Full Text Journal Articles by
Author Junhui Zhen

Advertisement

Find full text journal articles






CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

Cited: 0 times

View full text PDF listing >>



Role of SIK1 in the transition of acute kidney injury into chronic kidney disease.

Jinxiu Hu, Jiao Qiao, Qun Yu, Bing Liu, Junhui Zhen, Yue Liu, Qiqi Ma, Yanmei Li, Qianhui Wang, Cheng Wang, Zhimei Lv,

<h4>Background</h4>Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in renal diseases. Recently, studies have showed that salt inducible kinase 1 (SIK1) plays a role ... Read more >>

J Transl Med (Journal of translational medicine)
[2021, 19(1):69]

Cited: 0 times

View full text PDF listing >>



Advertisement

Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.

Xia Gu, Yi Liu, Na Wang, Junhui Zhen, Bo Zhang, Shaoshuai Hou, Zhengguo Cui, Qiang Wan, Hong Feng,

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Increasing evidences suggested that DKD correlates more closely to mitochondrial dysfunction than to hyperglycemia. Our previous study has reported that mitochondrial ribosomal protein L7/L12 (MRPL12) could positively control the mitochondrial oxidative phosphorylation ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 164:329-340]

Cited: 0 times

View full text PDF listing >>



Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Yi Fu, Yu Sun, Mei Wang, Yunfeng Hou, Wei Huang, Di Zhou, Ziying Wang, Shuting Yang, Wei Tang, Junhui Zhen, Yujia Li, Xiaojie Wang, Min Liu, Yan Zhang, Baobao Wang, Guangyi Liu, Xiao Yu, Jinpeng Sun, Chun Zhang, Fan Yi,

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD) and identification of potential therapeutic targets by mediating podocyte lipid metabolism has clinical importance. This study was to elucidate the role of JAML (junctional adhesion molecule-like protein) in the pathogenesis of DKD. We first confirmed the expression ... Read more >>

Cell Metab (Cell metabolism)
[2020, 32(6):1052-1062.e8]

Cited: 3 times

View full text PDF listing >>



Podocyte-derived extracellular vesicles mediate renal proximal tubule cells dedifferentiation via microRNA-221 in diabetic nephropathy.

Hong Su, Jiao Qiao, Jinxiu Hu, Yanmei Li, Jiangong Lin, Qun Yu, Junhui Zhen, Qiqi Ma, Qianhui Wang, Zhimei Lv, Rong Wang,

Podocyte injury is a key event in the initiation of Diabetic nephropathy (DN). Tubulointerstitium, especially the proximal tubule has been regarded as a target of injury. In the present study, we showed that podocytes induced dedifferentiation of proximal tubular epithelial cells(PTECs) in high-glucose conditions and extracellular vesicles (EVs) mediates the ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2020, 518:111034]

Cited: 0 times

View full text PDF listing >>



SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.

Yuan Ma, Suwei Zhu, Tingting Lv, Xia Gu, Hong Feng, Junhui Zhen, Wei Xin, Qiang Wan,

Mitochondrial DNA (mtDNA) encodes thirteen core components of OXPHOS complexes, and its steady expression is crucial for cellular energy homeostasis. However, the regulation of mtDNA expression machinery, along with its sensing mechanism to energetic stresses, is not fully understood. Here, we identified SQSTM1/p62 as an important regulator of mtDNA expression ... Read more >>

iScience (iScience)
[2020, 23(8):101428]

Cited: 2 times

View full text PDF listing >>



Resveratrol alleviates obesity-associated podocyte injury in ovariectomized obese rats.

Bing Li, Xiaoyan Xiao, Yulian Miao, Ling Guo, Junhui Zhen, Xianhua Li, Bei Jiang, Zhao Hu,

Obesity-associated podocyte injury increases in parallel with inflammatory responses. Resveratrol, as an anti-inflammatory and antioxidative agent, has been proven to be effective in obesity. The purpose of the present study was to investigate the function of resveratrol in the early stages of podocyte injury in ovariectomized rats fed a high-fat ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(1):123-130]

Cited: 0 times

View full text PDF listing >>



GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes.

Tingting Lv, Yanyan Hu, Yuan Ma, Junhui Zhen, Wei Xin, Qiang Wan,

Dyslipidemia is a common risk factor of chronic kidney disease (CKD). Current notion suggests that insufficient intracellular fatty acid oxidation (FAO) and subsequently enhanced fatty acid esterification within renal resident cells, a process termed as renal lipotoxicity, is the key pathogenic event responsible for dyslipidemia-induced kidney injury. However, the detailed ... Read more >>

J Physiol Biochem (Journal of physiology and biochemistry)
[2019, 75(4):597-606]

Cited: 3 times

View full text PDF listing >>



USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc and SOD2.

Qing Liu, Wei Sheng, Yuan Ma, Junhui Zhen, Satyajit Roy, Chowdhury Alvira Jafar, Wei Xin, Qiang Wan,

Acute kidney injury (AKI) is a progressive renal injury with high morbidity and mortality, however, the mechanism is far from being clarified and effective clinical interventions are lacking. USP36 is a deubiquitination enzyme involved in a variety of cellular biological processes, but its involvement in renal cell apoptosis and kidney ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2019, 513(2):502-508]

Cited: 2 times

View full text PDF listing >>



CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study.

Bing Zhao, Hui Han, Junhui Zhen, Xiaowei Yang, Jin Shang, Liang Xu, Rong Wang,

<h4>Background</h4>Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80 levels to diagnose MCD. There are no effective diagnostic methods to distinguish steroid-sensitive MCD from ... Read more >>

PeerJ (PeerJ)
[2018, 6:e5400]

Cited: 4 times

View full text PDF listing >>



Systemic lupus erythematosus with Guillian-Barre syndrome: A case report and literature review.

Zhaoli Gao, Xianhua Li, Tao Peng, Zhao Hu, Jie Liu, Junhui Zhen, Yanxia Gao,

<h4>Introduction</h4>We report a case of systemic lupus erythematosus (SLE) with Guillian-Barre syndrome (GBS) as the first symptom.<h4>Case presentation</h4>A 30-year-old Chinese female with numbness and inductance of lower extremities 2 months previously. The electromyographic and cerebrospinal fluid findings supported inflammatory demyelinating disease, and the renal biopsy findings and rheumatoid-related results considered ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(25):e11160]

Cited: 2 times

View full text PDF listing >>



Protective effect of calcitriol on podocytes in spontaneously hypertensive rat.

Weiwei Shi, Ling Guo, Guangyi Liu, Tao Peng, Hongyu Li, Tingting Xie, Dengren Li, Junhui Zhen, Yan Wang, Huimin Yang, Xiangdong Yang,

BACKGROUND:Hypertension is a major global public health issue. Uncontrolled hypertension leads to organ damage, especially renal damage. Calcitriol is used to treat osteoporosis, promote bone formation, and increase bone mass. Previous studies have demonstrated that 1,25(OH)2D3, in addition to its classic role, also has multiple immune regulation and renoprotective functions ... Read more >>

J Chin Med Assoc (Journal of the Chinese Medical Association : JCMA)
[2018, 81(8):691-698]

Cited: 3 times

View full text PDF listing >>



Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.

Zhimei Lv, Mengsi Hu, Minghua Fan, Xiaobing Li, Jiangong Lin, Junhui Zhen, Ziyang Wang, Haijun Jin, Rong Wang,

Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1 was able to attenuate ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(3):342]

Cited: 5 times

View full text PDF listing >>



Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Min Liu, Kaili Liang, Junhui Zhen, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Yu Sun, Zhuanli Zhou, Hua Su, Chun Zhang, Ningjun Li, Chengjiang Gao, Jun Peng, Fan Yi,

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies from patients with ... Read more >>

Nat Commun (Nature communications)
[2017, 8(1):413]

Cited: 53 times

View full text PDF listing >>



Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats.

Tao Peng, Xiangdi Chang, Jie Wang, Junhui Zhen, Xiangdong Yang, Zhao Hu,

The aim of the present study was to investigate the protective effect of tacrolimus on early podocyte damage in rats with diabetic nephropathy (DN). A total of 38 normal male Sprague‑Dawley rats were randomly divided into four groups: Normal control group (group N; n=8), DN group (n=10), tacrolimus (FK506) treatment ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2017, 15(5):3172-3178]

Cited: 5 times

View full text PDF listing >>



Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch-Schönlein Purpura Nephritis.

Yuanyuan Zhang, Aiju Li, Jiliang Wen, Junhui Zhen, Qiufa Hao, Yidan Zhang, Zhao Hu, Xiaoyan Xiao,

Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-Schönlein ... Read more >>

Arch Med Res (Archives of medical research)
[2017, 48(5):449-458]

Cited: 4 times

View full text PDF listing >>



LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin.

Mengsi Hu, Rong Wang, Xiaobing Li, Minghua Fan, Jiangong Lin, Junhui Zhen, Liqun Chen, Zhimei Lv,

Metastasis associated lung adenocarcinoma transcript 1(MALAT1) is a long non-coding RNA, broadly expressed in mammalian tissues including kidney and up-regulated in a variety of cancer cells. To date, its functions in podocytes are largely unknown. β-catenin is a key mediator in the canonical and non-canonical Wnt signalling pathway; its aberrant ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2017, 21(11):2732-2747]

Cited: 65 times

View full text PDF listing >>



Increasing prevalence of membranous nephropathy in patients with primary glomerular diseases: A cross-sectional study in China.

Lijun Tang, Jing Yao, Xianglei Kong, Qing Sun, Zunsong Wang, Ying Zhang, Ping Wang, Yipeng Liu, Wenbin Li, Meiyu Cui, Junhui Zhen, Dongmei Xu,

<h4>Aim</h4>Primary glomerular disease (PGD) remains the most common renal disease in China. A limited number of single centre studies show that the frequency of membranous nephropathy (MN) has increased; however, IgA nephropathy (IgAN) is still the most common PGD. To the best of our knowledge, there has been no multi-centre ... Read more >>

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2017, 22(2):168-173]

Cited: 9 times

View full text PDF listing >>



FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organization via activating p38 in response to ox-LDL.

Mengsi Hu, Minghua Fan, Junhui Zhen, Jiangong Lin, Qun Wang, Zhimei Lv, Rong Wang,

Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that regulates cell adhesion, proliferation and differentiation. In the present study, a rat model of high fat diet-induced hypercholesterolaemia was established to investigate the involvement of FAK in lipid disorder-related kidney diseases. We showed focal fusion of podocyte foot process ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2017, 21(3):552-567]

Cited: 7 times

View full text PDF listing >>



Resveratrol attenuates acute kidney injury by inhibiting death receptor‑mediated apoptotic pathways in a cisplatin‑induced rat model.

Qiufa Hao, Xiaoyan Xiao, Junhui Zhen, Jinbo Feng, Chun Song, Bei Jiang, Zhao Hu,

Acute kidney injury is a clinical syndrome characterized by a loss of renal function and acute tubular necrosis. Resveratrol exerts a wide range of pharmacological effects based on its anti‑inflammatory, antioxidant and cytoprotective properties. The present study aimed to evaluate whether resveratrol attenuates acute kidney injury in a cisplatin‑induced rat ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2016, 14(4):3683-3689]

Cited: 10 times

View full text PDF listing >>



Effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats.

Tao Peng, Jie Wang, Junhui Zhen, Zhao Hu, Xiangdong Yang,

The aim of this study was to investigate the effect of benazepril on the transdifferentiation of renal tubular epithelial cells from diabetic rats. Thirty male Sprague-Dawley rats were included in the present study. Eight of the 30 rats were randomly selected and served as the normal control group (N group), ... Read more >>

Biomed Rep (Biomedical reports)
[2014, 2(4):490-494]

Cited: 2 times

View full text PDF listing >>



Leptin promotes endothelial dysfunction in chronic kidney disease through AKT/GSK3β and β-catenin signals.

Nannan Ding, Bing Liu, Jiaguang Song, Shougang Bao, Junhui Zhen, Zhimei Lv, Rong Wang,

Endothelial dysfunction (ED) is a well-recognized instigator of cardiovascular diseases and develops in chronic kidney disease (CKD) with high rate. Recent studies have implicated that leptin is associated with endothelial dysfunction. We investigated the relationship between leptin and markers of ED in CKD patients and how leptin contributed to endothelial ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2016, 480(4):544-551]

Cited: 7 times

View full text PDF listing >>



IgG4-related disease: a case report with duration of more than 16 years and review of literature.

Tao Peng, Zhao Hu, Tingting Xie, Baodong Jiang, Junhui Zhen, Xiangdong Yang,

<h4>Introduction</h4>IgG4-related disease was first reported in 2001 and was officially named in 2010. It is now considered as a systemic disease that might affect any organ system. The characteristic pathological changes of IgG4-related disease are extensive infiltration of IgG4-positive plasma cells. IgG4-related disease is a kind of benign lesions, but ... Read more >>

Springerplus (SpringerPlus)
[2016, 5(1):804]

Cited: 3 times

View full text PDF listing >>



Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

Zhibo Gai, Michele Visentin, Christian Hiller, Evelin Krajnc, Tongzhou Li, Junhui Zhen, Gerd A Kullak-Ublick,

Nephrotoxicity is a relevant limitation of gentamicin, and obese patients have an increased risk for gentamicin-induced kidney injury. This damage is thought to depend on the accumulation of the drug in the renal cortex. Obese rats showed substantially higher levels of gentamicin in the kidney than did lean animals. This ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2016, 60(9):5573-5580]

Cited: 10 times

View full text PDF listing >>



A sensitive SERS detection of miRNA using a label-free multifunctional probe.

Hao Zhang, Yu Liu, Jian Gao, Junhui Zhen,

A novel surface enhanced Raman scattering (SERS) detection method is fabricated for miRNA based on a smart multifunctional probe for dual cyclical nucleic acid strand-displacement polymerization (CNDP), achieving high sensitivity, universality, rapid analysis, and good performance in real cell samples. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2015, 51(94):16836-16839]

Cited: 7 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2961 s