adaptation of cancer cells to targeted therapy follows ecological paradigms observed in natural populations that encounter resource depletion and changing environments, including activation of pro-survival mechanisms, migration to new locations, and escape of predation. We identified the p38 MAPK pathway as a common molecular driver of these three responses ... Read more >>

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Physical Chemistry of the Protein Backbone: Enabling the Mechanisms of Intrinsic Protein Disorder.

Justin A Drake, B Montgomery Pettitt,

Over the last two decades it has become clear that well-defined structure is not a requisite for proteins to properly function. Rather, spectra of functionally competent, structurally disordered states have been uncovered requiring canonical paradigms in molecular biology to be revisited or reimagined. It is enticing and oftentimes practical to ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2020, 124(22):4379-4390]

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Bidirectional chemotherapy in patients with gastric cancer and peritoneal metastasis.

Sean P Martin, Justin A Drake, Jonathan M Hernandez, Jeremy L Davis,

Gastric cancer is a lethal malignancy due to the combination of late-stage presentation, propensity for early metastasis, and lack of effective systemic therapies. Given the high rates of gastric peritoneal metastasis, both macro- and microscopic, regional therapy represents both an attractive and rational treatment option for patients given its success ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2020, 11(1):108-111]

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Elevated Serum α-Fetoprotein is Associated with Abbreviated Survival for Patients with Fibrolamellar Hepatocellular Carcinoma Who Undergo a Curative Resection.

James D McDonald, Shreya Gupta, Mackenzie L Shindorf, Lauren A Gamble, Samantha M Ruff, Justin Drake, Theo Heller, Jim Y Wan, Paxton V Dickson, Evan S Glazer, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Fibrolamellar hepatocellular carcinoma (FLC) is a rare variant of hepatocellular carcinoma (HCC), with most clinical data stemming from single-institution series. The variability in the literature lends support for analysis using a large national dataset. In doing so, we sought to (1) define the characteristics and outcomes of patients with FLC; ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(6):1900-1905]

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Rising BMI Is Associated with Increased Rate of Clinically Relevant Pancreatic Fistula after Distal Pancreatectomy for Pancreatic Adenocarcinoma.

Yixuan Zhou, Justin Drake, Jeremiah L Deneve, Stephen W Behrman, Paxton V Dickson, David Shibata, Evan S Glazer,

Clinically relevant pancreatic fistula (CR-POPF), after distal pancreatectomy (DP), remains a clinical challenge. Prior studies investigating the relationship between BMI and CR-POPF have yielded conflicting results. We hypothesized that BMI is associated with CR-POPF in patients having DP for pancreatic ductal adenocarcinoma (PDAC). Patients who underwent DP for PDAC at ... Read more >>

Am Surg (The American surgeon)
[2019, 85(12):1376-1380]

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Bile acid-induced "Minority MOMP" promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1.

Yuan Xu, Deborah R Surman, Laurence Diggs, Sichuan Xi, Shaojian Gao, Devikala Gurusamy, Kaitlin McLoughlin, Justin Drake, Paul Feingold, Kate Brown, Danny Wangsa, Darawalee Wangsa, Xi Zhang, Thomas Ried, Jeremy L Davis, Jonathan Hernandez, Chuong D Hoang, Rhonda F Souza, David S Schrump, R Taylor Ripley,

Barrett's esophagus (BE) is associated with reflux and is implicated the development of esophageal adenocarcinoma (EAC). Apoptosis induces cell death through mitochondrial outer membrane permeabilization (MOMP), which is considered an irreversible step in apoptosis. Activation of MOMP to levels that fail to reach the apoptotic threshold may paradoxically promote cancer-a ... Read more >>

Oncogene (Oncogene)
[2020, 39(4):877-890]

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DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway.

Vishal Kothari, Jonathan F Goodwin, Shuang G Zhao, Justin M Drake, Yi Yin, S Laura Chang, Joseph R Evans, Kari Wilder-Romans, Kristina Gabbara, Emanuela Dylgjeri, Jonathan Chou, Grace Sun, Scott A Tomlins, Rohit Mehra, Kristen Hege, Ellen H Filvaroff, Edward M Schaeffer, R Jeffrey Karnes, David A Quigley, Dana E Rathkopf, Housheng H He, Corey Speers, Daniel E Spratt, Luke A Gilbert, Alan Ashworth, Arul M Chinnaiyan, Ganesh V Raj, Karen E Knudsen, Felix Y Feng,

PURPOSE:Protein kinases are known to play a prominent role in oncogenic progression across multiple cancer subtypes, yet their role in prostate cancer progression remains underexplored. The purpose of this study was to identify kinases that drive prostate cancer progression.Experimental Design: To discover kinases that drive prostate cancer progression, we investigated ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(18):5608-5622]

Cited: 1 time

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Resection and chemotherapy is the optimal treatment approach for patients with clinically node positive intrahepatic cholangiocarcinoma.

Sean P Martin, Justin Drake, Michael M Wach, Samantha M Ruff, Laurence P Diggs, Jim Y Wan, Meghan L Good, Dana A Dominguez, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Clinically lymph node positive (cLNP) intrahepatic cholangiocarcinoma (ICC) carries a poor prognosis, without clear management guidelines for the practicing clinician. We sought to evaluate current practice patterns for cLNP ICC, including associations with survival. METHODS:The National Cancer Database was queried for patients with cLNP ICC, without extrahepatic metastases. RESULTS:We identified ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, 22(1):129-135]

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Adjuvant chemotherapy is associated with improved survival in patients with nodal metastases after neoadjuvant therapy and esophagectomy.

Justin Drake, Kurt Tauer, David Portnoy, Benny Weksler,

Background:Studies supporting adjuvant chemotherapy after complete resection of esophageal cancer are scarce, and current clinical guidelines recommend either adjuvant chemotherapy or observation. We aimed to clarify the role of adjuvant chemotherapy in patients found to have persistent nodal metastases after neoadjuvant chemoradiation and complete resection of esophageal adenocarcinoma. Methods:We queried ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2019, 11(6):2546-2554]

Cited: 2 times

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Targeting RET Kinase in Neuroendocrine Prostate Cancer

Halena VanDeusen, Johnny Ramroop, Katherine Morel, Anjali Sheahan, Zoi Sychev, Nathan Lau, Larry Cheng, Victor Tan, Zhen Li, Ashley Petersen, John Lee, Jung Wook Park, Rendong Yang, Ilsa Coleman, Owen Witte, Colm Morrissey, Eva Corey, Peter Nelson, Leigh Ellis, Justin Drake,

Abstract Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also express neuroendocrine markers, termed neuroendocrine prostate cancer (NEPC). Recent evidence ... Read more >>

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Laparoscopic Approach to Intrahepatic Cholangiocarcinoma is Associated with an Exacerbation of Inadequate Nodal Staging.

Sean P Martin, Justin Drake, Michael M Wach, Samantha Ruff, Laurence P Diggs, Jim Y Wan, Zachary J Brown, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

INTRODUCTION:Laparoscopic approach to liver resection is feasible and safe, though its utilization with intrahepatic cholangiocarcinoma (ICC) remains poorly documented. We sought to evaluate the use laparoscopy for ICC, and to examine adherence to oncologic standards. METHODS:The National Cancer Database was queried for patients who underwent resection for ICC. Patients were ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(6):1851-1857]

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Establishing a center of excellence for hereditary diffuse gastric cancer syndrome.

Justin Drake, Karen Chelcun Schreiber, Rachael Lopez, Grace-Ann Fasaye, Maureen Connolly, Martha Quezado, Theo Heller, Jonathan M Hernandez, Jeremy L Davis,

J Surg Oncol (Journal of surgical oncology)
[2019, 119(6):673-674]

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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.

Nicholas G Nickols, Ramin Nazarian, Shuang G Zhao, Victor Tan, Vladislav Uzunangelov, Zheng Xia, Robert Baertsch, Elad Neeman, Allen C Gao, George V Thomas, Lauren Howard, Amanda M De Hoedt, Josh Stuart, Theodore Goldstein, Kim Chi, Martin E Gleave, Julie N Graff, Tomasz M Beer, Justin M Drake, Christopher P Evans, Rahul Aggarwal, Adam Foye, Felix Y Feng, Eric J Small, William J Aronson, Stephen J Freedland, Owen N Witte, Jiaoti Huang, Joshi J Alumkal, Robert E Reiter, Matthew B Rettig,

BACKGROUND:Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal manipulation. We sought to identify activated kinases in mCRPC as therapeutic targets for existing, approved agents, with ... Read more >>

Prostate Cancer Prostatic Dis. (Prostate cancer and prostatic diseases)
[2019, 22(4):531-538]

Cited: 1 time

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Thermodynamics of Conformational Transitions in a Disordered Protein Backbone Model.

Justin A Drake, B Montgomery Pettitt,

Conformational entropy is expected to contribute significantly to the thermodynamics of structural transitions in intrinsically disordered proteins or regions in response to protein/ligand binding, posttranslational modifications, and environmental changes. We calculated the backbone (dihedral) conformational entropy of oligoglycine (GlyN), a protein backbone mimic and model intrinsically disordered region, as a ... Read more >>

Biophys. J. (Biophysical journal)
[2018, 114(12):2799-2810]

Cited: 3 times

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Adding Radiotherapy to Adjuvant Chemotherapy Does Not Improve Survival of Patients With N2 Lung Cancer.

Justin A Drake, David C Portnoy, Kurt Tauer, Benny Weksler,

BACKGROUND:The management of N2 non-small cell lung cancer (NSCLC) found at operation is controversial. Current guidelines recommend adjuvant chemotherapy or adjuvant chemoradiotherapy. We evaluated whether adjuvant chemoradiotherapy was associated with improved survival compared with adjuvant chemotherapy in patients with N2 NSCLC after complete resection. METHODS:We queried the National Cancer Database ... Read more >>

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2018, 106(4):959-965]

Cited: 0 times

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Tumor grade and sex should influence the utilization of portal lymphadenectomy for early stage intrahepatic cholangiocarcinoma.

Sean P Martin, Samantha Ruff, Laurence P Diggs, Justin Drake, Reed I Ayabe, Zachary J Brown, Michael M Wach, Seth M Steinberg, Jeremy L Davis, Jonathan M Hernandez,

BACKGROUND:Portal lymphadenectomy for intrahepatic cholangiocarcinoma (ICC) is encouraged for staging purposes, though it is under-utilized for clinically early-stage tumors. We sought to determine if any factor knowable prior to resection influences rates of portal lymph node metastases. METHODS:The Surveillance, Epidemiology, and End Results (SEER) Program (1973-2014) database was queried to ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2019, 21(4):419-424]

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Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.

Xianjuan Kou, Biao Li, Julia B Olayanju, Justin M Drake, Ning Chen,

Moringa oleifera Lam. (M. oleifera), which belongs to the Moringaceae family, is a perennial deciduous tropical tree, and native to the south of the Himalayan Mountains in northern India. M. oleifera is rich in proteins, vitamin A, minerals, essential amino acids, antioxidants, and flavonoids, as well as isothiocyanates. The extracts ... Read more >>

Nutrients (Nutrients)
[2018, 10(3):]

Cited: 9 times

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Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer.

Johnny R Ramroop, Mark N Stein, Justin M Drake,

Prostate cancer is the most common malignancy in men in the United States. While androgen deprivation therapy results in tumor responses initially, there is relapse and progression to metastatic castration-resistant prostate cancer. Currently, all prostate cancer patients receive essentially the same treatment, and there is a need for clinically applicable ... Read more >>

Front Oncol (Frontiers in oncology)
[2018, 8:28]

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Adjuvant chemotherapy improves survival in patients with completely resected T3N0 non-small cell lung cancer invading the chest wall.

Justin A Drake, Jennifer L Sullivan, Benny Weksler,

OBJECTIVE:Adjuvant chemotherapy prolongs survival in patients with non-small cell lung cancer with N1 disease or tumors larger than 4 cm. Patients with T3N0 disease due to chest wall invasion often receive adjuvant chemotherapy because their disease is classified as stage II non-small cell lung cancer. This study evaluated whether chemotherapy improves ... Read more >>

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2018, 155(4):1794-1802]

Cited: 1 time

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Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.

Xuetian Yue, Cen Zhang, Yuhan Zhao, Juan Liu, Alan W Lin, Victor M Tan, Justin M Drake, Lianxin Liu, Michael N Boateng, Jun Li, Zhaohui Feng, Wenwei Hu,

Tumor suppressor p53 is frequently mutated in human cancer. Mutant p53 often promotes tumor progression through gain-of-function (GOF) mechanisms. However, the mechanisms underlying mutant p53 GOF are not well understood. In this study, we found that mutant p53 activates small GTPase Rac1 as a critical mechanism for mutant p53 GOF ... Read more >>

Genes Dev. (Genes & development)
[2017, 31(16):1641-1654]

Cited: 6 times

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Integrating phosphoproteomics into the clinical management of prostate cancer.

Larry C Cheng, Victor M Tan, Shridar Ganesan, Justin M Drake,

Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcriptomic approaches. Phosphoproteomics could potentially aid drug development in clinical trial design as well as provide utility for oncologists in the personalized ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2017, 6(1):9]

Cited: 3 times

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Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.

Tanya Stoyanova, Mireille Riedinger, Shu Lin, Claire M Faltermeier, Bryan A Smith, Kelvin X Zhang, Catherine C Going, Andrew S Goldstein, John K Lee, Justin M Drake, Meghan A Rice, En-Chi Hsu, Behdokht Nowroozizadeh, Brandon Castor, Sandra Y Orellana, Steven M Blum, Donghui Cheng, Kenneth J Pienta, Robert E Reiter, Sharon J Pitteri, Jiaoti Huang, Owen N Witte,

Metastatic castration-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-specific mortality. Defining new mechanisms that can predict recurrence and drive lethal CRPC is critical. Here, we demonstrate that localized high-risk prostate cancer and metastatic CRPC, but not benign prostate tissues or low/intermediate-risk prostate cancer, express high levels of ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(42):E6457-E6466]

Cited: 9 times

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