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Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report.

Yi Bao, Shu Yu Lin, Zhao Hui Cheng, Jun Xia, Yan Peng Sun, Qi Zhao, Guang Jian Liu,

COVID-19 is currently a pandemic in the world, can invade multiple systems, and has a high morbidity and mortality. So far, no cases of acute cerebrovascular disease have been reported. This article reports the clinical features of a COVID-19 patient whose first symptom was cerebral hemorrhage. More importantly, after the ... Read more >>

SN Compr Clin Med (Sn Comprehensive Clinical Medicine)
[0, :1-7]

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Dehydration impeding ionic conductance through two-dimensional angstrom-scale slits.

YanZi Yu, JingCun Fan, Jun Xia, YinBo Zhu, HengAn Wu, FengChao Wang,

There has been long-standing academic interest in the study of ion transport in nanochannel systems, owing to its vast implications in understanding the nature of numerous environmental, biological and chemical processes. Here, we investigate ion transport through two-dimensional slits using molecular dynamics simulations. These slits with angstrom-scale height dimensions can ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(17):8449-8457]

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Innovation Strategy Selection Facilitates High-Performance Flexible Piezoelectric Sensors.

Shengshun Duan, Jun Wu, Jun Xia, Wei Lei,

Piezoelectric sensors with high performance and low-to-zero power consumption meet the growing demand in the flexible microelectronic system with small size and low power consumption, which are promising in robotics and prosthetics, wearable devices and electronic skin. In this review, the development process, application scenarios and typical cases are discussed. ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(10):]

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Clinical Features of COVID‐19 in a Young Man with Massive Cerebral Hemorrhage: Case Report

Yi Bao, Shu Yu Lin, Zhao Hui Cheng, Jun Xia, Yan Peng Sun, Qi Zhao, Guang Jian Liu,

Abstract COVID-19 is currently a pandemic in the world, can invade multiple systems, and has a high morbidity and mortality. So far, no cases of acute cerebrovascular disease have been reported. This article reports the clinical features of a COVID-19 patient whose first symptom was cerebral hemorrhage. More importantly, after ... Read more >>

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Glucocorticoid therapy delays the clearance of SARS-CoV-2 RNA in an asymptomatic COVID-19 patient.

Shu-Qing Ma, Jing Zhang, Yu-Shan Wang, Jun Xia, Peng Liu, Hong Luo, Ming-Yi Wang,

The outbreak of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) started in Wuhan China, has become a global health concern. At present, glucocorticoid therapy is one of the most typically controversial treatments with COVID-19 patients. Here, we reported an asymptomatic COVID-19 patient with persistent positive detection of SARS-CoV-2 for 3 ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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A single-center, retrospective study of COVID-19 features in children: a descriptive investigation.

Huijing Ma, Jiani Hu, Jie Tian, Xi Zhou, Hui Li, Maxwell Thomas Laws, Luke David Wesemann, Baiqi Zhu, Wei Chen, Rafael Ramos, Jun Xia, Jianbo Shao,

BACKGROUND:Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of computerized tomography (CT) lesions, and the role of CT in evaluating clinical recovery. The objective of this study ... Read more >>

BMC Med (BMC Medicine)
[2020, 18(1):123]

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Unidirectional and Selective Proton Transport in Artificial Heterostructured Nanochannels with Nano-to-Subnano Confined Water Clusters.

Xingya Li, Huacheng Zhang, Hao Yu, Jun Xia, Yin-Bo Zhu, Heng-An Wu, Jue Hou, Jun Lu, Ranwen Ou, Christopher D Easton, Cordelia Selomulya, Matthew R Hill, Lei Jiang, Huanting Wang,

The construction of biological proton channel analogues has attracted substantial interest owing to their wide potential in separation of ions, sensing, and energy conversion. Here, metal-organic framework (MOF)/polymer heterogeneous nanochannels are presented, in which water molecules are confined to disordered clusters in the nanometer-sized polymer regions and to ordered chains ... Read more >>

Adv. Mater. Weinheim (Advanced materials (Deerfield Beach, Fla.))
[2020, :e2001777]

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One-step utilization of inulin for docosahexaenoic acid (DHA) production by recombinant Aurantiochytrium sp. carrying Kluyveromyces marxianus inulinase.

Xin-Jun Yu, Zhi-Peng Wang, Miao-Jie Liang, Zhao Wang, Xiao-Yan Liu, Lei Hu, Jun Xia,

This study aimed to express an inulinase gene from the yeast Kluyveromyces marxianus (KmINU) in Aurantiochytrium sp. and realized one-step utilization of inulin resource for DHA production without any chemical pretreatment. An expression cassette with a length of 6052 bp for expressing the inulinase gene was constructed by a fast two-step ... Read more >>

Bioprocess Biosyst Eng (Bioprocess and biosystems engineering)
[2020, :]

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Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.

Haibo Liu, Haiyan Yu, Jun Xia, Ling Liu, Guan J Liu, Hong Sang, Frank Peinemann,

BACKGROUND:Acne is an inflammatory disorder with a high global burden. It is common in adolescents and primarily affects sebaceous gland-rich areas. The clinical benefit of the topical acne treatments azelaic acid, salicylic acid, nicotinamide, sulphur, zinc, and alpha-hydroxy acid is unclear. OBJECTIVES:To assess the effects of topical treatments (azelaic acid, ... Read more >>

Cochrane Database Syst Rev (The Cochrane Database of Systematic Reviews)
[2020, 5:CD011368]

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Predictive value of postoperative NLR, PLR and LMR for early periprosthetic joint infection after total joint arthroplasty: a pilot study

Guang lei Zhao, Jie Chen, Jin Wang, Siqun Wang, Jun Xia, Yibing Wei, Jianguo Wu, Gangyong Huang, Feiyan Chen, Jingsheng Shi, Xin Huang,

Abstract Background: The purpose of this study was to evaluate the predictive value of the postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) for early periprosthetic joint infection (PJI). Methods : During the period from January 2008 to December 2016, 104 patients (26 early PJI cases and ... Read more >>

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Assessment of aquatic ecological health based on determination of biological community variability of fish and macroinvertebrates in the Weihe River Basin, China.

Jintao Wu, Ruichen Mao, Mingyue Li, Jun Xia, Jingxi Song, Dandong Cheng, Haotian Sun,

A healthy aquatic ecosystem plays an important role in the operation of nature and the survival of human beings. Understanding the mechanism of its interaction with the habitat process is conducive to formulating targeted ecological recovery plans. In this study, fish and macroinvertebrates were collected from 49 investigation sites in ... Read more >>

J. Environ. Manage. (Journal of environmental management)
[2020, 267:110651]

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Harnessing artificial intelligence (AI) to increase wellbeing for all: The case for a new technology diplomacy.

Claudio Feijóo, Youngsun Kwon, Johannes M Bauer, Erik Bohlin, Bronwyn Howell, Rekha Jain, Petrus Potgieter, Khuong Vu, Jason Whalley, Jun Xia,

The field of artificial intelligence (AI) is experiencing a period of intense progress due to the consolidation of several key technological enablers. AI is already deployed widely and has a high impact on work and daily life activities. The continuation of this process will likely contribute to deep economic and ... Read more >>

Telecomm Policy (Telecommunications policy)
[2020, :101988]

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Optimization and validation of patient-based real-time quality control procedure using moving average and average of normals with multi-rules for TT3, TT4, FT3, FT3, and TSH on three analyzers.

Chao Song, Jun Zhou, Jun Xia, Deli Ye, Qian Chen, Weixing Li,

BACKGROUND:We have designed a patient-based real-time quality control (PBRTQC) procedure to detect analytical shifts and review analytical trends of measurement procedures. METHODS:All the nine months' patient results of total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin (TSH) measured by three identical analyzers were divided ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, :e23314]

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One-step utilization of non-detoxified pretreated lignocellulose for enhanced cellulolytic enzyme production using recombinant Trichoderma reesei RUT C30 carrying alcohol dehydrogenase and nicotinate phosphoribosyltransferase.

Jianlong He, Xiaoyan Liu, Jun Xia, Jiaxing Xu, Peng Xiong, Zhongyang Qiu,

Cell growth of Trichoderma reesei is greatly inhibited by furan derivatives (furfural and HMF) generated during pretreatment of lignocellulose, and the cellulase production is hence suppressed. In this study, a novel recombinant strain of T. reesei with high tolerance to furans was constructed by homologously co-expressing nicotinate phosphoribosyltransferase and alcohol ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 310:123458]

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Novel Coronavirus International Public Health Emergency: Guidance on Radiation Oncology Facility Operation.

Wei Chen, Xiao-Ye Su, Victoria J Wang, Edina C Wang, Ruizhen Xu, Shiyan Zhong, Guoping Sun, Jun Xia,

Adv Radiat Oncol (Advances in radiation oncology)
[2020, :]

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Prevalence of comorbidities and risk factors in spondyloarthritis: results of a cross-sectional study.

Yupeng Lai, Yanpeng Zhang, Shaozhen Mo, Jinsheng Ma, Tongxin Ni, Zhihao Lei, Jun Xia, Chiduo Xu,

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, :]

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Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.

Blanca Pijuan-Sala, Nicola K Wilson, Jun Xia, Xiaomeng Hou, Rebecca L Hannah, Sarah Kinston, Fernando J Calero-Nieto, Olivier Poirion, Sebastian Preissl, Feng Liu, Berthold Göttgens,

During mouse embryonic development, pluripotent cells rapidly divide and diversify, yet the regulatory programs that define the cell repertoire for each organ remain ill-defined. To delineate comprehensive chromatin landscapes during early organogenesis, we mapped chromatin accessibility in 19,453 single nuclei from mouse embryos at 8.25 days post-fertilization. Identification of cell-type-specific ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2020, 22(4):487-497]

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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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Identification of Frataxin as a regulator of ferroptosis.

Jing Du, Yi Zhou, Yanchun Li, Jun Xia, Yongjian Chen, Sufeng Chen, Xin Wang, Weidong Sun, Tongtong Wang, Xueying Ren, Xu Wang, Yihan An, Kang Lu, Wanye Hu, Siyuan Huang, Jianghui Li, Xiangmin Tong, Ying Wang,

Ferroptosis is a newly discovered form of non-apoptotic regulated cell death and is characterized by iron-dependent and lipid peroxidation. Due to the enhanced dependence on iron in cancer cells, induction of ferroptosis is becoming a promising therapeutic strategy. However, the precise underlying molecular mechanism and regulation process of ferroptosis remains ... Read more >>

Redox Biol (Redox Biology)
[2020, 32:101483]

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The effect of dietary garcinol supplementation on oxidative stability, muscle postmortem glycolysis and meat quality in pigs

Tongxin Wang, Juan Li, Yafei Shao, Weilei Yao, Jun Xia, Qiongyu He, Feiruo Huang,

The objective of this study was to evaluate the effects of dietary garcinol (0, 200, 400 and 600 mg/kg) on the growth performance, meat quality, postmortem glycolysis and antioxidative capacity of finishing pigs. Dietary garcinol increased pigs' average daily gain, pH 24h, a* and myoglobin content of longissimus dorsi (LM) ... Read more >>

Meat Sci. (Meat science)
[2020, 161:Not Available]

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Reply to Zhang et al.: Using long-term all-available Landsat data to study water bodies over large areas represents a paradigm shift.

Shuailong Feng, Shuguang Liu, Zhihong Huang, Lei Jing, Meifang Zhao, Xi Peng, Wende Yan, Yiping Wu, Yihe Lv, Andrew R Smith, Morag A McDonald, Sopan D Patil, Arbi J Sarkissian, Zhihua Shi, Jun Xia, U S Ogbodo,

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(12):6310-6311]

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Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets.

Tongxin Wang, Weilei Yao, Juan Li, Yafei Shao, Qiongyu He, Jun Xia, Feiruo Huang,

Background:The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated. Method:One hundred forty four weaned piglets (Duroc × Yorkshire × Landrace) from 16 pens (9 piglets per pen) were randomly divided into four treatment groups: controls (CON) ... Read more >>

J Anim Sci Biotechnol (Journal of Animal Science and Biotechnology)
[2020, 11:12]

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Adding evidence of the effects of treatments into relevant Wikipedia pages: a randomised trial.

Clive E Adams, Alan A Montgomery, Tony Aburrow, Sophie Bloomfield, Paul M Briley, Ebun Carew, Suravi Chatterjee-Woolman, Ghalia Feddah, Johannes Friedel, Josh Gibbard, Euan Haynes, Mohsin Hussein, Mahesh Jayaram, Samuel Naylor, Luke Perry, Lena Schmidt, Umer Siddique, Ayla Serena Tabaksert, Douglas Taylor, Aarti Velani, Douglas White, Jun Xia,

OBJECTIVES:To investigate the effects of adding high-grade quantitative evidence of outcomes of treatments into relevant Wikipedia pages on further information-seeking behaviour by the use of routinely collected data. SETTING:Wikipedia, Cochrane summary pages and the Cochrane Library. DESIGN:Randomised trial. PARTICIPANTS:Wikipedia pages which were highly relevant to up-to-date Cochrane Schizophrenia systematic reviews ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e033655]

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Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs.

Wenxiao Jiang, Jun Xia, Shangdan Xie, Ruanmin Zou, Shuya Pan, Zhi-Wei Wang, Yehuda G Assaraf, Xueqiong Zhu,

Chemoresistance including intrinsic and acquired anticancer drug resistance continues to be a primary hindrance towards curative cancer treatment. Therefore, deciphering the underlying molecular mechanisms is of paramount importance required towards the overcoming of chemoresistance. Cumulative evidence revealed that long non-coding RNAs (lncRNAs) play a pivotal role in conferring anticancer drug ... Read more >>

Drug Resist. Updat. (Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy)
[2020, 50:100683]

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PROTACs: A novel strategy for cancer therapy.

Jing Liu, Jia Ma, Yi Liu, Jun Xia, Yuyun Li, Z Peter Wang, Wenyi Wei,

Chemotherapeutic strategy has been widely used for treating malignance by targeting irregular expressed or mutant proteins with small molecular inhibitors (SMIs) or monoclonal antibodies (mAbs). However, most intracellular proteins lack of active sites or antigens where SMIs or mAbs bind with, and are called as non-druggable targets for a long ... Read more >>

Semin. Cancer Biol. (Seminars in cancer biology)
[2020, :]

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