Full Text Journal Articles by
Author Josef Zacher

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Time to Surgery and Outcome in the Treatment of Proximal Femoral Fractures.

Hanna Leicht, Thomas Gaertner, Christian Günster, Andreas M Halder, Reinhard Hoffmann, Elke Jeschke, Jürgen Malzahn, Almut Tempka, Josef Zacher,

<h4>Background</h4>It has not been conclusively established whether, or to what extent, the time to surgery affects mortality and the risk of complications after the surgical treatment of proximal femoral fractures.<h4>Methods</h4>Data on 106 187 hospitalizations over the period 2015-2017 involving insurees of the German AOK health insurance company aged 20 and ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

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[Opportunities and limitations of risk adjustment of quality indicators based on inpatient administrative health data - a workshop report].

Daniel Schwarzkopf, Ulrike Nimptsch, Raphael Graf, Jochen Schmitt, Josef Zacher, Ralf Kuhlen,

<h4>Introduction</h4>The quality indicators of the Initiative Qualitätsmedizin e. V. (IQM) have been developed as triggers to examine treatment processes for opportunities for improvement. Published quality results have partly been used for external quality comparisons in the media. Therefore, member hospitals of IQM demanded to investigate if methods of risk adjustment should ... Read more >>

Z Evid Fortbild Qual Gesundhwes (Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
[2021, 163:1-12]

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Low Hospital Volume Increases Re-Revision Rate Following Aseptic Revision Total Knee Arthroplasty: An Analysis of 23,644 Cases.

Andreas M Halder, Thorsten Gehrke, Christian Günster, Karl-Dieter Heller, Hanna Leicht, Jürgen Malzahn, Fritz U Niethard, Peter Schräder, Josef Zacher, Elke Jeschke,

<h4>Background</h4>Along with rising numbers of primary total knee arthroplasty (TKA), the number of revision total knee arthroplasties (R-TKAs) has been increasing. R-TKA is a complex procedure requiring special instruments, implants, and surgical skills. Therefore it is likely that hospitals with more R-TKAs have more experience with this type of surgery ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2020, 35(4):1054-1059]

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Low Hospital Volume Increases Revision Rate and Mortality Following Revision Total Hip Arthroplasty: An Analysis of 17,773 Cases.

Elke Jeschke, Thorsten Gehrke, Christian Günster, Karl-Dieter Heller, Hanna Leicht, Jürgen Malzahn, Fritz Uwe Niethard, Peter Schräder, Josef Zacher, Andreas M Halder,

<h4>Background</h4>With the number of primary total hip arthroplasty (THA), the amount of revision THA (R-THA) increases. R-THA is a complex procedure requiring special instruments, implants, and surgical skills. Therefore it is likely that hospitals performing a higher number of R-THAs have more experience with this type of surgery and therefore ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2019, 34(9):2045-2050]

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Obesity Increases the Risk of Postoperative Complications and Revision Rates Following Primary Total Hip Arthroplasty: An Analysis of 131,576 Total Hip Arthroplasty Cases.

Elke Jeschke, Mustafa Citak, Christian Günster, Andreas M Halder, Karl-Dieter Heller, Jürgen Malzahn, Fritz U Niethard, Peter Schräder, Josef Zacher, Thorsten Gehrke,

BACKGROUND:The aim of our study is to evaluate the association of body mass index (BMI) and the risk of postoperative complications, mortality, and revision rates following primary total hip arthroplasty given other potentially confounding patient characteristics in a large cohort study. METHODS:Using nationwide billing data for inpatient hospital treatment of ... Read more >>

J Arthroplasty (The Journal of arthroplasty)
[2018, 33(7):2287-2292.e1]

Cited: 6 times

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[Volume Growth of Inpatient Treatments for Spinal Disease - Analysis of German Nationwide Hospital Discharge Data from 2005 to 2014].

Ulrike Nimptsch, Claire Bolczek, Melissa Spoden, Ekkehard Schuler, Josef Zacher, Thomas Mansky,

BACKGROUND:Marked volume growth of inpatient treatments for spinal disease has been observed since diagnosis related groups (DRG) were introduced as payment for inpatient services in Germany. This study aims to analyse this increase by population and stratified by types of treatment. MATERIAL AND METHODS:Using German nationwide hospital discharge data (DRG ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2018, 156(2):175-183]

Cited: 0 times

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[Impact of Case Numbers on the 5-Year Survival Rate of Unicondylar Knee Replacements in Germany].

Elke Jeschke, Thorsten Gehrke, Christian Günster, Karl-Dieter Heller, Jürgen Malzahn, Axel Marx, Fritz-Uwe Niethard, Peter Schräder, Josef Zacher, Andreas Matthias Halder,

<h4>Background</h4>Reported survival rates of unicondylar knee arthroplasty (UKA) vary considerably. The influences of patient characteristics and the type of implant have already been examined. This analysis investigated the influence of hospital volume on 5-year-survival rate, using administrative claims data of Germany's largest health insurance provider.<h4>Methods</h4>We analysed administrative claims data for ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2018, 156(1):62-67]

Cited: 1 time

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Are TKAs Performed in High-volume Hospitals Less Likely to Undergo Revision Than TKAs Performed in Low-volume Hospitals?

Elke Jeschke, Mustafa Citak, Christian Günster, Andreas Matthias Halder, Karl-Dieter Heller, Jürgen Malzahn, Fritz Uwe Niethard, Peter Schräder, Josef Zacher, Thorsten Gehrke,

<h4>Background</h4>High-volume hospitals have achieved better outcomes for THAs and unicompartmental knee arthroplasties (UKAs). However, few studies have analyzed implant survival after primary TKA in high-volume centers.<h4>Questions/purposes</h4>Is the risk of revision surgery higher when receiving a TKA in a low-volume hospital than in a high-volume hospital?<h4>Methods</h4>Using nationwide billing data of the ... Read more >>

Clin Orthop Relat Res (Clinical orthopaedics and related research)
[2017, 475(11):2669-2674]

Cited: 12 times

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Five-Year Survival of 20,946 Unicondylar Knee Replacements and Patient Risk Factors for Failure: An Analysis of German Insurance Data.

Elke Jeschke, Thorsten Gehrke, Christian Günster, Joachim Hassenpflug, Jürgen Malzahn, Fritz Uwe Niethard, Peter Schräder, Josef Zacher, Andreas Halder,

<h4>Background</h4>Improvements in implant design and surgical technique of unicondylar knee arthroplasty have led to reduced revision rates, but patient selection seems to be crucial for success of such arthroplasties. The purpose of the present study was to analyze the 5-year implant survival rate of unicondylar knee replacements in Germany and ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2016, 98(20):1691-1698]

Cited: 7 times

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Prevalence of self-reported pain, joint complaints and knee or hip complaints in adults aged ≥ 40 years: a cross-sectional survey in Herne, Germany.

Ulrich Thiem, Rainer Lamsfuß, Sven Günther, Jochen Schumacher, Christian Bäker, Heinz G Endres, Josef Zacher, Gerd R Burmester, Ludger Pientka,

<h4>Background</h4>Pain and musculoskeletal complaints are among the most common symptoms in the general population. Despite their epidemiological, clinical and health economic importance, prevalence data on pain and musculoskeletal complaints for Germany are scarce.<h4>Methods</h4>A cross-sectional survey of a random sample of citizens of Herne, Germany, aged ≥ 40 years was performed. ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e60753]

Cited: 22 times

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V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis.

Tobias Scheel, Angelika Gursche, Josef Zacher, Thomas Häupl, Claudia Berek,

<h4>Objective</h4>To elucidate the development of synovial tissue-specific B cell immune responses, the clonality of individual naive B cells, memory B cells, and plasma cells and their organization and histologic localization in the inflamed tissue were investigated in patients with rheumatoid arthritis (RA).<h4>Methods</h4>B and plasma cells were isolated by laser capture ... Read more >>

Arthritis Rheum (Arthritis and rheumatism)
[2011, 63(1):63-72]

Cited: 45 times

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Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.

Bertold Renner, Josef Zacher, Asokumar Buvanendran, Gerrit Walter, Jochen Strauss, Kay Brune,

The perioperative administration of selective cyclooxygenase-2 (COX-2)-inhibitors to avoid postoperative pain is an attractive option: they show favorable gastro-intestinal tolerability, lack inhibition of blood coagulation, and carry a low risk of asthmatic attacks. The purpose of this study was to determine the cerebrospinal fluid (CSF), plasma, and tissue pharmacokinetics of ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2010, 381(2):127-136]

Cited: 10 times

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Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial.

Roy D Altman, Renée-Liliane Dreiser, Chester L Fisher, Walter F Chase, Donatus S Dreher, Josef Zacher,

<h4>Objective</h4>To measure the efficacy and safety of diclofenac sodium gel in patients with primary hand osteoarthritis (OA).<h4>Methods</h4>In a randomized, double-blind, placebo-controlled trial, men and women aged > or = 40 years diagnosed with primary OA in the dominant hand were randomly assigned to self-apply topical 1% diclofenac sodium gel (Voltaren ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2009, 36(9):1991-1999]

Cited: 62 times

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Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow.

Heiner Appel, Maren Kuhne, Simone Spiekermann, Dorothee Köhler, Josef Zacher, Harald Stein, Joachim Sieper, Christoph Loddenkemper,

<h4>Objective</h4>Previous histopathologic and magnetic resonance imaging studies suggest that the subchondral bone marrow might be the primary site of inflammation in patients with ankylosing spondylitis (AS) and that this might be reflected by inflammation found in hip joints. The aim of this study was to conduct an immunohistologic assessment of ... Read more >>

Arthritis Rheum (Arthritis and rheumatism)
[2006, 54(6):1805-1813]

Cited: 65 times

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Patient and physician satisfaction with rofecoxib in osteoarthritis: results of a post-marketing surveillance study in primary care in Germany.

Josef Zacher, Manfred Schattenkirchner,

A post-marketing surveillance study was conducted in Germany to assess the efficacy and tolerability of rofecoxib in the treatment of osteoarthritis (OA). Patients were eligible for inclusion in this study if they were being treated for the first time or being switched from other medications. More than three-quarters of the ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2002, 18(4):229-236]

Cited: 8 times

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Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice.

Dirk Wernicke, Claudia Schulze-Westhoff, Rolf Bräuer, Peter Petrow, Josef Zacher, Steffen Gay, Erika Gromnica-Ihle,

<h4>Objective</h4>To study the expression of collagenase 3 (matrix metalloproteinase 13 [MMP-13]) and collagenase 1 (MMP-1) in synovial fibroblasts from patients with rheumatoid arthritis (RA) when cultured within 3-dimensional collagen gels or coimplanted with normal cartilage in immunodeficient NOD/SCID mice.<h4>Methods</h4>Messenger RNA (mRNA) and protein expression of collagenase 3 and collagenase 1 ... Read more >>

Arthritis Rheum (Arthritis and rheumatism)
[2002, 46(1):64-74]

Cited: 14 times

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'Hip' pain.

Josef Zacher, Angelika Gursche,

'Hip' pain is usually located in the groin, upper thigh or buttock and is a common complaint. Slipped capital femoral epiphysis, avascular femoral head necrosis and apophyseal avulsion are the most common diagnoses in childhood and adolescents. Strains and fractures are common in sport-active adults. Osteoarthritis occurs in middle-aged and ... Read more >>

Best Pract Res Clin Rheumatol (Best practice & research. Clinical rheumatology)
[2003, 17(1):71-85]

Cited: 12 times

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