Full Text Journal Articles by
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Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors.

Dong-Jun Fu, Si-Meng Liu, Fu-Hao Li, Jia-Jia Yang, Jun Li,

Tubulin polymerisation inhibitors exhibited an important role in the treatment of patients with prostate cancer. Herein, we reported the medicinal chemistry efforts leading to a new series of benzothiazoles by a bioisosterism approach. Biological testing revealed that compound 12a could significantly inhibit in vitro tubulin polymerisation of a concentration dependent manner, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1050-1059]

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Recent advances in soft functional materials: preparation, functions and applications.

Jun Li, Wai-Yeung Wong, Xiao-Ming Tao,

Synthetic materials and biomaterials with elastic moduli lower than 10 MPa are generally considered as soft materials. Research studies on soft materials have been boosted due to their intriguing features such as light-weight, low modulus, stretchability, and a diverse range of functions including sensing, actuating, insulating and transporting. They are ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):1281-1306]

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Mechanistic molecular responses of the giant clam Tridacna crocea to Vibrio coralliilyticus challenge.

Duo Xu, Zehui Zhao, Zihua Zhou, Yue Lin, Xiangyu Zhang, Yang Zhang, Yuehuan Zhang, Jun Li, Fan Mao, Shu Xiao, Haitao Ma, Xiang Zhiming, Ziniu Yu,

Vibrio coralliilyticus is a pathogen of coral and mollusk, contributing to dramatic losses worldwide. In our study, we found that V. coralliilyticus challenge could directly affect adult Tridacna crocea survival; there were dead individuals appearing at 6 h post infection, and there were 45.56% and 56.78% mortality rates in challenged ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0231399]

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A water-stable zinc(ii)-organic framework as a multiresponsive luminescent sensor for toxic heavy metal cations, oxyanions and organochlorine pesticides in aqueous solution.

Xiao-Qing Wang, Dou-Dou Feng, Jing Tang, Yu-Di Zhao, Jun Li, Jie Yang, Chan Kyung Kim, Feng Su,

A novel metal-organic framework with the formula [Zn3(DDB)(DPE)]·H2O (1) (H5DDB = 3,5-di(2',4'-dicarboxylphenyl)benzoic acid and DPE = 1,2-di(4-pyridyl)ethylene) has been solvothermally synthesized by employing a rigid carboxylate ligand H5DDB to assemble with Zn(ii) ions in the presence of a flexible bis(pyridyl) linker DPE. The Zn-MOF is a 3D framework with six-nuclear ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(44):16776-16785]

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Exogenous-oxidant- and catalyst-free electrochemical deoxygenative C2 sulfonylation of quinoline N-oxides.

Minbao Jiang, Yong Yuan, Tao Wang, Yunkui Xiong, Jun Li, Huijiao Guo, Aiwen Lei,

An exogenous-oxidant- and catalyst-free electrochemical deoxygenative C2 sulfonylation reaction has been achieved. By employing quinoline N-oxides as the starting materials, the electrochemical C-H sulfonylation of electron-deficient quinolines was indirectly achieved at room temperature and a variety of sulfonylated quinoline derivatives were synthesized in modest to high yield with excellent regioselectivity. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(92):13852-13855]

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An accurate full-dimensional permutationally invariant potential energy surface for the interaction between H2O and CO.

Yang Liu, Jun Li,

The interaction between H2O and CO has been the subject of numerous experimental and theoretical investigations for a long time due to their important roles in various environments, such as the atmosphere, combustion of hydrocarbons, and the interstellar medium. In this work, the first full-dimensional accurate potential energy surface (PES) ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(43):24101-24111]

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Effects of stage I hypertension on the recovery of early postoperative attention network function in elderly patients undergoing elective hip or knee arthroplasty surgery

Dan Zhao, Jun Li, Rui Yang, Guanghong Xu,

Background/aim:Hypertension is an important risk factor for cognitive impairment. This study explored whether elderly patients with stage I hypertension (HPs) and normotensive patients (NPs) showed differences in the recovery of postoperative attention network function according to the attentional network test (ANT) performance. Materials and methods:Of 110 patients screened, 25 HPs ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(1):37-43]

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Self-supported nickel iron oxide nanospindles with high hydrophilicity for efficient oxygen evolution.

Jinlong Liu, Huimin Yuan, Zhenyu Wang, Jun Li, Mingyang Yang, Lujie Cao, Guiyu Liu, Dong Qian, Zhouguang Lu,

Engineering nanoarray structures with favorable hydrophilicity is proposed to unlock the electrocatalysis of NiFe2O4 for the oxygen evolution reaction (OER). The resulting electrode, consisting of NiFe2O4 nanospindles directly grown on FeNi3 foam, features enlarged active surface area, high hydrophilicity and increased electronic conductivity, which achieves superior OER activity and remarkable ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(73):10860-10863]

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Probing the structures and bonding of size-selected boron and doped-boron clusters.

Tian Jian, Xuenian Chen, Si-Dian Li, Alexander I Boldyrev, Jun Li, Lai-Sheng Wang,

Because of their interesting structures and bonding and potentials as motifs for new nanomaterials, size-selected boron clusters have received tremendous interest in recent years. In particular, boron cluster anions (Bn-) have allowed systematic joint photoelectron spectroscopy and theoretical studies, revealing predominantly two-dimensional structures. The discovery of the planar B36 cluster ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2019, 48(13):3550-3591]

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Two-dimensional bimetallic phosphide ultrathin nanosheets as non-noble electrocatalysts for a highly efficient oxygen evolution reaction.

Min Jiang, Jun Li, Junming Li, Yu Zhao, Lijia Pan, Qingqi Cao, Dunhui Wang, Youwei Du,

Highly efficient non-noble metal oxygen evolution reaction (OER) catalysts are urgently needed for the practical application of electrochemical energy technology. Herein, we report two-dimensional (2D) bimetallic phosphide (Co1-xFexP) ultrathin nanosheets as new OER catalysts. The two-dimensional (2D) morphology of the nanosheets and the synergistic effect between different transition-metal elements made ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(19):9654-9660]

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Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.

Zhan Zhou, Xiaojuan Chen, Ying Fu, Ye Zhang, Shuyan Dai, Jun Li, Lin Chen, Guangyu Xu, Zhuchu Chen, Yongheng Chen,

Biochemical and structural studies provide information on the mode of action of FGF401 as a selective, reversible covalent inhibitor of FGFR4. Kinase and proliferation assays reveal that FGF401 has the ability to overcome gatekeeper mutations in FGFR4. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(42):5890-5893]

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Triple bonds between iron and heavier group-14 elements in the AFe(CO)3- complexes (A = Ge, Sn, and Pb).

Jia-Qi Wang, Chaoxian Chi, Jun-Bo Lu, Luyan Meng, Mingbiao Luo, Han-Shi Hu, Mingfei Zhou, Jun Li,

Heteronuclear transition-metal-main-group element carbonyl anion complexes of AFe(CO)3- (A = Ge, Sn, and Pb) are prepared using a laser vaporization supersonic ion source in the gas phase, which were studied by mass-selected infrared (IR) photodissociation spectroscopy. The geometric and electronic structures of the experimentally observed species are identified by a ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(40):5685-5688]

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A critical comparison of neural network potentials for molecular reaction dynamics with exact permutation symmetry.

Jun Li, Kaisheng Song, Jörg Behler,

The availability of accurate full-dimensional potential energy surfaces (PESs) is a mandatory condition for efficient computer simulations of molecular systems. Much effort has been devoted to developing reliable PESs with physically sound properties, such as the invariance of the energy with respect to the permutation of chemically identical atoms. In ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(19):9672-9682]

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Overexpression of IL-8 in patients with abdominal tumor after radiotherapy leads to ureteral obstructive renal dysfunction: a case-control study

Liang Bai, Li Luo, Weicheng Gao, Chenfeng Bu, Jun Li, Huang Liu,

Abstract Purpose: To analyze the expression of interleukin-8 in patients with post-renal insufficiency after radiotherapy of abdominal tumors.Methods: 60 patients (experimental group) with post-renal insufficiency and 30 patients (control group) without renal insufficiency after the radiotherapy for abdominal tumors were collected for case-control study. Serum interleukin-8 levels were measured before ... Read more >>

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Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection during late pregnancy: A Report of 18 patients from Wuhan, China

Lu Zhang, Lan Dong, Lei Ming, Min Wei, Jun Li, Ruheng Hu, Jing Yang,

Abstract Background: Compared with Severe Acute Respiratory Syndrome(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with ... Read more >>

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Whole exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease.

Karl Desch, Ayse Bilge Ozel, Matt Halvorsen, Paula M Jacobi, Krista L Golden, Mary I Underwood, Marine Germain, David-Alexandre Trégouët, Pieter H Reitsma, Clive Kearon, Lauren Mokry, Brent Richards, Frances Williams, Jun Li, David B Goldstein, David Ginsburg,

Deep vein thrombosis and pulmonary embolism, collectively defined as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in the United States. Common genetic variants conferring increased varying degrees of VTE risk have been identified by genome-wide association studies (GWAS). Rare mutations in the anticoagulant genes PROC, PROS1 ... Read more >>

Blood (Blood)
[2020, :]

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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.

Bo Shen, Xiao Yi, Yaoting Sun, Xiaojie Bi, Juping Du, Chao Zhang, Sheng Quan, Fangfei Zhang, Rui Sun, Liujia Qian, Weigang Ge, Wei Liu, Shuang Liang, Hao Chen, Ying Zhang, Jun Li, Jiaqin Xu, Zebao He, Baofu Chen, Jing Wang, Haixi Yan, Yufen Zheng, Donglian Wang, Jiansheng Zhu, Ziqing Kong, Zhouyang Kang, Xiao Liang, Xuan Ding, Guan Ruan, Nan Xiang, Xue Cai, Huanhuan Gao, Lu Li, Sainan Li, Qi Xiao, Tian Lu, Yi Zhu, Huafen Liu, Haixiao Chen, Tiannan Guo,

Proteomic and metabolomic analysis of COVID-19 sera identifies differentially expressed factors that correlate with disease severity and highlight dysregulation of multiple immune and metabolic components in clinically severe patients. ... Read more >>

Cell (Cell)
[0, :]

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Author Correction: Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes.

Andrea Cortese, Yi Zhu, Adriana P Rebelo, Sara Negri, Steve Courel, Lisa Abreu, Chelsea J Bacon, Yunhong Bai, Dana M Bis-Brewer, Enrico Bugiardini, Elena Buglo, Matt C Danzi, Shawna M E Feely, Alkyoni Athanasiou-Fragkouli, Nourelhoda A Haridy, , Rosario Isasi, Alaa Khan, Matilde Laurà, Stefania Magri, Menelaos Pipis, Chiara Pisciotta, Eric Powell, Alexander M Rossor, Paola Saveri, Janet E Sowden, Stefano Tozza, Jana Vandrovcova, Julia Dallman, Elena Grignani, Enrico Marchioni, Steven S Scherer, Beisha Tang, Zhiqiang Lin, Abdullah Al-Ajmi, Rebecca Schüle, Matthis Synofzik, Thierry Maisonobe, Tanya Stojkovic, Michaela Auer-Grumbach, Mohamed A Abdelhamed, Sherifa A Hamed, Ruxu Zhang, Fiore Manganelli, Lucio Santoro, Franco Taroni, Davide Pareyson, Henry Houlden, David N Herrmann, Mary M Reilly, Michael E Shy, R Grace Zhai, Stephan Zuchner,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat. Genet. (Nature genetics)
[2020, :]

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MicroRNA-708 modulates Hepatic Stellate Cells activation and enhances extracellular matrix accumulation via direct targeting TMEM88.

Tao Xu, Linxin Pan, Liangyun Li, Shuang Hu, Hong Zhou, Chenchen Yang, Junfa Yang, Haodong Li, Yuming Liu, Xiaoming Meng, Jun Li,

Transmembrane protein 88 (TMEM88) is a potential 2-transmembrane-type protein that interacts with the PDZ domain of Dishevelled-1 (DVL-1), a crucial component of Wnt signalling pathway through its C-terminal Val-Trp-Val (VWV) motif in Xenopus embryo cells. Since the significant function of β-catenin in liver fibrosis, it is urgent to study the ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β-catenin signalling pathway.

Yu Chen, Xin Chen, Ya-Ru Ji, Sai Zhu, Fang-Tian Bu, Xiao-Sa Du, Xiao-Ming Meng, Cheng Huang, Jun Li,

As an outcome of chronic liver disease, liver fibrosis involves the activation of hepatic stellate cells (HSCs) caused by a variety of chronic liver injuries. It is important to explore approaches to inhibit the activation and proliferation of HSCs for the treatment of liver fibrosis. PLK1 is overexpressed in many ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

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Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer.

Chen Hu, Yu Bai, Jun Li, Guoyin Zhang, Libo Yang, Chengwei Bi, Bin Zhao, Yong Yang, Ruiqian Li, Hongyi Wu, Qilin Wang, Yang Qin,

BACKGROUND:Penile squamous cell carcinoma (PSCC) represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of ... Read more >>

BMC Urol (BMC urology)
[2020, 20(1):57]

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Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Chen Hu, Yu Bai, Jun Li, Guoyin Zhang, Libo Yang, Chengwei Bi, Bin Zhao, Yong Yang, Ruiqian Li, Hongyi Wu, Qilin Wang, Yang Qin,

Abstract Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% ... Read more >>

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A membrane-less direct formate fuel cell using a Fe-N-doped bamboo internode as the binder-free and monolithic air-breathing cathode.

Linghan Lan, Wei Yang, Jun Li, Liang Zhang, Qian Fu, Qiang Liao,

Commercial applications of direct liquid fuel cell require a high-performance, cost-effective, robust, and mechanically/chemically stable cathode for oxygen reduction reaction. In this study, a membrane-less direct formate fuel cell (DFFC) was constructed by using a Fe-N-doped bamboo internode as the binder-free and monolithic air-breathing cathode and a Pd-electrodeposited graphite rod ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Prevention and control of COVID-19 in neurointerventional surgery: expert consensus from the Chinese Federation of Interventional and Therapeutic Neuroradiology (CFITN) and the International Society for Neurovascular Disease (ISNVD).

Yingkun He, Tao Hong, Meiyun Wang, Liqun Jiao, Yulin Ge, E Mark Haacke, Tianxiao Li, Zhang Hongqi, ,

J Neurointerv Surg (Journal of neurointerventional surgery)
[2020, :]

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Prevalence and risk factors of myopia in Han and Yugur older adults in Gansu, China: a cross-sectional study.

Xuqian Wang, Huijing He, Xuejiao Wang, Guangliang Shan, Zhiyan Tao, Li Pan, Jun Li, Xiaolan Ren, Hongjun Zhao, Zhouxian Pan, Meng Wang, Yong Zhong, Jin Ma,

Few studies have investigated the prevalence of myopia in Northwest China. This cross-sectional study aimed to investigate the prevalence and associated factors of myopia and high myopia in adults aged 40-80 years in the Han and Yugur populations living in Gansu Province, Northwest China. A total of 3,845 participants were ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8249]

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