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Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.

Prashant Nasa, Elie Azoulay, Arunaloke Chakrabarti, Jigeeshu V Divatia, Ravi Jain, Camilla Rodrigues, Victor D Rosenthal, Waleed Alhazzani, Yaseen M Arabi, Jan Bakker, Matteo Bassetti, Jan De Waele, George Dimopoulos, Bin Du, Sharon Einav, Laura Evans, Simon Finfer, Claude Guérin, Naomi E Hammond, Samir Jaber, Ruth M Kleinpell, Younsuck Koh, Marin Kollef, Mitchell M Levy, Flavia R Machado, Jordi Mancebo, Ignacio Martin-Loeches, Mervyn Mer, Michael S Niederman, Paolo Pelosi, Anders Perner, John V Peter, Jason Phua, Lise Piquilloud, Mathias W Pletz, Andrew Rhodes, Marcus J Schultz, Mervyn Singer, Jéan-François Timsit, Balasubramanian Venkatesh, Jean-Louis Vincent, Tobias Welte, Sheila N Myatra,

During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, :]

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Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method

Prashant Nasa, Elie Azoulay, Arunaloke Chakrabarti, Jigeeshu V Divatia, Ravi Jain, Camilla Rodrigues, Victor D Rosenthal, Waleed Alhazzani, Yaseen M Arabi, Jan Bakker, Matteo Bassetti, Jan De Waele, George Dimopoulos, Bin Du, Sharon Einav, Laura Evans, Simon Finfer, Claude Guérin, Naomi E Hammond, Samir Jaber, Ruth M Kleinpell, Younsuck Koh, Marin Kollef, Mitchell M Levy, Flavia R Machado, Jordi Mancebo, Ignacio Martin-Loeches, Mervyn Mer, Michael S Niederman, Paolo Pelosi, Anders Perner, John V Peter, Jason Phua, Lise Piquilloud, Mathias W Pletz, Andrew Rhodes, Marcus J Schultz, Mervyn Singer, Jéan-François Timsit, Balasubramanian Venkatesh, Jean-Louis Vincent, Tobias Welte, Sheila N Myatra,

During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, :]

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Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort study.

Oscar Peñuelas, Laura Del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jiménez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad, Alfonso Canabal, Ana Abella, Federico Gordo, Javier García, Jessica García Suarez, Jamil Cedeño, Basilia Martínez-Palacios, Eva Manteiga, Óscar Martínez, Rafael Blancas, Tommaso Bardi, David Pestaña, José Ángel Lorente, Alfonso Muriel, Andrés Esteban, Fernando Frutos-Vivar,

<h4>Background</h4>Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive mechanical ventilation. We aimed to estimate 180-day mortality of patients with COVID-19 requiring invasive ventilation, and to develop a predictive model for long-term ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):143]

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The central nervous system during lung injury and mechanical ventilation: a narrative review.

Guillermo M Albaiceta, Laurent Brochard, Claudia C Dos Santos, Rafael Fernández, Dimitris Georgopoulos, Timothy Girard, Amal Jubran, Josefina López-Aguilar, Jordi Mancebo, Paolo Pelosi, Yoanna Skrobik, Arnaud W Thille, Mary E Wilcox, Lluis Blanch,

Mechanical ventilation induces a number of systemic responses for which the brain plays an essential role. During the last decade, substantial evidence has emerged showing that the brain modifies pulmonary responses to physical and biological stimuli by various mechanisms, including the modulation of neuroinflammatory reflexes and the onset of abnormal ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 127(4):648-659]

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Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

Jennie Johnstone, Maureen Meade, François Lauzier, John Marshall, Erick Duan, Joanna Dionne, Yaseen M Arabi, Diane Heels-Ansdell, Lehana Thabane, Daphnee Lamarche, Michael Surette, Nicole Zytaruk, Sangeeta Mehta, Peter Dodek, Lauralyn McIntyre, Shane English, Bram Rochwerg, Tim Karachi, William Henderson, Gordon Wood, Daniel Ovakim, Margaret Herridge, John Granton, M Elizabeth Wilcox, Alberto Goffi, Henry T Stelfox, Daniel Niven, John Muscedere, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Ian Ball, Dave Nagpal, Martin Girard, Pierre Aslanian, Emmanuel Charbonney, David Williamson, Wendy Sligl, Jan Friedrich, Neill K Adhikari, François Marquis, Patrick Archambault, Kosar Khwaja, Arnold Kristof, James Kutsogiannis, Ryan Zarychanski, Bojan Paunovic, Brenda Reeve, François Lellouche, Paul Hosek, Jennifer Tsang, Alexandra Binnie, Sébastien Trop, Osama Loubani, Richard Hall, Robert Cirone, Steve Reynolds, Paul Lysecki, Eyal Golan, Rodrigo Cartin-Ceba, Robert Taylor, Deborah Cook, ,

<h4>Importance</h4>Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported.<h4>Objective</h4>To evaluate the effect of Lactobacillus rhamnosus GG on ... Read more >>

JAMA (JAMA)
[2021, 326(11):1024-1033]

Cited: 2 times

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Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol.

Chiara Robba, Giuseppe Citerio, Fabio S Taccone, Stefania Galimberti, Paola Rebora, Alessia Vargiolu, Paolo Pelosi, , ,

<h4>Introduction</h4>Mechanical ventilatory is a crucial element of acute brain injured patients' management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e047100]

Cited: 0 times

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.

Domenico Luca Grieco, Salvatore Maurizio Maggiore, Oriol Roca, Elena Spinelli, Bhakti K Patel, Arnaud W Thille, Carmen Sílvia V Barbas, Marina Garcia de Acilu, Salvatore Lucio Cutuli, Filippo Bongiovanni, Marcelo Amato, Jean-Pierre Frat, Tommaso Mauri, John P Kress, Jordi Mancebo, Massimo Antonelli,

The role of non-invasive respiratory support (high-flow nasal oxygen and noninvasive ventilation) in the management of acute hypoxemic respiratory failure and acute respiratory distress syndrome is debated. The oxygenation improvement coupled with lung and diaphragm protection produced by non-invasive support may help to avoid endotracheal intubation, which prevents the complications ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(8):851-866]

Cited: 3 times

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Lower Vt and Prone Position: Quo Vadis?

Claude Guérin, Jordi Mancebo,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(11):1333-1334]

Cited: 0 times

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Long-Term Survival of Mechanically Ventilated Patients with Severe COVID-19: An Observational Cohort Study

Oscar Penuelas, Laura del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jimenez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad, Alfonso Canabal, Ana Abella, Federico Gordo, Javier García, Jessica García Suarez, Jamil Cedeño, Basilia Martínez-Palacios, Eva Manteiga, Óscar Martínez, Rafael Blancas, Tommaso Bardi, David Pestaña, José Ángel Lorente, Alfonso Muriel, Andrés Esteban, Fernando Frutos-Vivar,

<h4>Background: </h4> Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive mechanical ventilation. We aimed to estimate 90-day and 180-day survival of patients with COVID-19 requiring invasive ventilation and to develop a ... Read more >>

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 13 times

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Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score.

Juan Berenguer, Alberto M Borobia, Pablo Ryan, Jesús Rodríguez-Baño, Jose M Bellón, Inmaculada Jarrín, Jordi Carratalà, Jerónimo Pachón, Antonio J Carcas, María Yllescas, José R Arribas, ,

<h4>Objective</h4>To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.<h4>Design</h4>Multivariable prognostic prediction model.<h4>Setting</h4>127 Spanish hospitals.<h4>Participants</h4>Derivation (DC) and external validation (VC) cohorts were obtained from multicentre and single-centre databases, including 4035 and 2126 patients with confirmed COVID-19, respectively.<h4>Interventions</h4>Prognostic variables were identified using multivariable logistic ... Read more >>

Thorax (Thorax)
[2021, 76(9):920-929]

Cited: 7 times

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Automated detection and quantification of reverse triggering effort under mechanical ventilation.

Tài Pham, Jaume Montanya, Irene Telias, Thomas Piraino, Rudys Magrans, Rémi Coudroy, L Felipe Damiani, Ricard Mellado Artigas, Matías Madorno, Lluis Blanch, Laurent Brochard, ,

<h4>Background</h4>Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is challenging. Magnitude of effort generated by RT is currently unknown. Our objective was to validate supervised methods for automatic ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):60]

Cited: 0 times

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Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus.

Chiara Robba, Daniele Poole, Molly McNett, Karim Asehnoune, Julian Bösel, Nicolas Bruder, Arturo Chieregato, Raphael Cinotti, Jacques Duranteau, Sharon Einav, Ari Ercole, Niall Ferguson, Claude Guerin, Ilias I Siempos, Pedro Kurtz, Nicole P Juffermans, Jordi Mancebo, Luciana Mascia, Victoria McCredie, Nicolas Nin, Mauro Oddo, Paolo Pelosi, Alejandro A Rabinstein, Ary Serpa Neto, David B Seder, Markus B Skrifvars, Jose I Suarez, Fabio Silvio Taccone, Mathieu van der Jagt, Giuseppe Citerio, Robert D Stevens,

<h4>Purpose</h4>To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute brain injury (ABI).<h4>Methods</h4>An international consensus panel was convened including 29 clinician-scientists in intensive care medicine with expertise in acute respiratory failure, neurointensive care, or both, and two non-voting methodologists. The ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2397-2410]

Cited: 10 times

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Prone position in ARDS patients: why, when, how and for whom.

Claude Guérin, Richard K Albert, Jeremy Beitler, Luciano Gattinoni, Samir Jaber, John J Marini, Laveena Munshi, Laurent Papazian, Antonio Pesenti, Antoine Vieillard-Baron, Jordi Mancebo,

In ARDS patients, the change from supine to prone position generates a more even distribution of the gas-tissue ratios along the dependent-nondependent axis and a more homogeneous distribution of lung stress and strain. The change to prone position is generally accompanied by a marked improvement in arterial blood gases, which ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2385-2396]

Cited: 24 times

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The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline.

Bram Rochwerg, Sharon Einav, Dipayan Chaudhuri, Jordi Mancebo, Tommaso Mauri, Yigal Helviz, Ewan C Goligher, Samir Jaber, Jean-Damien Ricard, Nuttapol Rittayamai, Oriol Roca, Massimo Antonelli, Salvatore Maurizio Maggiore, Alexandre Demoule, Carol L Hodgson, Alain Mercat, M Elizabeth Wilcox, David Granton, Dominic Wang, Elie Azoulay, Lamia Ouanes-Besbes, Gilda Cinnella, Michela Rauseo, Carlos Carvalho, Armand Dessap-Mekontso, John Fraser, Jean-Pierre Frat, Charles Gomersall, Giacomo Grasselli, Gonzalo Hernandez, Sameer Jog, Antonio Pesenti, Elisabeth D Riviello, Arthur S Slutsky, Renee D Stapleton, Daniel Talmor, Arnaud W Thille, Laurent Brochard, Karen E A Burns,

<h4>Purpose</h4>High flow nasal cannula (HFNC) is a relatively recent respiratory support technique which delivers high flow, heated and humidified controlled concentration of oxygen via the nasal route. Recently, its use has increased for a variety of clinical indications. To guide clinical practice, we developed evidence-based recommendations regarding use of HFNC ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2226-2237]

Cited: 21 times

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How to ventilate obstructive and asthmatic patients.

Alexandre Demoule, Laurent Brochard, Martin Dres, Leo Heunks, Amal Jubran, Franco Laghi, Armand Mekontso-Dessap, Stefano Nava, Lamia Ouanes-Besbes, Oscar Peñuelas, Lise Piquilloud, Theodoros Vassilakopoulos, Jordi Mancebo,

Exacerbations are part of the natural history of chronic obstructive pulmonary disease and asthma. Severe exacerbations can cause acute respiratory failure, which may ultimately require mechanical ventilation. This review summarizes practical ventilator strategies for the management of patients with obstructive airway disease. Such strategies include non-invasive mechanical ventilation to prevent ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2436-2449]

Cited: 0 times

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Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial.

Tommaso Mauri, Giuseppe Foti, Carla Fornari, Giacomo Grasselli, Riccardo Pinciroli, Federica Lovisari, Daniela Tubiolo, Carlo Alberto Volta, Savino Spadaro, Roberto Rona, Egle Rondelli, Paolo Navalesi, Eugenio Garofalo, Rihard Knafelj, Vojka Gorjup, Riccardo Colombo, Andrea Cortegiani, Jian-Xin Zhou, Rocco D'Andrea, Italo Calamai, Ánxela Vidal González, Oriol Roca, Domenico Luca Grieco, Tomas Jovaisa, Dimitrios Bampalis, Tobias Becher, Denise Battaglini, Huiqing Ge, Mariana Luz, Jean-Michel Constantin, Marco Ranieri, Claude Guerin, Jordi Mancebo, Paolo Pelosi, Roberto Fumagalli, Laurent Brochard, Antonio Pesenti, ,

<h4>Background</h4>Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant.<h4>Research question</h4>Is the clinical application of sigh during pressure support ventilation (PSV) feasible?<h4>Study design and methods</h4>We ... Read more >>

Chest (Chest)
[2021, 159(4):1426-1436]

Cited: 1 time

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High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis.

David Granton, Dipayan Chaudhuri, Dominic Wang, Sharon Einav, Yigal Helviz, Tommaso Mauri, Jordi Mancebo, Jean-Pierre Frat, Sameer Jog, Gonzalo Hernandez, Salvatore M Maggiore, Carol L Hodgson, Samir Jaber, Laurent Brochard, Vatsal Trivedi, Jean-Damien Ricard, Ewan C Goligher, Karen E A Burns, Bram Rochwerg,

<h4>Objectives</h4>Reintubation after failed extubation is associated with increased mortality and longer hospital length of stay. Noninvasive oxygenation modalities may prevent reintubation. We conducted a systematic review and meta-analysis to determine the safety and efficacy of high-flow nasal cannula after extubation in critically ill adults.<h4>Data sources</h4>We searched MEDLINE, EMBASE, and Web ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):e1129-e1136]

Cited: 8 times

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Lung- and Diaphragm-Protective Ventilation.

Ewan C Goligher, Martin Dres, Bhakti K Patel, Sarina K Sahetya, Jeremy R Beitler, Irene Telias, Takeshi Yoshida, Katerina Vaporidi, Domenico Luca Grieco, Tom Schepens, Giacomo Grasselli, Savino Spadaro, Jose Dianti, Marcelo Amato, Giacomo Bellani, Alexandre Demoule, Eddy Fan, Niall D Ferguson, Dimitrios Georgopoulos, Claude Guérin, Robinder G Khemani, Franco Laghi, Alain Mercat, Francesco Mojoli, Coen A C Ottenheijm, Samir Jaber, Leo Heunks, Jordi Mancebo, Tommaso Mauri, Antonio Pesenti, Laurent Brochard,

Mechanical ventilation can cause acute diaphragm atrophy and injury, and this is associated with poor clinical outcomes. Although the importance and impact of lung-protective ventilation is widely appreciated and well established, the concept of diaphragm-protective ventilation has recently emerged as a potential complementary therapeutic strategy. This Perspective, developed from discussions ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(7):950-961]

Cited: 17 times

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Ventilator Sharing during Shortages. A Siren's Song?

Jordi Mancebo, Jean-Christophe Richard, Laurent Brochard,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(4):490-491]

Cited: 3 times

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Invasive Mechanical Ventilation in Chronic Obstructive Pulmonary Disease Exacerbations.

Óscar Peñuelas, Fernando Frutos-Vivar, Jordi Mancebo,

Chronic obstructive pulmonary disease (COPD) continues to be an important cause of morbidity, mortality, and health care costs worldwide. Although there exist some heterogeneity between patients, the course of COPD is characterized by recurrent acute exacerbations, which are among the most common causes of medical admission to hospital. Patients with ... Read more >>

Semin Respir Crit Care Med (Seminars in respiratory and critical care medicine)
[2020, 41(6):798-805]

Cited: 0 times

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What's new about pulmonary hyperinflation in mechanically ventilated critical patients.

Theodoros Vassilakopoulos, Dimitrios Toumpanakis, Jordi Mancebo,

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2381-2384]

Cited: 1 time

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Bronchoscopy in Patients with COVID-19 with Invasive Mechanical Ventilation: A Single-Center Experience.

Alfons Torrego, Virginia Pajares, Carmen Fernández-Arias, Paula Vera, Jordi Mancebo,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(2):284-287]

Cited: 26 times

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