Full Text Journal Articles by
Author Joseph McDermott

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Immune Cell Types and Secreted Factors Contributing to Inflammation-to-Cancer Transition and Immune Therapy Response.

Xingwei Chen, Chi Xu, Shengjun Hong, Xian Xia, Yaqiang Cao, Joseph McDermott, Yonglin Mu, Jing-Dong J Han,

Although chronic inflammation increases many cancers' risk, how inflammation facilitates cancer development is still not well studied. Recognizing whether and when inflamed tissues transition to cancerous tissues is of utmost importance. To unbiasedly infer molecular events, immune cell types, and secreted factors contributing to the inflammation-to-cancer (I2C) transition, we develop ... Read more >>

Cell Rep (Cell reports)
[2019, 26(7):1965-1977.e4]

Cited: 0 times

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Widespread roles of enhancer-like transposable elements in cell identity and long-range genomic interactions.

Yaqiang Cao, Guoyu Chen, Gang Wu, Xiaoli Zhang, Joseph McDermott, Xingwei Chen, Chi Xu, Quanlong Jiang, Zhaoxiong Chen, Yingying Zeng, Daosheng Ai, Yi Huang, Jing-Dong J Han,

A few families of transposable elements (TEs) have been shown to evolve into cis-regulatory elements (CREs). Here, to extend these studies to all classes of TEs in the human genome, we identified widespread enhancer-like repeats (ELRs) and find that ELRs reliably mark cell identities, are enriched for lineage-specific master transcription ... Read more >>

Genome Res. (Genome research)
[2019, 29(1):40-52]

Cited: 1 time

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Accurate loop calling for 3D genomic data with cLoops

Yaqiang Cao, Xingwei Chen, Daosheng Ai, Zhaoxiong Chen, Guoyu Chen, Joseph McDermott, Yi Huang, Jing-Dong Han,

Abstract Sequencing-based 3D genome mapping technologies can identify loops formed by interactions between regulatory elements hundreds of kilobases apart. Existing loop-calling tools are mostly restricted to a single data type, with accuracy dependent on a pre-defined resolution contact matrix or called peaks, and can have prohibitive hardware costs. Here we ... Read more >>

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Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes.

Chi Xu, Daosheng Ai, Shengbao Suo, Xingwei Chen, Yizhen Yan, Yaqiang Cao, Na Sun, Weizhong Chen, Joseph McDermott, Shiqiang Zhang, Yingying Zeng, Jing-Dong Jackie Han,

Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of single gene mutations' non-tissue-specific "core transcriptome signatures" (CSs) of 8,476 genes generated from the ... Read more >>

Cell Rep (Cell reports)
[2018, 25(2):523-535.e5]

Cited: 0 times

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Aging and Alzheimer's disease: Comparison and associations from molecular to system level.

Xian Xia, Quanlong Jiang, Joseph McDermott, Jing-Dong J Han,

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot ... Read more >>

Aging Cell (Aging cell)
[2018, 17(5):e12802]

Cited: 3 times

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Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation.

Hao Cheng, Hongwen Xuan, Christopher D Green, Yixing Han, Na Sun, Hongjie Shen, Joseph McDermott, David A Bennett, Fei Lan, Jing-Dong J Han,

Brain "inflammaging," a low-grade and chronic inflammation, is a major hallmark for aging-related neurodegenerative diseases. Here, by profiling H3K27ac and gene expression patterns in human and mouse brains, we found that age-related up-regulated (Age-Up) and down-regulated (Age-Down) genes have distinct H3K27ac patterns. Although both groups show promoter H3K27ac, the Age-Up ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(29):7611-7616]

Cited: 4 times

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Inference of differentiation time for single cell transcriptomes using cell population reference data.

Na Sun, Xiaoming Yu, Fang Li, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D Green, Joseph McDermott, Qin Shen, Naihe Jing, Jing-Dong J Han,

Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often discards cell-cycle events as confounding factors. Here using matched cell population RNA-seq (cpRNA-seq) as a reference, we developed an "iCpSc" package for integrative analysis of ... Read more >>

Nat Commun (Nature communications)
[2017, 8(1):1856]

Cited: 3 times

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Role of AQP9 in transport of monomethyselenic acid and selenite.

Xiangrong Geng, Joseph McDermott, Joseph Lundgren, Liu Liu, Kan-Jen Tsai, Jian Shen, Zijuan Liu,

AQP9 is an aquaglyceroporin with a very broad substrate spectrum. In addition to its orthodox nutrient substrates, AQP9 also transports multiple neutral and ionic arsenic species including arsenic trioxide, monomethylarsenous acid (MAsIII) and dimethylarsenic acid (DMAV). Here we discovered a new group of AQP9 substrates which includes two clinical relevant ... Read more >>

Biometals (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine)
[2017, 30(5):747-755]

Cited: 1 time

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Solitary nodule with white hairs.

Megan Wetzel, Amy Gagnon, Joseph McDermott,

Cutis (Cutis)
[2017, 100(2):E1-E2]

Cited: 0 times

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Left Lower Arm Hemichorea: An Unusual Presentation of New-Onset Type 2 Diabetes.

Maria Jose Velasco Acuna, Paul Labinson, Joseph McDermott,

Clin Diabetes (Clinical diabetes : a publication of the American Diabetes Association)
[2017, 35(3):183-184]

Cited: 0 times

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Molecular and phenotypic biomarkers of aging.

Xian Xia, Weiyang Chen, Joseph McDermott, Jing-Dong Jackie Han, Jing-Dong Jackie Han,

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of 'healthy aging', and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers ... Read more >>

F1000Res (F1000Research)
[2017, 6:860]

Cited: 3 times

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Molecular and phenotypic biomarkers of aging

Xian Xia, Weiyang Chen, Joseph McDermott, Jing-Dong Jackie Han,

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers ... Read more >>

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Cited: 4 times

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Seroprevalence of Toxoplasma gondii in American Black Bears ( Ursus americanus ) of the Central Appalachians, USA.

John J Cox, Sean M Murphy, Ben C Augustine, Joseph M Guthrie, John T Hast, Sutton C Maehr, Joseph McDermott,

We assessed Toxoplasma gondii seroprevalence in 53 free-ranging American black bears ( Ursus americanus ) in the Central Appalachian Mountains, US. Seroprevalence was 62% with no difference between males and females or between juvenile and adult bears. Wildlife agencies should consider warnings in hunter education programs to reduce the chances ... Read more >>

J. Wildl. Dis. (Journal of wildlife diseases)
[2017, 53(3):671-673]

Cited: 0 times

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Copper Deficiency in the Lungs of TNF-α Transgenic Mice.

Liu Liu, Xiangrong Geng, Joseph McDermott, Jian Shen, Cody Corbin, Stephanie Xuan, Jae Kim, Li Zuo, Zijuan Liu,

Tumor necrosis factor (TNF)-α is a well-known pro-inflammatory cytokine. Increased expression of Tnf-α is a feature of inflammatory lung diseases, such as asthma, emphysema, fibrosis, and smoking-induced chronic obstructive pulmonary disease (COPD). Using a mouse line with lung-specific Tnf-α overexpression (SPC-TNF-α) to mimic TNF-α-associated lung diseases, we investigated the role ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:234]

Cited: 1 time

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Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.

Joseph R McDermott, Xiangrong Geng, Lan Jiang, Marina Gálvez-Peralta, Fei Chen, Daniel W Nebert, Zijuan Liu,

Selenite (HSeO3-) is a monovalent anion of the essential trace element and micronutrient selenium (Se). In therapeutic concentrations, HSeO3- has been studied for treating certain cancers, serious inflammatory disorders, and septic shock. Little is known, however, about HSeO3- uptake into mammalian cells; until now, no mammalian HSeO3- uptake transporter has ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(23):35327-35340]

Cited: 7 times

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A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction.

Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, William B Mair, Jing-Dong J Han,

Dietary restriction (DR) is the most powerful natural means to extend lifespan. Although several genes can mediate responses to alternate DR regimens, no single genetic intervention has recapitulated the full effects of DR, and no unified system is known for different DR regimens. Here we obtain temporally resolved transcriptomes during ... Read more >>

Cell Metab. (Cell metabolism)
[2016, 23(3):529-540]

Cited: 12 times

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Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds.

Gui-Lan Duan, Ying Hu, Sabine Schneider, Joseph McDermott, Jian Chen, Norbert Sauer, Barry P Rosen, Birgit Daus, Zijuan Liu, Yong-Guan Zhu,

Arsenic contamination of groundwater and soils threatens the health of tens of millions of people worldwide. Understanding the way in which arsenic is taken up by crops such as rice, which serve as a significant source of arsenic in the human diet, is therefore important. Membrane transport proteins that catalyse ... Read more >>

Nat Plants (Nature plants)
[2016, 2(1):15202]

Cited: 11 times

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First case of NDM-1-producing Providencia rettgeri in Ecuador.

Jeannete Zurita, Henry Parra, Mónica Cartelle Gestal, Joseph McDermott, Pedro Barba,

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2015, 3(4):302-303]

Cited: 3 times

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Vascular anomalies of the neck.

David E Webb, Joseph McDermott, David Gover,

Atlas Oral Maxillofac Surg Clin North Am (Atlas of the oral and maxillofacial surgery clinics of North America)
[2015, 23(1):63-78]

Cited: 0 times

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Formation and activation of thermogenic fat.

Jun Wu, Heejin Jun, Joseph R McDermott,

Thermogenic fat cells that convert chemical energy into heat are present in both mice and humans. Recent years have witnessed great advances in our understanding of the regulation of these adipocytes and an increased appreciation of the potential these cells have to counteract obesity. We summarize recent efforts to understand ... Read more >>

Trends Genet. (Trends in genetics : TIG)
[2015, 31(5):232-238]

Cited: 13 times

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Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and hepatitis induced by phenytoin.

Maria Jose Velasco, Joseph McDermott,

Int. J. Dermatol. (International journal of dermatology)
[2014, 53(4):490-493]

Cited: 1 time

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Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio.

Mohamad Hamdi, Masafumi Yoshinaga, Charles Packianathan, Jie Qin, Janell Hallauer, Joseph R McDermott, Hung-Chi Yang, Kan-Jen Tsai, Zijuan Liu,

Arsenic methylation is an important cellular metabolic process that modulates arsenic toxicity and carcinogenicity. Biomethylation of arsenic produces a series of mono-, di- and tri-methylated arsenic metabolites that can be detected in tissues and excretions. Here we report that zebrafish exposed to arsenite (As(III)) produces organic arsenicals, including MMA(III), MMA(V) ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2012, 262(2):185-193]

Cited: 17 times

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Members of rice plasma membrane intrinsic proteins subfamily are involved in arsenite permeability and tolerance in plants.

Kareem A Mosa, Kundan Kumar, Sudesh Chhikara, Joseph Mcdermott, Zijuan Liu, Craig Musante, Jason C White, Om Parkash Dhankher,

Rice accumulates high level of arsenic (As) in its edible parts and thus plays an important role in the transfer of As into the food chain. However, the mechanisms of As uptake and its detoxification in rice are not well understood. Recently, members of the Nodulin 26-like intrinsic protein (NIP) ... Read more >>

Transgenic Res. (Transgenic research)
[2012, 21(6):1265-1277]

Cited: 33 times

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Leucocytoclastic vasculitis in severe ulcerative colitis.

Donald Martin, Tristan Handler, Joseph McDermott,

Ulcerative colitis may be associated with a number of extraintestinal skin manifestations including erythema nodosum and pyoderma gangrenosum. We describe an unusual case of a 26-year-old military pilot with ulcerative colitis and skin lesions diagnosed as leucocytoclastic vasculitis. The skin lesions occurred twice during the severe flare. The first occurrence ... Read more >>

Mil Med (Military medicine)
[2011, 176(5):581-583]

Cited: 1 time

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Jen1p: a high affinity selenite transporter in yeast.

Joseph R McDermott, Barry P Rosen, Zijuan Liu,

Selenium is a micronutrient in most eukaryotes, including humans, which is well known for having an extremely thin border between beneficial and toxic concentrations. Soluble tetravalent selenite is the predominant environmental form and also the form that is applied in the treatment of human diseases. To acquire this nutrient from ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2010, 21(22):3934-3941]

Cited: 25 times

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