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Author Jung Yun Lee

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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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Time for enhancing government-led primary prevention of cervical cancer.

Kyung Jin Min, Dong Hoon Suh, Tsukasa Baba, Xiaojun Chen, Jae Weon Kim, Yusuke Kobayashi, Janice Kwon, Myong Cheol Lim, Jung Yun Lee, Satoru Nagase, Jeong Yeol Park, Siriwan Tangjitgamol, Hidemichi Watari,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e12]

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Incorporating patient centered benefits as endpoints in randomized trials of maintenance therapies in advanced ovarian cancer: A position paper from the GCIG symptom benefit committee.

Jean-Emmanuel Kurtz, Val Gebski, Vladyslav Sukhin, Mark Carey, Iwa Kong, Rosalind M Glasspool, Jonathan S Berek, Mariana de Paiva Batista, Marcia Hall, Jae-Weon Kim, Effi Yeoshoua, Noriko Fujiwara, Byung-Ho Nam, Sandra Polleis, Jung-Yun Lee, Aleksandra Strojna, Laura Farrelly, Richard Schwameis, Roldano Fossati, Anne-Sophie Darlington, Chyong-Huey Lai, Alexi A Wright, Orgad Rosenblat, Phillip Harter, Patricia Roxburgh, Rahul Roy Chowdhury, Ting-Chang Chang, Xavier Paoletti, Michael Friedlander, ,

<h4>Background</h4>Quality of life and patient reported outcome measures (PROMs) are important secondary endpoints and incorporated in most contemporary clinical trials. There have been deficiencies in their assessment and reporting in ovarian cancer clinical trials, particularly in trials of maintenance treatment where they are of particular importance. The Gynecologic Cancer InterGroup ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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Association between PD-L1 expression and 18F-FDG uptake in ovarian cancer.

Yun Jung Choi, KwanHyeong Jo, Sang Hyun Hwang, YongHyu Jeong, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Won Jun Kang,

<h4>Objective</h4>Immunotherapy for programmed cell death 1 (PD-1) and its ligand, PD-L1, has been considered an effective treatment for ovarian cancer. <sup>18</sup>F-labeled fluoro-2-deoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) is a widely used noninvasive imaging tool for diagnosing several cancers. In this study, we investigated the association between PD-L1 expression and ... Read more >>

Ann Nucl Med (Annals of nuclear medicine)
[2021, 35(4):415-420]

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High false-positive rate of fluorodeoxyglucose positron emission tomography to detect lymph node metastasis in microinvasive cervical cancer after conization

Kidong Kim, Hayeon Kim, Hwajung Lee, Keun Ho Lee, Banghyun Lee, ChelHun Choi, Seung-Hyuk Shim, Jong-Min Lee, Miseon Kim, Jung-Yun Lee,

We aimed to estimate the positive predictive value of fluorodeoxyglucose positron emission tomography (FDG PET) to detect lymph node metastasis in patients with microinvasive cervical cancer who recently underwent conization. We retrospectively collected data of patients fulfilling the following criteria: 1) cervical cancer stage 1A1 (by FIGO staging revised in ... Read more >>

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Major clinical research advances in gynecologic cancer in 2019.

Miseon Kim, Dong Hoon Suh, Kyung Hun Lee, Keun Yong Eom, Jung Yun Lee, Yoo Young Lee, Hanne Falk Hansen, Mansoor Raza Mirza, Jae Weon Kim,

In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced cervical cancer based on the results of the phase 2 KEYNOTE-158 trial. Thereafter, we reviewed 5 topics, including systemic lymphadenectomy ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(3):e48]

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Corrigendum to "Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data" Gynecol. Oncol. 154 (2019) 441-448.

Paul A Cohen, Aime Powell, Steffen Böhm, C Blake Gilks, Colin J R Stewart, Tarek M Meniawy, Max Bulsara, Stefanie Avril, Eleanor C Brockbank, Tjalling Bosse, Gustavo Rubino de Azevedo Focchi, Raji Ganesan, Rosalind M Glasspool, Brooke E Howitt, Hyun-Soo Kim, Jung-Yun Lee, Nhu D Le, Michelle Lockley, Ranjit Manchanda, Trupti Mandalia, W Glenn McCluggage, Iain McNeish, Divya Midha, Radhika Srinivasan, Yun Yi Tan, Rachael van der Griend, Mayu Yunokawa, Gian F Zannoni, , Naveena Singh,

Gynecol Oncol (Gynecologic oncology)
[2021, 161(1):328-329]

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A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer.

Junsik Park, Kyung Jin Eoh, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Jung Yun Lee,

<h4>Purpose</h4>We evaluated whether adding bevacizumab to current platinum-based chemotherapy could improve clinical outcomes without affecting safety.<h4>Materials and methods</h4>We retrospectively reviewed medical records of patients with pathologically confirmed ovarian cancer who received neoadjuvant chemotherapy (NAC) at Yonsei Cancer Hospital. We divided the patients into groups based on the use of bevacizumab ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2020, 61(4):284-290]

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Anti-Obesity and Anti-Adipogenic Effects of Chitosan Oligosaccharide (GO2KA1) in SD Rats and in 3T3-L1 Preadipocytes Models.

Jung-Yun Lee, Tae Yang Kim, Hanna Kang, Jungbae Oh, Joo Woong Park, Se-Chan Kim, Minjoo Kim, Emmanouil Apostolidis, Young-Cheul Kim, Young-In Kwon,

Excess body weight is a major risk factor for type 2 diabetes (T2D) and associated metabolic complications, and weight loss has been shown to improve glycemic control and decrease morbidity and mortality in T2D patients. Weight-loss strategies using dietary interventions produce a significant decrease in diabetes-related metabolic disturbance. We have ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(2):]

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Comparison of single-port laparoscopy and laparotomy in early ovarian cancer surgical staging.

Kyu Hee Cho, Yeon Ju Lee, Kyung Jin Eoh, Yong Jae Lee, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim,

<h4>Objective</h4>s The aims of this study were to assess the feasibility of single-port laparoscopic surgical staging (SPLS) in early ovarian cancer and to compare the surgical outcomes of SPLS with those of staging laparotomy.<h4>Methods</h4>Between January 2014 and December 2018, 40 patients underwent SPLS and 41 patients underwent staging laparotomy at ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2021, 64(1):90-98]

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4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers.

Galam Leem, Junsik Park, Minwoo Jeon, Eui-Soon Kim, Sang Wun Kim, Yong Jae Lee, Seong Jin Choi, Baekgyu Choi, Seongyeol Park, Young Seok Ju, Inkyung Jung, Sunghoon Kim, Eui-Cheol Shin, Jung Yun Lee, Su-Hyung Park,

<h4>Background</h4>Responses to immunotherapy vary between different cancer types and sites. Here, we aimed to investigate features of exhaustion and activation in tumor-infiltrating CD8 T cells at both the primary and metastatic sites in epithelial ovarian cancer.<h4>Methods</h4>Tumor tissues and peripheral blood were obtained from 65 patients with ovarian cancer. From these ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(2):]

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Effects of Korean Red Ginseng (Panax ginseng C.A. Meyer) on Menopausal Symptoms in Premenopausal Women After Gynecologic Cancer Surgery: A Double-Blind, Randomized Controlled Trial.

Young Shin Chung, In Ok Lee, Jung-Yun Lee, Eun Ji Nam, Sang Wun Kim, Young Tae Kim, Sunghoon Kim,

<b><i>Objectives:</i></b> Korean red ginseng (KRG) has been widely used as an alternative medicine to relieve menopausal symptoms. However, there is still a lack of clinical studies showing the effects of KRG on menopausal symptoms after gynecologic cancer surgery. Therefore, the authors investigated the effects of KRG on surgical menopause symptoms ... Read more >>

J Altern Complement Med (Journal of alternative and complementary medicine (New York, N.Y.))
[2021, 27(1):66-72]

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Impact of the Learning Curve on the Survival of Abdominal or Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer.

Lan Ying Li, Lan Ying Wen, Sun Hee Park, Eun Ji Nam, Jung Yun Lee, Sunghoon Kim, Young Tae Kim, Sang Wun Kim,

<h4>Purpose</h4>The objective of this study was to define the learning curve required to attain satisfactory oncologic outcomes of cervical cancer patients who were undergoing open or minimally invasive surgery for radical hysterectomy, and to analyze the correlation between the learning curve and tumor size.<h4>Materials and methods</h4>Cervical cancer patients (stage IA-IIA) ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, 53(1):243-251]

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Real-World Experience of Pembrolizumab Monotherapy in Patients with Recurrent or Persistent Cervical Cancer: A Korean Multi-Center Retrospective Study (KGOG1041).

Min Chul Choi, Yong-Man Kim, Jeong-Won Lee, Yong Jae Lee, Dong Hoon Suh, Sung Jong Lee, Taek Sang Lee, Maria Lee, Dong Choon Park, Min Kyu Kim, Jong-Min Lee, Seung-Hyuk Shim, Seob Jeon, Kyung Jin Min, Mi Kyung Kim, Bo Wook Kim, Jeong Yeol Park, Byoung-Gie Kim, Dae Yeon Kim, Moon-Hong Kim, Hyun-Soo Kim, Jung-Yun Lee,

This study investigated the antitumor activity and safety of pembrolizumab in patients with recurrent cervical cancer in real-world practice. We conducted a multi-center retrospective study of patients with recurrent or persistent cervical cancer treated with pembrolizumab at sixteen institutions in Korea between January 2016 and March 2020. The primary endpoints ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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A phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in advanced-stage ovarian cancer: a Korean Gynecologic Oncology Group Study (KGOG 3046), TRU-D.

Jung Yun Lee, Jae Weon Kim, Myong Cheol Lim, Sunghoon Kim, Hee Seung Kim, Chel Hun Choi, Ju Yeon Yi, Sang Yoon Park, Byoung Gie Kim, ,

<h4>Background</h4>A single-arm phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in the treatment of advanced-stage ovarian cancer has begun in Korea. We hypothesized that adding durvalumab (anti-programmed death-ligand 1 antibody) and tremelimumab (anti-cytotoxic T-lymphocyte-associated protein 4 antibody) to chemotherapy in treating this cancer can increase progression-free survival (PFS) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(6):e112]

Cited: 2 times

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Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer.

Young Shin Chung, Ha Young Woo, Jung-Yun Lee, Eunhyang Park, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim,

<h4>Background</h4>Patients younger than 40 years usually present with early-stage endometrial cancer with favorable prognosis. However, such patients are usually in their childbearing age and may desire fertility-sparing options. The identification of biomarkers may improve the clinical outcomes in these patients and aid in fertility-sparing management; however, there has been no ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, 224(4):370.e1-370.e13]

Cited: 2 times

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Comparison between weekly versus 3-weekly paclitaxel in combination with carboplatin as neoadjuvant chemotherapy in advanced ovarian cancer.

Yoo Na Kim, Yong Jae Lee, Jung Yun Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim,

OBJECTIVE:To compare the efficacy and toxicity of dose-dense weekly paclitaxel and 3-weekly carboplatin (ddPC) as neoadjuvant chemotherapy (NAC) with the standard 3-weekly regimen. METHODS:A retrospective study of patients diagnosed with stage IIIc and IV ovarian cancer who received at least one cycle of NAC followed by interval debulking surgery between ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(2):e23]

Cited: 2 times

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Concordance between CA-125 and RECIST progression in patients with germline BRCA-mutated platinum-sensitive relapsed ovarian cancer treated in the SOLO2 trial with olaparib as maintenance therapy after response to chemotherapy.

Angelina Tjokrowidjaja, Chee K Lee, Michael Friedlander, Val Gebski, Laurence Gladieff, Jonathan Ledermann, Richard Penson, Amit Oza, Jacob Korach, Tomasz Huzarski, Luis Manso, Carmela Pisano, Rebecca Asher, Sarah J Lord, Se Ik Kim, Jung-Yun Lee, Nicoletta Colombo, Tjoung-Won Park-Simon, Keiichi Fujiwara, Gabe Sonke, Ignace Vergote, Jae-Weon Kim, Eric Pujade-Lauraine,

<h4>Background</h4>Limited evidence exists to support CA-125 as a valid surrogate biomarker for progression in patients with ovarian cancer on maintenance PARP inhibitor (PARPi) therapy. We aimed to assess the concordance between CA-125 and Response Evaluation Criteria in Solid Tumours (RECIST) criteria for progression in patients with BRCA mutations on maintenance ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 139:59-67]

Cited: 1 time

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Integrating a Next Generation Sequencing Panel into Clinical Practice in Ovarian Cancer.

Yong Jae Lee, Dachan Kim, Hyun Soo Kim, Kiyong Na, Jung Yun Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim,

<h4>Purpose</h4>Few efforts have been made to integrate a next generation sequencing (NGS) panel into standard clinical treatment of ovarian cancer. The aim of this study was to investigate the clinical utility of NGS and to identify clinically impactful information beyond targetable alterations.<h4>Materials and methods</h4>We conducted a retrospective review of 84 ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2019, 60(10):914-923]

Cited: 2 times

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How to use immune checkpoint inhibitor in ovarian cancer?

Junsik Park, Jung Yun Lee, Sunghoon Kim, Sunghoon Kim,

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(5):e105]

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Involved-field radiation therapy for selected cases of recurrent ovarian cancer.

Nalee Kim, Jee Suk Chang, Sang Wun Kim, Gun Min Kim, Jung Yun Lee, Yong Bae Kim,

<h4>Objectives</h4>In our institutional experience, involved-field radiation therapy (IFRT) yields favorable outcomes in patients with recurrent epithelial ovarian cancer (EOC). This retrospective study aimed to investigate the clinical benefits of IFRT in this patient population.<h4>Methods</h4>Among patients treated with IFRT for recurrent EOC between 2010 and 2017, 61 patients with 90 treatments ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(5):e67]

Cited: 1 time

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Pelvic malakoplakia presenting as endometrial cancer: a case report.

Jeong Soo Cho, Hye In Kim, Jung Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim,

Malakoplakia is a rare granulomatous, inflammatory disease generally manifesting as ulcers of the urogenital tract, especially in the bladder, but it can occur in any part of the body. Because of its varied clinical presentations, malakoplakia is considered for differential diagnosis upon suspicion. The final diagnosis is confirmed by the ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2020, 63(4):538-542]

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Impact of subcutaneous negative pressure drains on surgical wound healing in ovarian cancer.

Young Shin Chung, Jung-Yun Lee, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim,

<h4>Introduction</h4>Subcutaneous negative pressure wound drains have been used to reduce wound complication rates in various surgical procedures. However, research on the benefits of subcutaneous drains on wound healing after ovarian cancer surgery is limited. The aim of this study was to assess the effects of subcutaneous negative pressure drains on ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(2):245-250]

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Genetic characteristics of gastric-type mucinous carcinoma of the uterine cervix.

Eunhyang Park, Sang Wun Kim, Sunghoon Kim, Hyun-Soo Kim, Jung-Yun Lee, Young Tae Kim, Nam Hoon Cho,

Gastric-type mucinous carcinoma (GAS) is a recently established variant of endocervical mucinous adenocarcinoma that is characterized as being unrelated to HPV and having aggressive behavior and chemoresistance. GAS has a distinct morphology resembling nonneoplastic gastric glands or pancreaticobiliary adenocarcinoma, and their possible genetic similarity has been posed. In this study, ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, 34(3):637-646]

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Recommendations for gynecologic cancer care during the COVID-19 pandemic.

Sung Jong Lee, Taehun Kim, Miseon Kim, Dong Hoon Suh, Jeong Yeol Park, Myong Cheol Lim, Jung Yun Lee, Jae Weon Kim, Yong Bae Kim, Keun Yong Eom, Seung Cheol Kim,

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(4):e69]

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