Full Text Journal Articles by
Author Juan C Hernandez Prera

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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Concurrent Cetuximab and Nivolumab as a Second-Line or beyond Treatment of Patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results of Phase I/II Study.

Christine H Chung, Marcelo Bonomi, Conor E Steuer, Jiannong Li, Priyanka Bhateja, Matthew Johnson, Jude Masannat, Feifei Song, Juan C Hernandez-Prera, Bruce M Wenig, Helen Molina, Joaquim M Farinhas, Caitlin P McMullen, J Trad Wadsworth, Krupal B Patel, Julie A Kish, Jameel Muzaffar, Kedar Kirtane, James W Rocco, Michael J Schell, Nabil F Saba,

We hypothesized the combination of cetuximab and nivolumab would improve survival in recurrent and/or metastatic (R/M) HNSCC by providing synergy in cancer control and evaluated toxicities and efficacy of the combination. Effects of sequential administration of cetuximab and anti-Programmed Cell Death-1 checkpoint inhibitors (CPI) were also explored. Patients who failed ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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What is the role of sentinel lymph node biopsy in the management of oral cancer in 2020?

Remco de Bree, Bart de Keizer, Francisco J Civantos, Robert P Takes, Juan P Rodrigo, Juan C Hernandez-Prera, Gyorgy B Halmos, Alessandra Rinaldo, Alfio Ferlito,

Approximately 70-80% of patients with cT1-2N0 oral squamous cell carcinoma (OSCC) ultimately prove to have no cancer in the cervical lymphatics on final pathology after selective neck dissection. As a result, sentinel lymph node biopsy (SLNB) has been adopted during the last decade as a diagnostic staging method to intelligently identify ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.

Ritu Chaudhary, Robbert J C Slebos, Feifei Song, Keegan P McCleary-Sharpe, Jude Masannat, Aik Choon Tan, Xuefeng Wang, Nelusha Amaladas, Wenjuan Wu, Gerald E Hall, Jose R Conejo-Garcia, Juan C Hernandez-Prera, Christine H Chung,

Prognosis for patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains poor. Development of more effective and less toxic targeted therapies is necessary for HNSCC patients. Checkpoint kinase 1 (CHK1) plays a vital role in cell cycle regulation and is a promising therapeutic target in HNSCC. ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2021, 60(2):138-150]

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Pleomorphic Adenoma: The Great Mimicker of Malignancy.

Juan C Hernandez-Prera, Alena Skálová, Alessandro Franchi, Alessandra Rinaldo, Vincent Vander Poorten, Peter Zbären, Alfio Ferlito, Bruce M Wenig,

Pleomorphic adenoma is the most common salivary gland neoplasm and its diagnosis is straightforward in majority of cases. However; not infrequently PA exhibits unusual and uncommon histological findings that can erroneously be confused with malignancy. The diagnostic difficulties of PA arise from its ability of mimic invasion, show atypical or ... Read more >>

Histopathology (Histopathology)
[2020, :]

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Frozen section in thyroid gland follicular neoplasms: It's high time to abandon it!

Alvaro Sanabria, Mark Zafereo, Lester D R Thompson, Juan C Hernandez-Prera, Luiz P Kowalski, Iain J Nixon, Ashok Shaha, Juan P Rodrigo, Antti Mäkitie, Vincent Vander Poorten, Carlos Suarez, Peter Zbären, Alessandra Rinaldo, Alfio Ferlito,

Thyroid nodules are a very common clinical condition. The 2015 American Thyroid Association (ATA) guidelines recommend surgical excision for Bethesda IV nodules. The use of intraoperative frozen section (FS) has been recommended as a strategy to tailor the extent of the initial surgery. We critically evaluated the literature that discusses ... Read more >>

Surg Oncol (Surgical oncology)
[2021, 36:76-81]

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Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations.

Juan C Hernandez-Prera, Pablo Valderrabano, Jordan H Creed, Janis V de la Iglesia, Robbert J C Slebos, Barbara A Centeno, Valentina Tarasova, Julie Hallanger-Johnson, Colleen Veloski, Kristen J Otto, Bruce M Wenig, Sean J Yoder, Cesar A Lam, Derek S Park, Alexander R Anderson, Natarajan Raghunand, Anders Berglund, Jimmy Caudell, Travis A Gerke, Christine H Chung,

<b><i>Background:</i></b> <i>RAS</i> gene family mutations are the most prevalent in thyroid nodules with indeterminate cytology and are present in a wide spectrum of histological diagnoses. We evaluated differentially expressed genes and signaling pathways across the histological/clinical spectrum of <i>RAS</i>-mutant nodules to determine key molecular determinants associated with a high risk ... Read more >>

Thyroid (Thyroid : official journal of the American Thyroid Association)
[2021, 31(1):36-49]

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Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.

Andrés Coca-Pelaz, Jatin P Shah, Juan C Hernandez-Prera, Ronald A Ghossein, Juan P Rodrigo, Dana M Hartl, Kerry D Olsen, Ashok R Shaha, Mark Zafereo, Carlos Suarez, Iain J Nixon, Gregory W Randolph, Antti A Mäkitie, Luiz P Kowalski, Vincent Vander Poorten, Alvaro Sanabria, Orlando Guntinas-Lichius, Ricard Simo, Peter Zbären, Peter Angelos, Avi Khafif, Alessandra Rinaldo, Alfio Ferlito,

<h4>Introduction</h4>Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant.<h4>Methods</h4>We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(7):3112-3128]

Cited: 2 times

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Developing Classifications of Laryngeal Dysplasia: The Historical Basis.

Henrik Hellquist, Alfio Ferlito, Antti A Mäkitie, Lester D R Thompson, Justin A Bishop, Abbas Agaimy, Juan C Hernandez-Prera, Douglas R Gnepp, Stefan M Willems, Pieter J Slootweg, Alessandra Rinaldo,

During the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(6):2667-2677]

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Staging and grading of oral squamous cell carcinoma: An update.

Alhadi Almangush, Antti A Mäkitie, Asterios Triantafyllou, Remco de Bree, Primož Strojan, Alessandra Rinaldo, Juan C Hernandez-Prera, Carlos Suárez, Luiz P Kowalski, Alfio Ferlito, Ilmo Leivo,

Oral squamous cell carcinoma (OSCC) is a common malignancy of the head and neck region. OSCC has a relatively low survival rate and the incidence of the disease is increasing in some geographic areas. Staging and grading of OSCC are established prerequisites for management, as they influence risk stratification and ... Read more >>

Oral Oncol (Oral oncology)
[2020, 107:104799]

Cited: 3 times

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Parathyroid cancer: An update.

Juan P Rodrigo, Juan C Hernandez-Prera, Gregory W Randolph, Mark E Zafereo, Dana M Hartl, Carl E Silver, Carlos Suárez, Randall P Owen, Carol R Bradford, Antti A Mäkitie, Ashok R Shaha, Justin A Bishop, Alessandra Rinaldo, Alfio Ferlito,

Parathyroid cancer (PC) is a rare malignant tumor which comprises 0.5-5% of patients with primary hyperparathyroidism (PHPT). Most of these cancers are sporadic, although it may also occur as a feature of various genetic syndromes including hyperparathyroidism-jaw tumor syndrome (HPT-JT) and multiple endocrine neoplasia (MEN) types 1 and 2A. Although ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2020, 86:102012]

Cited: 2 times

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The evolving concept of aggressive histological variants of differentiated thyroid cancer.

Juan C Hernandez-Prera,

It is recommended by current clinical guidelines that pathologists identify and report aggressive histological variants of differentiated thyroid cancer (e.g., tall cell, columnar cell, and hobnail variants of papillary thyroid carcinoma; widely invasive follicular thyroid carcinoma). This review analyzes the historical evolution of these entities and highlights unresolved issues with ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2020, 37(5):228-233]

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Laryngeal Dysplasia: Persisting Dilemmas, Disagreements and Unsolved Problems-A Short Review.

Nina Gale, Antonio Cardesa, Juan C Hernandez-Prera, Pieter J Slootweg, Bruce M Wenig, Nina Zidar,

We present the historical review and current state of the histopathological classifications and terminology of laryngeal precursor lesions. Attention to recent genetic findings is also presented; although in need of additional confirmation, these raise possibility for early detection of patients at risk of dysplasia progression. Although a number of identified genetic ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2020, 14(4):1046-1051]

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Long noncoding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC).

Ritu Chaudhary, Xuefeng Wang, Biwei Cao, Janis De La Iglesia, Jude Masannat, Feifei Song, Juan C Hernandez-Prera, Nicholas T Gimbrone, Robbert Jc Slebos, Christine H Chung,

Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy characterized by frequent mutations and metastasis. Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis and serve as novel prognostic biomarkers in different cancers. To enhance our understanding of lncRNAs that may have biological significance in HNSCC and ... Read more >>

Am J Transl Res (American journal of translational research)
[2020, 12(2):684-696]

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Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma.

Janis V de la Iglesia, Robbert J C Slebos, Laura Martin-Gomez, Xuefeng Wang, Jamie K Teer, Aik Choon Tan, Travis A Gerke, Garrick Aden-Buie, Tessa van Veen, Jude Masannat, Ritu Chaudhary, Feifei Song, Michelle Fournier, Erin M Siegel, Matthew B Schabath, J Trad Wadsworth, Jimmy Caudell, Louis Harrison, Bruce M Wenig, Jose Conejo-Garcia, Juan C Hernandez-Prera, Christine H Chung,

<h4>Purpose</h4>Patients with head and neck squamous cell carcinoma (HNSCC) who actively smoke during treatment have worse survival compared with never-smokers and former-smokers. We hypothesize the poor prognosis in tobacco smokers with HNSCC is, at least in part, due to ongoing suppression of immune response. We characterized the tumor immune microenvironment ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(6):1474-1485]

Cited: 5 times

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Update on Neuroendocrine Carcinomas of the Larynx.

Carolina Strosberg, Alfio Ferlito, Asterios Triantafyllou, Douglas R Gnepp, Justin A Bishop, Henrik Hellquist, Primoz Strojan, Stefan M Willems, Göran Stenman, Alessandra Rinaldo, Juan C Hernandez-Prera,

<h4>Objectives</h4>Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.<h4>Methods</h4>A review of the literature was performed to comprehensively understand the classification and diagnosis of ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2019, 152(6):686-700]

Cited: 1 time

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Characterization of novel genetic alterations in salivary gland secretory carcinoma.

Kiyong Na, Juan C Hernandez-Prera, Jae-Yol Lim, Ha Young Woo, Sun Och Yoon,

Secretory carcinoma is a salivary gland tumor with a characteristic chromosomal translocation that results in an ETV6-NTRK3 fusion gene. Secretory carcinoma shows relatively frequent rates of lymph-node metastasis and tumor recurrence and has a characteristic histology. Except for the ETV6 translocation, genomic alterations in secretory carcinoma have not been reported. ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(4):541-550]

Cited: 2 times

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Macrocystic (Mammary Analogue) Secretory Carcinoma: An Unusual Variant and a Pitfall in the Differential Diagnosis of Cystic Lesions in the Head and Neck.

Juan C Hernandez-Prera, Brittany J Holmes, Alessandro Valentino, Manju Harshan, Carlos E Bacchi, Fredrik Petersson, Kenian K Liu, Vesna Najfeld, Bruce M Wenig,

Mammary analogue secretory carcinoma (MASC) is a relatively recently described salivary gland adenocarcinoma characterized by ETV6-NTRK3 gene fusion and in most cases indolent clinical behavior. The majority of tumors show an admixture of microcystic, solid, and tubular growth patterns but only a few cases with dominant macrocystic growth have been ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(11):1483-1492]

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Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.

Primož Strojan, Juan C Hernandez-Prera, Jonathan J Beitler, Avraham Eisbruch, Nabil F Saba, William M Mendenhall, Carlos Suarez Nieto, Robert Smee, Alessandra Rinaldo, Alfio Ferlito,

The poorly differentiated neuroendocrine carcinomas (NECs) of the larynx are rare tumors that comprise of a small cell-type (SCNEC) and a large cell-type (LCNEC). In order to consolidate the current knowledge about their characteristics and management a systematic review of the available literature was performed. The PubMed/Medline and Scopus databases ... Read more >>

Cancer Treat Rev (Cancer treatment reviews)
[2019, 78:42-51]

Cited: 1 time

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Early squamous cell carcinoma of the oral tongue with histologically benign lymph nodes: A model predicting local control and vetting of the eighth edition of the American Joint Committee on Cancer pathologic T stage.

Shaum Sridharan, Lester D R Thompson, Bibianna Purgina, Charles D Sturgis, Akeesha A Shah, Brian Burkey, Madalina Tuluc, David Cognetti, Bin Xu, Kevin Higgins, Juan C Hernandez-Prera, Dominick Guerrero, Manish M Bundele, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris, William E Gooding, Simion I Chiosea,

<h4>Background</h4>The eighth edition of the American Joint Committee on Cancer staging manual (AJCC8) added depth of invasion to the definition of pathologic T stage (pT). In the current study, the authors assess pT stage migration and the prognostic performance of the updated pT stage and compare it with other clinicopathologic ... Read more >>

Cancer (Cancer)
[2019, 125(18):3198-3207]

Cited: 2 times

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Evolving role of human papillomavirus as a clinically significant biomarker in head and neck squamous cell carcinoma.

Caitlin McMullen, Christine H Chung, Juan C Hernandez-Prera,

Introduction: The majority of squamous cell carcinoma (SCC) of the oropharynx, one of the sites within the head and neck region, is now associated with high-risk human papillomavirus (HPV) in North America. Several modalities are available to determine the HPV status, however, the understanding of each assay in its application ... Read more >>

Expert Rev Mol Diagn (Expert review of molecular diagnostics)
[2019, 19(1):63-70]

Cited: 2 times

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Enhanced interdisciplinary communication: development of an interactive thyroid nodule/cancer disease map.

Sami P Moubayed, Rosalie Machado, R Michael Tuttle, Lisa A Orloff, Gregory Randolph, Juan C Hernandez-Prera, Martha J Griffin, Mark L Urken,

<h4>Objectives</h4>Deficits related to inadequate clinical communication can result in incorrect diagnoses, inappropriate surgery, incorrect disease stratification, pathologic reporting, and/or interpretation. There are currently no validated or defined solutions to disease-specific communication with regard to thyroid care.<h4>Methods</h4>We propose a solution that could ameliorate problems arising from inadequate disease-specific communications between physicians ... Read more >>

Laryngoscope (The Laryngoscope)
[2019, 129(1):269-274]

Cited: 0 times

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Historical Evolution of the Polymorphous Adenocarcinoma.

Juan C Hernandez-Prera,

The 2017 World Health Organization Classification of Head and Neck Tumors introduced for the first time the diagnostic terminology "cribriform variant of polymorphous adenocarcinoma". This nomenclature attempts to reconciliate the ongoing taxonomical controversy related to cribriform adenocarcinoma of tongue. In order to better understand this classification conundrum, it is imperative ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2019, 13(3):415-422]

Cited: 1 time

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Putting All the Pieces Together: Clinical, Macroscopic and Microscopic Characteristics of Subacute Thyroiditis.

Shyam Prajapati, Juan C Hernandez-Prera,

Subacute thyroiditis (SAT) is a self-limiting inflammatory condition of the thyroid gland in which multinucleated giant cells constitute a key histological finding. SAT is generally a clinical diagnosis and consequently its histological features are rarely encountered by pathologist. Herein, we present a case that exemplifies the characteristic clinical and pathological ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2019, 13(2):231-234]

Cited: 0 times

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