Full Text Journal Articles by
Author Joseph D Mishkin

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Variation of heart transplant rates in the United States during holidays.

Justin L Grodin, Colby R Ayers, Jennifer T Thibodeau, Joseph D Mishkin, Pradeep P A Mammen, David W Markham, Mark H Drazner, Parag C Patel,

<h4>Background</h4>Some cardiac transplant programs may upgrade listed patients to United Network for Organ Sharing (UNOS) 1A-status during the holidays. Whether more transplants actually occur during holidays is unknown.<h4>Methods</h4>We assessed rates of single-organ heart transplantation from 2001 to 2010 for recipients age ≥18 yr using the UNOS database. Patients were stratified ... Read more >>

Clin Transplant (Clinical transplantation)
[2014, 28(8):877-882]

Cited: 1 time

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Characterization of a novel symptom of advanced heart failure: bendopnea.

Jennifer T Thibodeau, Aslan T Turer, Sarah K Gualano, Colby R Ayers, Mariella Velez-Martinez, Joseph D Mishkin, Parag C Patel, Pradeep P A Mammen, David W Markham, Benjamin D Levine, Mark H Drazner,

<h4>Objectives</h4>This study sought to examine the frequency and hemodynamic correlates of shortness of breath when bending forward, a symptom we have termed "bendopnea."<h4>Background</h4>Many heart failure patients describe bendopnea such as when putting on their shoes. This symptom has not previously been characterized.<h4>Methods</h4>We conducted a prospective study of 102 subjects with ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2014, 2(1):24-31]

Cited: 28 times

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High-sensitivity cardiac troponin I assay to screen for acute rejection in patients with heart transplant.

Parag C Patel, Douglas A Hill, Colby R Ayers, Bhavna Lavingia, Patricia Kaiser, Adrian K Dyer, Aliessa P Barnes, Jennifer T Thibodeau, Joseph D Mishkin, Pradeep P A Mammen, David W Markham, Peter Stastny, W Steves Ring, James A de Lemos, Mark H Drazner,

<h4>Background</h4>A noninvasive biomarker that could accurately diagnose acute rejection (AR) in heart transplant recipients could obviate the need for surveillance endomyocardial biopsies. We assessed the performance metrics of a novel high-sensitivity cardiac troponin I (cTnI) assay for this purpose.<h4>Methods and results</h4>Stored serum samples were retrospectively matched to endomyocardial biopsies in ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2014, 7(3):463-469]

Cited: 18 times

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Tolerability of sirolimus: a decade of experience at a single cardiac transplant center.

Jennifer T Thibodeau, Joseph D Mishkin, Parag C Patel, Patricia A Kaiser, Colby R Ayers, Pradeep P A Mammen, David W Markham, William Steves Ring, Matthias Peltz, Mark H Drazner,

Sirolimus is used in cardiac transplant recipients to prevent rejection, progression of cardiac allograft vasculopathy, and renal dysfunction. However, sirolimus has many potential side effects and its tolerability when used outside of clinical trials is not well established. We describe a decade of experience with sirolimus in cardiac transplant recipients ... Read more >>

Clin Transplant (Clinical transplantation)
[2013, 27(6):945-952]

Cited: 4 times

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Flash pulmonary oedema after relief of haemodialysis graft stenosis.

Mariella Vélez-Martínez, Brent D Weinberg, Joseph D Mishkin,

Heart failure (HF) and chronic kidney disease (CKD) are undoubtedly very much interrelated, especially in patients with end-stage renal disease (ESRD) who are dependent on renal replacement therapy. Haemodialysis (HD) is of particular interest in cardiovascular patients due to the creation of a haemodialysis vascular access and the haemodynamic changes ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2013, 22(8):672-676]

Cited: 0 times

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Association of cardiac troponin I with disease severity and outcomes in patients with pulmonary hypertension.

Mariella Vélez-Martínez, Colby Ayers, Joseph D Mishkin, Sonja B Bartolome, Christine K García, Fernando Torres, Mark H Drazner, James A de Lemos, Aslan T Turer, Kelly M Chin,

Previous studies have identified cardiac troponin I (cTnI) as an important marker in pulmonary hypertension (PH) prognosis. However, traditional assays are limited by poor sensitivity, even among patients at high risk. cTnI was measured in 255 PH patients using a new highly sensitive (hs) assay. Other measures included demographics, creatinine, ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2013, 111(12):1812-1817]

Cited: 12 times

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Sirolimus use and incidence of venous thromboembolism in cardiac transplant recipients.

Jennifer T Thibodeau, Joseph D Mishkin, Parag C Patel, Patricia A Kaiser, Colby R Ayers, Pradeep P A Mammen, David W Markham, W Steves Ring, Matthias Peltz, Mark H Drazner,

Sirolimus is an immunosuppressive agent increasingly used in cardiac transplant recipients in the setting of allograft vasculopathy or worsening renal function. Recently, sirolimus has been associated with increased risk of venous thromboembolism (VTE) in lung transplant recipients. To investigate whether this association is also present in cardiac transplant recipients, we ... Read more >>

Clin Transplant (Clinical transplantation)
[2012, 26(6):953-959]

Cited: 9 times

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Relationship of right- to left-sided ventricular filling pressures in advanced heart failure: insights from the ESCAPE trial.

Mark H Drazner, Mariella Velez-Martinez, Colby R Ayers, Sharon C Reimold, Jennifer T Thibodeau, Joseph D Mishkin, Pradeep P A Mammen, David W Markham, Chetan B Patel,

<h4>Background</h4>Although right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) are correlated in heart failure, in a sizeable minority of patients, the RAP and PCWP are not tightly coupled. The basis of this variability in the RAP/PCWP ratio, and whether it conveys prognostic value, is not known.<h4>Methods and results</h4>We ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2013, 6(2):264-270]

Cited: 32 times

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The natural history of new-onset heart failure with a severely depressed left ventricular ejection fraction: implications for timing of implantable cardioverter-defibrillator implantation.

William A Teeter, Jennifer T Thibodeau, Krishnasree Rao, M Elizabeth Brickner, Kathleen H Toto, Lauren L Nelson, Joseph D Mishkin, Colby R Ayers, Justin G Miller, Pradeep P A Mammen, Parag C Patel, David W Markham, Mark H Drazner,

<h4>Background</h4>Guidelines recommend that patients with new-onset systolic heart failure (HF) receive a trial of medical therapy before an implantable cardiac defibrillator (ICD). This strategy allows for improvement of left ventricular ejection fraction (LVEF), thereby avoiding an ICD, but exposes patients to risk of potentially preventable sudden cardiac death during the ... Read more >>

Am Heart J (American heart journal)
[2012, 164(3):358-364]

Cited: 18 times

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IIIB or not IIIB: a previously unanswered question.

Jennifer T Thibodeau, Joseph D Mishkin, Parag C Patel, Pradeep P A Mammen, David W Markham, Mark H Drazner,

The term New York Heart Association (NYHA) class IIIB has been used increasingly in clinical medicine, including as an inclusion criteria for many clinical trials assessing left ventricular assist devices (LVADs). Indeed, NYHA class IIIB is incorporated in the Food and Drug Administration's approved indication for the Heartmate II. However, ... Read more >>

J Card Fail (Journal of cardiac failure)
[2012, 18(5):367-372]

Cited: 2 times

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Utilization of cardiac computed tomography angiography for the diagnosis of left ventricular assist device thrombosis.

Joseph D Mishkin, Jonathan R Enriquez, Dan M Meyer, Brian T Bethea, Jennifer T Thibodeau, Parag C Patel, David W Markham, Pradeep P A Mammen, Mariella Velez-Martinez, Mark H Drazner,

Circ Heart Fail (Circulation. Heart failure)
[2012, 5(2):e27-9]

Cited: 17 times

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Concentric left ventricular hypertrophy as assessed by cardiac magnetic resonance imaging and risk of death in cardiac transplant recipients.

Parag C Patel, Sharon C Reimold, Faris G Araj, Colby R Ayers, Patricia A Kaiser, Ronald M Peshock, Clyde W Yancy, W Steves Ring, Sachin Gupta, Joseph D Mishkin, Pradeep P A Mammen, David W Markham, Mark H Drazner,

<h4>Background</h4>Although risk factors for left ventricular (LV) hypertrophy in the native heart are well known, as is its association with increased risk of adverse outcomes, such information is poorly defined in heart transplant (HTx) recipients. We determined whether increased LV mass and concentricity (mass/volume) were associated with death in patients ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2010, 29(12):1369-1379]

Cited: 6 times

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Appropriate evaluation and treatment of heart failure patients after implantable cardioverter-defibrillator discharge: time to go beyond the initial shock.

Joseph D Mishkin, Sherry J Saxonhouse, Gregory W Woo, Thomas A Burkart, William M Miles, Jamie B Conti, Richard S Schofield, Samuel F Sears, Juan M Aranda,

Multiple clinical trials support the use of implantable cardioverter-defibrillators (ICDs) for prevention of sudden cardiac death in patients with heart failure (HF). Unfortunately, several complicating issues have arisen from the universal use of ICDs in HF patients. An estimated 20% to 35% of HF patients who receive an ICD for ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2009, 54(22):1993-2000]

Cited: 38 times

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Trastuzumab-induced cardiomyopathy.

Maya Guglin, Raymond Cutro, Joseph D Mishkin,

Trastuzumab is a recombinant humanized monoclonal antibody used for the treatment of advanced breast cancer. It improves survival and increases response to chemotherapy. The major side effect of trastuzumab is cardiotoxicity manifesting as a reduction in left ventricular systolic function, either asymptomatic or with signs and symptoms of heart failure. ... Read more >>

J Card Fail (Journal of cardiac failure)
[2008, 14(5):437-444]

Cited: 36 times

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