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Author Jose L Pascual

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A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia.

Katharine J Bar, Pamela A Shaw, Grace H Choi, Nicole Aqui, Andrew Fesnak, Jasper B Yang, Haideliza Soto-Calderon, Lizette Grajales, Julie Starr, Michelle Andronov, Miranda Mastellone, Chigozie Amonu, Geoff Feret, Maureen DeMarshall, Marie Buchanan, Maria Caturla, James Gordon, Alan Wanicur, M Alexandra Monroy, Felicity Mampe, Emily Lindemuth, Sigrid Gouma, Anne M Mullin, Holly Barilla, Anastasiya Pronina, Leah Irwin, Raeann Thomas, Risa A Eichinger, Faye Demuth, Eline T Luning Prak, Jose L Pascual, William R Short, Michal A Elovitz, Jillian Baron, Nuala J Meyer, Kathleen O Degnan, Ian Frank, Scott E Hensley, Donald L Siegel, Pablo Tebas,

<h4>Background</h4>Antibody-based strategies for COVID-19 have shown promise in prevention and treatment of early disease. COVID-19 convalescent plasma (CCP) has been widely used but results from randomized trials supporting its benefit in hospitalized patients with pneumonia are limited. Here, we assess the efficacy of CCP in severely ill, hospitalized adults with ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, :]

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Factors Associated with Stroke Formation in Blunt Cerebrovascular Injury: An EAST Multicenter Study.

Emily Esposito, Joseph A Kufera, Timothy W Wolff, M Chance Spalding, Joshua Simpson, Julie A Dunn, Linda Zier, Sigrid Burruss, Paul Kim, Lewis E Jacobson, Jamie Williams, Jeffry Nahmias, Areg Grigorian, Laura Harmon, Anna Gergen, Matthew Chatoor, Rishi Rattan, Andrew J Young, Jose L Pascual, Jason Murry, Adrian W Ong, Alison Muller, Rovinder S Sandhu, Rachel Appelbaum, Nikolay Bugaev, Antony Tatar, Khaled Zreik, Leah Hustad, Mark J Lieser, Deborah M Stein, Thomas M Scalea, Margaret H Lauerman,

<h4>Background</h4>Stroke risk factors after blunt cerebrovascular injury (BCVI) are ill-defined. We hypothesized that factors associated with stroke for BCVI would include medical therapy (ie: Aspirin®), radiographic features, and protocolization of care.<h4>Methods</h4>An EAST-sponsored, 16 center, prospective, observational trial was undertaken. Stroke risk factors were analyzed individually for vertebral artery (VA) and ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, :]

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Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity.

Elizabeth R Steuber, Antonia V Seligowski, Alyssa R Roeckner, Mariam Reda, Lauren A M Lebois, Sanne J H van Rooij, Vishnu P Murty, Timothy D Ely, Steven E Bruce, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Scott L Rauch, Christopher Lewandowski, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Robert A Swor, Meghan E McGrath, Lauren A Hudak, Jose L Pascual, Anna M Chang, Claire Pearson, David A Peak, Robert M Domeier, Brian J O'Neil, Niels K Rathlev, Leon D Sanchez, Robert H Pietrzak, Jutta Joormann, Deanna M Barch, Diego A Pizzagalli, James M Elliott, Ronald C Kessler, Karestan C Koenen, Samuel A McLean, Kerry J Ressler, Tanja Jovanovic, Nathaniel G Harnett, Jennifer S Stevens,

Posttraumatic stress disorder (PTSD) is associated with lower gray matter volume (GMV) in brain regions critical for extinction of learned threat. However, relationships among volume, extinction learning, and PTSD symptom development remain unclear. We investigated subcortical brain volumes in regions supporting extinction learning and fear-potentiated startle (FPS) to understand brain-behavior ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2021, 141:325-332]

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Post-traumatic brain injury antithrombin III recovers Morris water maze cognitive performance, improving cued and spatial learning.

Mohamed ElSaadani, Syed M Ahmed, Christina Jacovides, Alfonso Lopez, Victoria E Johnson, Lewis J Kaplan, Douglas H Smith, Jose L Pascual,

<h4>Background</h4>Neuroinflammation and cerebral edema development following severe traumatic brain injury (TBI) affect subsequent cognitive recovery. Independent of its anticoagulant effects, antithrombin III (AT-III) has been shown to block neurovascular inflammation after severe TBI, reduce cerebral endothelial-leukocyte interactions, and decrease blood-brain barrier permeability. We hypothesized that AT-III administration after TBI would ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 91(1):108-113]

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Prolonged mechanical rib separation is a key element to prevent thoracic compartment syndrome in penetrating chest trauma: A case report.

Emily J MacKay, Ng T Niu, Jeremy W Cannon, Lewis J Kaplan, José L Pascual,

Penetrating cardiac injury in trauma patients is highly morbid. Most cases do not survive long enough to manifest the severe physiologic consequences of massive blood product resuscitation, namely, thoracic compartment syndrome and right ventricular (RV) failure. This case exhibits a thoracic compartment syndrome and RV failure so severe that the ... Read more >>

Trauma Case Rep (Trauma case reports)
[2021, 34:100498]

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Correction: The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.

Samuel A McLean, Kerry Ressler, Karestan Chase Koenen, Thomas Neylan, Laura Germine, Tanja Jovanovic, Gari D Clifford, Donglin Zeng, Xinming An, Sarah Linnstaedt, Francesca Beaudoin, Stacey House, Kenneth A Bollen, Paul Musey, Phyllis Hendry, Christopher W Jones, Christopher Lewandowski, Robert Swor, Elizabeth Datner, Kamran Mohiuddin, Jennifer S Stevens, Alan Storrow, Michael Christopher Kurz, Meghan E McGrath, Gregory J Fermann, Lauren A Hudak, Nina Gentile, Anna Marie Chang, David A Peak, Jose L Pascual, Mark J Seamon, Paulina Sergot, W Frank Peacock, Deborah Diercks, Leon D Sanchez, Niels Rathlev, Robert Domeier, John Patrick Haran, Claire Pearson, Vishnu P Murty, Thomas R Insel, Paul Dagum, Jukka-Pekka Onnela, Steven E Bruce, Bradley N Gaynes, Jutta Joormann, Mark W Miller, Robert H Pietrzak, Daniel J Buysse, Diego A Pizzagalli, Scott L Rauch, Steven E Harte, Larry J Young, Deanna M Barch, Lauren A M Lebois, Sanne J H van Rooij, Beatriz Luna, Jordan W Smoller, Robert F Dougherty, Thaddeus W W Pace, Elisabeth Binder, John F Sheridan, James M Elliott, Archana Basu, Menachem Fromer, Tushar Parlikar, Alan M Zaslavsky, Ronald Kessler,

Mol Psychiatry (Molecular psychiatry)
[2021, 26(7):3658]

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Antithrombin III ameliorates post-traumatic brain injury cerebral leukocyte mobilization enhancing recovery of blood brain barrier integrity.

Mohamed ElSaadani, Syed M Ahmed, Christina Jacovides, Alfonso Lopez, Victoria E Johnson, Lewis J Kaplan, C William Schwab, Douglas H Smith, Jose L Pascual,

<h4>Background</h4>Acute traumatic coagulopathy often accompanies traumatic brain injury (TBI) and may impair cognitive recovery. Antithrombin III (AT-III) reduces the hypercoagulability of TBI. Antithrombin III and heparinoids such as enoxaparin (ENX) demonstrate potent anti-inflammatory activity, reducing organ injury and modulating leukocyte (LEU) activation, independent of their anticoagulant effect. It is unknown ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(2):274-280]

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Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study.

Nathaniel G Harnett, Sanne J H van Rooij, Timothy D Ely, Lauren A M Lebois, Vishnu P Murty, Tanja Jovanovic, Sarah B Hill, Nathalie M Dumornay, Julia B Merker, Steve E Bruce, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, Christopher Lewandowski, Phyllis L Hendry, Sophia Sheikh, Alan B Storrow, Paul I Musey, John P Haran, Christopher W Jones, Brittany E Punches, Robert A Swor, Meghan E McGrath, Jose L Pascual, Mark J Seamon, Kamran Mohiuddin, Anna M Chang, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Leon D Sanchez, Robert H Pietrzak, Jutta Joormann, Deanna M Barch, Diego A Pizzagalli, John F Sheridan, Steven E Harte, James M Elliott, Ronald C Kessler, Karestan C Koenen, Samuel Mclean, Kerry J Ressler, Jennifer S Stevens,

Neurobiological markers of future susceptibility to posttraumatic stress disorder (PTSD) may facilitate identification of vulnerable individuals in the early aftermath of trauma. Variability in resting-state networks (RSNs), patterns of intrinsic functional connectivity across the brain, has previously been linked to PTSD, and may thus be informative of PTSD susceptibility. The ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2021, 46(7):1263-1271]

Cited: 3 times

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Eastern association for the surgery of trauma - quality, patient safety, and outcomes committee - transitions of care: healthcare handoffs in trauma.

Rachel Appelbaum, Shayn Martin, Glen Tinkoff, Jose L Pascual, Rajesh R Gandhi,

<h4>Background</h4>Handoffs are defined as the transfer of patient information, professional responsibility, and accountability between caregivers. This work aims to clarify the current state of transitions of care related to the management of trauma patients.<h4>Methods</h4>A PubMed database and web search were performed for articles published between 2000 and 2020 related to ... Read more >>

Am J Surg (American journal of surgery)
[2021, 222(3):521-528]

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Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.

George L Anesi, Juliane Jablonski, Michael O Harhay, Joshua H Atkins, Jasmeet Bajaj, Cameron Baston, Patrick J Brennan, Christina L Candeloro, Lauren M Catalano, Maurizio F Cereda, John M Chandler, Jason D Christie, Tara Collins, Katherine R Courtright, Barry D Fuchs, Emily Gordon, John C Greenwood, Steven Gudowski, Asaf Hanish, C William Hanson, Monica Heuer, Paul Kinniry, Zev Noah Kornfield, Gregory B Kruse, Meghan Lane-Fall, Niels D Martin, Mark E Mikkelsen, Dan Negoianu, Jose L Pascual, Maulik B Patel, Steven C Pugliese, Zaffer A Qasim, John P Reilly, John Salmon, William D Schweickert, Michael J Scott, Michael G S Shashaty, Corinna P Sicoutris, John K Wang, Wei Wang, Arshad A Wani, Brian J Anderson, Jacob T Gutsche,

<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally.<h4>Objective</h4>To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery.<h4>Design</h4>Single-health system, multihospital retrospective cohort study.<h4>Setting</h4>5 hospitals within the University of Pennsylvania Health System.<h4>Patients</h4>Adults with COVID-19-related critical illness who were admitted to ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(5):613-621]

Cited: 15 times

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Excluded but not forgotten: Veterinary emergency care during emergencies and disasters.

Niels D Martin, Jose L Pascual, Julie Hirsch, Daniel N Holena, Lewis J Kaplan,

BACKGROUND:Disasters or crises impact humans, pets, and service animals alike. Current preparation at the federal, state, and local level focuses on preserving human life. Hospitals, shelters, and other human care facilities generally make few to no provisions for companion care nor service animal care as part of their disaster management ... Read more >>

Am J Disaster Med (American journal of disaster medicine)
[2020, 15(1):25-31]

Cited: 0 times

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Increased Firearm Injury During the COVID-19 Pandemic: A Hidden Urban Burden.

Hatem O Abdallah, Cindy Zhao, Elinore Kaufman, Justin Hatchimonji, Robert A Swendiman, Lewis J Kaplan, Mark Seamon, C William Schwab, Jose L Pascual,

<h4>Background</h4>Public health measures were instituted to reduce COVID-19 spread. A decrease in total emergency department volume followed, but the impact on injury is unknown. With lockdown and social distancing potentially increasing domicile discord, we hypothesized that intentional injury increased during COVID-19, driven primarily by an increase in penetrating trauma.<h4>Study design</h4>A ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 232(2):159-168.e3]

Cited: 14 times

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Anticoagulation therapy in patients with traumatic brain injury: An Eastern Association for the Surgery of Trauma multicenter prospective study.

Kazuhide Matsushima, Stefan W Leichtle, Jeffrey Wild, Katelyn Young, Grace Chang, Demetrios Demetriades, ,

<h4>Background</h4>Trauma care providers often face a dilemma regarding anticoagulation therapy initiation in patients with traumatic brain injury owing to the associated risks of traumatic brain injury progression. The aims of this study were the following: (1) to describe the current practice of anticoagulation therapy in traumatic brain injury patients and ... Read more >>

Surgery (Surgery)
[2021, 169(2):470-476]

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A Partially Structured Postoperative Handoff Protocol Improves Communication in 2 Mixed Surgical Intensive Care Units: Findings From the Handoffs and Transitions in Critical Care (HATRICC) Prospective Cohort Study.

Meghan B Lane-Fall, Jose L Pascual, Hannah G Peifer, Laura J Di Taranti, Meredith L Collard, Juliane Jablonski, Jacob T Gutsche, Scott D Halpern, Frances K Barg, Lee A Fleisher, ,

<h4>Objective</h4>To assess the effectiveness of standardizing operating room (OR) to intensive care unit (ICU) handoffs in a mixed surgical population.<h4>Summary of background data</h4>Standardizing OR to ICU handoffs improves information transfer after cardiac surgery, but there is limited evidence in other surgical contexts.<h4>Methods</h4>This prospective interventional cohort study (NCT02267174) was conducted in ... Read more >>

Ann Surg (Annals of surgery)
[2020, 271(3):484-493]

Cited: 6 times

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Outcomes in patients with gunshot wounds to the brain.

Leigh Anna Robinson, Lauren M Turco, Bryce Robinson, Joshua G Corsa, Michael Mount, Amy V Hamrick, John Berne, Dalier R Mederos, Allison G McNickle, Paul J Chestovich, Jason Weinberger, Areg Grigorian, Jeffry Nahmias, Jane K Lee, Kevin L Chow, Erik J Olson, Jose L Pascual, Rachele Solomon, Danielle A Pigneri, Husayn A Ladhani, Joanne Fraifogl, Jeffrey Claridge, Terry Curry, Todd W Costantini, Manasnun Kongwibulwut, Haytham Kaafarani, Janika San Roman, Craig Schreiber, Anna Goldenberg-Sandau, Parker Hu, Patrick Bosarge, Rindi Uhlich, Nicole Lunardi, Farooq Usmani, Joseph Victor Sakran, Jessica M Babcock, Juan Carlos Quispe, Lawrence Lottenberg, Donna Cabral, Grace Chang, Jhoanna Gulmatico, Jonathan J Parks, Rishi Rattan, Jennifer Massetti, Onaona Gurney, Brandon Bruns, Alison A Smith, Chrissy Guidry, Matthew E Kutcher, Melissa S Logan, Michelle Y Kincaid, Chance Spalding, Matthew Noorbaksh, Frances H Philp, Benjamin Cragun, Robert D Winfield,

Introduction:Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, ... Read more >>

Trauma Surg Acute Care Open (Trauma surgery & acute care open)
[2019, 4(1):e000351]

Cited: 1 time

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An inflammatory pulmonary insult post-traumatic brain injury worsens subsequent spatial learning and neurological outcomes.

Christina L Jacovides, Syed Ahmed, Yujin Suto, Andrew J Paris, Ryan Leone, Jordan McCarry, Melpo Christofidou-Solomidou, Lewis J Kaplan, Douglas H Smith, Daniel N Holena, C William Schwab, Jose L Pascual,

<h4>Background</h4>Severe traumatic brain injury (TBI) patients are at high risk for early aspiration and pneumonia. How pneumonia impacts neurological recovery after TBI is not well characterized. We hypothesized that, independent of the cerebral injury, pneumonia after TBI delays and worsens neurological recovery and cognitive outcomes.<h4>Methods</h4>Fifteen CD1 male mice were randomized ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2019, 87(3):552-558]

Cited: 1 time

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A Statewide Assessment of Rib Fixation Patterns Reveals Missed Opportunities.

Cody L Mullens, Mark J Seamon, Adam Shiroff, Jeremy W Cannon, Lewis J Kaplan, Jose L Pascual, Daniel N Holena, Niels D Martin,

<h4>Background</h4>Rib fractures are a common consequence of traumatic injury and can result in significant debilitation. Rib fixation offers fracture stabilization, resulting in improved outcomes and decreased pulmonary complications, especially in high-risk groups such as those with flail segments. However, commercial rib fixation has only recently become clinically prevalent, and we ... Read more >>

J Surg Res (The Journal of surgical research)
[2019, 244:205-211]

Cited: 1 time

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The Location and Timing of Failure-to-Rescue Events Across a Statewide Trauma System.

Catherine E Sharoky, Niels D Martin, Brian P Smith, Jose L Pascual, Lewis J Kaplan, Patrick M Reilly, Daniel N Holena,

BACKGROUND:Failure to rescue (FTR) refers to death after a major complication. Defining the optimal context in which to reduce FTR after injury requires knowledge of where and when FTR events occur. MATERIALS AND METHODS:Retrospective observational study of patients >16 y with a minimum Abbreviated Injury Score ≥2 at all 30 ... Read more >>

J Surg Res (The Journal of surgical research)
[2019, 235:529-535]

Cited: 3 times

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Emergency response teams in and outside of medicine-structurally crafted to be worlds apart.

Joseph Fernandez-Moure, Jose L Pascual, Niels D Martin, Holly Rodgers, Lewis J Kaplan,

Medical emergency response teams (MERTs) are widespread throughout inpatient hospital care facilities. Besides the rise of the ubiquitous rapid response team, current MERTs span trauma, stroke, myocardial infarction, and sepsis in many hospitals. Given the multiplicity of teams with widely varying membership, leadership, and functionality, the structure of MERTs is ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2019, 86(1):134-140]

Cited: 0 times

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Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture.

Yujin Suto, Katsuhiro Nagata, Syed M Ahmed, Christina L Jacovides, Kevin D Browne, John Cognetti, Victoria E Johnson, Ryan Leone, Lewis J Kaplan, Douglas H Smith, Jose L Pascual,

Progression of severe traumatic brain injury (TBI) is associated with worsening cerebral inflammation, but it is unknown how a concomitant bone fracture (FX) affects this progression. Enoxaparin (ENX), a low molecular weight heparin often used for venous thromboembolic prophylaxis, decreases penumbral leukocyte (LEU) mobilization in isolated TBI and improves neurological ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2019, 36(4):609-618]

Cited: 2 times

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Emergency Laparotomy in the Critically Ill: Futility at the Bedside.

Niels D Martin, Sagar P Patel, Kristen Chreiman, Jose L Pascual, Benjamin Braslow, Patrick M Reilly, Lewis J Kaplan,

<h4>Background</h4>Critically ill patients are often evaluated for an intra-abdominal catastrophe. In the absence of a preoperative diagnosis, abdominal exploration may be offered despite desperate circumstances. We hypothesize that (1) abdominal exploration for such patients is associated with a high mortality and (2) commonly obtained physiologic measures at laparotomy anticipate mortality.<h4>Methods</h4>All ... Read more >>

Crit Care Res Pract (Critical care research and practice)
[2018, 2018:6398917]

Cited: 1 time

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A concomitant bone fracture delays cognitive recovery from traumatic brain injury.

Yujin Suto, Katsuhiro Nagata, Syed M Ahmed, Christina Jacovides, Kevin D Browne, John Cognetti, Maura T Weber, Victoria E Johnson, Ryan Leone, Lewis J Kaplan, Douglas H Smith, Jose L Pascual,

<h4>Background</h4>Brain injury progression after severe traumatic brain injury (TBI) is associated with worsening cerebral inflammation but it is unknown how a concomitant bone fracture (BF) affects this progression. Enoxaparin (ENX) decreases penumbral leukocyte mobilization after TBI and improves neurologic recovery. We hypothesized that a concomitant BF worsens learning/memory recovery weeks ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2018, 85(2):275-284]

Cited: 4 times

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Comfort at the crossroads: Service, therapy and emotional support animals in the intensive care unit and at the end-of-life.

Niels Martin, Jose L Pascual, Dennis T Tim Crowe, Christine Toevs, Maurizio F Cerada, Mark Mikkelsen, Lewis J Kaplan,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2018, 84(6):978-984]

Cited: 1 time

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Variations in institutional review board processes and consent requirements for trauma research: an EAST multicenter survey.

Jeffry Nahmias, Areg Grigorian, Scott Brakenridge, Randeep S Jawa, Daniel N Holena, John Varujan Agapian, Brandon Bruns, Paul J Chestovich, Bruce Chung, Jonathan Nguyen, Carl I Schulman, Kristan Staudenmayer, Rachel Dixon, Jason W Smith, Andrew C Bernard, Jose L Pascual,

Oversight of human subject research has evolved considerably since its inception. However, previous studies identified a lack of consistency of institutional review board (IRB) determination for the type of review required and whether informed consent is necessary, especially for prospective observational studies, which pose minimal risk of harm. We hypothesized ... Read more >>

Trauma Surg Acute Care Open (Trauma surgery & acute care open)
[2018, 3(1):e000176]

Cited: 2 times

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Developing a Standard Handoff Process for Operating Room-to-ICU Transitions: Multidisciplinary Clinician Perspectives from the Handoffs and Transitions in Critical Care (HATRICC) Study.

Meghan B Lane-Fall, Jose L Pascual, Scott Massa, Meredith L Collard, Hannah G Peifer, Laura J Di Taranti, Megan Linehan, Lee A Fleisher, Frances K Barg,

<h4>Background</h4>Operating room (OR)-to-ICU handoffs place patients at risk for preventable harm. Numerous studies have described standardized handoff procedures following cardiac surgery, but no existing literature describes a general OR-to-ICU handoff system.<h4>Methods</h4>As part of the Handoffs and Transitions in Critical Care (HATRICC) study, a postoperative handoff procedure was developed by conducting ... Read more >>

Jt Comm J Qual Patient Saf (Joint Commission journal on quality and patient safety)
[2018, 44(9):514-525]

Cited: 6 times

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