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Author Julie Di Bernardo

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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

Cited: 0 times

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A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

Mass spectrometry-based discovery proteomics is an essential tool for the proximal readout of cellular drug action. Here, we apply a robust proteomic workflow to rapidly profile the proteomes of five lung cancer cell lines in response to more than 50 drugs. Integration of millions of quantitative protein-drug associations substantially improved ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1111-1119]

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Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair.

Juan C Biancotti, Kendal A Walker, Guihua Jiang, Julie Di Bernardo, Lonnie D Shea, Shaun M Kunisaki,

Studying how the fetal spinal cord regenerates in an ex vivo model of spina bifida repair may provide insights into the development of new tissue engineering treatment strategies to better optimize neurologic function in affected patients. Here, we developed hydrogel surgical patches designed for prenatal repair of myelomeningocele defects and ... Read more >>

(Journal of tissue engineering)
[2020, 11:2041731420943833]

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Human Cardiomyocytes Prior to Birth by Integration-Free Reprogramming of Amniotic Fluid Cells.

Guihua Jiang, Todd J Herron, Julie Di Bernardo, Kendal A Walker, K Sue O'Shea, Shaun M Kunisaki,

: The establishment of an abundant source of autologous cardiac progenitor cells would represent a major advance toward eventual clinical translation of regenerative medicine strategies in children with prenatally diagnosed congenital heart disease. In support of this concept, we sought to examine whether functional, transgene-free human cardiomyocytes (CMs) with potential ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2016, 5(12):1595-1606]

Cited: 7 times

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Anoctamin 1 is apically expressed on thyroid follicular cells and contributes to ATP- and calcium-activated iodide efflux.

Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J Rhoden,

BACKGROUND/AIMS:Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified. A calcium-activated pathway of iodide efflux has long been recognized, but its molecular identity unknown. Anoctamin 1 (ANO1) is a calcium-activated chloride ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2014, 34(3):966-980]

Cited: 11 times

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Human transgene-free amniotic-fluid-derived induced pluripotent stem cells for autologous cell therapy.

Guihua Jiang, Julie Di Bernardo, Michael M Maiden, Luis G Villa-Diaz, Omar S Mabrouk, Paul H Krebsbach, K Sue O'Shea, Shaun M Kunisaki,

The establishment of a reliable prenatal source of autologous, transgene-free progenitor cells has enormous potential in the development of regenerative-medicine-based therapies for infants born with devastating birth defects. Here, we show that a largely CD117-negative population of human amniotic fluid mesenchymal stromal cells (AF-MSCs) obtained from fetuses with or without ... Read more >>

Stem Cells Dev. (Stem cells and development)
[2014, 23(21):2613-2625]

Cited: 15 times

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Amniotic fluid derived mesenchymal stromal cells augment fetal lung growth in a nitrofen explant model.

Julie Di Bernardo, Michael M Maiden, Marc B Hershenson, Shaun M Kunisaki,

Recent experimental work suggests the therapeutic role of mesenchymal stromal cells (MSCs) during lung morphogenesis. The purpose of this study was to investigate the potential paracrine effects of amniotic fluid-derived MSCs (AF-MSCs) on fetal lung growth in a nitrofen explant model.Pregnant Sprague-Dawley dams were gavage fed nitrofen on gestational day ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2014, 49(6):859-64; discussion 864-5]

Cited: 6 times

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Paracrine regulation of fetal lung morphogenesis using human placenta-derived mesenchymal stromal cells.

Julie Di Bernardo, Michael M Maiden, Guihua Jiang, Marc B Hershenson, Shaun M Kunisaki,

BACKGROUND: Recent experimental work suggests the therapeutic role of mesenchymal stromal cells (MSC) during perinatal lung morphogenesis. The purpose of this study was to investigate the potential paracrine effects of human placenta-derived mesenchymal stromal cells (PL-MSCs) on pulmonary development. METHODS: Human MSCs were isolated from preterm placental chorion. Normal E14.5-15.5 ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2014, 190(1):255-263]

Cited: 9 times

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Induced pluripotent stem cells from human placental chorion for perinatal tissue engineering applications.

Guihua Jiang, Julie Di Bernardo, Cynthia J DeLong, André Monteiro da Rocha, K Sue O'Shea, Shaun M Kunisaki,

The reliable derivation of induced pluripotent stem cells (iPSCs) from a noninvasive autologous source at birth would facilitate the study of patient-specific in vitro modeling of congenital diseases and would enhance ongoing efforts aimed at developing novel cell-based treatments for a wide array of fetal and pediatric disorders. Accordingly, we ... Read more >>

Tissue Eng Part C Methods (Tissue engineering. Part C, Methods)
[2014, 20(9):731-740]

Cited: 5 times

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Intracellular anion fluorescence assay for sodium/iodide symporter substrates.

Julie Di Bernardo, Carmela Iosco, Kerry J Rhoden,

The sodium/iodide symporter (NIS) is primarily responsible for iodide accumulation in the thyroid gland for the synthesis of thyroid hormones; however, it can also transport other lyotropic anions in the thyroid gland and nonthyroid tissues. Some NIS substrates have important physiological or clinical roles, and others are environmental contaminants with ... Read more >>

Anal. Biochem. (Analytical biochemistry)
[2011, 415(1):32-38]

Cited: 8 times

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Perchlorate transport and inhibition of the sodium iodide symporter measured with the yellow fluorescent protein variant YFP-H148Q/I152L.

Stefano Cianchetta, Julie di Bernardo, Giovanni Romeo, Kerry J Rhoden,

Perchlorate is an environmental contaminant that impairs thyroid function by interacting with the sodium iodide symporter (NIS), the transporter responsible for iodide uptake in the thyroid gland. Perchlorate is well known as a competitive inhibitor of iodide transport by NIS, and recent evidence demonstrates that NIS can also transport perchlorate. ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2010, 243(3):372-380]

Cited: 14 times

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Interaction proteomics of the HMGA chromatin architectural factors.

Riccardo Sgarra, Cristina Furlan, Salvina Zammitti, Alessandra Lo Sardo, Elisa Maurizio, Julie Di Bernardo, Vincenzo Giancotti, Guidalberto Manfioletti,

The high mobility group A (HMGA) chromatin architectural transcription factors are a group of proteins involved in development and neoplastic transformation. They take part in an articulated interaction network, both with DNA and other nuclear proteins, organizing multimolecular complexes at chromatin level. Here, we report the development of a novel ... Read more >>

Proteomics (Proteomics)
[2008, 8(22):4721-4732]

Cited: 15 times

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Discovering high mobility group A molecular partners in tumour cells.

Riccardo Sgarra, Michela A Tessari, Julie Di Bernardo, Alessandra Rustighi, Paola Zago, Sabrina Liberatori, Alessandro Armini, Luca Bini, Vincenzo Giancotti, Guidalberto Manfioletti,

DNA-based activities rely on an extremely coordinated sequence of events performed by several chromatin-associated proteins which act in concert. High Mobility Group A (HMGA) proteins are non-histone architectural nuclear factors that participate in the regulation of specific genes but they are also believed to have a more general role in ... Read more >>

Proteomics (Proteomics)
[2005, 5(6):1494-1506]

Cited: 25 times

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Differential HMGA expression and post-translational modifications in prostatic tumor cells.

Francesca Diana, Julie Di Bernardo, Riccardo Sgarra, Michela A Tessari, Alessandra Rustighi, Alfredo Fusco, Vincenzo Giancotti, Guidalberto Manfioletti,

The HMGA architectural nuclear factors are involved in chromatin dynamics and their overexpression has been strongly linked to the neoplastic transformation process. Here we investigate the expression and post-translational modifications (PTMs) of HMGA proteins (HMGA1a, HMGA1b and HMGA2) in the rat prostatic cancer Dunning model (G, AT-1, and MAT-Ly-Lu cell ... Read more >>

Int. J. Oncol. (International journal of oncology)
[2005, 26(2):515-520]

Cited: 6 times

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Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.

Riccardo Sgarra, Alessandra Rustighi, Michela A Tessari, Julie Di Bernardo, Sandro Altamura, Alfredo Fusco, Guidalberto Manfioletti, Vincenzo Giancotti,

The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their ... Read more >>

FEBS Lett. (FEBS letters)
[2004, 574(1-3):1-8]

Cited: 110 times

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