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Author Junjie Bai

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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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Human telomerase reverse transcriptase is a novel target of Hippo-YAP pathway.

Qian Zhang, Ning Liu, Junjie Bai, Qi Zhou, Jian Mao, Lu Xu, Jiang Liu, Haibin Wei, Chengcheng Ren, Xiaoying Wu, Miao Wang, Bin Zhao, Yu-Sheng Cong,

Telomerase plays a pivotal role in tumorigenesis by maintaining telomere homeostasis, a hallmark of cancer. However, the mechanisms by which telomerase is reactivated or upregulated during tumorigenesis remain incompletely understood. Here, we report that the Hippo pathway effector Yes-associated protein (YAP) regulates the expression of human telomerase reverse transcriptase (hTERT). ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(3):4178-4188]

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Learning tree-structured representation for 3D coronary artery segmentation.

Bin Kong, Xin Wang, Junjie Bai, Yi Lu, Feng Gao, Kunlin Cao, Jun Xia, Qi Song, Youbing Yin,

Extensive research has been devoted to the segmentation of the coronary artery. However, owing to its complex anatomical structure, it is extremely challenging to automatically segment the coronary artery from 3D coronary computed tomography angiography (CCTA). Inspired by recent ideas to use tree-structured long short-term memory (LSTM) to model the ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2020, 80:101688]

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Learning physical properties in complex visual scenes: An intelligent machine for perceiving blood flow dynamics from static CT angiography imaging.

Zhifan Gao, Xin Wang, Shanhui Sun, Dan Wu, Junjie Bai, Youbing Yin, Xin Liu, Heye Zhang, Victor Hugo C de Albuquerque,

Humans perceive physical properties such as motion and elastic force by observing objects in visual scenes. Recent research has proven that computers are capable of inferring physical properties from camera images like humans. However, few studies perceive the physical properties in more complex environment, i.e. humans have difficulty estimating physical ... Read more >>

Neural Netw (Neural networks : the official journal of the International Neural Network Society)
[2020, 123:82-93]

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High-Density Linkage Map and Mapping for Sex and Growth-Related Traits of Largemouth Bass (Micropterus salmoides).

Chuanju Dong, Peng Jiang, Jiangfan Zhang, Xuejun Li, Shengjie Li, Junjie Bai, Jiajia Fan, Peng Xu,

The largemouth bass is an important species, and its culture has risen sharply with the surge in fish aquaculture in China. Due to the lack of selective breeding technology for the largemouth bass, the growth rate and disease resistance are low, its sexual maturation is slow, and other serious problems ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:960]

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[Phenotypic and genetic analysis of a sibpair with partial deletion of SATB2 gene caused by 2q33.1 microdeletion].

Chunlei Jin, Yongliang Lei, Jiao Liu, Qunda Shan, Bixia Qian, Fen Zheng, Penglong Chen, Junjie Bai,

OBJECTIVE:To analyze the genotype and phenotype of a sibpair with partial deletion of SATB2 gene caused by 2q33.1 microdeletion. METHODS:Both children have featured mental retardation and development delay, and were subjected to karyotyping, single nucleotide microarray (SNP array) and real-time fluorescence quantitative PCR analysis. Karyotyping and SNP Array analysis were ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2019, 36(6):628-631]

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Selection of reference genes for quantitative real-time PCR normalisation in largemouth bass Micropterus salmoides fed on alternative diets.

Dongmei Ma, Jiajia Fan, Yuanyuan Tian, Peng Jiang, Junjie Wang, Huaping Zhu, Junjie Bai,

The partial cDNA sequences of eight reference genes (actb, tuba1, gapdh58, gapdh59, eef1a1, RNA 18 s, pabpc1, ube2I) were cloned from largemouth bass Micropterus salmoides. The expression levels of these eight genes were compared in the various tissues (eye, spleen, kidney, gill, muscle, brain, liver, heart, gut and gonad) of M. ... Read more >>

J. Fish Biol. (Journal of fish biology)
[2019, 95(2):393-400]

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Precise diagnosis of intracranial hemorrhage and subtypes using a three-dimensional joint convolutional and recurrent neural network.

Hai Ye, Feng Gao, Youbing Yin, Danfeng Guo, Pengfei Zhao, Yi Lu, Xin Wang, Junjie Bai, Kunlin Cao, Qi Song, Heye Zhang, Wei Chen, Xuejun Guo, Jun Xia,

OBJECTIVES:To evaluate the performance of a novel three-dimensional (3D) joint convolutional and recurrent neural network (CNN-RNN) for the detection of intracranial hemorrhage (ICH) and its five subtypes (cerebral parenchymal, intraventricular, subdural, epidural, and subarachnoid) in non-contrast head CT. METHODS:A total of 2836 subjects (ICH/normal, 1836/1000) from three institutions were included ... Read more >>

Eur Radiol (European radiology)
[2019, 29(11):6191-6201]

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FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho.

Lixia Ye, Xue Wang, Chenchen Cai, Shanshan Zeng, Junjie Bai, Kaiming Guo, Mingchu Fang, Jian Hu, Huan Liu, Liyun Zhu, Fei Liu, Dongxue Wang, Yingying Hu, Shulin Pan, Xiaokun Li, Li Lin, Zhenlang Lin,

Perinatal asphyxia often results in neonatal cerebral hypoxia-ischemia (HI), which is associated with high mortality and severe long-term neurological deficits in newborns. Currently, there are no effective drugs to mitigate the functional impairments post-HI. Previous studies have shown that fibroblast growth factor 21 (FGF21) has a potential neuroprotective effect against ... Read more >>

Exp. Neurol. (Experimental neurology)
[2019, 317:34-50]

Cited: 2 times

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Automated anatomical labeling of coronary arteries via bidirectional tree LSTMs.

Dan Wu, Xin Wang, Junjie Bai, Xiaoyang Xu, Bin Ouyang, Yuwei Li, Heye Zhang, Qi Song, Kunlin Cao, Youbing Yin,

PURPOSE:Automated anatomical labeling facilitates the diagnostic process for physicians and radiologists. One of the challenges in automated anatomical labeling problems is the robustness to handle the large individual variability inherited in human anatomy. A novel deep neural network framework, referred to Tree Labeling Network (TreeLab-Net), is proposed to resolve this ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2019, 14(2):271-280]

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Research on high-resolution imaging technology based on light field manipulation for a lenslet-based plenoptic camera.

Xincheng Liu, Haotong Ma, Ge Ren, Bo Qi, Zongliang Xie, Junqiu Chu, Junjie Bai,

In this paper, an aberration correction method for an extended target is proposed to solve the problem of the lenslet-based plenoptic camera not imaging clearly under the influence of aberrations. We propose a light field manipulation method to improve performance of the light field imaging system. The principle of this ... Read more >>

Appl Opt (Applied optics)
[2018, 57(33):9877-9886]

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Optimal multi-object segmentation with novel gradient vector flow based shape priors.

Junjie Bai, Abhay Shah, Xiaodong Wu,

Shape priors have been widely utilized in medical image segmentation to improve segmentation accuracy and robustness. A major way to encode such a prior shape model is to use a mesh representation, which is prone to causing self-intersection or mesh folding. Those problems require complex and expensive algorithms to mitigate. ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2018, 69:96-111]

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MULTI-SCALE SEGMENTATION USING DEEP GRAPH CUTS: ROBUST LUNG TUMOR DELINEATION IN MVCBCT.

Xiaodong Wu, Zisha Zhong, John Buatti, Junjie Bai,

Deep networks have been used in a growing trend in medical image analysis with the remarkable progress in deep learning. In this paper, we formulate the multi-scale segmentation as a Markov Random Field (MRF) energy minimization problem in a deep network (graph), which can be efficiently and exactly solved by ... Read more >>

Proc IEEE Int Symp Biomed Imaging (Proceedings. IEEE International Symposium on Biomedical Imaging)
[2018, 2018:514-518]

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Transcriptome assembly and identification of genes and SNPs associated with growth traits in largemouth bass (Micropterus salmoides).

Shengjie Li, Hao Liu, Junjie Bai, Xinping Zhu,

Growth is one of the most crucial economic traits of all aquaculture species, but the molecular mechanisms involved in growth of largemouth bass (Micropterus salmoides) are poorly understood. The objective of this study was to screen growth-related genes of M. salmoides by RNA sequencing and identify growth-related single-nucleotide polymorphism (SNP) ... Read more >>

Genetica (Genetica)
[2017, 145(2):175-187]

Cited: 5 times

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Copy number variation sequencing-based prenatal diagnosis using cell-free fetal DNA in amniotic fluid.

Qingwei Qi, Sijia Lu, Xiya Zhou, Fengxia Yao, Na Hao, Guangjun Yin, Wenhui Li, Junjie Bai, Ning Li, David S Cram,

The study aimed to determine whether cell-free fetal DNA (cffDNA) present in amniotic fluid supernatant can be used as a surrogate for amniocyte-based diagnosis of fetal chromosomal abnormalities.Amniocentesis was performed on 28 high-risk pregnancies. Amniocytes and the cffDNA fraction were prepared from the amniotic fluid samples. Chromosomal analysis of amniocytes ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2016, 36(6):576-583]

Cited: 2 times

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MASCG: Multi-Atlas Segmentation Constrained Graph method for accurate segmentation of hip CT images.

Chengwen Chu, Junjie Bai, Xiaodong Wu, Guoyan Zheng,

This paper addresses the issue of fully automatic segmentation of a hip CT image with the goal to preserve the joint structure for clinical applications in hip disease diagnosis and treatment. For this purpose, we propose a Multi-Atlas Segmentation Constrained Graph (MASCG) method. The MASCG method uses multi-atlas based mesh ... Read more >>

Med Image Anal (Medical image analysis)
[2015, 26(1):173-184]

Cited: 4 times

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Optimal co-segmentation of tumor in PET-CT images with context information.

Qi Song, Junjie Bai, Dongfeng Han, Sudershan Bhatia, Wenqing Sun, William Rockey, John E Bayouth, John M Buatti, Xiaodong Wu,

Positron emission tomography (PET)-computed tomography (CT) images have been widely used in clinical practice for radiotherapy treatment planning of the radiotherapy. Many existing segmentation approaches only work for a single imaging modality, which suffer from the low spatial resolution in PET or low contrast in CT. In this work, we ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2013, 32(9):1685-1697]

Cited: 25 times

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A new method of diaphragm apex motion detection from 2D projection images of mega-voltage cone beam CT.

Mingqing Chen, Junjie Bai, R Alfredo C Siochi,

To present a new method of estimating 3D positions of the ipsi-lateral hemi-diaphragm apex (IHDA) from 2D projection images of mega-voltage cone beam CT (MVCBCT). The detection framework reconstructs a 3D volume from all the 2D projection images. An initial estimated 3D IHDA position is determined in this volume based ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2013, 58(3):715-733]

Cited: 4 times

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Optimal multiple surface segmentation with shape and context priors.

Qi Song, Junjie Bai, Mona K Garvin, Milan Sonka, John M Buatti, Xiaodong Wu,

Segmentation of multiple surfaces in medical images is a challenging problem, further complicated by the frequent presence of weak boundary evidence, large object deformations, and mutual influence between adjacent objects. This paper reports a novel approach to multi-object segmentation that incorporates both shape and context prior knowledge in a 3-D ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2013, 32(2):376-386]

Cited: 28 times

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Genotypes, haplotypes and diplotypes of IGF-II SNPs and their association with growth traits in largemouth bass (Micropterus salmoides).

Xiaohui Li, Junjie Bai, Yinchang Hu, Xing Ye, Shengjie Li, Lingyun Yu,

Insulin-like growth factor II (IGF-II) is involved in the regulation of somatic growth and metabolism in many fishes. IGF-II is an important candidate gene for growth traits in fishes and its polymorphisms were associated with the growth traits. The aim of this study is to screen single nucleotide polymorphisms (SNPs) ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2012, 39(4):4359-4365]

Cited: 7 times

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3D lung tumor motion model extraction from 2D projection images of mega-voltage cone beam CT via optimal graph search.

Mingqing Chen, Junjie Bai, Yefeng Zheng, R Alfredo C Siochi,

In this paper, we propose a novel method to convert segmentation of objects with quasi-periodic motion in 2D rotational cone beam projection images into an optimal 3D multiple interrelated surface detection problem, which can be solved by a graph search framework. The method is tested on lung tumor segmentation in ... Read more >>

Med Image Comput Comput Assist Interv (Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention)
[2012, 15(Pt 1):239-246]

Cited: 1 time

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Surface-region context in optimal multi-object graph-based segmentation: robust delineation of pulmonary tumors.

Qi Song, Mingqing Chen, Junjie Bai, Milan Sonka, Xiaodong Wu,

Multi-object segmentation with mutual interaction is a challenging task in medical image analysis. We report a novel solution to a segmentation problem, in which target objects of arbitrary shape mutually interact with terrain-like surfaces, which widely exists in the medical imaging field. The approach incorporates context information used during simultaneous ... Read more >>

Inf Process Med Imaging (Information processing in medical imaging : proceedings of the ... conference)
[2011, 22:61-72]

Cited: 1 time

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Validation of reference genes of grass carp Ctenopharyngodon idellus for the normalization of quantitative real-time PCR

Xing Ye, Lili Zhang, Haiyan Dong, Yuanyuan Tian, Haihua Lao, Junjie Bai, Lingyun Yu,

Expression of four reference genes of grass carp, including β-actin (ACTB), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 18S rRNA (18S) and elongation factor-1 alpha (EF1α), was studied in tissues of normal individuals and bacteria-infected individuals. EF1α had the most stable expressions followed by 18S rRNA then GAPDH; ACTB had the least stability. After ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2010, 32(8):1031-1038]

Cited: 2 times

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A shared antigen among Vibrio species: outer membrane protein-OmpK as a versatile Vibriosis vaccine candidate in Orange-spotted grouper (Epinephelus coioides).

Ningqiu Li, Zhihui Yang, Junjie Bai, Xiaozhe Fu, Lihui Liu, Cunbin Shi, Shuqin Wu,

The outer membrane protein-OmpK has been considered as a vaccine candidate for the prevention of infections due to Vibrio harveyi, Vibrio alginolyticus and Vibrio parahaemolyticus in fish. Interestingly, the polyclonal antibody raised against the recombinant OmpK from V. harveyi strain EcGs020802 recognized the OmpK homologues from other strains of Vibrio ... Read more >>

Fish Shellfish Immunol. (Fish & shellfish immunology)
[2010, 28(5-6):952-956]

Cited: 12 times

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Validation of reference genes of grass carp Ctenopharyngodon idellus for the normalization of quantitative real-time PCR.

Xing Ye, Lili Zhang, Haiyan Dong, Yuanyuan Tian, Haihua Lao, Junjie Bai, Lingyun Yu,

Expression of four reference genes of grass carp, including beta-actin (ACTB), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 18S rRNA (18S) and elongation factor-1 alpha (EF1alpha), was studied in tissues of normal individuals and bacteria-infected individuals. EF1alpha had the most stable expressions followed by 18S rRNA then GAPDH; ACTB had the least stability. After ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2010, 32(8):1031-1038]

Cited: 7 times

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