Full Text Journal Articles by
Author Junmeng Zheng

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Development of SAB model for predicting mortality in intensive care unit after aortic aneurysm surgery.

Kai Huang, Runnan Shen, Senyi Peng, Ling Li, Guochang You, Shimao Kang, Xinyi Zhan, Dongxi Zhu, Junmeng Zheng,

<h4>Background</h4>Aortic aneurysm (AA) patients after vascular surgery are at high risk of death, some of them need intensive care. Our aim was to develop a simplified model with baseline data within 24 hours of intensive care unit (ICU) admission to early predict mortality.<h4>Methods</h4>Univariate analysis and least absolute shrinkage and selection ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2021, 10(10):10147-10159]

Cited: 0 times

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Prompt Graft Cooling Enhances Cardioprotection during Heart Transplantation Procedures through the Regulation of Mitophagy.

Zhichao Wu, Jialiang Liang, Wei Huang, Lin Jiang, Christian Paul, Bonnie Lin, Junmeng Zheng, Yigang Wang,

A complete and prompt cardiac arrest using a cold cardioplegic solution is routinely used in heart transplantation to protect the graft function. However, warm ischemic time is still inevitable during the procedure to isolate donor hearts in the clinical setting. Our knowledge of the mechanism changes prevented by cold storage, ... Read more >>

Cells (Cells)
[2021, 10(11):]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

Cited: 2 times

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Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury.

Ling Li, Jungang Huang, Zongkai Zhao, Zhuzhi Wen, Kang Li, Tianjiao Ma, Lisui Zhang, Junmeng Zheng, Shi Liang,

<h4>Background</h4>With the progress of shock therapy and the establishment and promotion of methods such as thrombolytic therapy and percutaneous coronary intervention (PCI), many tissues and organs have been reperfused after ischemia which may cause even worse disorder called ischemia-reperfusion injury (IRI). mRNAs have been found to have significant impacts on ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2021, 2021:3925136]

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Feasibility of anticoagulation using low molecular-weight heparin during catheter-directed thrombolysis for lower extremity deep venous thrombosis.

Yonghui Li, Junwei Wang, Rongzhou He, Junmeng Zheng, Zhibo Chen, Chen Yao, Kai Huang,

<h4>Background</h4>The optimal anticoagulant scheme during catheter-directed thrombolysis (CDT) for deep venous thrombosis (DVT) remains unknown. This study was performed to evaluate the feasibility of anticoagulation therapy using low molecular-weight heparin (LMWH) during CDT for DVT.<h4>Methods</h4>The clinical data of DVT patients who underwent CDT during the past six years was retrospectively ... Read more >>

Thromb J (Thrombosis journal)
[2021, 19(1):6]

Cited: 1 time

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Feasibility of Anticoagulation Using Low Molecular‑Weight Heparin During Catheter-Directed Thrombolysis for  Lower Extremity Deep Venous Thrombosis

Yonghui Li, Junwei Wang, Rongzhou He, Junmeng Zheng, Zhibo Chen, Chen Yao, Kai Huang,

<h4>Background: </h4> The optimal anticoagulant scheme during catheter-directed thrombolysis (CDT) for deep venous thrombosis (DVT) remains unknown. This study was performed to evaluate the feasibility of anticoagulation therapy using low molecular‑weight heparin (LMWH) during CDT for DVT. <h4>Methods: </h4>: The clinical data of DVT patients who underwent CDT during the ... Read more >>

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Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.

Zhi Zeng, Luoxing Xia, Shunyang Fan, Junmeng Zheng, Jinhong Qin, Xuejiao Fan, Yunfeng Liu, Jun Tao, Yingying Liu, Kang Li, Zhenwei Ling, Yun Bu, Kathleen A Martin, John Hwa, Renjing Liu, Wai Ho Tang,

<h4>Background</h4>Aberrant expression of circular RNA contributes to human diseases. Circular RNAs regulate gene expression by sequestering specific microRNAs. In this study, we investigated whether circMAP3K5 (circular mitogen-activated protein kinase 5) could act as a competing endogenous microRNA-22-3p (miR-22-3p) sponge and regulate neointimal hyperplasia.<h4>Methods</h4>Circular RNA profiling from genome-wide RNA sequencing data ... Read more >>

Circulation (Circulation)
[2021, 143(4):354-371]

Cited: 20 times

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Critical Roles of ELVOL4 and IL-33 in the Progression of Obesity-Related Cardiomyopathy via Integrated Bioinformatics Analysis.

Jun Tao, Yajing Wang, Ling Li, Junmeng Zheng, Shi Liang,

The molecular mechanisms underlying obesity-related cardiomyopathy (ORCM) progression involve multiple signaling pathways, and the pharmacological treatment for ORCM is still limited. Thus, it is necessary to explore new targets and develop novel therapies. Microarray analysis for gene expression profiles using different bioinformatics tools has been an effective strategy for identifying ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:542]

Cited: 3 times

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The role of exogenous CD4+CD25+ Treg cells in heart transplantation tolerance

Jinguo Zhu, Junmeng Zheng,

<h4>Background: </h4> CD4+CD25+regulatory T cells (CD4+CD25+ Treg cells) play major roles in immune regulation. Previous studies showed CD4+CD25+ Treg cells can maintain peripheral immune tolerance and increase survival time of transplanted organs. However, the biological characteristics and the functional roles of these exogenous CD4+CD25+ Treg cells in transplantation tolerance remain ... Read more >>

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Effects of left ventricular assist device on heart failure patients: A bioinformatics analysis.

Guanhua Li, Zhibo Chen, Yu Zhang, Zhichao Wu, Junmeng Zheng,

With the acceleration of demographic aging, heart failure has become a global public health issue. Left ventricular assist device (LVAD) provides a therapeutic option serving as a bridge to transplantation or destination treatment for end-stage heart failure. However, neither the molecular mechanism nor the gene expression profile of LVAD pathophysiology is well ... Read more >>

Artif Organs (Artificial organs)
[2020, 44(6):577-583]

Cited: 1 time

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Mid-term and long-term outcomes of endoscopic versus open vein harvesting for coronary artery bypass: A systematic review and meta-analysis.

Guanhua Li, Yu Zhang, Zhichao Wu, Zhaoyuan Liu, Junmeng Zheng,

BACKGROUND:Two prevalent harvesting techniques are routinely utilized in coronary artery bypass grafting (CABG): endoscopic vein harvesting (EVH) and open vein harvesting (OVH). Our purpose is to compare mid-term and long-term outcomes between these two techniques for CABG. METHODS:After the acquisition of evidence, available studies assessing both harvesting techniques with follow-up ... Read more >>

Int J Surg (International journal of surgery (London, England))
[2019, 72:167-173]

Cited: 3 times

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Comprehensive investigation of in vitro hemocompatibility of surface modified polyamidoamine nanocarrier.

Guanhua Li, Yu Zhang, Wei Tang, Junmeng Zheng,

<h4>Background</h4>Polyamidoamine (PAMAM) dendrimers have been investigated for decades and currently applied in various areas throughout nanomedicine, including gene therapy, drug delivery, anti-bacteria and imaging. It is therefore necessary to assess cytotoxicity of PAMAM dendrimers systematically. Because blood component is usually the initial step of contact with any therapeutic agent, comprehensive ... Read more >>

Clin Hemorheol Microcirc (Clinical hemorheology and microcirculation)
[2020, 74(3):267-279]

Cited: 0 times

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Arm port vs chest port: a systematic review and meta-analysis.

Guanhua Li, Yu Zhang, Hongmin Ma, Junmeng Zheng,

<h4>Background</h4>Two prevailing, totally implantable venous access ports are routinely utilized in oncology: chest port or arm port. This systematic review with meta-analysis was conducted to compare safety and efficiency of the two techniques.<h4>Methods</h4>We performed evidence acquisition intensively from PubMed, Embase, and Cochrane Library. Available comparative studies that evaluated both techniques ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:6099-6112]

Cited: 2 times

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Endoscopic versus Open Vein-Graft Harvesting for CABG.

Guanhua Li, Yu Zhang, Junmeng Zheng,

N Engl J Med (The New England journal of medicine)
[2019, 380(22):e43]

Cited: 0 times

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Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production.

Wu Duan, Yunchuan Ding, Xuefeng Yu, Dongxia Ma, Bo Yang, Yi Li, Li Huang, Zhonghua Chen, Junmeng Zheng, Chao Yang,

Type 1 diabetes mellitus (T1DM) is still one of the major threats on global public health. This autoimmune condition is mainly caused by the imbalance of auto-reactive inflammatory effector T cells (Teffs) and protective regulatory T cells (Tregs). Therefore, inhibiting the development of Teffs and/or promoting Tregs provides a therapeutic ... Read more >>

Am J Transl Res (American journal of translational research)
[2019, 11(4):2393-2402]

Cited: 13 times

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Syndecan-1 as an independent risk factor for the incidence of adverse cardiovascular events in patients having stage C and D heart failure with non-ischemic dilated cardiomyopathy.

Wei Liu, Yuan Wang, Junmeng Zheng, Deli Song, Shuai Zheng, Lu Ren, Yali Wang, Yan Yao, Yue Wang, Yuanyuan Liu, Rong Bai, Jianzeng Dong, Tong Liu,

<h4>Background</h4>Patients with heart failure (HF) having non-ischemic dilated cardiomyopathy (DCM) have high mortality rates. Syndecan-1 is reportedly associated with cardiac fibrosis and inflammation. This study explored the role of syndecan-1 in patients with non-ischemic DCM.<h4>Methods</h4>Patients with HF were prospectively enrolled. Comprehensive clinical and biochemical analysis were performed. All patients were ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2019, 490:63-68]

Cited: 3 times

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A Robust Nanoparticle Platform for RNA Interference in Macrophages to Suppress Tumor Cell Migration.

Shi Liang, Junmeng Zheng, Wei Wu, Quan Li, Phei Er Saw, Jianing Chen, Xiaoding Xu, Herui Yao, Yandan Yao,

Macrophages are one of the most abundant immune cells in the solid tumor and their increased density is associated with the specific pathological features of cancers, including invasiveness, metastasis, immunosuppression, neovascularization, and poor response to therapy. Therefore, reprogramming macrophage behavior is emerging as a promising therapeutic modality for cancer treatment. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1465]

Cited: 3 times

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Sutureless technique versus conventional surgery in the primary treatment of total anomalous pulmonary venous connection: a systematic review and meta-analysis.

Yuhao Wu, Zhichao Wu, Junmeng Zheng, Yonggang Li, Yuehang Zhou, Hongyu Kuang, Xin Jin, Chun Wu,

BACKGROUD:A meta-analysis was performed to compare the differences in outcomes between sutureless technique and conventional surgery for primary repair of Total Anomalous Pulmonary Venous Connection(TAPVC). METHODS:Electronic databases, including PubMed, EMbase, Medline, CNKI, Wanfang Data and Weipu Data were searched systematically for the literature aimed mainly at comparing the therapeutic effects ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2018, 13(1):69]

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LncRNA Expression Profile of Human Thoracic Aortic Dissection by High-Throughput Sequencing.

Jie Sun, Guojun Chen, Yuanwen Jing, Xiang He, Jianting Dong, Junmeng Zheng, Meisheng Zou, Hairui Li, Shifei Wang, Yili Sun, Wangjun Liao, Yulin Liao, Li Feng, Jianping Bin,

BACKGROUND/AIMS:In this study, the long non-coding RNA (lncRNA) expression profile in human thoracic aortic dissection (TAD), a highly lethal cardiovascular disease, was investigated. METHODS:Human TAD (n=3) and normal aortic tissues (NA) (n=3) were examined by high-throughput sequencing. Bioinformatics analyses were performed to predict the roles of aberrantly expressed lncRNAs. Quantitative ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2018, 46(3):1027-1041]

Cited: 6 times

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Association of miR-197-5p, a Circulating Biomarker for Heart Failure, with Myocardial Fibrosis and Adverse Cardiovascular Events among Patients with Stage C or D Heart Failure.

Wei Liu, Junmeng Zheng, Jianzeng Dong, Rong Bai, Deli Song, Xiaohai Ma, Lei Zhao, Yan Yao, Haibo Zhang, Tong Liu,

OBJECTIVE:The aim of this study was to identify heart failure (HF)-specific circulating micro-RNAs (miRNA), and examine whether the selected miRNAs correlate with myocardial fibrosis and are reflective of the incidence of adverse cardiovascular events in patients with stage C or D HF. METHODS:Circulating miRNAs which were expressed in end-stage HF ... Read more >>

Cardiology (Cardiology)
[2018, 141(4):212-225]

Cited: 6 times

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A case report of PVOD patient combined with pulmonary embolism: Anticoagulation or not?

Xiaoling Yuan, Xianghe Hou, Weihong Guo, Haiming Jiang, Junmeng Zheng, Stuti Paudyal, Yanhua Lyu,

<h4>Rationale</h4>Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH). Oral anticoagulation is confined to patients with idiopathic PAH (IPAH), but no oral anticoagulation has been recommended for PVOD, because occult pulmonary hemorrhage was a common finding in PVOD.<h4>Patient concerns</h4>We report a case of PVOD, who was ... Read more >>

Medicine (Baltimore) (Medicine)
[2017, 96(13):e6507]

Cited: 1 time

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Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy by Regulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-Activated Protein Kinase Pathways.

Wenjuan Liu, Jianxin Deng, Wenwen Ding, Gang Wang, Yuanyuan Shen, Junmeng Zheng, Xiaoming Zhang, Yizhi Luo, Chifei Lv, Yonghui Wang, Liqing Chen, Dewen Yan, Ryan L Boudreau, Long-Sheng Song, Jie Liu,

<h4>Background</h4>KCNE2 is a promiscuous auxiliary subunit of voltage-gated cation channels. A recent work demonstrated that KCNE2 regulates L-type Ca<sup>2+</sup> channels. Given the important roles of altered Ca<sup>2+</sup> signaling in structural and functional remodeling in diseased hearts, this study investigated whether KCNE2 participates in the development of pathological hypertrophy.<h4>Methods and results</h4>We ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2017, 10(6):]

Cited: 2 times

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Hook wire localization of pulmonary pure ground-glass opacities for video-assisted thoracoscopic surgery.

Weizhao Huang, Hongyu Ye, Yingmeng Wu, Wei Xu, Xuan Tang, Yi Liang, Junmeng Zheng, Haiming Jiang,

<h4>Objective</h4>We compared the success of preoperative hook wire localization of pulmonary pure ground-glass opacities (pGGOs) with intraoperative palpation during video-assisted thoracoscopic (VAT) surgery and examined the safety of the preoperative hook wire method.<h4>Methods</h4>A total of 39 patients with 41 pulmonary pGGOs less than 2 cm in diameter underwent preoperative hook ... Read more >>

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2014, 62(2):174-178]

Cited: 12 times

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Quantitative analysis of cell tracing by in vivo imaging system.

Junmeng Zheng, Lijun Xu, Hongmin Zhou, Weina Zhang, Zhonghua Chen,

In vivo imaging system (IVIS) is a new and rapidly expanding technology, which has a wide range of applications in life science such as cell tracing. By counting the number of photons emitted from a specimen, IVIS can quantify biological events such as tumor growth. We used B16F10-luc-G5 tumor cells ... Read more >>

J Huazhong Univ Sci Technolog Med Sci (Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban)
[2010, 30(4):541-545]

Cited: 2 times

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