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SARS-CoV-2-reactive interferon-γ-producing CD8+ T cells in patients hospitalized with Coronavirus viral disease-2019

Estela Gimenez, Eliseo Albert, Ignacio Torres, Maria Jose Remigia, Maria Jesus Alcaraz, Maria Jose Galindo, Maria Luisa Blasco, Carlos Solano, Maria Jose Forner, Josep Redon, Jaime Signes-Costa, David Navarro,

There is limited information on SARS-CoV-2 T-cell immune responses in patients with Covid-19. Both CD4+ and CD8+ T cells may be instrumental in the resolution of and protection from SARS-CoV-2 infection. Here, we tested 25 hospitalized patients with either microbiologically documented Covid-19 (n=19) or highly suspected of having the disease ... Read more >>

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Nutraceuticals and blood pressure control: a European Society of Hypertension position document.

Claudio Borghi, Konstantinos Tsioufis, Enrico Agabiti-Rosei, Michel Burnier, Arrigo F G Cicero, Denis Clement, Antonio Coca, Giovambattista Desideri, Guido Grassi, Dragan Lovic, Empar Lurbe, Thomas Kahan, Reinhold Kreutz, Bojan Jelakovic, Jorge Polonia, Josep Redon, Philippe Van De Borne, Giuseppe Mancia,

: High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The ... Read more >>

J. Hypertens. (Journal of hypertension)
[2020, 38(5):799-812]

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Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia.

María Luisa Blasco, Javier Buesa, Javier Colomina, María José Forner, María José Galindo, Jorge Navarro, José Noceda, Josep Redón, Jaime Signes-Costa, David Navarro,

Clinical, laboratory and imaging characteristics of Coronavirus disease 2019 (Covid-19) and risk factors associated with poor outcomes have been reported in various studies.1-2 Nevertheless, information on whether other respiratory pathogens (RP) were co-detected in patients in these series was not provided, despite the fact that coinfections with RP have been ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Optimization of small RNA library preparation protocol from human urinary exosomes.

Dolores Olivares, Javier Perez-Hernandez, Daniel Perez-Gil, Felipe J Chaves, Josep Redon, Raquel Cortes,

BACKGROUND:Sequencing of miRNAs isolated from exosomes has great potential to identify novel disease biomarkers, but exosomes have low amount of RNA, hindering adequate analysis and quantification. Here, we have assessed several steps in developing an optimized small RNA (sRNA) library preparation protocol for next-generation sequencing (NGS) miRNA analysis from urinary ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):132]

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Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia

Maria Luisa Blasco, Javier Buesa, Javier Colomina, Maria Jose Forner, Maria Jose Galindo, Jorge Navarro, Jose Noceda, Josep Redon, Jaime Signes-Costa, David Navarro,

Not applicable: New Data Letter ... Read more >>

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Redefining hypertension in children and adolescents: A review of the evidence considered by the European Society of Hypertension and American Academy of Pediatrics guidelines.

Stella Stabouli, Josep Redon, Empar Lurbe,

J. Hypertens. (Journal of hypertension)
[2020, 38(2):196-200]

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Acute kidney injury in heart failure: a population study.

Jose Luis Holgado, Cristina Lopez, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Sara Vela, Julio Nuñez, Josep Redon, Adrian Ruiz,

AIMS:The objective of the present study is to assess the prognostic value of acute kidney injury (AKI) in the evolution of patients with heart failure (HF) using real-world data. METHODS AND RESULTS:Patients with a diagnosis of HF and with serial measurements of renal function collected throughout the study period were ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(2):415-422]

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Blood Pressure Targets Achievement According to 2018 ESC/ESH Guidelines in Three European Excellence Centers for Hypertension.

Giuliano Tocci, Vivianne Presta, Claudio Ferri, Josep Redon, Massimo Volpe,

INTRODUCTION:The most recent European guidelines on hypertension redefined office blood pressure (BP) treatment targets according to age strata and cardiovascular (CV) risk profile. AIM:To evaluate proportions of adult outpatients achieving office BP treatment targets recommended by current compared to previous hypertension guidelines. METHODS:We extracted data from medical databases of adult ... Read more >>

High Blood Press Cardiovasc Prev (High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension)
[2020, 27(1):51-59]

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Resting heart rate and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk analysis from the ONTARGET/TRANSCEND trials.

Michael Böhm, Helmut Schumacher, Koon K Teo, Eva M Lonn, Felix Mahfoud, Christian Ukena, Johannes F E Mann, Giuseppe Mancia, Josep Redon, Roland E Schmieder, Karen Sliwa, Nikolaus Marx, Michael A Weber, Bryan Williams, Salim Yusuf,

AIMS:Resting heart rate (RHR) has been shown to be associated with cardiovascular outcomes in various conditions. It is unknown whether different levels of RHR and different associations with cardiovascular outcomes occur in patients with or without diabetes, because the impact of autonomic neuropathy on vascular vulnerability might be stronger in ... Read more >>

Eur. Heart J. (European heart journal)
[2020, 41(2):231-238]

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Unraveling new factors associated with hypertension: the Mendelian randomization approach.

Maria Grau-Perez, Josep Redon,

J. Hypertens. (Journal of hypertension)
[2020, 38(1):30-32]

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Impact of Renal Impairment on Beta-Blocker Efficacy in Patients With Heart Failure.

Dipak Kotecha, Simrat K Gill, Marcus D Flather, Jane Holmes, Milton Packer, Giuseppe Rosano, Michael Böhm, John J V McMurray, John Wikstrand, Stefan D Anker, Dirk J van Veldhuisen, Luis Manzano, Thomas G von Lueder, Alan S Rigby, Bert Andersson, John Kjekshus, Hans Wedel, Frank Ruschitzka, John G F Cleland, Kevin Damman, Josep Redon, Andrew J S Coats, ,

BACKGROUND:Moderate and moderately severe renal impairment are common in patients with heart failure and reduced ejection fraction, but whether beta-blockers are effective is unclear, leading to underuse of life-saving therapy. OBJECTIVES:This study sought to investigate patient prognosis and the efficacy of beta-blockers according to renal function using estimated glomerular filtration ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(23):2893-2904]

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Identifying poor cardiorespiratory fitness in overweight and obese children and adolescents by using heart rate variability analysis under resting conditions.

Pau Redón, Guido Grassi, Josep Redon, Julio Álvarez-Pitti, Empar Lurbe,

Background: Childhood obesity, including overweight, continues increasing worldwide affecting health expectancy, quality of life and healthcare expenditure. These subjects have higher probability of suffering or developing cardio metabolic risk factors. Recent studies have revealed cardiorespiratory fitness (CRF) as a valuable clinical parameter to identify these subjects and have even suggested ... Read more >>

Blood Press. (Blood pressure)
[2020, 29(1):13-20]

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Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology.

Massimo F Piepoli, Ana Abreu, Christian Albus, Marco Ambrosetti, Carlos Brotons, Alberico L Catapano, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Arno Hoes, Maja-Lisa Lochen, Benedetta Matrone, Josep Redon, Naveed Sattar, Yvo Smulders, Monica Tiberi,

European guidelines on cardiovascular prevention in clinical practice were first published in 1994 and have been regularly updated, most recently in 2016, by the Sixth European Joint Task Force. Given the amount of new information that has become available since then, components from the task force and experts from the ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(2):181-205]

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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.

Luis M Ruilope, Rajiv Agarwal, Stefan D Anker, George L Bakris, Gerasimos Filippatos, Christina Nowack, Peter Kolkhof, Amer Joseph, Nicole Mentenich, Bertram Pitt, ,

BACKGROUND:Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease ... Read more >>

Am. J. Nephrol. (American journal of nephrology)
[2019, 50(5):345-356]

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Impact of ESH and AAP hypertension guidelines for children and adolescents on office and ambulatory blood pressure-based classifications.

Empar Lurbe, Isabel Torró, Julio Álvarez, Francisco Aguilar, Giuseppe Mancia, Josep Redon, Pau Redon,

BACKGROUND:The objective was to assess the differences between the 2016 European Society of Hypertension (ESH) and the 2017 American Academy of Pediatrics (AAP) hypertension (HTN) guidelines in the distribution of office blood pressure (BP) categories as well as in the office and ambulatory BP mismatches. MATERIAL AND METHODS:The study included ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(12):2414-2421]

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The impact on office blood pressure categories and ambulatory blood pressure discrepancies of the European Society of Hypertension and American Academy of Pediatrics Guidelines for Management of Hypertension in Children and Adolescents.

Empar Lurbe, Isabel Torró, Julio Álvarez, Francisco Aguilar, Giuseppe Mancia, Josep Redon, Pau Redon,

BACKGROUND:The objective was to assess the differences between the 2016 European Society of Hypertension (ESH) and the 2017 American Academy of Pediatrics (AAP) hypertension (HTN) guidelines in the distribution of office blood pressure (BP) categories as well as in the office and ambulatory BP mismatches. MATERIAL AND METHODS:The study included ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, :]

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Number of drugs used in secondary cardiovascular prevention and late survival in the population of Valencia Community, Spain.

Josep Redón, Ruth Usó, Jose Luis Trillo, Cristina López, Francisco Morales-Olivas, Jorge Navarro, Juan Sanchís, Vicente Gil, Domingo Orozco-Beltrán,

BACKGROUND:Drug treatment for secondary prevention of cardiovascular disease is recommended by guidelines, but it is not always followed in real life. This study wanted to assess the size of this gap and its impact on mortality in subjects after a cardiovascular event (MACE). METHODS:Patients with any of MACE in the ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, 293:260-265]

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Immune-unreactive urinary albumin as a predictor of cardiovascular events: the Hortega Study.

Fernando Martínez, Gernot Pichler, Adrian Ruiz, Juan C Martín-Escudero, Felipe J Chaves, Veronica Gonzalez-Albert, Maria Tellez-Plaza, Hiddo J L Heerspink, Dick D E Zeeuw, Josep Redon,

BACKGROUND:We aimed to determine if immune-unreactive albumin excretion (IURAE) is associated with cardiovascular (CV) events in a representative sample of a general population from Spain. METHODS:We included 1297 subjects (mean age ± standard error 48.0 ± 0.2 years, 48% females), who participated in the Hortega Follow-Up Study. The primary endpoint was incidence of fatal and ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(4):633-641]

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Cardiovascular outcomes and achieved blood pressure in patients with and without diabetes at high cardiovascular risk.

Michael Böhm, Helmut Schumacher, Koon K Teo, Eva M Lonn, Felix Mahfoud, Johannes F E Mann, Giuseppe Mancia, Josep Redon, Roland E Schmieder, Nikolaus Marx, Karen Sliwa, Michael A Weber, Bryan Williams, Salim Yusuf,

AIMS:Studies have shown a non-linear relationship between systolic blood pressure (SBP) and diastolic blood pressure (DBP) and outcomes, with increased risk observed at both low and high blood pressure (BP) levels. We hypothesized that the BP-risk association is different in individuals with and without diabetes at high cardiovascular risk. METHODS ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(25):2032-2043]

Cited: 2 times

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Rising rural body-mass index is the main driver of the global obesity epidemic in adults.

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Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3-6. Here we use ... Read more >>

Nature (Nature)
[2019, 569(7755):260-264]

Cited: 6 times

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Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults.

Gernot Pichler, Maria Grau-Perez, Maria Tellez-Plaza, Jason Umans, Lyle Best, Shelley Cole, Walter Goessler, Kevin Francesconi, Jonathan Newman, Josep Redon, Richard Devereux, Ana Navas-Acien,

BACKGROUND:Arsenic exposure has been related to numerous adverse cardiovascular outcomes. The aim of this study was to investigate the cross-sectional and prospective association between arsenic exposure with echocardiographic measures of left ventricular (LV) geometry and functioning. METHODS:A total of 1337 young adult participants free of diabetes mellitus and cardiovascular disease ... Read more >>

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2019, 12(5):e009018]

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Immigration and hypertension in youths learning from one country's experience.

Empar Lurbe, Josep Redon,

J. Hypertens. (Journal of hypertension)
[2019, 37(4):680-682]

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[2018 ESC/ESH Guidelines for the management of arterial hypertension].

Bryan Williams, Giuseppe Mancia, Wilko Spiering, Enrico Agabiti Rosei, Michel Azizi, Michel Burnier, Denis L Clement, Antonio Coca, Giovanni de Simone, Anna Dominiczak, Thomas Kahan, Felix Mahfoud, Josep Redon, Luis Ruilope, Alberto Zanchetti, Mary Kerins, Sverre E Kjeldsen, Reinhold Kreutz, Stephane Laurent, Gregory Y H Lip, Richard McManus, Krzysztof Narkiewicz, Frank Ruschitzka, Roland E Schmieder, Evgeny Shlyakhto, Costas Tsioufis, Victor Aboyans, Ileana Desormais,

Kardiol Pol (Kardiologia polska)
[2019, 77(2):71-159]

Cited: 1 time

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Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study.

Pau Redon, Alessandro Maloberti, Rita Facchetti, Josep Redon, Empar Lurbe, Michele Bombelli, Giuseppe Mancia, Guido Grassi,

OBJECTIVE:Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed the gender-related relationships between serum uric acid (SUA) and cardionephrometabolic variables in central and east European hypertensive patients. METHODS:A total of 3206 treated hypertensive patients ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(2):380-388]

Cited: 4 times

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2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension.

Bryan Williams, Giuseppe Mancia, Wilko Spiering, Enrico Agabiti Rosei, Michel Azizi, Michel Burnier, Denis Clement, Antonio Coca, Giovanni De Simone, Anna Dominiczak, Thomas Kahan, Felix Mahfoud, Josep Redon, Luis Ruilope, Alberto Zanchetti, Mary Kerins, Sverre Kjeldsen, Reinhold Kreutz, Stéphane Laurent, Gregory Y H Lip, Richard McManus, Krzysztof Narkiewicz, Frank Ruschitzka, Roland Schmieder, Evgeny Shlyakhto, Konstantinos Tsioufis, Victor Aboyans, Ileana Desormais,

These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence ... Read more >>

Blood Press. (Blood pressure)
[2018, 27(6):314-340]

Cited: 2 times

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