Full Text Journal Articles by
Author Joseph H Friedman

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'How not to do things' - FDA approval of new Alzheimer's drug triggers controversy.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(6):65-66]

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Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.

Yuka Koike, Karen R Jansen-West, Rana Hanna Al-Shaikh, Yari Carlomagno, Yuping Song, Judith A Dunmore, Mark S LeDoux, Joseph H Friedman, Ashley B Pena, Ryan J Uitti, Jacek Zaremba, Jay A van Gerpen, Ronald F Pfeiffer, Venka Veerappan, Ikuko Aiba, Rina Hashimoto, Samuel S Giles, Jaimin S Shah, Philip W Tipton, Josephine F Huang, Klaas J Wierenga, Jan Aasly, John D Fryer, Leonard Petrucelli, Zbigniew K Wszolek, Mercedes Prudencio,

<h4>Introduction</h4>Accumulation of polyglutamine (polyQ) ataxin-3 (ATXN3) contributes to the pathobiology of spinocerebellar ataxia type 3 (SCA3). Recently, we showed that polyQ ATXN3 is elevated in the plasma and cerebrospinal fluid (CSF) of SCA3 patients, and has the potential to serve as a biological marker for this disease [1]. Based on ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2021, 89:151-154]

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Paroxysmal dyspnea in Parkinson's disease: Respiratory dyskinesias and autonomic hyperventilation are not the same.

Joseph H Friedman,

Respiratory complaints are not uncommon in patients with Parkinson's disease (PD). While many are explained by pulmonary and cardiovascular problems unrelated to PD, secondary effects of PD, such as kyphoscoliosis, respiratory muscle rigidity, repeated pneumonias, or side effects of medication such as dyskinesias, there is a small group of patients ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2021, :]

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Tardive Dyskinesia due to Aripiprazole.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(5):49]

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Cognitive Sinks & the Bermuda Triangle of fMRI Cognitive Studies.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(3):12-13]

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Getting Wiser, or Just More Crotchety?

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(2):8-9]

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Why don't doctors return phone calls?

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(1):8-9]

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Trends and outcomes associated with gastrostomy tube placement in common neurodegenerative disorders.

Duk Soo Kim, Richard N Jones, Theresa I Shireman, Benzi M Kluger, Joseph H Friedman, Umer Akbar,

<h4>Introduction</h4>Dysphagia causing aspiration pneumonia is a common complication in the advanced stages of neurodegenerative disorders. Historically, physicians attempted to prevent this complication with gastrostomy tube (GT) placement. Its use is supported in amyotrophic lateral sclerosis (ALS), not supported in Alzheimer's disease (AD), and without disease-specific guidelines in Parkinson's disease (PD).<h4>Method</h4>The ... Read more >>

Clin Park Relat Disord (Clinical parkinsonism & related disorders)
[2021, 4:100088]

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Apathy in Parkinson disease: Why we should care.

Joseph H Friedman, Christopher G Goetz,

Neurology (Neurology)
[2020, 95(20):893-894]

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Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.

Mercedes Prudencio, Hector Garcia-Moreno, Karen R Jansen-West, Rana Hanna Al-Shaikh, Tania F Gendron, Michael G Heckman, Matthew R Spiegel, Yari Carlomagno, Lillian M Daughrity, Yuping Song, Judith A Dunmore, Natalie Byron, Björn Oskarsson, Katharine A Nicholson, Nathan P Staff, Sorina Gorcenco, Andreas Puschmann, João Lemos, Cristina Januário, Mark S LeDoux, Joseph H Friedman, James Polke, Robin Labrum, Vikram Shakkottai, Hayley S McLoughlin, Henry L Paulson, Takuya Konno, Osamu Onodera, Takeshi Ikeuchi, Mari Tada, Akiyoshi Kakita, John D Fryer, Christin Karremo, Inês Gomes, John N Caviness, Mark R Pittelkow, Jan Aasly, Ronald F Pfeiffer, Venka Veerappan, Eric R Eggenberger, William D Freeman, Josephine F Huang, Ryan J Uitti, Klaas J Wierenga, Iris V Marin Collazo, Philip W Tipton, Jay A van Gerpen, Marka van Blitterswijk, Guojun Bu, Zbigniew K Wszolek, Paola Giunti, Leonard Petrucelli,

Spinocerebellar ataxia type 3 (SCA3), caused by a CAG repeat expansion in the ataxin-3 gene (<i>ATXN3</i>), is characterized by neuronal polyglutamine (polyQ) ATXN3 protein aggregates. Although there is no cure for SCA3, gene-silencing approaches to reduce toxic polyQ ATXN3 showed promise in preclinical models. However, a major limitation in translating ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(566):]

Cited: 3 times

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Presence Hallucinations" in PD Patients.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(7):8-9]

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Effects of Vestibular Rehabilitation on Fatigue and Activities of Daily Living in People with Parkinson's Disease: A Pilot Randomized Controlled Trial Study.

Amirabas Abasi, Parvin Raji, Joseph H Friedman, Mohammad-Reza Hadian, Reza Hoseinabadi, Somaye Abbasi, Ahmadreza Baghestani,

One of the most disabling nonmotor symptoms in persons with Parkinson's disease is fatigue, which can decrease the quality of life by restricting the function and activities of daily living (ADL). Nonetheless, sufficient evidence for treating fatigue, including drug or nondrug treatment, is not available. In this study, we evaluated ... Read more >>

Parkinsons Dis (Parkinson's disease)
[2020, 2020:8624986]

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Movement disorders induced by psychiatric drugs that do not block dopamine receptors.

Joseph H Friedman,

Most movement disorders in psychiatric patients are induced by neuroleptic antipsychotic medications, all of which are dopamine D2 receptor blocking drugs. These include: acute onset disorders: dystonic reactions, akathisia and the neuroleptic malignant syndrome (NMS); non-acute onset parkinsonism; and the tardive syndromes. However, many other medications, when used at recommended ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 79:60-64]

Cited: 1 time

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Recognising hemihypomimia as a mimic of 'facial weakness'.

Oliver Phillips, Anelyssa D'Abreu, Joseph H Friedman, Umer Akbar,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(12):1357-1358]

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Sleep disturbances in Parkinson's disease: beyond a regional perspective. Time to do something about it.

Joseph H Friedman,

Int Psychogeriatr (International psychogeriatrics)
[2020, 32(7):793-794]

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Author Correction: Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson's disease.

Gregory M Pontone, Nadeeka Dissanayaka, Liana Apostolova, Richard G Brown, Roseanne Dobkin, Kathy Dujardin, Joseph H Friedman, Albert F G Leentjens, Eric J Lenze, Laura Marsh, Lynda Mari, Oury Monchi, Irene H Richard, Anette Schrag, Antonio P Strafella, Beth Vernaleo, Daniel Weintraub, Zoltan Mari,

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2020, 6(1):10]

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Erratum: Author Correction: Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson's disease.

Gregory M Pontone, Nadeeka Dissanayaka, Liana Apostolova, Richard G Brown, Roseanne Dobkin, Kathy Dujardin, Joseph H Friedman, Albert F G Leentjens, Eric J Lenze, Laura Marsh, Lynda Mari, Oury Monchi, Irene H Richard, Anette Schrag, Antonio P Strafella, Beth Vernaleo, Daniel Weintraub, Zoltan Mari,

[This corrects the article DOI: 10.1038/s41531-019-0102-8.]. ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2020, 6:10]

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Subjective Memory Impairment and Subjective Cognitive Improvement: Role for D-C2H5OH (Deuterated Ethyl Alcohol)? Results of a Double-Blind, Crossover Trial.

Joseph H Friedman,

Subjective memory impairment (SMI) is a common complaint among older people. We performed a double-blind, placebo-controlled study1 which showed that deuterated two carbon fragments ameliorated the condition but at the expense of objective memory function. Future studies are needed to confirm the results before endorsing the treatment of SMI with ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(3):13-14]

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Report from a multidisciplinary meeting on anxiety as a non-motor manifestation of Parkinson's disease.

Gregory M Pontone, Nadeeka Dissanayka, Liana Apostolova, Richard G Brown, Roseanne Dobkin, Kathy Dujardin, Joseph H Friedman, Albert F G Leentjens, Eric J Lenze, Laura Marsh, Lynda Mari, Oury Monchi, Irene H Richard, Anette Schrag, Antonio P Strafella, Beth Vernaleo, Daniel Weintraub, Zoltan Mari,

Anxiety is a severe problem for at least one-third of people living with Parkinson's disease (PD). Anxiety appears to have a greater adverse impact on quality of life than motor impairment. Despite its high prevalence and impact on daily life, anxiety is often undiagnosed and untreated. To better address anxiety ... Read more >>

NPJ Parkinsons Dis (NPJ Parkinson's disease)
[2019, 5:30]

Cited: 3 times

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Valbenazine-induced parkinsonism.

Umer Akbar, Duk Soo Kim, Joseph H Friedman,

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 70:13-14]

Cited: 1 time

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Editorial to "Increases in institutionalization, healthcare resource utilization, and mortality risk associated with Parkinson disease psychosis: retrospective cohort study" by Friedman et al.

Joseph H Friedman, Mayela Rodriguez Violante, Janis M Miyasaki,

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2019, 68:93-94]

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A Shot to the Gut.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2019, 102(8):8-9]

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Physician overextenders.

Joseph H Friedman,

R I Med J (2013) (Rhode Island medical journal (2013))
[2019, 102(7):11-12]

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The Naranjo Scale and Tardive Syndromes, a Historical Perspective.

Joseph H Friedman,

Clin Neuropharmacol (Clinical neuropharmacology)
[2019, 42(5):188]

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Tardive Syndromes.

Joseph H Friedman,

<h4>Purpose of review</h4>This article reviews the history, nosology, clinical features, epidemiology, and treatment of tardive syndromes.<h4>Recent findings</h4>The major advance in the field of tardive syndromes has been the development and US Food and Drug Administration (FDA) approval of two vesicular monoamine transporter type 2 inhibitors, valbenazine and deutetrabenazine, for treating ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2019, 25(4):1081-1098]

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