Full Text Journal Articles by
Author Jue Hou

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Kinetic Analysis of Lipid Metabolism in Breast Cancer Cells via Nonlinear Optical Microscopy.

Jue Hou, Nellone E Reid, Bruce J Tromberg, Eric O Potma,

Investigating the behavior of breast cancer cells via reaction kinetics may help unravel the mechanisms that underlie metabolic changes in tumors. However, obtaining human in vivo kinetic data is challenging because of difficulties associated with measuring these parameters. Nondestructive methods of measuring lipid content in live cells provide a novel approach ... Read more >>

Biophys. J. (Biophysical journal)
[2020, :]

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Effect of Anion Species on Ion Current Rectification Properties of Positively Charged Nanochannels.

Chen Zhao, Huacheng Zhang, Jue Hou, Ranwen Ou, Yinlong Zhu, Xingya Li, Lei Jiang, Huanting Wang,

Biological ion channels can realize delicate mass transport under complicated physiological conditions. Artificial nanochannels can achieve biomimetic ion current rectification (ICR), gating, and selectivity that are mostly performed in pure salt solutions. Synthetic nanochannels that can function under mixed ion systems are highly desirable, yet their performances are hard to ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(25):28915-28922]

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Unidirectional and Selective Proton Transport in Artificial Heterostructured Nanochannels with Nano-to-Subnano Confined Water Clusters.

Xingya Li, Huacheng Zhang, Hao Yu, Jun Xia, Yin-Bo Zhu, Heng-An Wu, Jue Hou, Jun Lu, Ranwen Ou, Christopher D Easton, Cordelia Selomulya, Matthew R Hill, Lei Jiang, Huanting Wang,

The construction of biological proton channel analogues has attracted substantial interest owing to their wide potential in separation of ions, sensing, and energy conversion. Here, metal-organic framework (MOF)/polymer heterogeneous nanochannels are presented, in which water molecules are confined to disordered clusters in the nanometer-sized polymer regions and to ordered chains ... Read more >>

Adv. Mater. Weinheim (Advanced materials (Deerfield Beach, Fla.))
[2020, 32(24):e2001777]

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Efficient Gating of Ion Transport in Three-Dimensional Metal-Organic Framework Sub-Nanochannels with Confined Light-Responsive Azobenzene Molecules.

Tianyue Qian, Huacheng Zhang, Xingya Li, Jue Hou, Chen Zhao, Qinfen Gu, Huanting Wang,

1D nanochannels modified with responsive molecules are fabricated to replicate gating functionalities of biological ion channels, but gating effects are usually weak because small molecular gates cannot efficiently block the large channels in the closed states. Now, 3D metal-organic framework (MOF) sub-nanochannels (SNCs) confined with azobenzene (AZO) molecules achieve efficient ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Sulfonated Sub-1-nm Metal-Organic Framework Channels with Ultrahigh Proton Selectivity.

Xingya Li, Huacheng Zhang, Jue Hou, Ranwen Ou, Yinlong Zhu, Chen Zhao, Tianyue Qian, Christopher D Easton, Cordelia Selomulya, Matthew R Hill, Huanting Wang,

Biological proton channels are sub-1-nm protein pores with ultrahigh proton (H+) selectivity over other ions. Inspired by biological proton channels, developing artificial proton channels with biological-level selectivity is of fundamental significance for separation science. Herein we report synthetic proton channels fabrication based on sulfonated metal-organic frameworks (MOFs), UiO-66-X, X = ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(21):9827-9833]

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Efficient metal ion sieving in rectifying subnanochannels enabled by metal-organic frameworks.

Jun Lu, Huacheng Zhang, Jue Hou, Xingya Li, Xiaoyi Hu, Yaoxin Hu, Christopher D Easton, Qinye Li, Chenghua Sun, Aaron W Thornton, Matthew R Hill, Xiwang Zhang, Gengping Jiang, Jefferson Zhe Liu, Anita J Hill, Benny D Freeman, Lei Jiang, Huanting Wang,

Biological ion channels have remarkable ion selectivity, permeability and rectification properties, but it is challenging to develop artificial analogues. Here, we report a metal-organic framework-based subnanochannel (MOFSNC) with heterogeneous structure and surface chemistry to achieve these properties. The asymmetrically structured MOFSNC can rapidly conduct K+, Na+ and Li+ in the ... Read more >>

Nat Mater (Nature materials)
[2020, 19(7):767-774]

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Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes.

Qiang Huang, Jue Hou, Peng Yang, Jun Yan, Xiaoliang Yu, Ying Zhuo, Sudan He, Feng Xu,

BACKGROUND:HSV-1 is a common pathogen that infects 50-90% of the human population worldwide. HSV-1 causes numerous infection-related diseases, some of which are severely life-threatening. There are antiviral medications with activity against HSV-1. However, with the emergence of drug-resistant mutant strains of HSV-1, there is an urgent need to develop new ... Read more >>

BMC Microbiol. (BMC microbiology)
[2019, 19(1):274]

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Polycrystalline Advanced Microporous Framework Membranes for Efficient Separation of Small Molecules and Ions.

Jue Hou, Huacheng Zhang, George P Simon, Huanting Wang,

Advanced porous framework membranes with excellent selectivity and high permeability of small molecules and ions are highly desirable for many important industrial separation applications. There has been significant progress in the fabrication of polycrystalline microporous framework membranes (PMFMs) in recent years, such as metal-organic framework and covalent organic framework membranes. ... Read more >>

Adv. Mater. Weinheim (Advanced materials (Deerfield Beach, Fla.))
[2020, 32(18):e1902009]

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Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis.

Jue Hou, Jie Ju, Zili Zhang, Cong Zhao, Zhanhui Li, Jiyue Zheng, Tian Sheng, Hongjian Zhang, Linkun Hu, Xiaoliang Yu, Wei Zhang, Yangxin Li, Meng Wu, Haikuo Ma, Xiaohu Zhang, Sudan He,

Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein (MLKL). Increasing evidence suggests that necroptosis is closely associated with pathologies including inflammatory diseases, neurodegenerative diseases, and cancer metastasis. Herein, we discovered the small-molecule PK6 and ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(7):493]

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Prx1 Expressing Cells Are Required for Periodontal Regeneration of the Mouse Incisor.

Seyed Hossein Bassir, Sasan Garakani, Katarzyna Wilk, Zahra A Aldawood, Jue Hou, Shu-Chi A Yeh, Charles Sfeir, Charles P Lin, Giuseppe Intini,

Previous studies have shown that post-natal skeletal stem cells expressing Paired-related homeobox 1 (PRX1 or PRRX1) are present in the periosteum of long bones where they contribute to post-natal bone development and regeneration. Our group also identified post-natal PRX1 expressing cells (pnPRX1+ cells) in mouse calvarial synarthroses (sutures) and showed ... Read more >>

Front Physiol (Frontiers in Physiology)
[2019, 10:591]

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Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.

Weijian Ye, Marvin Chew, Jue Hou, Fritz Lai, Stije J Leopold, Hooi Linn Loo, Aniruddha Ghose, Ashok K Dutta, Qingfeng Chen, Eng Eong Ooi, Nicholas J White, Arjen M Dondorp, Peter Preiser, Jianzhu Chen,

Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular basis underlying the variation in NK cell responses to malaria infection in the human population. Here, we ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2018, 14(10):e1007298]

Cited: 4 times

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Functionalized Boron Nitride Nanosheets: A Thermally Rearranged Polymer Nanocomposite Membrane for Hydrogen Separation.

Yuqi Wang, Ze-Xian Low, Seungju Kim, Huacheng Zhang, Xiaofang Chen, Jue Hou, Jong Geun Seong, Young Moo Lee, George P Simon, Chris H J Davies, Huanting Wang,

Amino functionalized boron nitride nanosheets (FBN) were incorporated into a crosslinked, thermally rearranged polyimide (XTR) to fabricate FBN-XTR nanocomposite membrane. The FBN-XTR membrane exhibited a small decrease in H2 permeability but demonstrated a remarkably increased H2 gas selectivity over other gases, compared with XTR. The XTR membrane heat-treated at 425 °C ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2018, 57(49):16056-16061]

Cited: 0 times

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Carbon Nanotube Networks as Nanoscaffolds for Fabricating Ultrathin Carbon Molecular Sieve Membranes.

Jue Hou, Huacheng Zhang, Yaoxin Hu, Xingya Li, Xiaofang Chen, Seungju Kim, Yuqi Wang, George P Simon, Huanting Wang,

Carbon molecular sieve (CMS) membranes have shown great potential for gas separation owing to their low cost, good chemical stability, and high selectivity. However, most of the conventional CMS membranes exhibit low gas permeance due to their thick active layer, which limits their practical applications. Herein, we report a new ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(23):20182-20188]

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High-dimensional variable selection and prediction under competing risks with application to SEER-Medicare linked data.

Jiayi Hou, Anthony Paravati, Jue Hou, Ronghui Xu, James Murphy,

Competing risk analysis considers event times due to multiple causes or of more than one event types. Commonly used regression models for such data include (1) cause-specific hazards model, which focuses on modeling one type of event while acknowledging other event types simultaneously, and (2) subdistribution hazards model, which links ... Read more >>

Stat Med (Statistics in medicine)
[2018, 37(24):3486-3502]

Cited: 1 time

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The impact of confounder selection in propensity scores when applied to prospective cohort studies in pregnancy.

Ronghui Xu, Jue Hou, Christina D Chambers,

Our work was motivated by small cohort studies on the risk of birth defects in infants born to pregnant women exposed to medications. We controlled for confounding using propensity scores (PS). The extremely rare events setting renders the matching or stratification infeasible. In addition, the PS itself may be formed ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2018, 78:75-80]

Cited: 1 time

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Single Nanochannel-Aptamer-Based Biosensor for Ultrasensitive and Selective Cocaine Detection.

Jian Wang, Jue Hou, Huacheng Zhang, Ye Tian, Lei Jiang,

Ultrasensitive and selective detection of molecules at nano or sub-nanomolar level is very important for many areas such as early diagnosis and drug testing. Herein, we report a high-sensitive cocaine sensor based on a single nanochannel coupled with DNA aptamers. The single nanochannel-aptamer-based biosensor can recognize cocaine molecules with an ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(2):2033-2039]

Cited: 2 times

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Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State.

Jue Hou, Joshua Williams, Elliot L Botvinick, Eric O Potma, Bruce J Tromberg,

Label-free nonlinear optical microscopy (NLOM) based on two-photon excited fluorescence (TPEF) from cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD+) is widely used for high-resolution cellular redox imaging. In this work, we combined three label-free NLOM imaging methods to quantitatively characterize breast cancer cells and their relative invasive ... Read more >>

Cancer Res. (Cancer research)
[2018, 78(10):2503-2512]

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Ultrafast selective transport of alkali metal ions in metal organic frameworks with subnanometer pores.

Huacheng Zhang, Jue Hou, Yaoxin Hu, Peiyao Wang, Ranwen Ou, Lei Jiang, Jefferson Zhe Liu, Benny D Freeman, Anita J Hill, Huanting Wang,

Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report metal organic framework (MOF) ... Read more >>

Sci Adv (Science Advances)
[2018, 4(2):eaaq0066]

Cited: 8 times

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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Seong M Kim, Tricia T Nguyen, Archna Ravi, Peter Kubiniok, Brendan T Finicle, Vaishali Jayashankar, Leonel Malacrida, Jue Hou, Jane Robertson, Dong Gao, Jonathan Chernoff, Michelle A Digman, Eric O Potma, Bruce J Tromberg, Pierre Thibault, Aimee L Edinger,

We report that PTEN-deficient prostate cancer cells use macropinocytosis to survive and proliferate under nutrient stress. PTEN loss increased macropinocytosis only in the context of AMPK activation, revealing a general requirement for AMPK in macropinocytosis and a novel mechanism by which AMPK promotes survival under stress. In prostate cancer cells, ... Read more >>

Cancer Discov (Cancer discovery)
[2018, 8(7):866-883]

Cited: 18 times

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A nonparametric maximum likelihood approach for survival data with observed cured subjects, left truncation and right-censoring.

Jue Hou, Christina D Chambers, Ronghui Xu,

We consider observational studies in pregnancy where the outcome of interest is spontaneous abortion (SAB). This at first sight is a binary 'yes' or 'no' variable, albeit there is left truncation as well as right-censoring in the data. Women who do not experience SAB by gestational week 20 are 'cured' ... Read more >>

Lifetime Data Anal (Lifetime data analysis)
[2018, 24(4):612-651]

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Patterned Colloidal Photonic Crystals.

Jue Hou, Mingzhu Li, Yanlin Song,

Colloidal photonic crystals (PCs) have been well developed because they are easy to prepare, cost-effective, and versatile with regards to modification and functionalization. Patterned colloidal PCs contribute a novel approach to constructing high-performance PC devices with unique structures and specific functions. In this review, an overview of the strategies for ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2018, 57(10):2544-2553]

Cited: 13 times

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A Systems Vaccinology Approach Reveals Temporal Transcriptomic Changes of Immune Responses to the Yellow Fever 17D Vaccine.

Jue Hou, Shuhui Wang, Manxue Jia, Dan Li, Ying Liu, Zhengpeng Li, Hong Zhu, Huifang Xu, Meiping Sun, Li Lu, Zhinan Zhou, Hong Peng, Qichen Zhang, Shihong Fu, Guodong Liang, Lena Yao, Xuesong Yu, Lindsay N Carpp, Yunda Huang, Julie McElrath, Steve Self, Yiming Shao,

In this study, we used a systems vaccinology approach to identify temporal changes in immune response signatures to the yellow fever (YF)-17D vaccine, with the aim of comprehensively characterizing immune responses associated with protective immunity. We conducted a cohort study in which 21 healthy subjects in China were administered one ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2017, 199(4):1476-1489]

Cited: 8 times

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Periodic oscillation of ion conduction of nanofluidic diodes using a chemical oscillator.

Huacheng Zhang, Jue Hou, Ranwen Ou, Yaoxin Hu, Huanting Wang, Lei Jiang,

Periodic ion-conduction oscillation of biological ion channels in a living system is essential for numerous life processes. Here we report an oscillatory nanofluidic system that can self-regulate its ion-conduction states under constant conditions. The oscillatory nanofluidic system is constructed by integrating a chemical oscillator into an artificial single nanochannel system. ... Read more >>

Nanoscale (Nanoscale)
[2017, 9(21):7297-7304]

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Serum Metabolomics Investigation of Humanized Mouse Model of Dengue Virus Infection.

Liang Cui, Jue Hou, Jinling Fang, Yie Hou Lee, Vivian Vasconcelos Costa, Lan Hiong Wong, Qingfeng Chen, Eng Eong Ooi, Steven R Tannenbaum, Jianzhu Chen, Choon Nam Ong,

Dengue is an acute febrile illness caused by dengue virus (DENV) and a major cause of morbidity and mortality in tropical and subtropical regions of the world. The lack of an appropriate small-animal model of dengue infection has greatly hindered the study of dengue pathogenesis and the development of therapeutics. ... Read more >>

J. Virol. (Journal of virology)
[2017, 91(14):]

Cited: 6 times

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CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation.

Heather J Wright, Jue Hou, Binzhi Xu, Marvin Cortez, Eric O Potma, Bruce J Tromberg, Olga V Razorenova,

Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to high rates of fatty acid oxidation (FAO). Here we report the mechanism of lipid metabolism dysregulation in TNBC through the prometastatic protein, CUB-domain containing protein 1 (CDCP1). We show that a "low-lipid" phenotype ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(32):E6556-E6565]

Cited: 14 times

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