Full Text Journal Articles by
Author Jorge M Blando

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Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers.

Kwang-Yu Chang, Nai-Jung Chiang, Shang-Yin Wu, Chia-Jui Yen, Shang-Hung Chen, Yu-Min Yeh, Chien-Feng Li, Xiaoxing Feng, Katherine Wu, Amanda Johnston, John S Bomalaski, Bor-Wen Wu, Jianjun Gao, Sumit K Subudhi, Ahmed O Kaseb, Jorge M Blando, Shalini S Yadav, Peter W Szlosarek, Li-Tzong Chen,

<h4>Background</h4>Pegylated arginine deiminase (ADI-PEG 20) is a metabolism-based strategy that depletes arginine, resulting in tumoral stress and cytotoxicity. Preclinically, ADI-PEG 20 modulates T-cell activity and enhances the therapeutic efficacy of programmed death-1 (PD-1) inhibition.<h4>Methods</h4>A phase 1b study, including a dose-escalation cohort and an expansion cohort, was undertaken to explore the ... Read more >>

Oncoimmunology (Oncoimmunology)
[2021, 10(1):1943253]

Cited: 0 times

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Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma.

Jianjun Gao, Neema Navai, Omar Alhalabi, Arlene Siefker-Radtke, Matthew T Campbell, Rebecca Slack Tidwell, Charles C Guo, Ashish M Kamat, Surena F Matin, John C Araujo, Amishi Y Shah, Pavlos Msaouel, Paul Corn, Jianbo Wang, John N Papadopoulos, Shalini S Yadav, Jorge M Blando, Fei Duan, Sreyashi Basu, Wenbin Liu, Yu Shen, Yuwei Zhang, Marc Daniel Macaluso, Ying Wang, Jianfeng Chen, Jianhua Zhang, Andrew Futreal, Colin Dinney, James P Allison, Sangeeta Goswami, Padmanee Sharma,

Immune checkpoint therapy is being tested in the neoadjuvant setting for patients with localized urothelial carcinoma<sup>1,2</sup>, with one study reporting data in cisplatin-ineligible patients who received anti-PD-L1 monotherapy<sup>2</sup>. The study reported that patients with bulky tumors, a known high-risk feature defined as greater than clinical T2 disease, had fewer responses, ... Read more >>

Nat Med (Nature medicine)
[2020, 26(12):1845-1851]

Cited: 8 times

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ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC.

Sangeeta Goswami, Yulong Chen, Swetha Anandhan, Peter M Szabo, Sreyashi Basu, Jorge M Blando, Wenbin Liu, Jan Zhang, Seanu Meena Natarajan, Liangwen Xiong, Baoxiang Guan, Shalini Singh Yadav, Abdel Saci, James P Allison, Matthew D Galsky, Padmanee Sharma,

Immune checkpoint therapy (ICT) can produce durable antitumor responses in metastatic urothelial carcinoma (mUCC); however, the responses are not universal. Despite multiple approvals of ICT in mUCC, we lack predictive biomarkers to guide patient selection. The identification of biomarkers may require interrogation of both the tumor mutational status and the ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(548):]

Cited: 8 times

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Characterization and Comparison of GITR Expression in Solid Tumors.

Luis Vence, Samantha L Bucktrout, Irina Fernandez Curbelo, Jorge Blando, Bevin M Smith, Ashley E Mahne, John C Lin, Terrence Park, Edward Pascua, Tao Sai, Javier Chaparro-Riggers, Sumit K Subudhi, Jorge B Scutti, Maria G Higa, Hao Zhao, Shalini S Yadav, Anirban Maitra, Ignacio I Wistuba, James P Allison, Padmanee Sharma,

<h4>Purpose</h4>Determine the differential effect of a FcγR-binding, mIgG2a anti-GITR antibody in mouse tumor models, and characterize the tumor microenvironment for the frequency of GITR expression in T-cell subsets from seven different human solid tumors.<b>Experimental Design:</b> For mouse experiments, wild-type C57BL/6 mice were subcutaneously injected with MC38 cells or B16 cells, ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(21):6501-6510]

Cited: 3 times

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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Yinghong Wang, Diana H Wiesnoski, Beth A Helmink, Vancheswaran Gopalakrishnan, Kati Choi, Hebert L DuPont, Zhi-Dong Jiang, Hamzah Abu-Sbeih, Christopher A Sanchez, Chia-Chi Chang, Edwin R Parra, Alejandro Francisco-Cruz, Gottumukkala S Raju, John R Stroehlein, Matthew T Campbell, Jianjun Gao, Sumit K Subudhi, Dipen M Maru, Jorge M Blando, Alexander J Lazar, James P Allison, Padmanee Sharma, Michael T Tetzlaff, Jennifer A Wargo, Robert R Jenq,

We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may ... Read more >>

Nat Med (Nature medicine)
[2018, 24(12):1804-1808]

Cited: 104 times

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Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

Yinghong Wang, Diana H Wiesnoski, Beth A Helmink, Vancheswaran Gopalakrishnan, Kati Choi, Hebert L DuPont, Zhi-Dong Jiang, Hamzah Abu-Sbeih, Christopher A Sanchez, Chia-Chi Chang, Edwin R Parra, Alejandro Francisco-Cruz, Gottumukkala S Raju, John R Stroehlein, Matthew T Campbell, Jianjun Gao, Sumit K Subudhi, Dipen M Maru, Jorge M Blando, Alexander J Lazar, James P Allison, Padmanee Sharma, Michael T Tetzlaff, Jennifer A Wargo, Robert R Jenq,

In the version of this article originally published, an author was missing from the author list. Alexander J. Lazar should have been included between Jorge M. Blando and James P. Allison. The author has been added to the list, and the author contributions section has been updated to include Alexander ... Read more >>

Nat Med (Nature medicine)
[2019, 25(1):188]

Cited: 0 times

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COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer.

Rachana Garg, Jorge M Blando, Carlos J Perez, Priti Lal, Michael D Feldman, Emer M Smyth, Emanuela Ricciotti, Tilo Grosser, Fernando Benavides, Marcelo G Kazanietz,

The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma. However, the effectors driving PKCε-mediated phenotypes remain poorly defined. Here, using cellular and mouse models, we showed that PKCε overexpression acts synergistically with Pten loss ... Read more >>

Oncogene (Oncogene)
[2018, 37(34):4735-4749]

Cited: 12 times

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Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway.

Rachana Garg, Jorge M Blando, Carlos J Perez, Martin C Abba, Fernando Benavides, Marcelo G Kazanietz,

PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial cancers. To date, little is known about functional interactions of PKCε with other genetic alterations, as well as the effectors contributing to its tumorigenic and metastatic phenotype. Here, we demonstrate that PKCε cooperates with the loss of ... Read more >>

Cell Rep (Cell reports)
[2017, 19(2):375-388]

Cited: 26 times

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Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

Lewis Zhichang Shi, Tihui Fu, Baoxiang Guan, Jianfeng Chen, Jorge M Blando, James P Allison, Liangwen Xiong, Sumit K Subudhi, Jianjun Gao, Padmanee Sharma,

Combination therapy with α-CTLA-4 and α-PD-1 has shown significant clinical responses in different types of cancer. However, the underlying mechanisms remain elusive. Here, combining detailed analysis of human tumour samples with preclinical tumour models, we report that concomitant blockade of CTLA-4 and PD-1 improves anti-tumour immune responses and synergistically eradicates ... Read more >>

Nat Commun (Nature communications)
[2016, 7:12335]

Cited: 37 times

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Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice.

Jorge M Blando, Steve Carbajal, Erika Abel, Linda Beltran, Claudio Conti, Susan Fischer, John DiGiovanni,

In this report, we describe the development of a transgenic mouse in which a rat probasin promoter (ARR(2)Pb) was used to direct prostate specific expression of a constitutively active form of signal transducer and activator of transcription 3 (i.e., Stat3C). ARR(2)Pb.Stat3C mice exhibited hyperplasia and prostate intraepithelial neoplasia (PIN) lesions ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2011, 13(3):254-265]

Cited: 26 times

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