Full Text Journal Articles by
Author Jose Carlos Davila

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Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.

Juan Antonio García-León, Beatriz García-Díaz, Kristel Eggermont, Laura Cáceres-Palomo, Katrien Neyrinck, Rodrigo Madeiro da Costa, José Carlos Dávila, Anne Baron-Van Evercooren, Antonia Gutiérrez, Catherine M Verfaillie,

Oligodendrocytes (OLs) are responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). This protocol describes a method to generate oligodendrocyte precursor cells (OPCs) from human pluripotent stem cells (hPSCs) in only ~20 ... Read more >>

Nat Protoc (Nature protocols)
[2020, 15(11):3716-3744]

Cited: 3 times

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Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches.

Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Raquel Sanchez-Varo, Juan Antonio Garcia-Leon, Cristina Nuñez-Diaz, Jose Carlos Davila, Javier Vitorica, Frank M LaFerla, Ines Moreno-Gonzalez, Antonia Gutierrez, David Baglietto-Vargas,

Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biology of the human disease ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211001753]

Cited: 0 times

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Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease.

Juan Antonio Garcia-Leon, Laura Caceres-Palomo, Elisabeth Sanchez-Mejias, Marina Mejias-Ortega, Cristina Nuñez-Diaz, Juan Jose Fernandez-Valenzuela, Raquel Sanchez-Varo, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez,

Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer's disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(18):]

Cited: 7 times

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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.

Juan Jose Fernandez-Valenzuela, Raquel Sanchez-Varo, Clara Muñoz-Castro, Vanessa De Castro, Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Cristina Nuñez-Diaz, Angela Gomez-Arboledas, Ines Moreno-Gonzalez, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez,

In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to neurofibrillary pathology. AD brains also accumulate amyloid-beta (Aβ) deposits. However, the effect of microtubule stabilizing agents on Aβ pathology has ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14776]

Cited: 2 times

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SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.

Juan Antonio García-León, Manoj Kumar, Ruben Boon, David Chau, Jennifer One, Esther Wolfs, Kristel Eggermont, Pieter Berckmans, Nilhan Gunhanlar, Femke de Vrij, Bas Lendemeijer, Benjamin Pavie, Nikky Corthout, Steven A Kushner, José Carlos Dávila, Ivo Lambrichts, Wei-Shou Hu, Catherine M Verfaillie,

Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel therapies. Here, we demonstrate that overexpression of the transcription factor SOX10 is sufficient to generate surface antigen O4-positive ... Read more >>

Stem Cell Reports (Stem cell reports)
[2018, 10(2):655-672]

Cited: 15 times

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The Insulin Receptor in Astrocytes is Involved in the Entrance of Circulating Insulin into the Brain

Ana Fernandez, Navarrete, Jose Carlos Davila, Cristina Garcia-Caceres, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Matthias Tschöp, Antonia Gutierrez, Ignacio Torres Aleman,

Circulating insulin enters into the brain through mechanisms that are not yet entirely understood. We now report that mice lacking insulin receptors (IR) in astrocytes show reduced uptake of circulating insulin and blunted brain responses to this circulating hormone, suggesting that astrocytes form part of the cellular pathway in the ... Read more >>

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Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.

David Baglietto-Vargas, Elisabeth Sánchez-Mejias, Victoria Navarro, Sebastián Jimenez, Laura Trujillo-Estrada, Angela Gómez-Arboledas, Maria Sánchez-Mico, Raquel Sánchez-Varo, Marisa Vizuete, José Carlos Dávila, José Manuel García-Verdugo, Javier Vitorica, Antonia Gutierrez,

Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer's patients. In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):10085]

Cited: 11 times

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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L Hsieh, Luis M Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J Nilsson, Guy C Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierborg,

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2019, 138(2):251-273]

Cited: 38 times

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Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease

Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Yiyi Yang, Juan García-Revilla, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, Christopher Dunning, John Stegmayr, Sebastian Jiménez, Maria Angustias Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine Hsieh, Luis Miguel-Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf Nilsson, Antonia Gutierrez, Guy Brown, Javier Vitorica, Jose Luis Venero, Tomas Deierborg, ,

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, intraneuronal tau neurofibrillary tangles and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the ... Read more >>

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Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.

Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Maria Sanchez-Mico, Raquel Sanchez-Varo, Cristina Nuñez-Diaz, Laura Trujillo-Estrada, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

The role of microglial cells in the development and progression of Alzheimer's disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in contrast to the massive microglial activation observed in APP-based models. Most importantly, microglial cells displayed ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2016, 132(6):897-916]

Cited: 51 times

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Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.

Laura Trujillo-Estrada, José Carlos Dávila, Elisabeth Sánchez-Mejias, Raquel Sánchez-Varo, Angela Gomez-Arboledas, Marisa Vizuete, Javier Vitorica, Antonia Gutiérrez,

The progressive cognitive decline leading to dementia in Alzheimer's disease (AD) patients is the consequence of a severe loss of synapses and neurons affecting particular cell subpopulations in selected brain areas, with the subiculum being one of the earliest regions displaying severe atrophy and pathology. The lack of significant neuronal ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2014, 42(2):521-541]

Cited: 20 times

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Disruption of amyloid plaques integrity affects the soluble oligomers content from Alzheimer disease brains.

Sebastian Jimenez, Victoria Navarro, Javier Moyano, María Sanchez-Mico, Manuel Torres, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of soluble extracellular Abeta species, such as monomeric and/or oligomeric Abeta, seems to correlate with the clinico-pathological dysfunction observed in AD patients. However, the nature (monomeric, dimeric or other oligomers), the relative ... Read more >>

PLoS One (PloS one)
[2014, 9(12):e114041]

Cited: 12 times

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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.

Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. However, no effective disease-modifying treatment has been yet developed. In this work we have evaluated whether chronic lithium ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2013, 1:73]

Cited: 12 times

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Expression of somatostatin and neuropeptide Y in the embryonic, postnatal, and adult mouse amygdalar complex.

María Angeles Real, Raúl Heredia, María Del Carmen Labrador, José Carlos Dávila, Salvador Guirado,

Recent developmental studies indicate that distinct neuronal subpopulations in the amygdala, including somatostatin (SOM)-containing neurons, originate from progenitor domains in the anterior entopeduncular area, thus suggesting a different origin from subpallial territories for amygdalar versus cortical SOM-expressing interneurons, the latter derived from the dorsal part of the medial ganglionic eminence. ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2009, 513(4):335-348]

Cited: 23 times

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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also proposed that ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2012, 7:59]

Cited: 53 times

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Efferent retinal projections visualized by immunohistochemical detection of the estrogen-related receptor beta in the postnatal and adult mouse brain.

María Angeles Real, Raúl Heredia, José Carlos Dávila, Salvador Guirado,

Recently, a new nuclear receptor subfamily has been identified and referred to as estrogen-related receptors. This new group shares sequence similarity, target genes, co-regulatory proteins, and action sites with the estrogen receptors; however, natural estrogens are not estrogen-related receptors ligands. One of the receptors belonging to this group, estrogen-related receptor ... Read more >>

Neurosci Lett (Neuroscience letters)
[2008, 438(1):48-53]

Cited: 9 times

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Distinct immunohistochemically defined areas in the medial amygdala in the developing and adult mouse.

Salvador Guirado, M Angeles Real, José Carlos Dávila,

The medial amygdala has been considered a subpallial structure, but various studies have shown that is a somewhat complex structure expressing both pallial and subpallial gene markers. In this regard, we analyzed the immunohistochemical expression of the neurotransmitter GABA, the vesicular glutamate transporter type 2 (VGLUT2), the neuronal nitric oxide ... Read more >>

Brain Res Bull (Brain research bulletin)
[2008, 75(2-4):214-217]

Cited: 11 times

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Development and adult organization of the lateral part of the bed nucleus of the stria terminalis in the chicken.

M Angeles Real, Daniel Pineda, José Carlos Dávila, Salvador Guirado,

The lateral part of the bed nucleus of the stria terminalis (BSTL) is a component of the subpallial amygdala located near the ventral sulcus of the lateral ventricle, but its limits have not been well defined in birds. In this study, we analyzed the expression patterns of a number of ... Read more >>

Brain Res Bull (Brain research bulletin)
[2008, 75(2-4):410-413]

Cited: 6 times

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Dynamic patterns of colocalization of calbindin, parvalbumin and GABA in subpopulations of mouse basolateral amygdalar cells during development.

José Carlos Dávila, Luis Olmos, Isabel Legaz, Loreta Medina, Salvador Guirado, Maria Angeles Real,

Calbindin cells represent a major interneuron subtype of the cortical/pallial regions, such as the basolateral amygdala, which are often analyzed in studies of tangential migration of interneurons from the subpallial ganglionic eminences to the pallium/cortex. However, previous evidence suggests that during development the calbindin cells may include more than one ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2008, 35(1):67-76]

Cited: 24 times

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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

Raquel Sanchez-Varo, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Vanessa De Castro, Sebastian Jimenez, Diego Ruano, Marisa Vizuete, Jose Carlos Davila, Jose Manuel Garcia-Verdugo, Antonio Jesus Jimenez, Javier Vitorica, Antonia Gutierrez,

Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer's disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1(M146L)/APP(751SL) mice model, as the initial degenerative process underlying functional disturbance prior to neuronal loss. Neuritic ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2012, 123(1):53-70]

Cited: 95 times

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Calcium-binding proteins, neuronal nitric oxide synthase, and GABA help to distinguish different pallial areas in the developing and adult chicken. I. Hippocampal formation and hyperpallium.

Juan Suárez, José Carlos Dávila, M Angeles Real, Salvador Guirado, Loreta Medina,

To better understand the formation and adult organization of the avian pallium, we studied the expression patterns of gamma-aminobutyric acid (GABA), calbindin (CB), calretinin (CR), and neuronal nitric oxide synthase (nNOS) in the hippocampal formation and hyperpallium of developing and adult chicks. Each marker showed a specific spatiotemporal expression pattern ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2006, 497(5):751-771]

Cited: 31 times

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Immunohistochemical localization of the vesicular glutamate transporter VGLUT2 in the developing and adult mouse claustrum.

Maria Angeles Real, José Carlos Dávila, Salvador Guirado,

We studied the immunoreactive expression pattern for the vesicular glutamate transporter VGLUT2 in the embryonic, postnatal and adult mouse dorsal claustrum, at the light and electron microscopic levels. VGLUT2 immunoreactivity in the dorsal claustrum starts to be observed at E16.5, with a dramatic increase towards P0. At this age, abundant ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2006, 31(3):169-177]

Cited: 10 times

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The ascending tectofugal visual system in amniotes: new insights.

Salvador Guirado, M A Angeles Real, José Carlos Dávila,

Ascending tectal axons carrying visual information constitute a fiber pathway linking the mesencephalon with the dorsal thalamus and then with a number of telencephalic centers. The sauropsidian nucleus rotundus and its mammalian homologue(s) occupy a central position in this pathway. The aim of this study was analyzing the rotundic connections ... Read more >>

Brain Res Bull (Brain research bulletin)
[2005, 66(4-6):290-296]

Cited: 16 times

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Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex.

Isabel Legaz, Luis Olmos, M Angeles Real, Salvador Guirado, José Carlos Dávila, Loreta Medina,

We studied the development of neurons and fibers containing calbindin, calretinin, and parvalbumin in the mouse pallial amygdala, with special emphasis on those of the basolateral amygdalar complex. Numerous calbindin-immunoreactive (CB+) cells were observed in the incipient basolateral amygdalar complex and cortical amygdalar area from E13.5. At E16.5, CB+ cells ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2005, 488(4):492-513]

Cited: 33 times

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Distribution of nitric oxide-producing neurons in the developing and adult mouse amygdalar basolateral complex.

José Luis Olmos, M Angeles Real, Loreta Medina, Salvador Guirado, José Carlos Dávila,

We analysed the expression of neuronal nitric oxide synthase (nNOS) in the mouse amygdalar basolateral complex (BLC) from embryonic day 15.5 to adult, using standard immunohistochemical methods. Our results indicate that each nucleus of the amygdalar basolateral complex displays a distinct nNOS expression pattern, which is established during the ontogenesis ... Read more >>

Brain Res Bull (Brain research bulletin)
[2005, 66(4-6):465-469]

Cited: 16 times

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