Full Text Journal Articles by
Author Justin A Drake

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Physical Chemistry of the Protein Backbone: Enabling the Mechanisms of Intrinsic Protein Disorder.

Justin A Drake, B Montgomery Pettitt,

Over the last two decades it has become clear that well-defined structure is not a requisite for proteins to properly function. Rather, spectra of functionally competent, structurally disordered states have been uncovered requiring canonical paradigms in molecular biology to be revisited or reimagined. It is enticing and oftentimes practical to ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2020, 124(22):4379-4390]

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Bidirectional chemotherapy in patients with gastric cancer and peritoneal metastasis.

Sean P Martin, Justin A Drake, Jonathan M Hernandez, Jeremy L Davis,

Gastric cancer is a lethal malignancy due to the combination of late-stage presentation, propensity for early metastasis, and lack of effective systemic therapies. Given the high rates of gastric peritoneal metastasis, both macro- and microscopic, regional therapy represents both an attractive and rational treatment option for patients given its success ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2020, 11(1):108-111]

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Thermodynamics of Conformational Transitions in a Disordered Protein Backbone Model.

Justin A Drake, B Montgomery Pettitt,

Conformational entropy is expected to contribute significantly to the thermodynamics of structural transitions in intrinsically disordered proteins or regions in response to protein/ligand binding, posttranslational modifications, and environmental changes. We calculated the backbone (dihedral) conformational entropy of oligoglycine (GlyN), a protein backbone mimic and model intrinsically disordered region, as a ... Read more >>

Biophys. J. (Biophysical journal)
[2018, 114(12):2799-2810]

Cited: 3 times

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Adding Radiotherapy to Adjuvant Chemotherapy Does Not Improve Survival of Patients With N2 Lung Cancer.

Justin A Drake, David C Portnoy, Kurt Tauer, Benny Weksler,

BACKGROUND:The management of N2 non-small cell lung cancer (NSCLC) found at operation is controversial. Current guidelines recommend adjuvant chemotherapy or adjuvant chemoradiotherapy. We evaluated whether adjuvant chemoradiotherapy was associated with improved survival compared with adjuvant chemotherapy in patients with N2 NSCLC after complete resection. METHODS:We queried the National Cancer Database ... Read more >>

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2018, 106(4):959-965]

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Adjuvant chemotherapy improves survival in patients with completely resected T3N0 non-small cell lung cancer invading the chest wall.

Justin A Drake, Jennifer L Sullivan, Benny Weksler,

OBJECTIVE:Adjuvant chemotherapy prolongs survival in patients with non-small cell lung cancer with N1 disease or tumors larger than 4 cm. Patients with T3N0 disease due to chest wall invasion often receive adjuvant chemotherapy because their disease is classified as stage II non-small cell lung cancer. This study evaluated whether chemotherapy improves ... Read more >>

J. Thorac. Cardiovasc. Surg. (The Journal of thoracic and cardiovascular surgery)
[2018, 155(4):1794-1802]

Cited: 1 time

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Multibody correlations in the hydrophobic solvation of glycine peptides.

Robert C Harris, Justin A Drake, B Montgomery Pettitt,

Protein collapse during folding is often assumed to be driven by a hydrophobic solvation energy (ΔGvdw) that scales linearly with solvent-accessible surface area (A). In a previous study, we argued that ΔGvdw, as well as its attractive (ΔGatt) and repulsive (ΔGrep) components, was not simply a linear function of A. ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2014, 141(22):22D525]

Cited: 4 times

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SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism.

Nicolas M Bertagnolli, Justin A Drake, Jason M Tennessen, Orly Alter,

To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD) to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance levels across gel electrophoresis migration distances that were previously measured by DNA ... Read more >>

PLoS ONE (PloS one)
[2013, 8(11):e78913]

Cited: 7 times

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Outlier Detection through Bipartite Visual Analytics.

Suresh K Bhavnani, Justin A Drake, Bryant Dang, Shyam Vishweswaran,

A critical goal of outlier detection is to determine whether an outlying value was caused by experimental/human error, or by natural biological diversity. However, because univariate or multivariate methods (e.g., box plots and principle component analysis) typically used for outlier detection use unipartite representations, they cannot distinguish whether outliers across ... Read more >>

AMIA Jt Summits Transl Sci Proc (AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science)
[2013, 2013:20]

Cited: 0 times

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