Full Text Journal Articles by
Author Juraj Sprung

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Postoperative respiratory depression after hysterectomy.

Mariana L Laporta, Michelle O Kinney, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with postoperative respiratory depression in a gynecologic surgical cohort. Only hysterectomies performed under general anesthesia from 2012 to 2017 were included to minimize interprocedural variability. Respiratory depression was defined ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Association Between Behavioral and Learning Outcomes and Single Exposures to Procedures Requiring General Anesthesia Before Age 3: Secondary Analysis of Data From Olmsted County, MN.

David O Warner, Danqing Hu, Michael J Zaccariello, Darrell R Schroeder, Andrew C Hanson, Robert T Wilder, Juraj Sprung, Randall P Flick,

BACKGROUND:Two prior population-based (children born in Olmsted County, MN), retrospective cohort studies both found that multiple exposures to anesthesia before age 3 were associated with a significant increase in the frequency of attention-deficit hyperactivity disorder (ADHD) and learning disabilities (LD) later in life. The primary purpose of this secondary analysis ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, :]

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New-Onset Atrial Fibrillation Detected by Continuous Capnography Monitoring: A Case Report.

Toby N Weingarten, Hiroshi Morimatsu, Juan Fiorda-Diaz, Sergio D Bergese, Makiko Ariyoshi, Juraj Sprung, Albert Dahan, Frank J Overdyk,

BACKGROUND Asymptomatic postoperative atrial fibrillation (AF) may go undetected. As part of a multicenter observational trial designed to develop a risk prediction score for respiratory depression, the respiratory patterns of patients admitted to standard wards were continuously assessed with capnography and pulse oximetry. The monitor measured end-tidal carbon dioxide, respiratory ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e925510]

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Intravenous Versus Oral Acetaminophen in Outpatient Cystoscopy Procedures: Retrospective Comparison of Postoperative Opioid Requirements and Analgesia Scores.

Todd M Kor, Julian Naranjo, Atousa Deljou, Kimberly D Evans, Darrell Schroeder, Juraj Sprung, Toby N Weingarten,

PURPOSE:To assess if the choice of acetaminophen formulation (intravenous vs oral) when administered preoperatively for ambulatory cystoscopy procedures is associated with differences in anesthetic outcomes. METHODS:Medical records of adult patients undergoing ambulatory cystoscopy procedures at an outpatient procedural center from July 1, 2014, through November 30, 2017, were abstracted. The ... Read more >>

Am Surg (The American surgeon)
[2020, :3134820945204]

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Individualized PEEP to optimise respiratory mechanics during abdominal surgery: a pilot randomised controlled trial.

Ana Fernandez-Bustamante, Juraj Sprung, Robert A Parker, Karsten Bartels, Toby N Weingarten, Carolina Kosour, B Taylor Thompson, Marcos F Vidal Melo,

BACKGROUND:Higher intraoperative driving pressures (ΔP) are associated with increased postoperative pulmonary complications (PPC). We hypothesised that dynamic adjustment of PEEP throughout abdominal surgery reduces ΔP, maintains positive end-expiratory transpulmonary pressures (Ptp_ee) and increases respiratory system static compliance (Crs) with PEEP levels that are variable between and within patients. METHODS:In a ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(3):383-392]

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Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.

Juraj Sprung, Arnoley S Arney Abcejo, David S Knopman, Ronald C Petersen, Michelle M Mielke, Andrew C Hanson, Darrell R Schroeder, Phillip J Schulte, David P Martin, Toby N Weingarten, Jeffrey J Pasternak, David O Warner,

BACKGROUND:We evaluated the hypothesis that the rate of postoperative decline in global cognition is greater in older adults exposed to general anesthesia with nitrous oxide (N2O) compared to general anesthesia without N2O. METHODS:Longitudinal measures of cognitive function were analyzed in nondemented adults, 70-91 years of age, enrolled in the Mayo ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2020, 131(2):594-604]

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Anesthesia Management and Postanesthetic Recovery Following Endoscopic Sinus Surgery.

Mariana L Laporta, Erin K O'Brien, Janalee K Stokken, Garret Choby, Juraj Sprung, Toby N Weingarten,

OBJECTIVES:Delayed anesthesia recovery following endoscopic sinus surgery (ESS) can be an indicator of immediate complications and negatively impact healthcare efficiency. This study aims to examine clinical factors with a focus on improving clinical practice. METHODS:Medical records of patients undergoing ESS under general anesthesia from 2014 to 2018 were reviewed. Based ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Postoperative outcomes in patients with treatment-emergent central sleep apnea: a case series.

Ross A Barman, Amanda R Fields, Austin J Eells, Ioanna Kouri, Meghna P Mansukhani, Bhargavi Gali, Juraj Sprung, Toby N Weingarten,

PURPOSE:Treatment-emergent central sleep apnea (TECSA) is a central sleep-related breathing disorder, characterized by either the persistence or emergence of central sleep apnea during the initiation of positive airway pressure therapy for obstructive sleep apnea. The purpose of this study was to review the perioperative course of patients diagnosed with TECSA. ... Read more >>

J Anesth (Journal of anesthesia)
[2020, :]

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Postoperative Nausea and Vomiting and Pain After Robotic-Assisted Mitral Valve Repair.

Melissa A Burtoft, Shane M Gillespie, Mariana L Laporta, Erica D Wittwer, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

OBJECTIVE:To determine the rate and clinical factors associated with postoperative nausea and vomiting (PONV) and severe pain after robotic-assisted mitral valve repair. DESIGN:Retrospective chart review. SETTING:Major quaternary academic medical center. PARTICIPANTS:Adult patients undergoing robotic-assisted mitral valve repair from May 5, 2018 through September 13, 2019. INTERVENTIONS:Participant electronic medical records were ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, :]

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Respiratory depression in the post-anesthesia care unit: Mayo Clinic experience.

Mariana L Laporta, Juraj Sprung, Toby N Weingarten,

The anesthesia recovery is a complex physiologic process as systems recover from the effects of surgery and anesthesia. Inadequate recovery of respiratory physiology can lead to severe hypoxemia-induced end-organ damage and even death. Emerging evidence suggests that signs of respiratory depression during early anesthesia recovery may portend increased risk for ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Risk factors and outcomes of postoperative emergency response team activation: a matched case-control study.

Matthew I Hardman, S Chandralekha Kruthiventi, Michelle R Schmugge, Alexandre N Cavalcante, Jeffrey B Jensen, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

OBJECTIVE:To determine patient and perioperative characteristics associated with unexpected postoperative clinical deterioration as determined for the need of a postoperative emergency response team (ERT) activation. DESIGN:Retrospective case-control study. SETTING:Tertiary academic hospital. PARTICIPANTS:Patients who underwent general anaesthesia discharged to regular wards between 1 January 2013 and 31 December 2015 and required ... Read more >>

Crit Care Resusc (Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine)
[2020, 22(1):6-14]

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Exposure to surgery with regional anesthesia and cortical thickness in older adults.

Juraj Sprung, David S Knopman, Ronald C Petersen, Prashanthi Vemuri, Michelle M Mielke, Toby N Weingarten, Phillip J Schulte, Darrell R Schroeder, David O Warner,

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12012]

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Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study.

Chiara Robba, Sabrine N T Hemmes, Ary Serpa Neto, Thomas Bluth, Jaume Canet, Michael Hiesmayr, M Wiersma Hollmann, Gary H Mills, Marcos F Vidal Melo, Christian Putensen, Samir Jaber, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Denise Battaglini, Lorenzo Ball, Marcelo Gama de Abreu, Marcus J Schultz, Paolo Pelosi, , ,

BACKGROUND:Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):73]

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Preoperative cognitive impairment associated with oversedation during recovery from anesthesia.

S Chandralekha Kruthiventi, Mariana L Laporta, Atousa Deljou, David S Knopman, Ronald C Petersen, Darrell R Schroeder, Juraj Sprung, Toby N Weingarten,

PURPOSE:Our objective was to examine the association between preoperative cognitive status and postoperative recovery from anesthesia. METHODS:We included patients (70-91 years old) from the Mayo Clinic Study of Aging who received general anesthesia and were admitted to the postanesthesia care unit from January 1, 2010 through April 30, 2018. Procedures were ... Read more >>

J Anesth (Journal of anesthesia)
[2020, 34(3):390-396]

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Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults.

Juraj Sprung, David O Warner, David S Knopman, Ronald C Petersen, Michelle M Mielke, Clifford R Jack, Val J Lowe, David P Martin, Andrew C Hanson, Darrell R Schroeder, Scott A Przybelski, Phillip J Schulte, Toby N Weingarten, Prashanthi Vemuri,

BACKGROUND:Exposure to surgery with general anaesthesia (surgery/GA) is associated with cortical atrophy, but the aetiology remains unknown. Amyloid-β (Aβ) deposition is one of the hallmark pathological characteristics of Alzheimer's disease (AD). We examined brain Aβ burden in study participants exposed to surgery/GA. METHODS:We performed a cross-sectional analysis of residents of ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 124(5):594-602]

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Postoperative nausea and vomiting after bariatric surgery and dexmedetomidine anesthetic: a propensity-weighted analysis.

S Chandralekha Kruthiventi, Roger E Hofer, Mary E Warner, Juraj Sprung, Todd A Kellogg, Toby N Weingarten,

BACKGROUND:Patients undergoing laparoscopic bariatric surgery have high rates of postoperative nausea and vomiting (PONV). Dexmedetomidine based anesthetic could reduce PONV rates. OBJECTIVES:To determine if PONV rates differ in patients undergoing laparoscopic bariatric surgery with anesthesia primarily based on dexmedetomidine or standard anesthetic management with inhalational agents and opioids. SETTING:University hospital. ... Read more >>

Surg Obes Relat Dis (Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery)
[2020, 16(4):545-553]

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Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension.

S Chandralekha Kruthiventi, Garvan C Kane, Juraj Sprung, Toby N Weingarten, Mary Ellen Warner,

Patients with pulmonary hypertension are at increased risk for postoperative pulmonary complications (PPCs). Herein, we review PPCs in pulmonary hypertension patients undergoing non-cardiac procedures under general anesthesia. The medical records of pulmonary hypertension patients who underwent surgery with general anesthesia between 2010 and 2017 were reviewed for PPCs. In addition ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2019, 19(4):392-399]

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Black Seed Oil and Perioperative Serotonin Syndrome: A Case Report.

Mary E Warner, Paul A Warner, Juraj Sprung, Mark A Warner,

Perioperative serotonin syndrome has been associated with a number of medications and herbal supplements. We report a patient who developed serotonin syndrome immediately after an endoscopic procedure in which the preoperative use of black seed oil appears to have played a role in stimulating the syndrome. Black seed oil has ... Read more >>

A A Pract (A&A practice)
[2019, 13(11):420-422]

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Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults.

Juraj Sprung, S Chandralekha Kruthiventi, David O Warner, David S Knopman, Ronald C Petersen, Michelle M Mielke, Clifford R Jack, Jonathan Graff-Radford, David P Martin, Andrew C Hanson, Darrell R Schroeder, Scott A Przybelski, Phillip J Schulte, Toby N Weingarten, Prashanthi Vemuri,

BACKGROUND:Preclinical studies suggest that exposure to general anaesthesia (GA) could cause neurodegeneration consistent with Alzheimer's disease (AD) pathology. Brain magnetic resonance imaging (MRI) is useful to study structural brain changes. We tested the hypothesis that exposure to surgery with GA (surgery/GA) is associated with greater cortical thinning and increased frequency ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 123(6):808-817]

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Outcomes After Noncardiac Surgery for Patients with Pulmonary Hypertension: A Historical Cohort Study.

Atousa Deljou, Moldovan Sabov, Garvan C Kane, Robert P Frantz, Hilary M DuBrock, David P Martin, Darrell R Schroeder, Madeline Q Johnson, Toby N Weingarten, Juraj Sprung,

OBJECTIVE:Pulmonary hypertension (PH) is a substantial preoperative risk factor. For this study, morbidity and mortality were examined after noncardiac surgery in patients with precapillary PH. DESIGN:A retrospective cohort study. SETTING:Quaternary medical center in Rochester, MN. PARTICIPANTS:Adults with PH undergoing noncardiac surgery. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:The PH and surgical databases ... Read more >>

J. Cardiothorac. Vasc. Anesth. (Journal of cardiothoracic and vascular anesthesia)
[2020, 34(6):1506-1513]

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Postoperative Respiratory Depression May Be Related to Undiagnosed Sleep-Disordered Breathing or Obstructive Sleep Apnea.

Liselotte M Elleby, Juraj Sprung, Toby N Weingarten,

Anesth. Analg. (Anesthesia and analgesia)
[2019, 129(3):e104-e105]

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Lung-protective ventilation for the surgical patient: international expert panel-based consensus recommendations.

Christopher C Young, Erica M Harris, Charles Vacchiano, Stephan Bodnar, Brooks Bukowy, R Ryland D Elliott, Jaclyn Migliarese, Chad Ragains, Brittany Trethewey, Amanda Woodward, Marcelo Gama de Abreu, Martin Girard, Emmanuel Futier, Jan P Mulier, Paolo Pelosi, Juraj Sprung,

Postoperative pulmonary complications (PPCs) occur frequently and are associated with substantial morbidity and mortality. Evidence suggests that reduction of PPCs can be accomplished by using lung-protective ventilation strategies intraoperatively, but a consensus on perioperative management has not been established. We sought to determine recommendations for lung protection for the surgical ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 123(6):898-913]

Cited: 7 times

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Cognitive function after surgery with regional or general anesthesia: A population-based study.

Juraj Sprung, Phillip J Schulte, David S Knopman, Michelle M Mielke, Ronald C Petersen, Toby N Weingarten, David P Martin, Andrew C Hanson, Darrell R Schroeder, David O Warner,

INTRODUCTION:Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). METHODS:Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2019, 15(10):1243-1252]

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Postoperative Corneal Injuries: Incidence and Risk Factors.

Atousa Deljou, Toby N Weingarten, Michael A Mahr, Juraj Sprung, David P Martin,

BACKGROUND:Previous studies of postoperative corneal injury rates relied on provider-initiated incident reports, which may underestimate the true incidence. Postoperative administration of proparacaine eye drops is used almost exclusively to diagnose corneal injury; therefore, identifying instances of administration may provide a better estimate of corneal injuries. We compared proparacaine administration versus ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2019, 129(3):737-742]

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Effects of Sugammadex on Time of First Postoperative Bowel Movement: A Retrospective Analysis.

Atousa Deljou, Darrell R Schroeder, Beth A Ballinger, Juraj Sprung, Toby N Weingarten,

Objective:To determine whether time to first postoperative bowel movement after intraperitoneal surgery differs among neuromuscular blockade reversal with either anticholinesterase/anticholinergic combination vs sugammadex. Patients and Methods:Sugammadex was introduced to our practice in October 2016. Patients were identified who underwent intraperitoneal surgery between January 1, through June 30, 2016, and January ... Read more >>

(Mayo Clinic proceedings. Innovations, quality & outcomes)
[2019, 3(3):294-301]

Cited: 2 times

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