Full Text Journal Articles by
Author Joseph J Eron

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Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

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Drug and alcohol use among people living with HIV in care in the United States by geographic region.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Stephanie Ruderman, Judith I Tsui, Geetanjali Chander, Mary E McCaul, Bryan Lau, Kenneth H Mayer, D Scott Batey, Steven A Safren, Richard D Moore, Joseph J Eron, Sonia Napravnik, W Chris Mathews, Rob J Fredericksen, Andrew W Hahn, Michael J Mugavero, William B Lober, Michael S Saag, Mari M Kitahata, Joseph A C Delaney,

Substance use in the U.S. varies by geographic region. Opioid prescribing practices and marijuana, heroin, and methamphetamine availability are evolving differently across regions. We examined self-reported substance use among people living with HIV (PLWH) in care at seven sites from 2017-2019 to understand current regional substance use patterns. We calculated ... Read more >>

AIDS Care (AIDS care)
[2021, :1-8]

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Novel Criteria for Diagnosing Acute and Early HIV Infection in a Multi-National Study of Early Antiretroviral Therapy Initiation.

Trevor A Crowell, Justin Ritz, Robert W Coombs, Lu Zheng, Joseph J Eron, John W Mellors, Joan Dragavon, Gert U van Zyl, Javier R Lama, Kiat Ruxrungtham, Beatriz Grinsztejn, Roberto C Arduino, Lawrence Fox, Jintanat Ananworanich, Eric S Daar, ,

<h4>Background</h4>Antiretroviral therapy (ART) initiation during acute and early HIV infection (AEHI) limits HIV reservoir formation and may facilitate post-ART control but is logistically challenging. We evaluated the performance of new AEHI diagnostic criteria from a multi-national prospective study of ART initiation during AEHI.<h4>Methods</h4>ACTG 5354 enrolled adults at 30 sites in ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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HIV-specific T-cell responses reflect substantive in vivo interactions with antigen despite long-term therapy.

Eva M Stevenson, Adam R Ward, Ronald Truong, Allison S Thomas, Szu-Han Huang, Thomas R Dilling, Sandra Terry, John K Bui, Talia M Mota, Ali Danesh, Guinevere Q Lee, Andrea Gramatica, Pragya Khadka, Winiffer D Conce Alberto, Rajesh T Gandhi, Deborah K McMahon, Christina M Lalama, Ronald J Bosch, Bernard J Macatangay, Joshua C Cyktor, Joseph J Eron, John W Mellors, R Brad Jones,

Antiretroviral therapies (ART) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which re-seed replication if ART is interrupted. A central tenet of our current understanding of this persistence is that infected cells are shielded from immune recognition and elimination through a lack of ... Read more >>

JCI Insight (JCI insight)
[2021, :]

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Current and Past Immunodeficiency are Associated with Higher Hospitalization Rates among Persons on Virologically Suppressive Antiretroviral Therapy for up to Eleven Years.

Thibaut Davy-Mendez, Sonia Napravnik, Joseph J Eron, Stephen R Cole, David van Duin, David A Wohl, Brenna C Hogan, Keri N Althoff, Kelly A Gebo, Richard D Moore, Michael J Silverberg, Michael A Horberg, M John Gill, W Christopher Mathews, Marina B Klein, Jonathan A Colasanti, Timothy R Sterling, Angel M Mayor, Peter F Rebeiro, Kate Buchacz, Jun Li, Ni Gusti Ayu Nanditha, Jennifer E Thorne, Ank Nijhawan, Stephen A Berry, ,

<h4>Background</h4>Persons with HIV (PWH) with persistently low CD4 counts despite efficacious antiretroviral therapy could have higher hospitalization risk.<h4>Methods</h4>In six US and Canadian clinical cohorts, PWH with virologic suppression for ≥1 year in 2005-2015 were followed until virologic failure, loss to follow-up, death, or study end. Stratified by early (Years 2-5) ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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CD4 count at entry into HIV care and at antiretroviral therapy prescription in the US, 2005-2018.

Jennifer S Lee, Elizabeth A Humes, Brenna C Hogan, Kate Buchacz, Joseph J Eron, M John Gill, Timothy R Sterling, Peter F Rebeiro, Viviane Dias Lima, Angel Mayor, Michael J Silverberg, Michael A Horberg, Richard D Moore, Keri N Althoff, ,

From 2005 to 2018, among 32013 adults entering HIV care in the US, median time to ART prescription declined from 69 to 6 days, median CD4 count at entry into care increased from 300 to 362 cells/µL, and median CD4 count at ART prescription increased from 160 to 364 cells/µL. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Longitudinal dynamics of intact HIV proviral DNA and outgrowth virus frequencies in a cohort of ART-treated individuals.

Shane D Falcinelli, Kayla W Kilpatrick, Jenna Read, Ross Murtagh, Brigitte Allard, Simon Ghofrani, Jennifer Kirchherr, Katherine S James, Erin Stuelke, Caroline Baker, JoAnn D Kuruc, Joseph J Eron, Michael G Hudgens, Cynthia L Gay, David M Margolis, Nancie M Archin,

<h4>Background</h4>The replication-competent HIV reservoir is the major barrier to cure. The quantitative viral outgrowth assay (QVOA), the gold-standard method to quantify replication competent HIV, is resource-intensive which limits its application in large clinical trials. The Intact Proviral DNA Assay (IPDA) requires minimal cell input relative to QVOA and quantifies both ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Substantial decline in heavily treated therapy-experienced persons with HIV with limited antiretroviral treatment options.

Kristina L Bajema, Robin M Nance, Joseph A C Delaney, Ellen Eaton, Thibaut Davy-Mendez, Maile Y Karris, Richard D Moore, Joseph J Eron, Benigno Rodriguez, Kenneth H Mayer, Elvin Geng, Cindy Garris, Michael S Saag, Heidi M Crane, Mari M Kitahata, ,

<h4>Objective</h4>Historically, a high burden of resistance to antiretroviral therapy (ART) in heavily treatment-experienced (HTE) persons with HIV (PWH) resulted in limited treatment options (LTOs). We evaluated the prevalence, risk factors, and virologic control of HTE PWH with LTO throughout the modern ART era.<h4>Design</h4>We examined all ART-experienced PWH in care between ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(14):2051-2059]

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Hospitalization Rates and Causes among Persons with HIV in the US and Canada, 2005-2015.

Thibaut Davy-Mendez, Sonia Napravnik, Brenna C Hogan, Keri N Althoff, Kelly A Gebo, Richard D Moore, Michael A Horberg, Michael J Silverberg, M John Gill, Heidi M Crane, Vincent C Marconi, Ronald J Bosch, Jonathan A Colasanti, Timothy R Sterling, W Christopher Mathews, Angel M Mayor, Ni Gusti Ayu Nanditha, Kate Buchacz, Jun Li, Peter F Rebeiro, Jennifer E Thorne, Ank Nijhawan, David van Duin, David A Wohl, Joseph J Eron, Stephen A Berry, ,

<h4>Background</h4>To assess the possible impact of antiretroviral therapy improvements, aging, and comorbidities, we examined trends in all-cause and cause-specific hospitalization rates among persons with HIV (PWH) from 2005 to 2015.<h4>Methods</h4>In six clinical cohorts, we followed PWH in care (≥1 outpatient CD4 count or HIV viral load [VL] every 12 months) ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Genetic architecture of cardiometabolic risks in people living with HIV.

Haoxiang Chang, Anshuman Sewda, Carla Marquez-Luna, Sierra R White, Bridget M Whitney, Jessica Williams-Nguyen, Robin M Nance, Won Jun Lee, Mari M Kitahata, Michael S Saag, Amanda Willig, Joseph J Eron, W Christopher Mathews, Peter W Hunt, Richard D Moore, Allison Webel, Kenneth H Mayer, Joseph A Delaney, Paul K Crane, Heidi M Crane, Ke Hao, Inga Peter,

<h4>Background</h4>Advances in antiretroviral therapies have greatly improved the survival of people living with human immunodeficiency virus (HIV) infection (PLWH); yet, PLWH have a higher risk of cardiovascular disease than those without HIV. While numerous genetic loci have been linked to cardiometabolic risk in the general population, genetic predictors of the ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):288]

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Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy.

Shane D Falcinelli, Bonnie E Shook-Sa, Morgan G Dewey, Sumati Sridhar, Jenna Read, Jennifer Kirchherr, Katherine S James, Brigitte Allard, Simon Ghofrani, Erin Stuelke, Caroline Baker, Nadia R Roan, Joseph J Eron, JoAnn D Kuruc, Catalina Ramirez, Cynthia Gay, Katie R Mollan, David M Margolis, Adaora A Adimora, Nancie M Archin,

<h4>Background</h4>Persistent HIV infection of long-lived resting CD4 T cells, despite antiretroviral therapy (ART), remains a barrier to HIV cure. Women have a more robust type 1 interferon response during HIV infection relative to men, contributing to lower initial plasma viremia. As lower viremia during acute infection is associated with reduced ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(11):1843-1852]

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Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel.

Michael S Saag, Rajesh T Gandhi, Jennifer F Hoy, Raphael J Landovitz, Melanie A Thompson, Paul E Sax, Davey M Smith, Constance A Benson, Susan P Buchbinder, Carlos Del Rio, Joseph J Eron, Gerd Fätkenheuer, Huldrych F Günthard, Jean-Michel Molina, Donna M Jacobsen, Paul A Volberding,

<h4>Importance</h4>Data on the use of antiretroviral drugs, including new drugs and formulations, for the treatment and prevention of HIV infection continue to guide optimal practices.<h4>Objective</h4>To evaluate new data and incorporate them into current recommendations for initiating HIV therapy, monitoring individuals starting on therapy, changing regimens, preventing HIV infection for those ... Read more >>

JAMA (JAMA)
[2020, 324(16):1651-1669]

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Hospitalization Rates and Outcomes Among Persons Living With Human Immunodeficiency Virus in the Southeastern United States, 1996-2016.

Thibaut Davy-Mendez, Sonia Napravnik, David A Wohl, Amy L Durr, Oksana Zakharova, Claire E Farel, Joseph J Eron,

<h4>Background</h4>Antiretroviral therapy (ART) advances, aging, and comorbidities impact hospitalizations in human immunodeficiency virus (HIV)-positive populations. We examined temporal trends and patient characteristics associated with hospitalization rates and outcomes.<h4>Methods</h4>Among patients in the University of North Carolina Center for AIDS Research HIV Clinical Cohort receiving care during 1996-2016, we estimated annual hospitalization ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(7):1616-1623]

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Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.

Cynthia L Gay, Dayna T Neo, Aaron S Devanathan, Joann D Kuruc, Kara S McGee, John L Schmitz, Joe Sebastian, Nicholas J Shaheen, Guido Ferrari, Mehri McKellar, Susan A Fiscus, Charles B Hicks, Kevin Robertson, Angela D M Kashuba, Joseph J Eron, David M Margolis,

<h4>Objectives</h4>The aim of this study was to evaluate penetration of antiretrovirals into compartments and efficacy of a dual, NRTI-sparing regimen in acute HIV infection (AHI).<h4>Design</h4>Single-arm, open-label pilot study of participants with AHI initiating ritonavir-boosted darunavir 800 mg once daily and etravirine 400 mg once daily or 200 mg twice daily within 30 days ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(13):1923-1931]

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1704. Regional and Racial Disparities in Response to Antiretroviral Therapy (ART) among People Living with Human Immunodeficiency Virus (PLWH)

Keith M Rawlings, Joseph J Eron, Julie Priest, Janna Radtchenko, Joseph Mrus, Moti Rampogal, Alan Oglesby, Faith Fletcher, Richard A Elion,

Abstract <h4>Background</h4> This study evaluated differences in viral suppression by race and region among PLWH in care at 10 community practices. <h4>Methods</h4> PLWH (≥18 yrs) starting a new ART between Jan’15-Sept’19 with viral load at regimen prescription (Rx) and ≥6 months (mo) of prior history were selected from Trio Health ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S835-S835]

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108. Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

Rajesh Gandhi, Joshua Cyktor, Ronald Bosch, Hanna Mar, Gregory Laird, Albine Martin, Ann Collier, Sharon Riddler, Bernard Macatangay, Charles Rinaldo, Joseph J Eron, Janet Siliciano, Deborah McMahon, John Mellors,

Abstract <h4>Background</h4> HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are defective and do not constitute a replication-competent reservoir. The decay of infected cells carrying intact compared with defective HIV-1 proviruses has not been well-defined in people on ART. <h4>Methods</h4> We separately quantified intact and defective proviruses ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S183-S183]

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1002. A Daily Single Tablet Regimen (STR) of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in Virologically-Suppressed Adults Living with HIV and End Stage Renal Disease on Chronic Hemodialysis

Joseph J Eron, Aimee Wilkin, Moti Ramgopal, Olayemi Osiyemi, Mehri McKellar, Mehri McKellar, Jihad Slim, David Asmuth, Edwin DeJesus, Polina German, Christiana Blair, Christoph C Carter, Diana M Brainard, Sean E Collins, Hal Martin,

Abstract <h4>Background</h4> Treatment for people living with HIV (PLWH) and end stage renal disease (ESRD) on hemodialysis (HD) has previously required complex dose-adjusted regimens. We evaluated a daily regimen of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) and established this treatment as effective and safe, showing that daily TAF resulted in lower plasma tenofovir ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S529-S530]

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Evaluating the Efficacy of Therapies in COVID-19 Patients.

Dan-Yu Lin, Donglin Zeng, Joseph J Eron,

There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Clinical effectiveness of integrase strand transfer inhibitor-based antiretroviral regimens among adults with human immunodeficiency virus: a collaboration of cohort studies in the United States and Canada.

Haidong Lu, Stephen R Cole, Daniel Westreich, Michael G Hudgens, Adaora A Adimora, Keri N Althoff, Michael J Silverberg, Kate Buchacz, Jun Li, Jessie K Edwards, Peter F Rebeiro, Viviane D Lima, Vincent C Marconi, Timothy R Sterling, Michael A Horberg, M John Gill, Mari M Kitahata, Joseph J Eron, Richard D Moore, ,

BACKGROUND:Integrase strand transfer inhibitor (InSTI)-based regimens are now recommended as first-line antiretroviral therapy (ART) for adults with human immunodeficiency virus. But evidence on long-term clinical effectiveness of InSTI-based regimens remains limited. We examined whether InSTI-based regimens improved longer-term clinical outcomes. METHODS:We included participants from clinical cohorts in the North American ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy.

Rajesh T Gandhi, Joshua C Cyktor, Ronald J Bosch, Hanna Mar, Gregory M Laird, Albine Martin, Ann C Collier, Sharon A Riddler, Bernard J Macatangay, Charles R Rinaldo, Joseph J Eron, Janet D Siliciano, Deborah K McMahon, John W Mellors, ,

<h4>Background</h4>HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are defective and do not constitute a replication-competent reservoir. The decay of infected cells carrying intact compared with defective HIV-1 proviruses has not been well-defined in people on ART.<h4>Methods</h4>We separately quantified intact and defective proviruses, residual plasma viremia, and ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Estimating a Set of Mortality Risk Functions with Multiple Contributing Causes of Death.

Tiffany L Breger, Jessie K Edwards, Stephen R Cole, Michael Saag, Peter F Rebeiro, Richard D Moore, Joseph J Eron,

<h4>Background</h4>There are few methodologic examples of how multiple causes of death may be summarized in cause-specific mortality analyses to address limitations of attributing death to a single underlying cause. We propose a cause-of-death weighting approach to estimate the set of risk functions of specific causes of mortality using both underlying ... Read more >>

Epidemiology (Epidemiology (Cambridge, Mass.))
[2020, 31(5):704-712]

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Male sex and obesity are associated with residual plasma HIV-1 viremia in persons on long-term antiretroviral therapy.

Joshua C Cyktor, Ronald J Bosch, Hanna Mar, Bernard J Macatangay, Ann C Collier, Evelyn Hogg, Catherine Godfrey, Joseph J Eron, Deborah K McMahon, John W Mellors, Rajesh T Gandhi, ,

<h4>Background</h4>Although adipose tissue has been proposed to harbor part of the HIV-1 reservoir, the influence of host characteristics, including sex and body-mass index (BMI), on measures of HIV-1 persistence during ART are incompletely understood.<h4>Methods</h4>We evaluated age, sex, BMI, waist circumference, years on ART, pre-ART HIV-1 RNA, pre-ART CD4+ T cell ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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Neighborhood Poverty and Control of HIV, Hypertension, and Diabetes in the Women's Interagency HIV Study.

Anna B Cope, Andrew Edmonds, Christina Ludema, Stephen R Cole, Joseph J Eron, Kathryn Anastos, Jennifer Cocohoba, Mardge Cohen, Igho Ofotokun, Elizabeth T Golub, Seble Kassaye, Deborah Konkle-Parker, Lisa R Metsch, Tracey E Wilson, Adaora A Adimora,

Neighborhoods with high poverty rates have limited resources to support residents' health. Using census data, we calculated the proportion of each Women's Interagency HIV Study participant's census tract (neighborhood) living below the poverty line. We assessed associations between neighborhood poverty and (1) unsuppressed viral load [VL] in HIV-seropositive women, (2) ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(7):2033-2044]

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Tail-phase safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in HIV-uninfected adults: a secondary analysis of the HPTN 077 trial.

Raphael J Landovitz, Sue Li, Joseph J Eron, Beatriz Grinsztejn, Halima Dawood, Albert Y Liu, Manya Magnus, Mina C Hosseinipour, Ravindre Panchia, Leslie Cottle, Gordon Chau, Paul Richardson, Mark A Marzinke, Susan H Eshleman, Ryan Kofron, Adeola Adeyeye, David Burns, Alex R Rinehart, David Margolis, Myron S Cohen, Marybeth McCauley, Craig W Hendrix,

<h4>Background</h4>Long-acting injectable cabotegravir is a novel integrase inhibitor currently in advanced clinical development for HIV prevention and treatment. We aimed to assess the terminal phase pharmacokinetics and safety of long-acting injectable cabotegravir in participants included in the HPTN 077 trial.<h4>Methods</h4>HPTN 077 was a multicentre, double-blind, randomised, placebo-controlled phase 2a trial ... Read more >>

Lancet HIV (The lancet. HIV)
[2020, 7(7):e472-e481]

Cited: 2 times

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Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection.

Cynthia L Gay, Joann D Kuruc, Shane D Falcinelli, Joanna A Warren, Sarah A Reifeis, Jennifer L Kirchherr, Katherine S James, Morgan G Dewey, Alyson Helms, Brigitte Allard, Erin Stuelke, Alicia Gamble, Ana Plachco, Robert J Gorelick, Joseph J Eron, Michael Hudgens, Carolina Garrido, Nilu Goonetilleke, Mark A DeBenedette, Irina Y Tcherepanova, Charles A Nicolette, Nancie M Archin, David M Margolis,

Approaches to deplete persistent HIV infection are needed. We investigated the combined impact of the latency reversing agent vorinostat (VOR) and AGS-004, an autologous dendritic cell immunotherapeutic, on the HIV reservoir. HIV+, stably treated participants in whom resting CD4<sup>+</sup> T cell-associated HIV RNA (rca-RNA) increased after VOR exposure ex vivo ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5134]

Cited: 1 time

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