Full Text Journal Articles by
Author Jordan J Baker

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Peroxisome compartmentalization of a toxic enzyme improves alkaloid production.

Parbir S Grewal, Jennifer A Samson, Jordan J Baker, Brian Choi, John E Dueber,

Eukaryotic cells compartmentalize metabolic pathways in organelles to achieve optimal reaction conditions and avoid crosstalk with cytosolic factors. We found that cytosolic expression of norcoclaurine synthase (NCS), the enzyme that catalyzes the first committed reaction in benzylisoquinoline alkaloid biosynthesis, is toxic in Saccharomyces cerevisiae and, consequently, restricts (S)-reticuline production. We ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning.

Jordan J Baker, Dana McDaniel, David Cain, Paula Lee Tao, Charlene Li, Yuting Huang, Hongbin Liu, Judith Zhu-Shimoni, Milady Niñonuevo,

Bispecific antibodies are regarded as the next generation of therapeutic modalities as they can simultaneously bind multiple targets, increasing the efficacy of treatments for several diseases and opening up previously unattainable treatment designs. Linking two half antibodies to form the knob-into-hole bispecific antibody requires an additional in vitro assembly step, ... Read more >>

Anal. Chem. (Analytical chemistry)
[2019, 91(1):965-976]

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Microfluidic bubbler facilitates near complete mass transfer for sustainable multiphase and microbial processing.

Jordan J Baker, Francesca Crivellari, Zachary Gagnon, Michael J Betenbaugh,

A microfluidic device (channels <70 μm) was utilized to create micro-scale bubbles to significantly increase mass transfer efficiency at low flow rates. The convergence of one gas and two liquid channels at a Y-junction generates bubbles via cyclic changes in pressure. At low flow rates, the bubbles had an average diameter ... Read more >>

Biotechnol. Bioeng. (Biotechnology and bioengineering)
[2016, 113(9):1924-1933]

Cited: 1 time

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