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A silk-based high impact composite for the core decompression of the femoral head.

Jin Wang, Ruixin Mi, Guanglei Zhao, Jingsheng Shi, Jie Chen, Changquan Liu, Zhengzhong Shao, Jun Xia,

Core decompression of the femoral head is a recommended head-conserving strategy for early-stage osteonecrosis of the femoral head. However, no ideal filling material has been found so far. In this study, we fabricated a "solid core-porous coating" composite scaffold, which is a silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) scaffold, by a "two-step" ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(42):9734-9743]

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Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window.

Hailey I Kilian, Homan Kang, Nikhila Nyayapathi, Takeshi Fukuda, Eeswar Adluru, Huijuan Zhang, Breandan Quinn, Jun Xia, Hak Soo Choi, Jonathan F Lovell,

The second near-infrared window (NIR-II) beyond 1000 nm has attracted attention for optical contrast imaging in small animals. We sought to assess whether commercially available NIR-II dyes could be easily formulated for this purpose. 13 hydrophobic NIR-II dyes were purchased and screened by formulating them in simple solubilizing agents with ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(15):4199-4205]

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Computational fluid dynamics study of the effect of transverse sinus stenosis on the blood flow pattern in the ipsilateral superior curve of the sigmoid sinus.

Yanjing Han, Jun Xia, Long Jin, Aike Qiao, Tianhao Su, ZhenFeng Li, Jianping Xiong, Haochen Wang, Zhiyuan Zhang,

<h4>Objective</h4>To investigate the effect of different types of transverse sinus stenosis on blood flow patterns in the ipsilateral superior curve of the sigmoid sinus.<h4>Methods</h4>According to the morphology of transverse and sigmoid sinus sections in pulsatile tinnitus patients, ten idealized models with different degrees and positions of transverse sinus stenosis were ... Read more >>

Eur Radiol (European radiology)
[2021, :]

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Lung cancer molecular mutations and abnormal glycosylation as biomarkers for early diagnosis.

Shuang Yang, Jun Xia, Zeren Yang, Mingming Xu, Shuwei Li,

Lung cancer is the leading cause of mortality and morbidity in tumor-related deaths in the world. Early detection of tumors can greatly improve the survival rate of patients. However, the lack of reliable blood biomarkers remains a major challenge for early diagnosis. The blood proteins secreted by the lung bronchi ... Read more >>

Cancer Treat Res Commun (Cancer treatment and research communications)
[2021, 27:100311]

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The potential role of leukoaraiosis in remodeling the brain network to buffer cognitive decline: a Leukoaraiosis And Disability study from Alzheimer's Disease Neuroimaging Initiative.

Wei Chen, Hai Lin, Minrui Lyu, Victoria J Wang, Xiang Li, Shixing Bao, Guoping Sun, Jun Xia, Peijun Wang, ,

<h4>Background</h4>Leukoaraiosis (LA) is a phenomenon of the brain that is often observed in elderly people. However, little is known about the role of LA in cognitive impairment in neurodegeneration and disease. This cross-sectional, retrospective Leukoaraiosis And Disability (LADIS) study aimed to characterize the relationship between brain white matter connectivity properties ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2021, 11(1):183-203]

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Comprehensive preimplantation genetic testing by massively parallel sequencing.

Songchang Chen, Xuyang Yin, Sijia Zhang, Jun Xia, Ping Liu, Pingyuan Xie, Huijuan Yan, Xinming Liang, Junyu Zhang, Yiyao Chen, Hongjun Fei, Lanlan Zhang, Yuting Hu, Hui Jiang, Ge Lin, Fang Chen, Chenming Xu,

<h4>Study question</h4>Can whole genome sequencing (WGS) offer a relatively cost-effective approach for embryonic genome-wide haplotyping and preimplantation genetic testing (PGT) for monogenic disorders (PGT-M), aneuploidy (PGT-A) and structural rearrangements (PGT-SR)?<h4>Summary answer</h4>Reliable genome-wide haplotyping, PGT-M, PGT-A and PGT-SR could be performed by WGS with 10× depth of parental and 4× depth ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2021, 36(1):236-247]

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Effects of dietary iron level on growth performance, haematological status and intestinal function in growing-finishing pigs.

Qingqing Deng, Yancan Wang, Xin Wang, Qiye Wang, Zhenfeng Yi, Jun Xia, Yuyao Hu, Yiming Zhang, Jingjing Wang, Lei Wang, Shuzhong Jiang, Rong Li, Dan Wan, Huansheng Yang, Yulong Yin,

This study investigated the different addition levels of iron (Fe) in growing-finishing pigs and the effect of different Fe levels on growth performance, haematological status, intestinal barrier function, and intestinal digestion. A total of 1,200 barrows and gilts [(Large White × Landrace) × Duroc]with average initial body weight (BW; 27.74 ... Read more >>

J Anim Sci (Journal of animal science)
[2021, :]

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Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes.

Ting Yu, Enze Zheng, Yanping Li, Yuqi Li, Jun Xia, Qiuying Ding, Zhengping Hou, Xiong Z Ruan, Lei Zhao, Yaxi Chen,

Palmitic acid (PA)-induced hepatocyte apoptosis is critical for the progression of nonalcoholic fatty liver disease (NAFLD). Inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) is an intracellular Ca<sup>2+</sup>-release channel and is involved in PA-induced hepatocyte apoptosis. While the expression of IP3R1 is elevated in patients with NAFLD and in hepatocytes treated with ... Read more >>

Exp Cell Res (Experimental cell research)
[2021, 399(2):112438]

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Strengthening and Toughening Hierarchical Nanocellulose via Humidity-Mediated Interface.

YuanZhen Hou, Qing-Fang Guan, Jun Xia, Zhang-Chi Ling, ZeZhou He, Zi-Meng Han, Huai-Bin Yang, Ping Gu, YinBo Zhu, Shu-Hong Yu, HengAn Wu,

Undoubtedly humidity is a non-negligible and sensitive problem for cellulose, which is usually regarded as one disadvantage to cellulose-based materials because of the uncontrolled deformation and mechanical decline. But the lack of an in-depth understanding of the interfacial behavior of nanocellulose in particular makes it challenging to maintain anticipated performance ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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Nonanatomical Reduction of Femoral Neck Fractures in Young Patients (≤65 Years Old) with Internal Fixation Using Three Parallel Cannulated Screws.

Guanglei Zhao, Changquan Liu, Kangming Chen, Jinyang Lyu, Jie Chen, Jingsheng Shi, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Gangyong Huang,

<h4>Purpose</h4>The study is aimed at investigating the association between different reduction classifications (anatomic reduction, positive buttress position reduction, and negative buttress position reduction) and two end points (complications and reoperations).<h4>Methods</h4>The study retrospectively analyzed 110 patients undergoing internal fixation with three parallel cannulated screws from January 2012 to January 2019 in ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:3069129]

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Evaluation of magnetic resonance image segmentation in brain low-grade gliomas using support vector machine and convolutional neural network.

Qifan Yang, Huijuan Zhang, Jun Xia, Xiaoliang Zhang,

<h4>Background</h4>Image segmentation of brain low-grade glioma (LGG) magnetic resonance imaging (MRI) contributes tremendously to diagnosis, classification and treatment of the disease. A tangible, accurate, reliable and fast image segmentation technique is demanded in clinical diagnosis and research.<h4>Methods</h4>The emerging machine learning technique has been demonstrated its unique capability in the field ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2021, 11(1):300-316]

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High-resolution Cell Atlas of Domestic Pig Lung and Online Platform Exploring for Lung Single Cell

Lijing Zhang, Jiacheng Zhu, Haoyu Wang, Jun Xia, Ping Liu, Fang Chen, Hui Jiang, Weiying Wu, Lihua Luo, Dongsheng Chen, Xingliang Zhang,

Due to the comparable organ sizes and physiology to human beings, genetically engineered pig is gradually regarded as an optimal source of human for transplantation and an excellent model for human diseases research. The major barrier between pig and human is mainly cellular heterogeneity and immune incompatibilities. Myriad scRNA-seq data ... Read more >>

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Systematic and Comprehensive Automated Ventricle Segmentation on Ventricle Images of the Elderly Patients: A Retrospective Study.

Xi Zhou, Qinghao Ye, Yinghui Jiang, Minhao Wang, Zhangming Niu, Wade Menpes-Smith, Evandro Fei Fang, Zhi Liu, Jun Xia, Guang Yang,

<b>Background and Objective:</b> Ventricle volume is closely related to hydrocephalus, brain atrophy, Alzheimer's, Parkinson's syndrome, and other diseases. To accurately measure the volume of the ventricles for elderly patients, we use deep learning to establish a systematic and comprehensive automated ventricle segmentation framework. <b>Methods:</b> The study participation included 20 normal ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:618538]

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Preoperative Prognostic Nutritional Index Is Useful Factor for Predicting Postoperative Delirium After Primary Total Joint Arthroplasty

JIE CHEN, JIE Yu, CHAOJUN ZHENG, JINXIU ZHONG, GUANGLEI ZHAO, JINGSHENG SHI, GANGYONG HUANG, YIBIN WEI, SIQUN WANG, JUN XIA,

<h4>Background: </h4> Postoperative delirium (PD), as an acute brain failure, is widely reported as a very common postoperative complication, and it is closely associated with increased morbidity and mortality. Recently, malnutrition is reported as one of the risk factors for PD. The prognostic nutritional index (PNI) is a simple method ... Read more >>

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Can the Preoperative Prognostic Nutrition Index (PNI) Predict Surgical Site Infection Following Primary Total Knee Arthroplasty?

JINGSHENG SHI, JIE YU, JINGDE DENG, CHAOJUN ZHENG, GUANGLEI ZHAO, JUN XIA, YIBIN WEI, GANGYONG HUANG, SIQUN WANG, JIE CHEN,

<h4>Background: </h4> Malnutrition is reported as one of the risk factors for surgical site infection (SSI). The prognostic nutritional index (PNI) is a simple method for nutritional evaluation. However, few studies have discussed the effectiveness of PNI as a nutritional assessment in predicting SSI after primary total knee arthroplasty (TKA). ... Read more >>

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Nitidine chloride suppresses NEDD4 expression in lung cancer cells.

Jing Zhang, Ruoxue Cao, Chaoqun Lian, Tong Cao, Ying Shi, Jia Ma, Peter Wang, Jun Xia,

Nitidine chloride (NC) possesses anticancer properties in various types of human malignancies. However, the effects of NC on lung cancer cells have not been elucidated. Moreover, the molecular mechanism of NC-involved antitumor activity is unclear. Therefore, we aimed to determine the biological effect of NC and the underlying molecular insights ... Read more >>

Aging (Albany NY) (Aging)
[2020, 13(1):782-793]

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Predictive values of the postoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio for the diagnosis of early periprosthetic joint infections: a preliminary study.

Guanglei Zhao, Jie Chen, Jin Wang, Siqun Wang, Jun Xia, Yibing Wei, Jianguo Wu, Gangyong Huang, Feiyan Chen, Jingsheng Shi, Jinyang Lyu, Changquan Liu, Xin Huang,

<h4>Background</h4>Several studies have been conducted to report diagnostic values of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in the many diseases, such as oncological, inflammatory, and some infectious diseases. However, the predictive value of these laboratory parameters for early periprosthetic joint infections (PJIs) has not yet ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2020, 15(1):571]

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Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance.

Tongxin Wang, Kai Chen, Weilei Yao, Ruilong Zheng, Qiongyu He, Jun Xia, Juan Li, Yafei Shao, Li Zhang, Lu Huang, Longshan Qin, Mingming Xu, Zheng Zhang, Dingyu Pan, Zhen Li, Feiruo Huang,

<h4>Background and aims</h4>Lactate has been recently reported to accumulate in the liver with the progression of hepatosteatosis to non-alcoholic steatohepatitis (NASH). However, the underlying mechanism(s) for lactate accumulation and the role of lactate in the NAFLD progression is essentially unknown.<h4>Methods</h4>Acetylome of normal, nonalcoholic fatty liver (NAFL), and nonalcoholic steatohepatitis (NASH) ... Read more >>

J Hepatol (Journal of hepatology)
[2020, :]

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Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis.

Yanchun Li, Jun Xia, Fangchun Shao, Yan Zhou, Jiaqi Yu, Hengyu Wu, Jing Du, Xueying Ren,

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide. The prognosis of HCC remains poor. Currently, sorafenib is the first-line drug for advanced HCC. Although sorafenib's mechanism of action involving several established cancer-related protein kinase targets is well-characterized, the underlying molecular mechanism is still unclear. Here, we ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 534:877-884]

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Comparison of Supervised and Unsupervised Deep Learning Methods for Medical Image Synthesis between Computed Tomography and Magnetic Resonance Images.

Yafen Li, Wen Li, Jing Xiong, Jun Xia, Yaoqin Xie,

Cross-modality medical image synthesis between magnetic resonance (MR) images and computed tomography (CT) images has attracted increasing attention in many medical imaging area. Many deep learning methods have been used to generate pseudo-MR/CT images from counterpart modality images. In this study, we used U-Net and Cycle-Consistent Adversarial Networks (CycleGAN), which ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:5193707]

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Correlation between the subchondral bone marrow lesions and cartilage repair tissue after matrix-associated autologous chondrocyte implantation in the knee: a cross-sectional study.

Jialing Lyu, Yindi Zhang, Weimin Zhu, Dingfu Li, Weiqiang Lin, Kang Chen, Jun Xia, Jun Xia,

<h4>Background</h4>The contribution of the subchondral bone in the development and progression of osteoarthritis (OA) has long been recognized, but its role in cartilage repair procedures has only recently attracted more attention.<h4>Purpose</h4>To explore the correlation between the cartilage repair tissue (RT) and the subchondral bone marrow lesions (BMLs) after matrix-associated autologous ... Read more >>

Acta Radiol (Acta radiologica (Stockholm, Sweden : 1987))
[2020, :284185120969955]

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Critical Factors Facilitating Candidatus Nitrotoga To Be Prevalent Nitrite-Oxidizing Bacteria in Activated Sludge.

Min Zheng, Siqi Li, Gaofeng Ni, Jun Xia, Shihu Hu, Zhiguo Yuan, Yanchen Liu, Xia Huang,

Nitrite oxidation is the primary pathway that generates nitrate in engineered systems. However, little is known about the role of a novel nitrite-oxidizing bacteria (NOB) genus <i>Candidatus</i> Nitrotoga in activated sludge systems. To elucidate key factors that impact NOB community composition, laboratory-scale sequencing batch reactors (SBRs) were designed and operated ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2020, 54(23):15414-15423]

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Idiopathic Normal Pressure Hydrocephalus and Elderly Acquired Hydrocephalus: Evaluation With Cerebrospinal Fluid Flow and Ventricular Volume Parameters.

Wen-Jie He, Xi Zhou, Jia Long, Qi-Zhong Xu, Xian-Jian Huang, Jun Jiang, Jun Xia, Guang Yang,

<h4>Purpose</h4>To investigate differences in cerebrospinal fluid (CSF) flow through the aqueduct and to determine whether there is a relationship between CSF flow and ventricular volume parameters in idiopathic normal pressure hydrocephalus (iNPH) patients, elderly acquired hydrocephalus patients and age-matched healthy volunteers by phase-contrast MR (PC-MR).<h4>Methods</h4>A total of 40 iNPH patients ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:584842]

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Predictive value of adipose to muscle area ratio based on MRI at knee joint for postoperative functional outcomes in elderly osteoarthritis patients following total knee arthroplasty.

Guanglei Zhao, Changquan Liu, Kangming Chen, Feiyan Chen, Jinyang Lyu, Jie Chen, Jingsheng Shi, Gangyong Huang, Yibing Wei, Siqun Wang, Jun Xia,

<h4>Background</h4>The current research used a new index-adipose to muscle area ratio (AMR)-to measure fatness compared with body mass index (BMI) in elderly osteoarthritis (OA) patients following total knee arthroplasty. Our study aimed to test the relationship between the two indexes (AMR and BMI) and to examine whether AMR was a ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2020, 15(1):494]

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Co-Expression of Stem Cell and Epithelial Mesenchymal Transition Markers in Circulating Tumor Cells of Bladder Cancer Patients.

Ruiyun Zhang, Jun Xia, Yiqiu Wang, Ming Cao, Di Jin, Wei Xue, Yiran Huang, Haige Chen,

<h4>Objective</h4>Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT) features display enhanced malignant and metastatic potential. This study aimed to introduce a new methodology developed in order to investigate the co-expression of a stemness (OCT4) and EMT markers on single circulating tumor cells (CTCs) of patients with localized urinary bladder cancer ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:10739-10748]

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