Full Text Journal Articles by
Author Junhai Han

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Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes.

Yuqian Shen, Wenhua Liu, Jian Zuo, Junhai Han, Zi Chao Zhang,

Selective identification of newly synthesized proteins is challenging because all proteins, both existing and nascent, have the same amino acid pool and are therefore chemically indistinguishable. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa ... Read more >>

STAR Protoc (STAR protocols)
[2021, 2(3):100616]

Cited: 0 times

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Protocol for interfering peptide injection into adult mouse hippocampus and spatial memory testing.

Shanshan Cheng, Yuqian Shen, Zi Chao Zhang, Junhai Han,

Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) occurs in diverse brain regions and contributes to the plasticity of behavior, learning, and memory. mGluR-LTD relies on rapid (in minutes) local protein synthesis. Here, we describe a detailed protocol for delivering an interfering peptide into the adult mouse hippocampus. The delivered peptide disrupts ... Read more >>

STAR Protoc (STAR protocols)
[2021, 2(3):100679]

Cited: 0 times

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Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.

Li-Da Su, Na Wang, Junhai Han, Ying Shen,

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211021018]

Cited: 0 times

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Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.

Yuqian Shen, Junhai Han, Zi Chao Zhang,

J Mol Cell Biol (Journal of molecular cell biology)
[2021, :]

Cited: 0 times

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A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling.

Xi Jin, Yao Tian, Zi Chao Zhang, Pengyu Gu, Chang Liu, Junhai Han,

Sleep is an essential and evolutionarily conserved behavior that is modulated by many environmental factors. Ambient temperature shifting usually occurs during climatic or seasonal change or travel from high-latitude area to low-latitude area that affects animal physiology. Increasing ambient temperature modulates sleep in both humans and Drosophila. Although several thermosensory ... Read more >>

Curr Biol (Current biology : CB)
[2021, 31(10):2075-2087.e6]

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PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.

Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Han,

Eukaryotic elongation factor 2 (eEF2) mediates translocation of peptidyl-tRNA from the ribosomal A site to the P site to promote translational elongation. Its phosphorylation on Thr56 by its single known kinase eEF2K inactivates it and inhibits translational elongation. Extensive studies have revealed that different signal cascades modulate eEF2K activity, but whether ... Read more >>

Mol Cell (Molecular cell)
[2021, 81(7):1425-1438.e10]

Cited: 1 time

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Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior in Drosophila.

Jinglin Wu, Xiaoxiao Ji, Qiuxiang Gu, Buxin Liao, Wei Dong, Junhai Han,

Appropriate termination of the photoresponse in image-forming photoreceptors and downstream neurons is critical for an animal to achieve high temporal resolution. Although the cellular and molecular mechanisms of termination in image-forming photoreceptors have been extensively studied in <i>Drosophila</i>, the underlying mechanism of termination in their downstream large monopolar cells remains ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2021, 41(10):2164-2176]

Cited: 0 times

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The First National Prevalence of Autism Spectrum Disorder in China.

Zi Chao Zhang, Junhai Han,

Neurosci Bull (Neuroscience bulletin)
[2020, 36(9):959-960]

Cited: 0 times

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Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila.

Qiuxiang Gu, Jinglin Wu, Yao Tian, Shanshan Cheng, Zi Chao Zhang, Junhai Han,

Heterotrimeric G proteins mediate a variety of signaling processes by coupling G protein-coupled receptors to intracellular effector molecules. In <i>Drosophila,</i> the <i>G</i>α<i>q</i> gene encodes several Gαq splice variants, with the Gαq1 isoform protein playing a major role in fly phototransduction. However, <i>G</i>α<i>q1</i> null mutant flies still exhibit a residual light ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, 295(17):5554-5563]

Cited: 1 time

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Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2.

Yawen Mu, Yao Tian, Zi Chao Zhang, Junhai Han,

Light-induced endocytosis of rhodopsin in the retina is critical for preventing photoreceptor hyperactivity and for the survival of photoreceptor cells. In <i>Drosophila</i>, this process is mediated by arrestin1 (Arr1). Because Arr1 lacks a clathrin-binding domain required for receptor internalization and the C-terminal sequence that interacts with the β-subunit of the ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2019, 294(35):12892-12900]

Cited: 1 time

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Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor.

Qian Li, Yi Li, Xiao Wang, Junxia Qi, Xi Jin, Huawei Tong, Zikai Zhou, Zi Chao Zhang, Junhai Han,

The timing of sleep is tightly governed by the circadian clock, which contains a negative transcriptional feedback loop and synchronizes the physiology and behavior of most animals to daily environmental oscillations. However, how the circadian clock determines the timing of sleep is largely unclear. In vertebrates and invertebrates, the status ... Read more >>

Curr Biol (Current biology : CB)
[2017, 27(23):3616-3625.e5]

Cited: 15 times

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Proteolytic maturation of Drosophila Neuroligin 3 by tumor necrosis factor α-converting enzyme in the nervous system.

Jun Wu, Nana Tao, Yao Tian, Guanglin Xing, Huihui Lv, Junhai Han, Chengqi Lin, Wei Xie,

The functions of autism-associated Neuroligins (Nlgs) are modulated by their post-translational modifications, such as proteolytic cleavage. A previous study has shown that there are different endogenous forms of DNlg3 in Drosophila, indicating it may undergo proteolytic processing. However, the molecular mechanism underlying DNlg3 proteolytic processing is unknown. Here, we report ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2018, 1862(3):440-450]

Cited: 1 time

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A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.

Fang Qiu, Ruqi Tang, Xianbo Zuo, Xingjuan Shi, Yiran Wei, Xiaodong Zheng, Yaping Dai, Yuhua Gong, Lan Wang, Ping Xu, Xiang Zhu, Jian Wu, Chongxu Han, Yueqiu Gao, Kui Zhang, Yuzhang Jiang, Jianbo Zhou, Youlin Shao, Zhigang Hu, Ye Tian, Haiyan Zhang, Na Dai, Lei Liu, Xudong Wu, Weifeng Zhao, Xiaomin Zhang, Zhidong Zang, Jinshan Nie, Weihao Sun, Yi Zhao, Yuan Mao, Po Jiang, Hualiang Ji, Qing Dong, Junming Li, Zhenzhong Li, Xinli Bai, Li Li, Maosong Lin, Ming Dong, Jinxin Li, Ping Zhu, Chan Wang, Yanqiu Zhang, Peng Jiang, Yujue Wang, Rohil Jawed, Jing Xu, Yu Zhang, Qixia Wang, Yue Yang, Fan Yang, Min Lian, Xiang Jiang, Xiao Xiao, Yanmei Li, Jingyuan Fang, Dekai Qiu, Zhen Zhu, Hong Qiu, Jianqiong Zhang, Wenyan Tian, Sufang Chen, Ling Jiang, Bing Ji, Ping Li, Guochang Chen, Tianxue Wu, Yan Sun, Jianjiang Yu, Huijun Tang, Michun He, Min Xia, Hao Pei, Lihua Huang, Zhuye Qing, Jianfang Wu, Qinghai Huang, Junhai Han, Wei Xie, Zhongsheng Sun, Jian Guo, Gengsheng He, M Eric Gershwin, Zhexiong Lian, Xiang Liu, Michael F Seldin, Xiangdong Liu, Weichang Chen, Xiong Ma,

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a strong hereditary component. Here, we report a genome-wide association study that included 1,122 PBC cases and 4,036 controls of Han Chinese descent, with subsequent replication in a separate cohort of 907 PBC cases and 2,127 controls. Our results show ... Read more >>

Nat Commun (Nature communications)
[2017, 8:14828]

Cited: 28 times

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Drosophila Studies on Autism Spectrum Disorders.

Yao Tian, Zi Chao Zhang, Junhai Han,

In the past decade, numerous genes associated with autism spectrum disorders (ASDs) have been identified. These genes encode key regulators of synaptogenesis, synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2017, 33(6):737-746]

Cited: 12 times

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Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering.

Lina Liu, Yao Tian, Xiao-Yan Zhang, Xinwang Zhang, Tao Li, Wei Xie, Junhai Han,

Columnar restriction of neurites is critical for forming nonoverlapping receptive fields and preserving spatial sensory information from the periphery in both vertebrate and invertebrate nervous systems, but the underlying molecular mechanisms remain largely unknown. Here, we demonstrate that Drosophila homolog of α-neurexin (DNrx) plays an essential role in columnar restriction during L4 axon ... Read more >>

Dev Cell (Developmental cell)
[2017, 41(1):94-106.e4]

Cited: 5 times

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The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering.

Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie,

Synaptic vesicles (SVs) form distinct pools at synaptic terminals, and this well-regulated separation is necessary for normal neurotransmission. However, how the SV cluster, in particular synaptic compartments, maintains normal neurotransmitter release remains a mystery. The presynaptic protein Neurexin (NRX) plays a significant role in synaptic architecture and function, and some ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2017, 292(35):14334-14348]

Cited: 6 times

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Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila.

Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie,

Neuroligins (Nlgs) are transmembrane cell adhesion molecules playing essential roles in synapse development and function. Genetic mutations in neuroligin genes have been linked with some neurodevelopmental disorders such as autism. These mutated Nlgs are mostly retained in the endoplasmic reticulum (ER). However, the mechanisms underlying normal Nlg maturation and trafficking ... Read more >>

J Mol Cell Biol (Journal of molecular cell biology)
[2017, 9(3):231-242]

Cited: 3 times

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Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.

Xiao Wang, Yawen Mu, Mengshi Sun, Junhai Han,

Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photoreceptors. The major fly rhodopsin, Rh1, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how translation of Rh1 is regulated. ... Read more >>

J Mol Cell Biol (Journal of molecular cell biology)
[2017, 9(2):104-116]

Cited: 6 times

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Neurexin regulates nighttime sleep by modulating synaptic transmission.

Huawei Tong, Qian Li, Zi Chao Zhang, Yi Li, Junhai Han,

Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:38246]

Cited: 7 times

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Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction.

Xiao-Yan Zhang, Junxia Qi, Yu-Qian Shen, Xian Liu, An Liu, Zikai Zhou, Junhai Han, Zi Chao Zhang,

Renpenning syndrome is a group of X-linked intellectual disability syndromes caused by mutations in human polyglutamine-binding protein 1 (PQBP1) gene. Little is known about the molecular pathogenesis of the various mutations that cause the notable variability in patients. In this study, we examine the cellular and synaptic functions of the ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2017, 26(5):955-968]

Cited: 5 times

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TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.

Qin Xia, Hongfeng Wang, Zongbing Hao, Cheng Fu, Qingsong Hu, Feng Gao, Haigang Ren, Dong Chen, Junhai Han, Zheng Ying, Guanghui Wang,

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA-binding protein 43 (TDP-43) was identified as a major component of disease pathogenesis in ALS, frontotemporal lobar degeneration (FTLD), and other neurodegenerative disease. Despite the fact ... Read more >>

EMBO J (The EMBO journal)
[2016, 35(2):121-142]

Cited: 69 times

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The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression.

Tao Li, Yao Tian, Qian Li, Huiying Chen, Huihui Lv, Wei Xie, Junhai Han,

Although Neurexins, which are cell adhesion molecules localized predominantly to the presynaptic terminals, are known to regulate synapse formation and synaptic transmission, their roles in the regulation of synaptic vesicle release during repetitive nerve stimulation are unknown. Here, we show that nrx mutant synapses exhibit rapid short term synaptic depression ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(29):17656-17667]

Cited: 10 times

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X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs.

Didi Wan, Zi Chao Zhang, Xiaoyan Zhang, Qian Li, Junhai Han,

X chromosome-linked intellectual disability is a common developmental disorder, and mutations of the polyglutamine-binding protein 1 (PQBP1) gene have been linked to this disease. In addition to existing in the nucleus as a splicing factor, PQBP1 is also found in cytoplasmic RNA granules, where it associates with RNA-binding proteins. However, ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2015, 24(16):4599-4614]

Cited: 7 times

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Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila.

Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu, Wenqing Wu, Junhai Han, Zhaocai Zhou, Hai Jiang, Lei Zhang, Yun Zhao,

Intestinal homeostasis is maintained by intestinal stem cells (ISCs) and their progenies. A complex autonomic nervous system spreads over posterior intestine. However, whether and how neurons regulate posterior intestinal homeostasis is largely unknown. Here we report that neurons regulate Drosophila posterior intestinal homeostasis. Specifically, downregulation of neuronal Hedgehog (Hh) signaling ... Read more >>

Cell Discov (Cell discovery)
[2015, 1:15006]

Cited: 9 times

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Ih channels control feedback regulation from amacrine cells to photoreceptors.

Wen Hu, Tingting Wang, Xiao Wang, Junhai Han,

In both vertebrates and invertebrates, photoreceptors' output is regulated by feedback signals from interneurons that contribute to several important visual functions. Although synaptic feedback regulation of photoreceptors is known to occur in Drosophila, many questions about the underlying molecular mechanisms and physiological implementation remain unclear. Here, we systematically investigated these ... Read more >>

PLoS Biol (PLoS biology)
[2015, 13(4):e1002115]

Cited: 23 times

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