Full Text Journal Articles by
Author Joseph Deering

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Resonance vibration interventions in the femur: Experimental-numerical modelling approaches.

Alexandre Presas, David Valentin, Joseph Deering, Marian Kampschulte, Bosco Yu, Kathryn Grandfield, Elisa Mele, Christoph Biehl, Gabriele A Krombach, Christian Heiss, Wolfram A Bosbach,

<h4>Motive</h4>External vibration excitation might be key to many novel non-surgical interventions for pathologies in the musculoskeletal system and in other parts of the human organism. Lack of understanding about vibration patterns, their controllability, and reproducibility are three limitations of ongoing research. This study establishes a bovine vibration model and animal ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2021, 124:104850]

Cited: 0 times

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Implant resonance and the mechanostat theory: Applications of therapeutic ultrasound for porous metallic scaffolds.

Joseph Deering, Alexandre Presas, Bosco Yu, David Valentin, Christian Heiss, Wolfram A Bosbach, Kathryn Grandfield,

The development of treatment strategies for improving secondary stability at the bone-implant interface is a challenge. Porous implants are one solution for improving long-term implant stability, but the osteoconduction process of implants into the bone can be slow. Strain-driven osteogenesis from the mechanostat theory offers insight into pathways for post-operative ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2021, 125:112070]

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Selective Voronoi tessellation as a method to design anisotropic and biomimetic implants.

Joseph Deering, Kierdra I Dowling, Liza-Anastasia DiCecco, Griffin D McLean, Bosco Yu, Kathryn Grandfield,

The geometry of a metallic scaffold is important for the success of bone implants, where the introduction of porosity can reduce stress shielding effects and allow for bone tissue integration. In this work, porous scaffolds were designed to closely mimic the natural structure of trabecular bone using selective Voronoi tessellation ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2021, 116:104361]

Cited: 1 time

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Ellipsoidal mesoscale mineralization pattern in human cortical bone revealed in 3D by plasma focused ion beam serial sectioning.

Dakota M Binkley, Joseph Deering, Hui Yuan, Aurélien Gourrier, Kathryn Grandfield,

Visualizing bone mineralization and collagen fibril organization at intermediate scales between the nanometer and the hundreds of microns range, is still an important challenge. Similarly, visualizing cellular components which locally affect the tissue structure requires a precision of a few tens of nanometers at maximum while spanning several tens of ... Read more >>

J Struct Biol (Journal of structural biology)
[2020, 212(2):107615]

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Human bone mesoscale 3D structure revisited by plasma focused ion beam serial sectioning

Dakota Marie Binkley, Joseph Deering, Hui Yuan, Aurélien Gourrier, Kathryn Grandfield,

Visualizing bone mineralization and collagen microfibril organization at intermediate scales between the nanometer and the 100s of microns range, the mesoscale, is still an important challenge. Similarly, visualizing cellular components which locally affect the tissue structure requires a precision of a few tens of nanometers at maximum while spanning several ... Read more >>

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Response of Saos-2 osteoblast-like cells to kilohertz-resonance excitation in porous metallic scaffolds.

Joseph Deering, Alexandre Presas, Bryan E J Lee, David Valentin, Bosco Yu, Christian Heiss, Kathryn Grandfield, Wolfram A Bosbach,

Post-operative therapy for joint replacement is often performed to optimize bone volume and bone-implant contact. Methods, such as pulsed therapeutic ultrasound, have been shown to be a valuable addition to regular physiotherapy to increase bone regeneration. To evaluate the efficacy of kilohertz-frequency (kHz) resonant stimuli to additively manufactured implant analogues, ... Read more >>

J Mech Behav Biomed Mater (Journal of the mechanical behavior of biomedical materials)
[2020, 106:103726]

Cited: 1 time

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Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial.

Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A Harrington, ,

BACKGROUND:Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ... Read more >>

Lancet (Lancet (London, England))
[2019, 394(10204):1169-1180]

Cited: 29 times

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Ticagrelor in Patients with Stable Coronary Disease and Diabetes.

P Gabriel Steg, Deepak L Bhatt, Tabassome Simon, Kim Fox, Shamir R Mehta, Robert A Harrington, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Maria Leonsson-Zachrisson, Yuyin Liu, Grzegorz Opolski, Dmitry Zateyshchikov, Junbo Ge, José C Nicolau, Ramón Corbalán, Jan H Cornel, Petr Widimský, Lawrence A Leiter, ,

<h4>Background</h4>Patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke are at high risk for cardiovascular events. Whether adding ticagrelor to aspirin improves outcomes in this population is unclear.<h4>Methods</h4>In this randomized, double-blind trial, we assigned patients who were 50 years of age ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(14):1309-1320]

Cited: 37 times

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Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

Faiez Zannad, Stefan D Anker, William M Byra, John G F Cleland, Min Fu, Mihai Gheorghiade, Carolyn S P Lam, Mandeep R Mehra, James D Neaton, Christopher C Nessel, Theodore E Spiro, Dirk J van Veldhuisen, Barry Greenberg, ,

<h4>Background</h4>Heart failure is associated with activation of thrombin-related pathways, which predicts a poor prognosis. We hypothesized that treatment with rivaroxaban, a factor Xa inhibitor, could reduce thrombin generation and improve outcomes for patients with worsening chronic heart failure and underlying coronary artery disease.<h4>Methods</h4>In this double-blind, randomized trial, 5022 patients who ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(14):1332-1342]

Cited: 62 times

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Cardiac ischemia model for +Gz using miniature swine and baboons.

John W Burns, William B Kruyer, Paul V Celio, Joseph Deering, Thomas H Loecker, Londe A Richardson, John W Fanton, Harold Davis, Edward J Dick,

<h4>Background</h4>Military aircrew with minimal coronary artery disease (MCAD) may be restricted from flying high-performance aircraft due to possible ischemia during high +Gz. An animal model is presented to provide ischemia data for a more informed decision.<h4>Methods</h4>There were 18 swine that were placed on a high cholesterol/high fat diet for up ... Read more >>

Aviat Space Environ Med (Aviation, space, and environmental medicine)
[2008, 79(4):374-383]

Cited: 1 time

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