Full Text Journal Articles by
Author Josh Rowe

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Mechanistic Investigations Support Liver Safety of Ubrogepant.

Brenda Smith, Josh Rowe, Paul B Watkins, Messoud Ashina, Jeffrey L Woodhead, Frank D Sistare, Peter J Goadsby,

Small-molecule calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated therapeutic efficacy for the treatment of migraine. However, previously investigated CGRP receptor antagonists, telcagepant and MK-3207, were discontinued during clinical development because of concerns about drug-induced liver injury. A subsequent effort to identify novel CGRP receptor antagonists less likely to cause ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2020, 177(1):84-93]

Cited: 2 times

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Liver and muscle glycogen oxidation and performance with dose variation of glucose-fructose ingestion during prolonged (3 h) exercise.

Andy J King, John P O'Hara, Nicola C Arjomandkhah, Josh Rowe, Douglas J Morrison, Thomas Preston, Roderick F G J King,

<h4>Purpose</h4>This study investigated the effect of small manipulations in carbohydrate (CHO) dose on exogenous and endogenous (liver and muscle) fuel selection during exercise.<h4>Method</h4>Eleven trained males cycled in a double-blind randomised order on 4 occasions at 60% [Formula: see text] for 3 h, followed by a 30-min time-trial whilst ingesting either 80 g h<sup>-1</sup> ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2019, 119(5):1157-1169]

Cited: 6 times

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Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways.

Alison E M Vickers, Jason Heale, John R Sinclair, Stephen Morris, Josh M Rowe, Robyn L Fisher,

Drug induced thyroid effects were evaluated in organotypic models utilizing either a rat thyroid lobe or human thyroid slices to compare rodent and human response. An inhibition of thyroid peroxidase (TPO) function led to a perturbation in the expression of key genes in thyroid hormone synthesis and release pathways. The ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2012, 260(1):81-88]

Cited: 15 times

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Sensitivity and proportionality assessment of metabolites from microdose to high dose in rats using LC-MS/MS.

Jinsong Ni, Hui Ouyang, Carmai Seto, Takeo Sakuma, Robert Ellis, Josh Rowe, Andrew Acheampong, Devin Welty, Gabriella Szekely-Klepser,

<h4>Background</h4>The objective of this study was to evaluate the sensitivity requirement for LC-MS/MS as an analytical tool to characterize metabolites in plasma and urine at microdoses in rats and to investigate proportionality of metabolite exposure from a microdose of 1.67 µg/kg to a high dose of 5000 µg/kg for atorvastatin, ... Read more >>

Bioanalysis (Bioanalysis)
[2010, 2(3):407-419]

Cited: 1 time

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