Full Text Journal Articles by
Author Joseph L Jilek


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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling.

Siennah R Miller, Xiaohong Zhang, Raymond K Hau, Joseph L Jilek, Erin Q Jennings, James J Galligan, Daniel H Foil, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington,

Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the testes with drugs that use endogenous transport pathways may lead to more effective treatments for diseases within the reproductive tract. In this study, CRISPR/CRISPR-associated protein 9 was used to generate ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, 99(2):147-162]

Cited: 2 times

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Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability.

Joseph L Jilek, Mei-Juan Tu, Chao Zhang, Ai-Ming Yu,

Pharmacological interventions for hepatocellular carcinoma (HCC) are hindered by complex factors, and rational combination therapy may be developed to improve therapeutic outcomes. Very recently, we have identified a bioengineered microRNA let-7c-5p (or let-7c) agent as an effective inhibitor against HCC in vitro and in vivo. In this study, we sought ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2020, 48(12):1257-1263]

Cited: 4 times

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Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity.

Joseph L Jilek, Qian-Yu Zhang, Mei-Juan Tu, Pui Yan Ho, Zhijian Duan, Jing-Xin Qiu, Ai-Ming Yu,

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths, warranting better therapies. Restoration of tumor-suppressive microRNAs depleted in hepatocellular carcinoma represents a new therapeutic strategy. Herein, we sought to identify a potent microRNA (miRNA) agent that could alleviate HCC tumor burden and improve survival. Among a collection of bioengineered ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2019, 14:498-508]

Cited: 12 times

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Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells.

Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Joseph L Jilek, Zhijian Duan, Qian-Yu Zhang, Ai-Xi Yu, Ai-Ming Yu,

The nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor in the regulation of many oxidative enzymes and efflux transporters critical for oxidative stress and cellular defense against xenobiotics. NRF2 is dysregulated in patient osteosarcoma (OS) tissues and correlates with therapeutic outcomes. Nevertheless, research on the NRF2 regulatory pathways ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2018, 46(1):2-10]

Cited: 20 times

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Bioengineered Noncoding RNAs Selectively Change Cellular miRNome Profiles for Cancer Therapy.

Pui Yan Ho, Zhijian Duan, Neelu Batra, Joseph L Jilek, Mei-Juan Tu, Jing-Xin Qiu, Zihua Hu, Theodore Wun, Primo N Lara, Ralph W DeVere White, Hong-Wu Chen, Ai-Ming Yu,

Noncoding RNAs (ncRNAs) produced in live cells may better reflect intracellular ncRNAs for research and therapy. Attempts were made to produce biologic ncRNAs, but at low yield or success rate. Here we first report a new ncRNA bioengineering technology using more stable ncRNA carrier (nCAR) containing a pre-miR-34a derivative identified ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2018, 365(3):494-506]

Cited: 19 times

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Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression.

Karilyn E Sant, Dana C Dolinoy, Joseph L Jilek, Maureen A Sartor, Craig Harris,

Mono-2-ethylhexl phthalate (MEHP) is the primary metabolite of di-2-ethylhexyl phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how structural defects caused by MEHP in mouse whole embryo culture were related to temporal and spatial patterns of redox state and gene expression. MEHP reduced morphology scores along ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2016, 63:32-48]

Cited: 10 times

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MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy.

Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho, Joseph L Jilek,

Knowledge of drug absorption, distribution, metabolism, and excretion (ADME) or pharmacokinetics properties is essential for drug development and safe use of medicine. Varied or altered ADME may lead to a loss of efficacy or adverse drug effects. Understanding the causes of variations in drug disposition and response has proven critical ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2016, 44(3):308-319]

Cited: 29 times

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Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs.

Craig Harris, Joseph L Jilek, Karilyn E Sant, Jan Pohl, Matthew Reed, Jason M Hansen,

The process of embryonic nutrition in rodent conceptuses during organogenesis has been shown to involve a dominant histiotrophic mechanism where essential developmental substrates and micronutrients are supplied as whole maternal proteins or cargoes associated with proteins. The histiotrophic nutrition pathways (HNP) responsible for uptake and initial processing of proteins across ... Read more >>

J Nutr Biochem (The Journal of nutritional biochemistry)
[2015, 26(12):1589-1598]

Cited: 4 times

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Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis.

Joseph L Jilek, Karilyn E Sant, Katherine H Cho, Matthew S Reed, Jan Pohl, Jason M Hansen, Craig Harris,

Ethanol (EtOH) is a reactive oxygen-generating teratogen involved in the etiology of structural and functional developmental defects. Embryonic nutrition, redox environment, and changes in the thiol proteome following EtOH exposures (1.56.0 mg/ml) were studied in rat whole embryo culture. Glutathione (GSH) and cysteine (Cys) concentrations with their respective intracellular redox ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2015, 147(2):475-489]

Cited: 7 times

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