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Author Junchao Huang

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A Network Pharmacology Study: Reveal the Mechanisms of Palovarotene Against Heterotopic Ossification.

Junchao Huang, Dachuan Liu, Jingwei Zhang, Haijun Xiao,

Heterotopic ossification (HO) occurs when bone forms within non-ossifying tissues, such as in muscle. Palovarotene, an activator of retinoic acid receptor γ (RAR-γ), has been shown to inhibit the formation of ectopic bone in HO model mice, but its specific mechanism of action remains unclear. This study will explore the ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2022, 9:897392]

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Palovarotene inhibits the NF-κB signalling pathway to prevent heterotopic ossification.

Junchao Huang, Jiang Wu, Jialiang Lin, Congbin Li, Bo Tang, Haijun Xiao,

Heterotopic ossification (HO) is a common disease characterized by pain, dysfunction and calcification. The mechanisms underlying HO have not been completely elucidated. Palovarotene, a retinoic acid receptor γ agonist, significantly inhibits the formation of HO in vivo. However, its specific mechanism of action remains unclear. Therefore, we aimed to evaluate ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2022, :]

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