Full Text Journal Articles by
Author Joseph Tector

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HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes.

Gregory R Martens, Joseph M Ladowski, Jose Estrada, Zheng-Yu Wang, Luz M Reyes, Juliet Easlick, Clarkson Smith, James R Butler, Richard A Sidner, Devin E Eckhoff, Matthew Tector, Joseph Tector,

BACKGROUND:Highly sensitized patients are difficult to match with suitable renal allograft donors and may benefit from xenotransplant trials. We evaluate antibody binding from sensitized patients to pig cells and engineered single allele cells to identify anti-human leukocyte antigen (HLA) antibody cross-species reactivity with swine leukocyte antigen (SLA). These novel testing ... Read more >>

Transplantation (Transplantation)
[2019, 103(8):1620-1629]

Cited: 0 times

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Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens.

Joseph M Ladowski, Gregory R Martens, Luz M Reyes, Vera Hauptfeld-Dolejsek, Matthew Tector, Joseph Tector,

Xenotransplantation of pig organs into people may help alleviate the critical shortage of donors which faces organ transplantation. Unfortunately, human antibodies vigorously attack pig tissues preventing the clinical application of xenotransplantation. The swine leukocyte antigens (SLA), homologs of human HLA molecules, can be xenoantigens. SLA molecules, encoded by genes in ... Read more >>

Immunogenetics (Immunogenetics)
[2019, 71(7):479-487]

Cited: 0 times

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Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation.

Wayne J Hawthorne, Peter J Cowan, Léo H Bühler, Shounan Yi, Rita Bottino, Richard N Pierson, Curie Ahn, Agnes Azimzadeh, Emanuele Cozzi, Pierre Gianello, Jonathan R T Lakey, Minhua Luo, Shuji Miyagawa, Muhammad M Mohiuddin, Chung-Gyu Park, Henk-Jan Schuurman, Linda Scobie, Megan Sykes, Joseph Tector, Ralf Reinhard Tönjes, Eckhard Wolf, José R Nuñez, Wei Wang,

Xenotransplantation (Xenotransplantation)
[2019, 26(2):e12513]

Cited: 0 times

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The desirable donor pig to eliminate all xenoreactive antigens.

Joseph Ladowski, Greg Martens, Jose Estrada, Matthew Tector, Joseph Tector,

The humoral barrier has been the limiting factor in moving xenotransplantation towards the clinic. Improvements in somatic cell nuclear transfer and genome editing, particularly CRISPR-Cas9, have made it possible to create pigs with multiple glycan xenoantigen deletions for the purposes of reducing xenoreactive antibody binding to the xenografted organ. Recent ... Read more >>

Xenotransplantation (Xenotransplantation)
[2019, 26(4):e12504]

Cited: 0 times

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B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy.

Takayuki Yamamoto, Qi Li, Hidetaka Hara, Liaoran Wang, Hongmin Zhou, Juan Li, Devin E Eckhoff, A Joseph Tector, Edwin C Klein, Ray Lovingood, Mohamed Ezzelarab, David Ayares, Yi Wang, David K C Cooper, Hayato Iwase,

BACKGROUND:In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from an α1,3-galactosyltransferase gene-knockout (GTKO) pig elicits a significant anti-nonGal IgG response, indicating sensitization to the graft. A costimulation blockade-based regimen, e.g., anti-CD154mAb or anti-CD40mAb, prevents sensitization. However, neither of these agents is currently FDA-approved. The aim of ... Read more >>

Transpl. Immunol. (Transplant immunology)
[2018, 51:12-20]

Cited: 1 time

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Thomas E. Starzl, MD, PhD, 1926-2017.

David K C Cooper, A Joseph Tector,

Xenotransplantation (Xenotransplantation)
[2017, 24(2):]

Cited: 0 times

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Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes.

Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio,

To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT).The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 97(5):931-938]

Cited: 9 times

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Optimization of Perioperative Conditions to Prevent Ischemic Cholangiopathy in Donation After Circulatory Death Donor Liver Transplantation.

Chandrashekhar Kubal, Richard Mangus, Jonathan Fridell, Romil Saxena, Natalia Rush, Matthew Wingler, Burcin Ekser, Joseph Tector,

Donation after circulatory death (DCD) donor pool remains underutilized for liver transplantation (LT). We describe optimizing "modifiable risk factors," such as cold ischemia time (CIT) recipient warm ischemia time (WIT) and the use of thrombolytic flush at the time of procurement to minimize ischemic cholangiopathy (IC).From July 2011 (era II), ... Read more >>

Transplantation (Transplantation)
[2016, 100(8):1699-1704]

Cited: 12 times

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New Hope for Liver Xenotransplantation.

Joseph Tector,

Ann. Surg. (Annals of surgery)
[2016, 263(6):1072]

Cited: 3 times

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Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation.

James R Butler, Gregory R Martens, Jose L Estrada, Luz M Reyes, Joseph M Ladowski, Cesare Galli, Andrea Perota, Conor M Cunningham, Matthew Tector, A Joseph Tector,

The future of solid organ transplantation is challenged by an increasing shortage of available allografts. Xenotransplantation of genetically modified porcine organs offers an answer to this problem. Strategies of genetic modification have 'humanized' the porcine model towards clinical relevance. Most notably, these approaches have aimed at either antigen reduction or ... Read more >>

Transgenic Res. (Transgenic research)
[2016, 25(5):751-759]

Cited: 19 times

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Worse Long-term Patient Survival and Higher Cancer Rates in Liver Transplant Recipients With a History of Smoking.

Richard S Mangus, Jonathan A Fridell, Chandrashekhar A Kubal, Amanda L Loeffler, Audrey A Krause, Jeffrey A Bell, Sarika Tiwari, Joseph Tector,

This study is a retrospective review of liver transplant (LT) recipients to determine the impact of tobacco exposure on 10-year survival and de novo cancer (CA) incidence.The records of 1275 consecutive LT patients were reviewed (2001 to 2011). Patients were categorized as current, previous, or never smokers (NS) at listing ... Read more >>

Transplantation (Transplantation)
[2015, 99(9):1862-1868]

Cited: 10 times

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Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes.

Jose L Estrada, Greg Martens, Ping Li, Andrew Adams, Kenneth A Newell, Mandy L Ford, James R Butler, Richard Sidner, Matt Tector, Joseph Tector,

Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan-based species incompatibilities, we examined human and non-human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate-modifying genes.The Cas9 endonuclease and ... Read more >>

Xenotransplantation (Xenotransplantation)
[2015, 22(3):194-202]

Cited: 65 times

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Role of cardiac catheterization and percutaneous coronary intervention in the preoperative assessment and management of patients before orthotopic liver transplantation.

Haripriya Maddur, Patrick D Bourdillon, Suthat Liangpunsakul, A Joseph Tector, Jonathan A Fridell, Marwan Ghabril, Marco A Lacerda, Charlotte Bourdillon, Changyu Shen, Paul Y Kwo,

Limited data regarding the optimal risk assessment strategy for evaluating candidates for orthotopic liver transplantation (OLT) exist. Our center has adopted a policy of performing cardiac catheterization (CATH) in patients with predefined risk factors, and this is followed by percutaneous coronary intervention (PCI) when it is indicated, even in the ... Read more >>

Liver Transpl. (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2014, 20(6):664-672]

Cited: 17 times

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Alcohol abuse in deceased liver donors: impact on post-transplant outcomes.

Richard S Mangus, Chandrashekhar A Kubal, Jonathan A Fridell, Jose M Pena, Evan M Frost, A Joseph Tector,

BACKGROUND: Many deceased liver donors with a history of alcohol abuse are excluded based upon medical history alone. This paper summarizes the transplant outcomes for a large number of deceased liver donors with a documented history of alcohol abuse. METHODS: The records for 1478 consecutive deceased liver donors were reviewed ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2015, 35(1):171-175]

Cited: 2 times

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Telaprevir with peginterferon/ribavirin for retreatment of null responders with advanced fibrosis post-orthotopic liver transplant.

Paul Y Kwo, Marwan Ghabril, Marco A Lacerda, Alfred Joseph Tector, Jonathan A Fridell, Rodrigo Vianna,

Aggressive recurrence of hepatitis C remains problematic post-orthotopic liver transplant (OLT). There are limited data on treatment of HCV infection with telaprevir/boceprevir therapy with peginterferon/ribavirin (PR) post-OLT.To review our experience with telaprevir addition to peginterferon/ribavirin in treatment of aggressive hepatitis C in null responders to PR post-OLT.Adult patients with recurrent ... Read more >>

Clin Transplant (Clinical transplantation)
[2014, 28(6):722-727]

Cited: 6 times

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A new vascular approach to the modified multivisceral graft procurement.

Jonathan A Fridell, A Joseph Tector, Richard S Mangus, Marwan M Kazimi, Edward F Hollinger, Rodrigo M Vianna,

Modified multivisceral (MMV) transplantation including the stomach, pancreaticoduodenal complex and intestine requires preservation of the left gastric and splenic arteries. The previously described techniques require division of the hepatic artery proximal to the gastroduodenal artery leaving the liver transplant team with a very short and small caliber vessel. To increase ... Read more >>

Clin Transplant (Clinical transplantation)
[2009, 23(6):784-787]

Cited: 7 times

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Initiation of an intestinal transplant program: the Indiana experience.

Rodrigo M Vianna, Richard S Mangus, Jonathan A Fridell, Marwan Kazimi, Edward Hollinger, Joseph Tector,

INTRODUCTION: Establishment of a new intestinal transplant (Itx) program in the United States entails significant programmatic costs and a steep learning curve. We report results of the first 4 years of the program at Indiana University. METHODS: Forty-six intestinal and multivisceral transplants (MVtx) were performed between 2003 and 2007. All ... Read more >>

Transplantation (Transplantation)
[2008, 85(12):1784-1790]

Cited: 7 times

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Stem cells as a potential future treatment of pediatric intestinal disorders.

Troy A Markel, Paul R Crisostomo, Tim Lahm, Nathan M Novotny, Frederick J Rescorla, Joseph Tector, Daniel R Meldrum,

All surgical disciplines encounter planned and unplanned ischemic events that may ultimately lead to cellular dysfunction and death. Stem cell therapy has shown promise for the treatment of a variety of ischemic and inflammatory disorders where tissue damage has occurred. As stem cells have proven beneficial in many disease processes, ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2008, 43(11):1953-1963]

Cited: 23 times

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Intestinal and multivisceral transplantation at Indiana University: 6 years' experience with 100 cases.

Rodrigo Vianna, Chandrashekhar Kubal, Richard Mangus, Jonathan Fridell, Joseph Tector,

Intestinal transplantation has shown exceptional growth over the past 20 years with extraordinary progress. As with other solid organ transplants, intestinal transplantation has now transitioned from being experimental to being the standard of care for patients with intestinal failure. The currently reported 1-year graft and patient survival rate is 80%, ... Read more >>

Clin Transpl (Clinical transplants)
[2009, :219-228]

Cited: 1 time

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Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas.

Jonathan A Fridell, Rodrigo Vianna, Richard S Mangus, Marwan Kazimi, Edward Hollinger, A Joseph Tector,

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. METHODS: The recipient was a 65-yr-old man with hepatocellular carcinoma in a ... Read more >>

Clin Transplant (Clinical transplantation)
[2008, 22(5):681-684]

Cited: 3 times

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Induction immunosuppression with thymoglobulin and rituximab in intestinal and multivisceral transplantation.

Rodrigo M Vianna, Richard S Mangus, Jonathan A Fridell, Sheila Weigman, Marwan Kazimi, Joseph Tector,

BACKGROUND: Induction immunosuppression is now a common practice after intestinal and multivisceral transplantation. We report our experience in 27 adult recipients who received rituximab and rabbit antithymocyte globulin (rATG) in combination as induction agents. MATERIAL AND METHODS: Twenty-seven adult patients received 29 intestinal transplants between July 2004 and March 2007. ... Read more >>

Transplantation (Transplantation)
[2008, 85(9):1290-1293]

Cited: 28 times

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