Full Text Journal Articles by
Author Jordan M Symons

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Healthcare recommendations for Joubert syndrome.

Ruxandra Bachmann-Gagescu, Jennifer C Dempsey, Sara Bulgheroni, Maida L Chen, Stefano D'Arrigo, Ian A Glass, Theo Heller, Elise Héon, Friedhelm Hildebrandt, Nirmal Joshi, Dana Knutzen, Hester Y Kroes, Stephen H Mack, Sara Nuovo, Melissa A Parisi, Joseph Snow, Angela C Summers, Jordan M Symons, Wadih M Zein, Eugen Boltshauser, John A Sayer, Meral Gunay-Aygun, Enza Maria Valente, Dan Doherty,

Joubert syndrome (JS) is a recessive neurodevelopmental disorder defined by a characteristic cerebellar and brainstem malformation recognizable on axial brain magnetic resonance imaging as the "Molar Tooth Sign". Although defined by the neurological features, JS is associated with clinical features affecting many other organ systems, particularly progressive involvement of the ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2020, 182(1):229-249]

Cited: 0 times

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

Cited: 0 times

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Paediatric acute kidney injury: can we match therapy with resources around the world?

Akash Deep, Jordan M Symons, Mignon McCulloch,

Intensive Care Med (Intensive care medicine)
[2019, 45(1):86-88]

Cited: 0 times

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C septicum Complicating Hemolytic Uremic Syndrome: Survival Without Surgical Intervention.

Rachel M Engen, Elizabeth Y Killien, Jessica L Davis, Jordan M Symons, Silvia M Hartmann,

Clostridium septicum is an anaerobic bacterium that causes rapidly progressive myonecrosis, bacteremia, and central nervous system infection. It has been reported as a complication of Escherichia coli hemolytic uremic syndrome (HUS) in 8 children worldwide; 5 children died, and the 3 reported survivors had surgically treated disease. We present 3 ... Read more >>

Pediatrics (Pediatrics)
[2017, 139(3):]

Cited: 1 time

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Acute kidney injury.

David T Selewski, Jordan M Symons,

Pediatr Rev (Pediatrics in review)
[2014, 35(1):30-41]

Cited: 5 times

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Pediatric nephrologists' beliefs regarding randomized controlled trials.

Aaron G Wightman, Assaf P Oron, Jordan M Symons, Joseph T Flynn,

Pediatrics and pediatric nephrology lag behind adult medicine in producing randomized controlled trials (RCTs). Physician attitudes have been shown to play a significant role in RCT enrollment.We surveyed members of the American Society of Pediatric Nephrology regarding beliefs about RCTs and factors influencing decisions to recommend RCT enrollment. Regression analyses ... Read more >>

J. Investig. Med. (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2014, 62(1):84-87]

Cited: 0 times

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Moving beyond supportive care--current status of specific therapies in pediatric acute kidney injury.

Jordan M Symons,

Acute kidney injury (AKI) remains a significant challenge, leading to increased morbidity, mortality, and medical costs. Therapy for AKI to this point has largely been supportive; specific interventions to treat established AKI have had minimal effect. Review of the pathogenesis of AKI reveals complex, interacting mechanisms, including changes in microcirculation, ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2014, 29(2):173-181]

Cited: 3 times

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Nonrenal indications for continuous renal replacement therapy: A report from the Prospective Pediatric Continuous Renal Replacement Therapy Registry Group.

Geoffrey M Fleming, Scott Walters, Stuart L Goldstein, Steven R Alexander, Michelle A Baum, Douglas L Blowey, Timothy E Bunchman, Annabelle N Chua, Sarah A Fletcher, Francisco X Flores, James D Fortenberry, Richard Hackbarth, Kevin McBryde, Michael J G Somers, Jordan M Symons, Patrick D Brophy, ,

OBJECTIVE: Continuous renal replacement therapy is the most often implemented dialysis modality in the pediatric intensive care unit setting for patients with acute kidney injury. However, it also has a role in the management of patients with nonrenal indications such as clearance of drugs and intermediates of disordered cellular metabolism. ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2012, 13(5):e299-304]

Cited: 11 times

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Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry.

Scott M Sutherland, Michael Zappitelli, Steven R Alexander, Annabelle N Chua, Patrick D Brophy, Timothy E Bunchman, Richard Hackbarth, Michael J G Somers, Michelle Baum, Jordan M Symons, Francisco X Flores, Mark Benfield, David Askenazi, Deepa Chand, James D Fortenberry, John D Mahan, Kevin McBryde, Douglas Blowey, Stuart L Goldstein,

BACKGROUND: Critically ill children with hemodynamic instability and acute kidney injury often develop fluid overload. Continuous renal replacement therapy (CRRT) has emerged as a favored modality in the management of such children. This study investigated the association between fluid overload and mortality in children receiving CRRT. STUDY DESIGN: Prospective observational ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2010, 55(2):316-325]

Cited: 234 times

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Acute kidney injury: can we improve prognosis?

Christine W Hsu, Jordan M Symons,

The incidence of pediatric acute kidney injury (AKI) is increasing. AKI has been found to be independently associated with increased mortality, and current management options are limited in that they are mainly supportive. The use of various definitions of AKI can still be found in the literature, making it difficult ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2010, 25(12):2401-2412]

Cited: 19 times

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Acute kidney injury and dialysis in children: illustrative cases.

Jordan M Symons, Stefano Picca,

Pediatric nephrologists and critical care physicians are faced with a heterogeneous patient population with varied epidemiology caring for children with acute kidney injury or other diseases that may require renal replacement therapy provision. We have composed 4 detailed case scenarios to highlight the challenges and interdisciplinary approach required for optimal ... Read more >>

Semin. Nephrol. (Seminars in nephrology)
[2008, 28(5):431-435]

Cited: 4 times

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Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group.

Francisco X Flores, Patrick D Brophy, Jordan M Symons, James D Fortenberry, Annabelle N Chua, Steven R Alexander, John D Mahan, Timothy E Bunchman, Douglas Blowey, Michael J G Somers, Michelle Baum, Richard Hackbarth, Deepa Chand, Kevin McBryde, Mark Benfield, Stuart L Goldstein,

Pediatric stem cell transplant (SCT) recipients commonly develop acute renal failure (ARF). We report the demographic and survival data of pediatric SCT patients enrolled in the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry. Since 1 January 2001, 51/370 (13.8%) patients entered in the ppCRRT Registry had received a SCT. ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2008, 23(4):625-630]

Cited: 44 times

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Protein and calorie prescription for children and young adults receiving continuous renal replacement therapy: a report from the Prospective Pediatric Continuous Renal Replacement Therapy Registry Group.

Michael Zappitelli, Stuart L Goldstein, Jordan M Symons, Michael J G Somers, Michelle A Baum, Patrick D Brophy, Douglas Blowey, James D Fortenberry, Annabelle N Chua, Francisco X Flores, Mark R Benfield, Steven R Alexander, David Askenazi, Richard Hackbarth, Timothy E Bunchman, ,

OBJECTIVE: Few published reports describe nutrition provision for critically ill children and young adults with acute kidney injury receiving continuous renal replacement therapy. The goals of this study were to describe feeding practices in pediatric continuous renal replacement therapy and to evaluate factors associated with over- and under-prescription of protein ... Read more >>

Crit. Care Med. (Critical care medicine)
[2008, 36(12):3239-3245]

Cited: 20 times

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Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry.

Jordan M Symons, Annabelle N Chua, Michael J G Somers, Michelle A Baum, Timothy E Bunchman, Mark R Benfield, Patrick D Brophy, Douglas Blowey, James D Fortenberry, Deepa Chand, Francisco X Flores, Richard Hackbarth, Steven R Alexander, John Mahan, Kevin D McBryde, Stuart L Goldstein,

BACKGROUND: This article reports demographic characteristics and intensive care unit survival for 344 patients from the Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry, a voluntary multicenter observational network. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Ages were newborn to 25 yr, 58% were male, and weights were 1.3 to 160 kg. ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2007, 2(4):732-738]

Cited: 101 times

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Effect of fluid overload and dose of replacement fluid on survival in hemofiltration.

Robert S Gillespie, Kristy Seidel, Jordan M Symons,

Continuous renal replacement therapy (CRRT) is used to treat renal failure in children. Despite widespread use of the technique, little research has evaluated how variations in dose of replacement fluid or degree of fluid overload at initiation relate to outcomes. We conducted a retrospective review of patients treated with convective ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2004, 19(12):1394-1399]

Cited: 106 times

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Sodium ferric gluconate for post-transplant anemia in pediatric and young adult renal transplant recipients.

Robert S Gillespie, Jordan M Symons,

Post-transplant anemia is a widespread problem among pediatric renal transplant recipients. Many clinicians treat post-transplant anemia in a manner similar to treatment of anemia in dialysis patients, including the use of intravenous iron, such as sodium ferric gluconate (SFG). Data on pediatric dosing of SFG are limited to rare small ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2005, 9(1):43-46]

Cited: 6 times

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Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy.

Stuart L Goldstein, Michael J G Somers, Michelle A Baum, Jordan M Symons, Patrick D Brophy, Douglas Blowey, Timothy E Bunchman, Cheryl Baker, Theresa Mottes, Nancy McAfee, Joni Barnett, Gloria Morrison, Kristine Rogers, James D Fortenberry,

BACKGROUND: Critical illness leading to multi-organ dysfunction syndrome (MODS) and associated acute renal failure (ARF) is less common in children compared to adult patients. As a result, many issues plague the pediatric ARF outcome literature, including a relative lack of prospective study, a lack of modality stratification in subject populations ... Read more >>

Kidney Int. (Kidney international)
[2005, 67(2):653-658]

Cited: 209 times

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Multi-centre evaluation of anticoagulation in patients receiving continuous renal replacement therapy (CRRT).

Patrick D Brophy, Michael J G Somers, Michelle A Baum, Jordan M Symons, Nancy McAfee, James D Fortenberry, Kristine Rogers, Joni Barnett, Douglas Blowey, Cheryl Baker, Timothy E Bunchman, Stuart L Goldstein,

BACKGROUND: Heparin (hepACG) and regional citrate anticoagulation (citACG) remain the most commonly reported continuous renal replacement therapy (CRRT) ACG methods employed. No prospective multi-centre published data exist that compare different ACG methods with respect to CRRT filter life span or patient complications. METHODS: A total of 138 patients from seven ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2005, 20(7):1416-1421]

Cited: 79 times

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Nephrotic syndrome in the newborn.

Laura S Finn, Jordan M Symons, Jodi M Smith,

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2003, 42(6):1318-1323]

Cited: 2 times

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Peritonitis due to Leuconostoc species in a child receiving peritoneal dialysis.

Robert S Gillespie, Jordan M Symons, Ruth A McDonald,

Leuconostoc species are rarely pathogenic in humans, but may cause infection in patients at risk. A 7-year-old girl with p-ANCA-positive crescentic glomerulonephritis, treated with peritoneal dialysis, developed peritonitis due to Leuconostoc species. She had a history of treatment with vancomycin and a brief course of immunosuppressive therapy. The peritonitis responded ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2002, 17(11):966-968]

Cited: 6 times

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A nurse-led education and direct access service for the management of urinary tract infections in children: prospective controlled trial.

Jordan M Symons,

J. Pediatr. (The Journal of pediatrics)
[2004, 144(3):405]

Cited: 0 times

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Nephrotic syndrome in childhood.

Allison A Eddy, Jordan M Symons,

Childhood nephrotic syndromes are most commonly caused by one of two idiopathic diseases: minimal-change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS). A third distinct type, membranous nephropathy, is rare in children. Other causes of isolated nephrotic syndrome can be subdivided into two major categories: rare genetic disorders, and secondary ... Read more >>

Lancet (Lancet (London, England))
[2003, 362(9384):629-639]

Cited: 280 times

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Continuous renal replacement therapy in children up to 10 kg.

Jordan M Symons, Patrick D Brophy, Melissa J Gregory, Nancy McAfee, Michael J G Somers, Timothy E Bunchman, Stuart L Goldstein,

BACKGROUND:There is growing use of continuous renal replacement therapy (CRRT) for pediatric patients, but no large studies reporting CRRT use and outcome in young children. We describe a cohort of patients weighing 10 kg or less who underwent CRRT at five US children's hospitals between 1993 and 2001. METHODS:We reviewed ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2003, 41(5):984-989]

Cited: 45 times

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