Full Text Journal Articles by
Author Joshua P Fessel

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Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials.

Timothy G Buchman, Ruxandra Draghia-Akli, Stacey J Adam, Neil R Aggarwal, Joshua P Fessel, Elizabeth S Higgs, Joseph P Menetski, Sarah W Read, Eric A Hughes, ,

Given the urgent need for coronavirus disease 2019 therapeutics, early in the pandemic the Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership rapidly designed a unique therapeutic agent intake and assessment process for candidate treatments of coronavirus disease 2019. These treatments included antivirals, immune modulators, severe acute ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1963-1973]

Cited: 0 times

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NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.

William M Oldham, Anna R Hemnes, Micheala A Aldred, John Barnard, Evan L Brittain, Stephen Y Chan, Feixiong Cheng, Michael H Cho, Ankit A Desai, Joe G N Garcia, Mark W Geraci, Susan D Ghiassian, Kathryn T Hall, Evelyn M Horn, Mohit Jain, Rachel S Kelly, Jane A Leopold, Sara Lindstrom, Brian D Modena, William C Nichols, Christopher J Rhodes, Wei Sun, Andrew J Sweatt, Rebecca R Vanderpool, Martin R Wilkins, Beth Wilmot, Roham T Zamanian, Joshua P Fessel, Neil R Aggarwal, Joseph Loscalzo, Lei Xiao,

The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(16):2040-2052]

Cited: 0 times

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Enhanced Expression of Catalase in Mitochondria Modulates NF-κB-Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages.

Wei Han, Joshua P Fessel, Taylor Sherrill, Emily G Kocurek, Fiona E Yull, Timothy S Blackwell,

NF-κB is a reduction-oxidation-sensitive transcription factor that plays a key role in regulating the immune response. In these studies, we intended to investigate the role of mitochondrial-derived reactive oxygen species in regulating NF-κB activation by studying transgenic mice that overexpress mitochondrial-targeted human catalase (mCAT). We treated wild-type (WT) and mCAT ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 205(4):1125-1134]

Cited: 1 time

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BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.

Anna R Hemnes, Joshua P Fessel, Xinping Chen, Shijun Zhu, Niki L Fortune, Christopher Jetter, Michael Freeman, John H Newman, James D West, Megha H Talati,

Insulin resistance and right ventricular (RV) dysfunction are associated with lipotoxicity in heritable forms of pulmonary arterial hypertension (PAH), commonly due to mutations in bone morphogenetic protein receptor type 2 (BMPR2). How BMPR2 dysfunction in cardiomyocytes alters glucose metabolism and the response of these cells to insulin are unknown. We ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 318(2):L429-L441]

Cited: 4 times

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Mitochondrial DNA Haplogroups and Delirium During Sepsis.

David C Samuels, Todd Hulgan, Joshua P Fessel, Frederic T Billings, Jennifer L Thompson, Rameela Chandrasekhar, Timothy D Girard,

<h4>Objectives</h4>Studies suggest that mitochondrial dysfunction underlies some forms of sepsis-induced organ failure. We sought to test the hypothesis that variations in mitochondrial DNA haplogroup affect susceptibility to sepsis-associated delirium, a common manifestation of acute brain dysfunction during sepsis.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Medical and surgical ICUs at a large tertiary care center.<h4>Patients</h4>Caucasian and ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(8):1065-1071]

Cited: 4 times

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Low-grade albuminuria in pulmonary arterial hypertension.

Nils P Nickel, Vinicio A de Jesus Perez, Roham T Zamanian, Joshua P Fessel, Joy D Cogan, Rizwam Hamid, James D West, Mark P de Caestecker, Haichun Yang, Eric D Austin,

Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and is increasingly recognized as a systemic disease. In ... Read more >>

Pulm Circ (Pulmonary circulation)
[2019, 9(2):2045894018824564]

Cited: 3 times

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Treatment of Acute Intoxication From Inhaled 1,2-Difluoroethane.

Juan Pablo Arroyo, Daniel C Johnson, Julia B Lewis, Ahmed Al Sheyyab, Adam King, Matthew R Danter, Stuart McGrane, Joshua P Fessel,

Ann Intern Med (Annals of internal medicine)
[2018, 169(11):820-822]

Cited: 2 times

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A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.

Anna R Hemnes, Anandharajan Rathinasabapathy, Eric A Austin, Evan L Brittain, Erica J Carrier, Xinping Chen, Joshua P Fessel, Candice D Fike, Peter Fong, Niki Fortune, Robert E Gerszten, Jennifer A Johnson, Mark Kaplowitz, John H Newman, Robert Piana, Meredith E Pugh, Todd W Rice, Ivan M Robbins, Lisa Wheeler, Chang Yu, James E Loyd, James West,

Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate conversion of angiotensin II (AngII) to angiotensin-(1-7) (Ang-(1-7)) by angiotensin-converting enzyme 2 (ACE2) resulting in Mas receptor (Mas1) activation improves rodent models of PAH. Effects of recombinant human (rh) ACE2 in human PAH are unknown. Our objective was ... Read more >>

Eur Respir J (The European respiratory journal)
[2018, 51(6):]

Cited: 83 times

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Lower Concentrations of Circulating Medium and Long-Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV.

Samuel S Bailin, Cathy A Jenkins, Christopher Petucci, Jeffrey A Culver, Bryan E Shepherd, Joshua P Fessel, Todd Hulgan, John R Koethe,

In human immunodeficiency virus (HIV)-negative individuals, a plasma metabolite profile, characterized by higher levels of branched-chain amino acids (BCAA), aromatic amino acids, and C3/C5 acylcarnitines, is associated with insulin resistance and increased risk of diabetes. We sought to characterize the metabolite profile accompanying insulin resistance in HIV-positive persons to assess ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2018, 34(6):536-543]

Cited: 3 times

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Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation.

Priscila Gubert, Bruna Puntel, Tassia Lehmen, Joshua P Fessel, Pan Cheng, Julia Bornhorst, Lucas Siqueira Trindade, Daiana S Avila, Michael Aschner, Felix A A Soares,

Manganese (Mn) is an essential trace element for physiological functions since it acts as an enzymatic co-factor. Nevertheless, overexposure to Mn has been associated with a pathologic condition called manganism. Furthermore, Mn has been reported to affect lipid metabolism by mechanisms which have yet to be established. Herein, we used ... Read more >>

Neurotoxicology (Neurotoxicology)
[2018, 67:65-72]

Cited: 6 times

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Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA.

Orrette R Wauchope, Michelle M Mitchener, William N Beavers, James J Galligan, Jeannie M Camarillo, William D Sanders, Philip J Kingsley, Ha-Na Shim, Thomas Blackwell, Thong Luong, Mark deCaestecker, Joshua P Fessel, Lawrence J Marnett,

Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogenous peroxidation-derived DNA adduct, are 50-100-fold higher in mtDNA than in nuclear DNA in several ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2018, 46(7):3458-3467]

Cited: 10 times

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A Metabolic Basis for Endothelial-to-Mesenchymal Transition.

Jianhua Xiong, Hiroyuki Kawagishi, Ye Yan, Jie Liu, Quinn S Wells, Lia R Edmunds, Maria M Fergusson, Zu-Xi Yu, Ilsa I Rovira, Evan L Brittain, Michael J Wolfgang, Michael J Jurczak, Joshua P Fessel, Toren Finkel,

Endothelial-to-mesenchymal transition (EndoMT) is a cellular process often initiated by the transforming growth factor β (TGF-β) family of ligands. Although required for normal heart valve development, deregulated EndoMT is linked to a wide range of pathological conditions. Here, we demonstrate that endothelial fatty acid oxidation (FAO) is a critical in vitro and ... Read more >>

Mol Cell (Molecular cell)
[2018, 69(4):689-698.e7]

Cited: 55 times

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Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.

Shilpy Dixit, Joshua P Fessel, Fiona E Harrison,

Mitochondrial dysfunction is elevated in very early stages of Alzheimer's disease and exacerbates oxidative stress, which contributes to disease pathology. Mitochondria were isolated from 4-month-old wild-type mice, transgenic mice carrying the APP<sub>SWE</sub> and PSEN1<sub>dE9</sub> mutations, mice with decreased brain and mitochondrial ascorbate (vitamin C) via heterozygous knockout of the sodium ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2017, 112:515-523]

Cited: 19 times

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Nicotine Adenine Dinucleotides: The Redox Currency of the Cell.

Joshua P Fessel, William M Oldham,

There has been tremendous and rapidly growing interest in understanding intermediary metabolism as a key aspect of both normal cellular function and as a participant in the molecular pathogenesis of many different complex diseases. This area of research naturally intersects at virtually every level with the substantial and expanding body ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2018, 28(3):165-166]

Cited: 2 times

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Pyridine Dinucleotides from Molecules to Man.

Joshua P Fessel, William M Oldham,

<h4>Significance</h4>Pyridine dinucleotides, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), were discovered more than 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, these molecules have been recognized as fundamental players in a variety of cellular processes, including energy metabolism, redox homeostasis, cellular ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2018, 28(3):180-212]

Cited: 10 times

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Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease.

Christa Gaskill, Shennea Marriott, Sidd Pratap, Swapna Menon, Lora K Hedges, Joshua P Fessel, Jonathan A Kropski, DeWayne Ames, Lisa Wheeler, James E Loyd, Anna R Hemnes, Dennis R Roop, Dwight J Klemm, Eric D Austin, Susan M Majka,

Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the potential to ... Read more >>

Pulm Circ (Pulmonary circulation)
[2016, 6(4):483-497]

Cited: 10 times

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Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.

Keisha N Hardeman, Chengwei Peng, Bishal B Paudel, Christian T Meyer, Thong Luong, Darren R Tyson, Jamey D Young, Vito Quaranta, Joshua P Fessel,

Dysregulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and expanding proliferation. Given many BRAF-mutated melanoma patients experience disease progression with targeted BRAF inhibitors, we hypothesized therapeutic response is related to tumor metabolic phenotype, and that altering tumor metabolism could change therapeutic outcome. We demonstrated the proliferative kinetics ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:42604]

Cited: 23 times

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Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.

Xinping Chen, Eric D Austin, Megha Talati, Joshua P Fessel, Eric H Farber-Eger, Evan L Brittain, Anna R Hemnes, James E Loyd, James West,

Increased oestrogen is a strong epidemiological risk factor for development of pulmonary arterial hypertension (PAH) in patients, associated with metabolic defects. In addition, oestrogens drive penetrance in mice carrying mutations in bone morphogenetic protein receptor type II (BMPR2), the cause of most heritable PAH. The goal of the present study ... Read more >>

Eur Respir J (The European respiratory journal)
[2017, 50(2):]

Cited: 21 times

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Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension.

Anna E Dikalova, Hana A Itani, Rafal R Nazarewicz, William G McMaster, Charles R Flynn, Roman Uzhachenko, Joshua P Fessel, Jorge L Gamboa, David G Harrison, Sergey I Dikalov,

<h4>Rationale</h4>Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by 65 years of age paralleling the increased incidence of hypertension and metabolic conditions further inactivate Sirt3 because of increased NADH (nicotinamide adenine dinucleotide, reduced form) and acetyl-CoA levels. Sirt3 impairment reduces the activity of a key mitochondrial ... Read more >>

Circ Res (Circulation research)
[2017, 121(5):564-574]

Cited: 49 times

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Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.

Quinn S Wells, Olivia J Veatch, Joshua P Fessel, Aron Y Joon, Rebecca T Levinson, Jonathan D Mosley, Elizabeth P Held, Chase S Lindsay, Christian M Shaffer, Peter E Weeke, Andrew M Glazer, Kevin R Bersell, Sara L Van Driest, Jason H Karnes, Marcia A Blair, Lore W Lagrone, Yan R Su, Erica A Bowton, Ziding Feng, Bonnie Ky, Daniel J Lenihan, Michael J Fisch, Joshua C Denny, Dan M Roden,

<h4>Background</h4>Anthracyclines are important chemotherapeutic agents, but their use is limited by cardiotoxicity. Candidate gene and genome-wide studies have identified putative risk loci for overt cardiotoxicity and heart failure, but there has been no comprehensive assessment of genomic variation influencing the intermediate phenotype of anthracycline-related changes in left ventricular (LV) function. ... Read more >>

Pharmacogenet Genomics (Pharmacogenetics and genomics)
[2017, 27(7):247-254]

Cited: 19 times

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Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension.

Aaron W Trammell, Megha Talati, Thomas R Blackwell, Niki L Fortune, Kevin D Niswender, Joshua P Fessel, John H Newman, James D West, Anna R Hemnes,

Pulmonary arterial hypertension (PAH) is associated with metabolic derangements including insulin resistance, although their effects on the cardiopulmonary disease are unclear. We hypothesized that insulin resistance promotes pulmonary hypertension (PH) development and mutations in type 2 bone morphogenetic protein receptor (BMPR2) cause cellular insulin resistance. Using a BMPR2 transgenic murine ... Read more >>

Pulm Circ (Pulmonary circulation)
[2017, 7(3):624-634]

Cited: 6 times

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Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension.

Robert A Egnatchik, Evan L Brittain, Amy T Shah, Wassim H Fares, H James Ford, Ken Monahan, Christie J Kang, Emily G Kocurek, Shijun Zhu, Thong Luong, Thuy T Nguyen, Erik Hysinger, Eric D Austin, Melissa C Skala, Jamey D Young, L Jackson Roberts, Anna R Hemnes, James West, Joshua P Fessel,

Pulmonary arterial hypertension (PAH) is increasingly recognized as a systemic disease driven by alteration in the normal functioning of multiple metabolic pathways affecting all of the major carbon substrates, including amino acids. We found that human pulmonary hypertension patients (WHO Group I, PAH) exhibit systemic and pulmonary-specific alterations in glutamine ... Read more >>

Pulm Circ (Pulmonary circulation)
[2017, 7(1):186-199]

Cited: 18 times

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Mitochondrial Haplogroups as a Risk Factor for Herpes Zoster.

Rebecca T Levinson, Todd Hulgan, Spyros A Kalams, Joshua P Fessel, David C Samuels,

<b><i>Background.</i></b>  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine mitochondrial haplogroups as a potential host factor related to herpes zoster incidence. <b><i>Methods.</i></b> ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2016, 3(4):ofw184]

Cited: 1 time

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Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.

Evan L Brittain, Megha Talati, Joshua P Fessel, He Zhu, Niki Penner, M Wade Calcutt, James D West, Mitch Funke, Gregory D Lewis, Robert E Gerszten, Rizwan Hamid, Meredith E Pugh, Eric D Austin, John H Newman, Anna R Hemnes,

<h4>Background</h4>The mechanisms of right ventricular (RV) failure in pulmonary arterial hypertension (PAH) are poorly understood. Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism has not been studied in human PAH.<h4>Methods and results</h4>We used human blood, RV tissue, and ... Read more >>

Circulation (Circulation)
[2016, 133(20):1936-1944]

Cited: 58 times

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Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.

Megha H Talati, Evan L Brittain, Joshua P Fessel, Niki Penner, James Atkinson, Mitch Funke, Carrie Grueter, W Gray Jerome, Michael Freeman, John H Newman, James West, Anna R Hemnes,

<h4>Rationale</h4>In heritable pulmonary arterial hypertension with germline mutation in the bone morphogenetic protein receptor type 2 (BMPR2) gene, right ventricle (RV) dysfunction is associated with RV lipotoxicity; however, the underlying mechanism for lipid accumulation is not known.<h4>Objectives</h4>We hypothesized that lipid accumulation in cardiomyocytes with BMPR2 mutation occurs owing to alterations ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2016, 194(6):719-728]

Cited: 39 times

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