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Author Julianne C Flanagan

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A Preliminary Examination of Endogenous Peripheral Oxytocin in a Pilot Randomized Clinical Trial of Oxytocin-Enhanced Psychotherapy for Posttraumatic Stress Disorder.

Lauren M Sippel, Courtney E King, Amy E Wahlquist, Julianne C Flanagan,

BACKGROUND:Preclinical and clinical research suggests that the oxytocin system is implicated in the development and maintenance of stress and anxiety-related psychiatric conditions, such as posttraumatic stress disorder (PTSD). Recent research also suggests that intranasal oxytocin holds promise as a treatment for PTSD. However, little is known about the relationship between ... Read more >>

J Clin Psychopharmacol (Journal of clinical psychopharmacology)
[2020, 40(4):401-404]

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Effects of couple conflict on alcohol craving: Does intimate partner violence play a role?

Julianne C Flanagan, Amber M Jarnecke, Ruschelle M Leone, Daniel W Oesterle,

OBJECTIVE:Social stress in the form of maladaptive relationship conflict is a common precipitant to alcohol misuse and problems. Research has also established a clear causal association between alcohol misuse and relationship conflict in the form of intimate partner violence (IPV). Despite the robust literature linking relationship conflict and problematic drinking ... Read more >>

Addict Behav (Addictive behaviors)
[2020, 109:106474]

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Cannabis and Alcohol Co-Use in a Smoking Cessation Pharmacotherapy Trial for Adolescents and Emerging Adults.

Erin A McClure, Nathaniel L Baker, Caitlyn O Hood, Rachel L Tomko, Lindsay M Squeglia, Julianne C Flanagan, Matthew J Carpenter, Kevin M Gray,

INTRODUCTION:The co-use of cannabis and alcohol among tobacco-using youth is common. Alcohol co-use is associated with worse tobacco cessation outcomes, but results are mixed regarding the impact of cannabis on tobacco outcomes and if co-use leads to increased use of non-treated substances. This secondary analysis from a youth smoking cessation ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2020, 22(8):1374-1382]

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Staying safe during COVID-19: How a pandemic can escalate risk for intimate partner violence and what can be done to provide individuals with resources and support.

Amber M Jarnecke, Julianne C Flanagan,

The emergence of COVID-19 presents unprecedented challenges in keeping individuals experiencing intimate partner violence (IPV) safe in the United States and abroad. This commentary explores how COVID-19 may be increasing risk for IPV and what strategies may be used presently, and in the future, to mitigate IPV risk during crises. ... Read more >>

Psychol Trauma (Psychological trauma : theory, research, practice and policy)
[2020, 12(S1):S202-S204]

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Enhancing prolonged exposure therapy for PTSD among veterans with oxytocin: Design of a multisite randomized controlled trial.

Julianne C Flanagan, Jennifer M Mitchell, Nathaniel L Baker, Joshua Woolley, Bethany Wangelin, Sudie E Back, John R McQuaid, Thomas C Neylan, William R Wolfe, Kathleen T Brady,

Posttraumatic stress disorder (PTSD) is the most highly prevalent mental health disorder among U.S. military Veterans. Prolonged Exposure (PE) therapy is one of the most widely used evidence-based treatments for PTSD, but there is substantial room for improvement in outcomes and retention rates. Accumulating data suggest that oxytocin offers a ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 95:106074]

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Examining sex, adverse childhood experiences, and oxytocin on neuroendocrine reactivity in smokers.

Caitlyn O Hood, Rachel L Tomko, Nathaniel L Baker, Breanna M Tuck, Julianne C Flanagan, Matthew J Carpenter, Kevin M Gray, Michael E Saladin, Erin A McClure,

Adverse childhood experiences (ACE) are associated with greater neuroendocrine responses to social stress in substance users. The neuropeptide oxytocin might attenuate this relationship. Given sex differences in ACE exposure and neuroendocrine stress reactivity, it is unknown whether this association is similar for males and females. Therefore, this secondary analysis evaluated ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2020, 120:104752]

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N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial.

Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kalivas,

Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are two prevalent psychiatric conditions in the U.S. The co-occurrence of AUD and PTSD is also common, and associated with a more severe clinical presentation and worse treatment outcomes across the biopsychosocial spectrum (e.g., social and vocational functioning, physical health) as ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 91:105961]

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Association of Cannabis Use With Intimate Partner Violence Among Couples With Substance Misuse.

Julianne C Flanagan, Ruschelle M Leone, Amanda K Gilmore, Erin A McClure, Kevin M Gray,

BACKGROUND AND OBJECTIVES:There is a well-established causal link between substance use and intimate partner violence (IPV) perpetration and victimization. However, little is known about the complex emerging relationship between cannabis use and IPV. Because cannabis is the most commonly used drug in the United States and is associated with numerous ... Read more >>

Am J Addict (The American journal on addictions)
[2020, 29(4):323-330]

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The moderating role of infidelity on the relation between oxytocin and conflict behaviors among substance misusing couples.

Ruschelle M Leone, Amber M Jarnecke, Sudie E Back, Kathleen T Brady, Julianne C Flanagan,

The neuropeptide oxytocin (OT) may be beneficial to augmenting behavioral therapies for couples given its ability to alleviate stress reactivity and increase pro-social behavior. However, there is growing evidence demonstrating inconsistent effects of OT on social behavior. Infidelity may represent a relational vulnerability that modulates the OT response. The present ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2019, :]

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Usability Testing of a Mobile Health Intervention to Address Acute Care Needs after Sexual Assault.

Amanda K Gilmore, Tatiana M Davidson, Ruschelle M Leone, Lauren B Wray, Daniel W Oesterle, Christine K Hahn, Julianne C Flanagan, Kathleen Gill-Hopple, Ron Acierno,

Sexual assault is associated with a range of poor mental health outcomes. To enhance access to care by this population, technology-based mental health interventions have been implemented in the emergency room; however, more accessible and easily disseminated interventions are needed. The aim of the present study was to test the ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(17):]

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Design of a randomized controlled trial examining the efficacy of oxytocin to enhance alcohol behavioral couple therapy.

Julianne C Flanagan, Jane E Joseph, Paul J Nietert, Sudie E Back, Barbara S McCrady,

Combining pharmacological interventions with evidence-based behavioral interventions may help optimize treatment outcomes for alcohol use disorder (AUD). While several effective behavioral interventions for AUD have been developed, the vast majority target individual patients, despite evidence that behavioral interventions for couples have the ability to outperform individual treatments for AUD. Alcohol ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2019, 82:1-8]

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Veterans with PTSD and comorbid substance use disorders: Does single versus poly-substance use disorder affect treatment outcomes?

Stephanie M Jeffirs, Amber M Jarnecke, Julianne C Flanagan, Therese K Killeen, Taylor F Laffey, Sudie E Back,

INTRODUCTION:Substance use disorders (SUD) frequently co-occur with posttraumatic stress disorder (PTSD). Little is known, however, about how individuals with a single SUD diagnosis (relating to only one substance) compare to individuals with poly-SUD diagnoses (relating to more than one substance) on substance use and PTSD treatment outcomes. To address this ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2019, 199:70-75]

Cited: 1 time

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Impact of Oxytocin on the neural correlates of fearful face processing in PTSD related to childhood Trauma.

Julianne C Flanagan, Lauren M Sippel, Megan M Moran Santa Maria, Karen J Hartwell, Kathleen T Brady, Jane E Joseph,

Background: Posttraumatic stress disorder (PTSD) related to exposure to abuse and neglect during childhood is associated with particularly severe and persistent deleterious outcomes. Amygdala hyperreactivity has been observed in childhood trauma survivors and implicated in symptoms of PTSD. Objective: The neuropeptide oxytocin holds promise as a potential treatment for PTSD ... Read more >>

(European journal of psychotraumatology)
[2019, 10(1):1606626]

Cited: 1 time

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Augmenting Treatment for Posttraumatic Stress Disorder and Co-Occurring Conditions with Oxytocin.

Julianne C Flanagan, Jennifer M Mitchell,

Purpose of review:The goal of this manuscript is to review the extant literature examining the neurobiological and behavioral mechanisms underlying the potential utility of intranasal oxytocin as a novel pharmacologic intervention for the treatment of posttraumatic stress disorder (PTSD), and for the treatment of co-morbid PTSD and alcohol and substance ... Read more >>

(Current treatment options in psychiatry)
[2019, 6(2):132-142]

Cited: 1 time

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Acute mental health symptoms among individuals receiving a sexual assault medical forensic exam: the role of previous intimate partner violence victimization.

Amanda K Gilmore, Julianne C Flanagan,

Sexual assault and intimate partner violence (IPV) are common in the USA, and they often co-occur. Individuals with multiple victimization experiences have more severe mental health outcomes compared to those with one victimization. The current study examined mental health symptoms and their association with IPV victimization history among a sample ... Read more >>

Arch Womens Ment Health (Archives of women's mental health)
[2020, 23(1):81-89]

Cited: 1 time

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Concurrent treatment of substance use disorders and PTSD using prolonged exposure: A randomized clinical trial in military veterans.

Sudie E Back, Therese Killeen, Christal L Badour, Julianne C Flanagan, Nicholas P Allan, Elizabeth Santa Ana, Brian Lozano, Kristina J Korte, Edna B Foa, Kathleen T Brady,

OBJECTIVE:A substantial amount of individuals with substance use disorders (SUD) also meet criteria for posttraumatic stress disorder (PTSD). Prolonged Exposure (PE) is an effective, evidence-based treatment for PTSD, but there is limited data on its use among individuals with current alcohol or drug use disorders. This study evaluated the efficacy ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 90:369-377]

Cited: 4 times

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Preliminary development of a neuroimaging paradigm to examine neural correlates of relationship conflict.

Julianne C Flanagan, Shayla Yonce, Casey D Calhoun, Sudie E Back, Kathleen T Brady, Jane E Joseph,

Social stress in the form of conflict between romantic partners is a salient correlate of substance use disorders (SUD), and also plays an integral role in SUD treatment outcomes. Neuroimaging has advanced the study of social stress on SUD etiology, course, and treatment. However, no neuroimaging paradigms have yet been ... Read more >>

Psychiatry Res Neuroimaging (Psychiatry research. Neuroimaging)
[2019, 283:125-134]

Cited: 1 time

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Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder.

Julianne C Flanagan, Nicholas P Allan, Casey D Calhoun, Christal L Badour, Megan Moran-Santa Maria, Kathleen T Brady, Sudie E Back,

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly prevalent and commonly co-occur. The dual diagnosis of PTSD/AUD is associated with serious negative sequalae, and there are currently no effective pharmacological treatments for this comorbidity. Both PTSD and AUD are characterized by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2019, 27(1):45-54]

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Intimate partner violence moderates the association between oxytocin and reactivity to dyadic conflict among couples.

Amber M Jarnecke, Eileen Barden, Sudie E Back, Kathleen T Brady, Julianne C Flanagan,

Emerging literature indicates individual and contextual differences impact response to oxytocin (OT). Intimate partner violence (IPV) is one chronic stressor that may moderate OT response. To test the hypothesis that IPV moderates the association between OT and reactivity to a dyadic conflict task, data from a larger randomized controlled study ... Read more >>

Psychiatry Res (Psychiatry research)
[2018, 270:404-411]

Cited: 1 time

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Substance use disorders and PTSD: Examining substance use, PTSD symptoms, and dropout following imaginal exposure.

Amber M Jarnecke, Nicholas P Allan, Christal L Badour, Julianne C Flanagan, Therese K Killeen, Sudie E Back,

Integrated exposure-based interventions to treat substance use disorders (SUD) and posttraumatic stress disorder (PTSD) may not be widely utilized, in part, because of clinician concerns that such interventions will worsen symptomatology and lead to treatment dropout. In order to address this question, the current pilot study examined whether participants' ratings ... Read more >>

Addict Behav (Addictive behaviors)
[2019, 90:35-39]

Cited: 2 times

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Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans.

Sudie E Back, Julianne C Flanagan, Jennifer L Jones, Isabel Augur, Alan L Peterson, Stacey Young-McCaughan, David W Shirley, Aisling Henschel, Jane E Joseph, Brett T Litz, Allison K Hancock, John D Roache, Jim Mintz, Jennifer S Wachen, Terence M Keane, Kathleen T Brady, ,

Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) are two of the most common mental health disorders affecting civilians as well as military populations. If left untreated, individuals with co-occurring PTSD/AUD are at increased risk for developing other mental health problems (e.g., depression, anxiety), physical health problems, reduced resiliency ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2018, 73:8-15]

Cited: 2 times

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Effects of oxytocin on working memory and executive control system connectivity in posttraumatic stress disorder.

Julianne C Flanagan, Anne Hand, Amber M Jarnecke, Megan M Moran-Santa Maria, Kathleen T Brady, Jane E Joseph,

Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition for which effective medications are scant and little is known about neural correlates of risk versus resilience. Oxytocin is a hypothalamic neuropeptide that has demonstrated promise in modulating neurobiological and behavioral correlates of PTSD. Cognitive deficits in areas such as working ... Read more >>

Exp Clin Psychopharmacol (Experimental and clinical psychopharmacology)
[2018, 26(4):391-402]

Cited: 5 times

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Effects of Oxytocin on Emotional and Physiological Responses to Conflict in Couples with Substance Misuse.

David T Solomon, Paul J Nietert, Casey Calhoun, Daniel W Smith, Sudie E Back, Eileen Barden, Kathleen T Brady, Julianne C Flanagan,

Social stress, especially dyadic conflict among couples, is an important correlate of addiction. Several authors have suggested that the neuropeptide oxytocin (OT) may be useful in the treatment of couples with substance misuse. However, the literature examining OT among couples is scant and has yielded mixed findings. The current study ... Read more >>

(Couple & family psychology)
[2018, 7(2):91-102]

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Effects of oxytocin on cortisol reactivity and conflict resolution behaviors among couples with substance misuse.

Julianne C Flanagan, Melanie S Fischer, Paul J Nietert, Sudie E Back, Megan Moran-Santa Maria, Alexandra Snead, Kathleen T Brady,

Social stress, particularly in the form of dyadic conflict, is a well-established correlate of substance use disorders (SUD). The neuropeptide oxytocin can enhance prosocial behavior and mitigate addictive behaviors. These effects may be, in part, a result of oxytocin's ability to attenuate hypothalamic-pituitary-adrenal (HPA) axis dysregulation. However, only one study ... Read more >>

Psychiatry Res (Psychiatry research)
[2018, 260:346-352]

Cited: 7 times

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Behavioral Treatments for Alcohol Use Disorder and Post-Traumatic Stress Disorder.

Julianne C Flanagan, Jennifer L Jones, Amber M Jarnecke, Sudie E Back,

Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly prevalent and debilitating psychiatric conditions that commonly co-occur. Individuals with comorbid AUD and PTSD incur heightened risk for other psychiatric problems (e.g., depression and anxiety), impaired vocational and social functioning, and poor treatment outcomes. This review describes evidence-supported behavioral ... Read more >>

Alcohol Res (Alcohol research : current reviews)
[2018, 39(2):181-192]

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